Medica Hospitalia : Journal of Clinical Medicine最新文献

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Association Of Neuropathic Pain Improvement And hs-CRP Changes Among Trigeminal Neuralgia Patients Experienced Radiofrequency Ablation 60o and 65o Celcius: 6 months follow up 射频消融术治疗三叉神经痛患者的神经性疼痛改善与hs-CRP变化的关系:随访6个月
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.876
Yani Arlina, Trianggoro Budisulistyo, D. Pudjonarko, D. Tugasworo, Herlina Suryawati, Elta Diah Pasmanasari
{"title":"Association Of Neuropathic Pain Improvement And hs-CRP Changes Among Trigeminal Neuralgia Patients Experienced Radiofrequency Ablation 60o and 65o Celcius: 6 months follow up","authors":"Yani Arlina, Trianggoro Budisulistyo, D. Pudjonarko, D. Tugasworo, Herlina Suryawati, Elta Diah Pasmanasari","doi":"10.36408/mhjcm.v10i2.876","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.876","url":null,"abstract":"INTRODUCTION: Trigeminal neuralgia (NT) is a neuropathic pain that involves the trigeminal nerve in the face. The first-line medical management of patients with NT is Carbamazepine (CBZ). Radiofrequency ablation (RFA) procedure is a minimally invasive procedure using a high-frequency current-generating device that produced heat ablate of C-fibers with effectiveness around 76% for 10 yeas follow-up. Inflammed trigeminal nerve (TG) or the branch(es) might be one of the underlying mechanisms unless vascular compression is a common etiology. The heat effects might be according to the temperature set up varies recently from 60°C to 95°C.\u0000METHOD: This observational study enrolled 75 severe NT subjects without satisfactory improvement of treatments, divided into 3 groups: analgesics prescription (Control), RFA 60, and RFA 65 Groups. The LANSS scores and hs-CRP levels were followed-up before (baseline), 2 weeks, 3, and 6 months experienced the treatments. Subjects ages in the range of 48.32 + 12.73 to 50.88 + 14.59 years old, and the duration of illness from 4.48 to 10.32 months.\u0000RESULT: The LANSS score >12 before treatments showed significance improvements (p<0.001), as in the Control (64% with neuropathic pain), RFA 60 (100% with neuropathic pain), and RFA 65 group (92% with nociceptive pain) at 2 weeks followed-up. At 3 and 6 months observed 100% subjects with nociceptive pain but without significancies. Even though the hs-CRP levels observed reduced for all groups, especially RFA 60 and RFA 65, but have no significances.\u0000CONCLUSION: The LANSS scores changes observed significant improvement in all groups, which mentioned if the neuropathic pain syndromes might be better under each treatment. The Hs-CRP levels improvement is better in the neuro ablation groups than analgesic drugs treatment. Even though the Hs-CRP are following of systemic nonspecific inflammation, NT is a focal inflammation.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133414517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy 1%聚维酮碘漱口水对头颈部恶性肿瘤患者口腔黏膜炎和咽痰发生率的影响
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.854
Peny Handayani, Rery Budiarti, Willy Yusmawan, D. Antono, A. Dewi, P. Widodo
{"title":"Effect of 1% Povidone Iodine Mouthwash on The Incidence of Oral Mucositis and Odynophagia in Patients with Head and Neck Malignancy","authors":"Peny Handayani, Rery Budiarti, Willy Yusmawan, D. Antono, A. Dewi, P. Widodo","doi":"10.36408/mhjcm.v10i2.854","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.854","url":null,"abstract":"BACKGROUND: Oral mucositis is an injury of normal mucosal tissue with an acute inflammation of the oral, tongue, and pharyngeal mucosa after exposure to chemo-radiotherapy. Post chemoradiotherapy oral mucositis is commonly accompanied by painful swallowing or odynophagia. Povidone iodine 1% is an antiseptic mouthwash that widely used to prevent infections in the oral cavity.\u0000OBJECTIVE: The aim of this study was to determine the effect of 1% povidone iodine mouthwash on the incidence of oral mucositis in patients with head and neck malignancy at Dr. Kariadi General Hospital Semarang.   \u0000METHOD: This study was single random blinded experimental study, with total samples of 44 patients with head and neck malignancy after chemoradiotherapy. The samples divided into treatment group of 22 samples with 1% povidone iodine mouthwash and control group of 22 samples with NaCl 0.9% recruited using single random sampling at Dr. Kariadi Semarang General Central Hospital in 2022. The effect of 1% povidone iodine mouthwash on the incidence of oral mucositis and odynophagia was analyzed using the Fischer Exact and Mann Whitney test.\u0000RESULT: In the 1% povidone iodine mouthwash group day 15th, 21 patients (95.5%) were found without mucositis and 1 patient (4.5%) with mucositis oral grade I. In the 1% povidone iodine mouthwash group, 21 people (4.5%) were found without odynophagia and 1 people (4.5%) had odynophagia. There was an association between oral mucositis and odynophagia on povidone iodine 1% group (p < 0.05).       \u0000CONCLUSION: Povidone iodine 1% mouthwash can affect the incidence of oral mucositis in patients with head and neck carcinoma. Povidone iodine 1% mouthwash can reduce the incidence of oral mucositis and odynophagia compared to placebo in patients with head and neck carcinoma.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129617213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coping Strategies And Dass Scores Among Nurses On Duty In Covid-19 Isolation Room: A Cross-Sectional Study Covid-19隔离室值班护士的应对策略和及格分数:一项横断面研究
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.875
Septo Pero Adinoto, Alifiati Fitrikasari, Natalia Dewi Wardani, Elly Noerhidajati
{"title":"Coping Strategies And Dass Scores Among Nurses On Duty In Covid-19 Isolation Room: A Cross-Sectional Study","authors":"Septo Pero Adinoto, Alifiati Fitrikasari, Natalia Dewi Wardani, Elly Noerhidajati","doi":"10.36408/mhjcm.v10i2.875","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.875","url":null,"abstract":"BACKGROUNDS: Nurses are at risk for mental health problems while caring for Corona Virus Disease 2019 (COVID-19) patients. The COVID-19 pandemic had impacted not only on emotions but also nurses' coping strategies. The difference between this study and previous research in this study adds up the total DASS 42 (Depression Anxiety Stress Scale) scores as parameter to assess mental health problems of the subjects.\u0000OBJECTIVE: To determine the association between coping strategies and the DASS score among nurses on duty in the COVID-19 isolation room of Dr Kariadi Hospital.\u0000METHODS: This cross-sectional study involved nurses who treated patients in the COVID-19 isolation ward, the COVID-19 intensive room, and the COVID-19 emergency room. All participants were involved by the consecutive sampling method. The research instrument used a sociodemographic questionnaire, the Brief COPE, and the DASS 42. Inclusion criteria included nurses who served in the COVID-19 isolation room and aged 22-60 years. Higher DASS score indicates that the subject is experiencing general psychological distress compared to subjects with a lower score.\u0000RESULTS: Most of the respondents in this study (n=112 subjects) had problem-focused coping strategies. The mean DASS score on the subjects is 14.29 ± 13.25. There was an association between coping strategies (p=0.048), sex (p < 0.001), place of work (p = 0.041), and DASS score.\u0000CONCLUSION: There was a relationship between coping strategies and the DASS score of nurses on duty in the COVID-19-19 isolation room. Further research needs to explore environmental factors and social support, also examine physical illnesses in more detail.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121643329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CT Scan Imaging in Tuberculosis and Lung Cancer: A Case Report in Lung Hospital 肺结核和肺癌的CT扫描成像:肺科医院1例报告
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.938
L. Lestari, Muhammad Harris Sis Sultansyah
