Environmental Health and Toxicology最新文献_第5页

The exposome and the future of epidemiology: a vision and prospect. 暴露与流行病学的未来:远景与展望。

Environmental Health and Toxicology Pub Date : 2017-05-03 eCollection Date: 2017-01-01 DOI: 10.5620/eht.e2017009

Kyoung-Nam Kim, Yun-Chul Hong

{"title":"The exposome and the future of epidemiology: a vision and prospect.","authors":"Kyoung-Nam Kim, Yun-Chul Hong","doi":"10.5620/eht.e2017009","DOIUrl":"https://doi.org/10.5620/eht.e2017009","url":null,"abstract":"It is widely accepted that a relatively small proportion of chronic disease can be explained by genetic factors alone. Although information about environmental exposure is important to comprehensively evaluate chronic diseases, this information is not sufficiently or accurately assessed by comparison with genomic factors. To emphasize the importance of more complete evaluation of environmental exposure, the concept of the exposome, which indicates the entirety of environmental exposure from conception onwards, was introduced in 2005. Since the 2010s several epidemiological studies, such as the Human Early-Life Exposome project, have applied the exposome concept. The exposome consists of three overlapping domains: the general external, the specific external, and the internal environments. General external factors include the broader socioeconomic environment, and specific external factors include lifestyles, occupations, and pollutant exposures. Internal factors include biological effects and responses. Because the exposome covers exposures from conception to death, the birth cohort is an important part of the exposome study. Although there is not yet an established consensus in selecting what, when, and where to measure concerning the exposome, the use of omics analyses, especially analysis of the metabolome, should be considered in order to implement the exposome concept in the birth cohort. The exposome needs to be measured repeatedly in certain important phases of life, such as during pregnancy and infancy. To perform exposome-informed epidemiological studies, untargeted data-driven approaches in conjunction with dimension reduction techniques need to be developed and refined. The exposome concept has the potential to make a breakthrough in overcoming some of the limitations of conventional epidemiology. Concerted national and international efforts are required for future exposome studies.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/6e/eht-32-e2017009.PMC5575673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34986592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Thank you for our reviewers of 2016 Environmental Health and Toxicology 感谢我们2016年《环境健康与毒理学》的审稿人

Environmental Health and Toxicology Pub Date : 2017-04-25 DOI: 10.5620/eht.2017008

M. Ha

引用次数: 0

Accelerated ecotoxicity of photoreactive nanoparticles on Moina macrocopa. 光反应纳米颗粒对大月牙蛾的加速生态毒性研究。

Environmental Health and Toxicology Pub Date : 2017-03-22 eCollection Date: 2017-01-01 DOI: 10.5620/eht.e2017007

Sun-Hwa Nam, Yu-Jin Shin, Youn-Joo An

引用次数: 5

Study of the removal difference in indoor particulate matter and volatile organic compounds through the application of plants. 应用植物对室内颗粒物和挥发性有机物去除差异的研究。

Environmental Health and Toxicology Pub Date : 2017-02-22 eCollection Date: 2017-01-01 DOI: 10.5620/eht.e2017006

Seung-Han Hong, Jiyeon Hong, Jihyeon Yu, Youngwook Lim

引用次数: 8

Are children with asthma in South Korea also associated with vitamin D deficiency? 韩国哮喘儿童是否也与维生素D缺乏有关?

Environmental Health and Toxicology Pub Date : 2017-02-14 eCollection Date: 2017-01-01 DOI: 10.5620/eht.e2017005

