Mads Dam Lyhne, Andrew Liteplo, Alona Muzikansky, Christopher Kabrhel, David M Dudzinski
{"title":"Association and discrimination of TAPSE and S' for short-term outcomes in acute pulmonary embolism.","authors":"Mads Dam Lyhne, Andrew Liteplo, Alona Muzikansky, Christopher Kabrhel, David M Dudzinski","doi":"10.1093/ehjacc/zuag081","DOIUrl":"10.1093/ehjacc/zuag081","url":null,"abstract":"","PeriodicalId":11861,"journal":{"name":"European Heart Journal: Acute Cardiovascular Care","volume":" ","pages":"706-708"},"PeriodicalIF":7.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PRAGUE-26 in perspective: convincing early stabilization, but durable benefit remains unproven.","authors":"Johannes Grand, David A Morrow","doi":"10.1093/ehjacc/zuag119","DOIUrl":"10.1093/ehjacc/zuag119","url":null,"abstract":"","PeriodicalId":11861,"journal":{"name":"European Heart Journal: Acute Cardiovascular Care","volume":" ","pages":"709-711"},"PeriodicalIF":7.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hans C Helseth, Pedro Mansur, Mazen El-Baba, Jesse T T McLaren, José Nunes de Alencar, Stephen W Smith
{"title":"Electrocardiographic Principles for the Diagnosis of Occlusion Myocardial Infarction.","authors":"Hans C Helseth, Pedro Mansur, Mazen El-Baba, Jesse T T McLaren, José Nunes de Alencar, Stephen W Smith","doi":"10.1093/ehjacc/zuag114","DOIUrl":"https://doi.org/10.1093/ehjacc/zuag114","url":null,"abstract":"<p><p>The ECG is the only rapid, noninvasive diagnostic test that can identify coronary occlusion warranting reperfusion therapy at the bedside. The diagnostic paradigm of STEMI/NSTEMI is based on millimeter ST Elevation (STE) criteria as stated in the 4th Universal Definition of MI. It has identified candidates for emergent reperfusion for decades, but is limited by the low sensitivity and specificity of STE for acute coronary occlusion. A paradigm shift to Occlusion MI/Non-Occlusion MI (OMI/NOMI) has been proposed in response. Although the ECG is not embedded in the OMI/NOMI nomenclature as it is in STEMI/NSTEMI, it remains critical to the initial diagnosis of OMI. This review outlines six principles, dynamicity, acuteness, reciprocity, proportionality, totality, and surrogacy, that organize expert interpretation of the ischemic ECG and are essential to the electrocardiographic diagnosis of OMI. Each is drawn from established scholarship; the contribution here is their integration into one framework linked to coronary pathology.</p>","PeriodicalId":11861,"journal":{"name":"European Heart Journal: Acute Cardiovascular Care","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Zhou, Burcu Tas Özbek, Jasmine Melissa Marquard, Utsho Islam, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Dan Eik Høfsten, Ashkan Eftekhari, Kasper Kyhl, Christoffer Göransson, Lars Køber, Lene Holmvang, Frants Pedersen, Henning Kelbæk, Niels Vejlstrup, Jacob Thomsen Lønborg, Thomas Engstrøm
{"title":"Complete revascularization according to age in patients with ST-segment elevation myocardial infarction and multivessel disease: 10-year outcome from the DANAMI-3-PRIMULTI trial.","authors":"Yan Zhou, Burcu Tas Özbek, Jasmine Melissa Marquard, Utsho Islam, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Dan Eik Høfsten, Ashkan Eftekhari, Kasper Kyhl, Christoffer Göransson, Lars Køber, Lene Holmvang, Frants Pedersen, Henning Kelbæk, Niels Vejlstrup, Jacob Thomsen Lønborg, Thomas Engstrøm","doi":"10.1093/ehjacc/zuag112","DOIUrl":"https://doi.org/10.1093/ehjacc/zuag112","url":null,"abstract":"<p><strong>Aims: </strong>The benefit of complete revascularization after primary percutaneous coronary intervention (PCI) is well established in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease, but the long-term effect in older patients remains uncertain. We aimed to evaluate the 10-year outcome of complete revascularization in older patients (aged ≥75 years) compared with younger patients.</p><p><strong>Methods and results: </strong>Patients with STEMI and multivessel disease were randomized to either culprit-only or fractional flow reserve-guided complete revascularization in the DANAMI-3-PRIMULTI trial. This long-term sub-study stratified the included 627 patients by <75 years (517) and ≥75 years (110). The primary outcome was a composite of all-cause mortality, recurrent myocardial infarction, or any revascularization occurring during a median follow-up of 10.5 years. Of the older patients, 50 underwent complete and 60 culprit-only revascularization, and of the younger patients, 264 were completely revascularized compared to 253 who had culprit-only PCI performed.In the older group, complete revascularization showed no association with the primary outcome (adjusted hazard ratio [HR] 1.29, 95% confidence interval [CI]: 0.82-2.03, P = 0.27). In contrast, complete revascularization was associated with a lower risk of the primary outcome (adjusted HR 0.68, 95% CI: 0.53-0.88, P = 0.003) in younger patients, primarily driven by a reduction in any revascularization (adjusted HR 0.60, 95% CI: 0.44-0.83, P = 0.002.</p><p><strong>Conclusion: </strong>In patients aged ≥75 years, clear evidence of a long-term (10 years) benefit of complete revascularization was not demonstrated. However, the elderly subgroup was small with limited events, and the finding should be interpreted as inconclusive. In contrast, complete revascularization was associated with a 32% lower risk of adverse outcomes among younger patients, primarily driven by a reduction in repeat revascularization, without evidence of reduced all-cause death or recurrent myocardial infarction.</p>","PeriodicalId":11861,"journal":{"name":"European Heart Journal: Acute Cardiovascular Care","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}