Yu-Ri Kim, Sung Chul Seo, Young Yoo, Ji Tae Choung

{"title":"Are children with asthma in South Korea also associated with vitamin D deficiency?","authors":"Yu-Ri Kim, Sung Chul Seo, Young Yoo, Ji Tae Choung","doi":"10.5620/eht.e2017005","DOIUrl":"https://doi.org/10.5620/eht.e2017005","url":null,"abstract":"Recently, epidemiologic studies have shown that the lack of serum vitamin D levels may be associated with high asthma prevalence, but its effect is still controversial, depending on season, area, and food consumption. We aimed to examine the association of serum vitamin D levels with the prevalence of pediatric asthma in Korea. A total of 80 children (50 asthmatic children and 30 healthy controls) aged 6-14 years were participated in this study. Serum vitamin D levels were measured and compared between the two groups. Moreover, the relationship of serum vitamin D levels with results of pulmonary function test and environmental factors (lifestyle habits and residential factors) collected by a questionnaire survey were examined in asthmatic patients. Serum vitamin D levels in asthmatic children (16.63±4.20 ng/mL) were significantly lower than that in healthy controls (24.24±6.76 ng/mL) (p<0.05). Also, we found that the prevalence of asthma increase to 0.79-fold (odds ratio, 0.79; 95% confidence interval, 0.71 to 0.88; p<0.001) as serum vitamin D level is 1 ng/mL decreases. The increased time spent in outdoor could affect the increases of serum vitamin D levels significantly. However, no associations of serum vitamin D with pulmonary function and residential environmental factors (i.e., housing type, living floor, and indoor activity time) were observed. Our findings suggest that serum vitamin D levels were also associated with pediatric asthma in Korea. Moreover, management of serum vitamin D level in asthmatic children would be a promising approach for preventing exaggeration of their severity.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/b9/eht-32-e2017005.PMC5480427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34758934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Estrogenic activity of zinc pyrithione: an in vivo and in vitro study 吡硫酮锌的体内体外雌激素活性研究

Environmental Health and Toxicology Pub Date : 2017-02-09 DOI: 10.5620/eht.e2017004

Kyung Sik Yoon, N. Youn, H. Gu, S. Kwack

{"title":"Estrogenic activity of zinc pyrithione: an in vivo and in vitro study","authors":"Kyung Sik Yoon, N. Youn, H. Gu, S. Kwack","doi":"10.5620/eht.e2017004","DOIUrl":"https://doi.org/10.5620/eht.e2017004","url":null,"abstract":"Zinc pyrithione (ZP) is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of ZP, causing serious concerns about its toxicity. The reproductive and developmental toxicities were previously reported in pregnant rats. However, the estrogenic activity of ZP at varying degrees of exposure has been rarely studied. Thus, we performed an uterotrophic assay, E-screen assay, and gene expression profiling to assess the estrogenic activity of ZP. For the uterotrophic assay, ZP (2, 10, or 50 mg/kg/d) was subcutaneously administered to ovariectomized rats every day for three days. Uteri were extracted 24 hours after the last dose. Then, wet and blotted uterine weights were measured. For the E-screen essay, MCF-7 cells (a breast cancer cell line) were exposed to 10-9 to 10-6 M of ZP, and cell proliferation was then measured. For the gene expression analysis, changes of gene expression levels in uterine samples taken for the uterotrophic assay were analyzed. In the uterotrophic assay, the concentration of ZP had no significant effect on uterine weight. In the E-screen assay, ZP at any concentration showed no significant increase in MCF-7 cell proliferation, compared to the control group. However, 10-6 M of ZP significantly reduced cell viability. The changes in gene expression slightly differed between the ZP and control groups. The in vivo and in vitro assays, together with gene expression analysis, demonstrated that ZP showed no significant estrogenic activity.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48766398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

A follow-up study of the association between mobile phone use and symptoms of ill health 一项关于手机使用与不健康症状之间关系的后续研究

Environmental Health and Toxicology Pub Date : 2016-12-29 DOI: 10.5620/eht.e2017001

Y. Cho, H. Lim, Hoon-Ho Jang, Kyung-hee Kim, J. Choi, C. Shin, S. K. Lee, Jong Hwa Kwon, Nam Kim

{"title":"A follow-up study of the association between mobile phone use and symptoms of ill health","authors":"Y. Cho, H. Lim, Hoon-Ho Jang, Kyung-hee Kim, J. Choi, C. Shin, S. K. Lee, Jong Hwa Kwon, Nam Kim","doi":"10.5620/eht.e2017001","DOIUrl":"https://doi.org/10.5620/eht.e2017001","url":null,"abstract":"The duration and frequency of mobile phone calls, and their relationship with various health effects, have been investigated in our previous cross-sectional study. This 2-year period follow-up study aimed to assess the changes in these variables of same subjects. The study population comprised 532 non-patient adult subjects sampled from the Korean Genome Epidemiology Study. The subjects underwent a medical examination at a hospital in 2012/2013 and revisited the same hospital in 2014/2015 to have the same examination for the characteristics of mobile phone use performed. In addition, to evaluate the effects on health, the Headache Impact Test-6 (HIT-6), Psychosocial Well-being Index-Short Form, Beck Depression Inventory, Korean-Instrumental Activities of Daily Living, Perceived Stress Scale, Pittsburgh Sleep Quality Index, and 12-item Short Form Health Survey were analyzed. For all these tests, the higher the score, the greater the effect on health. Variances between scores in all the indices in the baseline and follow-up surveys were calculated, and correlations of each index were analyzed. The average duration per call and HIT-6 score of the subjects decreased significantly compared with those recorded two years ago. The results showed a slight but significant correlation between call duration changes and HIT-6 score changes for female subjects, but not for males. HIT-6 scores in the follow-up survey significantly decreased compared to those in the baseline survey, but long-time call users (subjects whose call duration was ≥5 minutes in both the baseline and follow-up surveys) had no statistically significant reduction in HIT-6 scores. This study suggests that increased call duration is a greater risk factor for increases in headache than any other type of adverse health effect, and that this effect can be chronic.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5620/eht.e2017001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review 儿童过氧化氢灌肠致化学性结肠炎1例报告并文献复习

Environmental Health and Toxicology Pub Date : 2016-12-29 DOI: 10.5620/eht.e2017002

Joon-Sang Lee, Jung Kyung Yoo

引用次数: 5

Combined approaches using adverse outcome pathways and big data to find potential diseases associated with humidifier disinfectant 利用不良后果途径和大数据寻找与加湿器消毒剂相关的潜在疾病的综合方法

Environmental Health and Toxicology Pub Date : 2016-12-23 DOI: 10.5620/eht.e2017003

J. Leem, K. Chung

{"title":"Combined approaches using adverse outcome pathways and big data to find potential diseases associated with humidifier disinfectant","authors":"J. Leem, K. Chung","doi":"10.5620/eht.e2017003","DOIUrl":"https://doi.org/10.5620/eht.e2017003","url":null,"abstract":"According to previous survey, about two million of people were expected to suffer from toxic effects due to humidifier disinfectant (HD), regardless of healing or not. Extremely small group are recognized as HDs’ victims. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole because it is specific finding, compared with other diseases. To figure out overall effects from HDs, we recommend adverse outcome pathways (AOPs) as new approach. Reactive oxygen species (ROS) generation, decreased T-cell and pro-inflammatory cytokine release from macrophage could be key events between the exposure to HDs and diseases. ROS generation, decreased cell and pro-inflammatory cytokine release from macrophage could be cause of interstitial fibrosis, pneumonia and many other diseases such as asthma, allergic rhinitis, allergic dermatitis, fetal death, premature baby, autoimmune disease, hepatic toxicity, renal toxicity, cancer, and so on. We predict potential disease candidate by AOPs. We can validate the real risk of the adverse outcome by epidemiologic and toxicologic study using big data such as National Health Insurance data and AOPs knowledge base. Application of these kinds of new methods can find the potential disease list from the exposure to HD.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices 化学品注册和评估法案(K-REACH)和替代、减少或改进最佳实践

Environmental Health and Toxicology Pub Date : 2016-12-19 DOI: 10.5620/eht.e2016026

Soojin Ha, T. Seidle, Kyung-Min Lim

{"title":"Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices","authors":"Soojin Ha, T. Seidle, Kyung-Min Lim","doi":"10.5620/eht.e2016026","DOIUrl":"https://doi.org/10.5620/eht.e2016026","url":null,"abstract":"Objectives Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed. Methods Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory documents regarding the limitation of animal experiments and its alternatives in order to discuss the regulatory adoption of alternative tests. Results Depending on the tonnage of the chemical used, the data required ranges from acute and other short-term studies for a single exposure route to testing via multiple exposure routes and costly, longer-term studies such as a full two-generation reproducibility toxicity. The European Registration, Evaluation, Authorization and Restriction of Chemicals regulation provides for mandatory sharing of vertebrate test data to avoid unnecessary duplication of animal use and test costs, and obligation to revise data requirements and test guidelines “as soon as possible” after relevant, validated replacement, reduction or refinement (3R) methods become available. Furthermore, the Organization for Economic Cooperation and Development actively accepts alternative animal tests and 3R to chemical toxicity tests. Conclusions Alternative tests which are more ethical and efficient than animal experiments should be widely used to assess the toxicity of chemicals for K-REACH registration. The relevant regulatory agencies will have to make efforts to actively adopt and uptake new alternative tests and 3R to K-REACH.","PeriodicalId":11853,"journal":{"name":"Environmental Health and Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24