{"title":"CT Scan Imaging in Tuberculosis and Lung Cancer: A Case Report in Lung Hospital","authors":"L. Lestari, Muhammad Harris Sis Sultansyah","doi":"10.36408/mhjcm.v10i2.938","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.938","url":null,"abstract":"Background: Tuberculosis is a contagious infectious disease that attacks various organs, especially the lungs. Chest CT scan modalities have a role in helping the diagnosis of tuberculosis and lung cancer. This case report presents a rare case of two women diagnosed with tuberculosis and lung cancer.\u0000Cases Presentation: Two women aged 43 and 42 years came to the radiology department with a history of chest pain, loss of appetite, and cough, and underwent tuberculosis therapy by taking medication for two months. The patient underwent chest x photo thorax, abdominal ultrasound, thoracic CT scan, and a biopsy was performed with CT scan guiding.\u0000Discussion:  The findings of this case are consistent with previous studies which explained that radiological CT scans found tuberculosis with lung cancer. In the lung window, CT scan chest contrast found cystic bronchiectasis. Other results showed an encapsulated pleural effusion in the right hemithorax, compression atelectasis, and multiple lymphadenopathies.\u0000Conclusion: CT scan imaging simultaneously can show the occurrence of tuberculosis and lung cancer. Lung cancer that worsens can cause adenocarcinoma with metastasis spreading to other organs.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129457238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Effleurage along with Moisturizing Application on Skin Elasticity 排液配合保湿液对皮肤弹性的影响
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.900
Afrianti Wahyu Widiarti, Dwi Kurniawati
{"title":"Effect of Effleurage along with Moisturizing Application on Skin Elasticity","authors":"Afrianti Wahyu Widiarti, Dwi Kurniawati","doi":"10.36408/mhjcm.v10i2.900","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.900","url":null,"abstract":"Background: A decrease in skin elasticity is a problem often complained of, especially by women. Changes in some of the structure and elasticity of the skin occur with age as a result of reduced production of natural oils and skin collagen. There are several ways to increase skin elasticity, including by stimulating collagen. One of them is by using topical skin care such as using a moisturizer that suits skin type.\u0000Aim: This study intends to determine the effect of effleurage in the application of moisturizer on skin elasticity.  \u0000Method: The research design was a randomized controlled-trial with two groups pre and posttests conducted on 30 students of the Physiotherapy Department Surakarta randomly selected and divided into two groups. The treatment group applied moisturizer to the skin using the effleurage technique, while the control group applied only moisturizer. The groups were intervened for two weeks. Skin elasticity was measured using the EH-900U skin analysis system.\u0000Result: The Pre-Posttests of group one’s skin elasticity with the Paired Samples T-Test yielded a p value = 0.013, which means that there is an effect of effleurage in applying moisturizer on skin elasticity. The Pre-Posttests of group two's skin elasticity with the Wilcoxon Test yielded a p value = 0.551, which means that there is no effect of topical moisturizer on skin elasticity. There were significant differences in the treatment and control groups\u0000Conclusion: The application of moisturizer along with effleurage for skin elasticity is more robust than applying only topical moisturizer.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129435433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Fixed‐Dose Combinations Antituberculosis and Separate Formulations on Clinical Symptoms, Weight Gain, Adverse Effect and Plasma Concentration in Tuberculosis and HIV Coinfection Cases 抗结核固定剂量联合用药和单独用药对结核和HIV合并感染患者临床症状、体重增加、不良反应和血药浓度的影响
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.867
T. Sundari, N. Mariana, Debby Intan Permatasari, A. Rusli, Pompini Agustina Sitompul, Rosamarlina Rosamarlina, Aninda Dinar Widiantari, S. Maemun, V. Lisdawati
{"title":"Effect of Fixed‐Dose Combinations Antituberculosis and Separate Formulations on Clinical Symptoms, Weight Gain, Adverse Effect and Plasma Concentration in Tuberculosis and HIV Coinfection Cases","authors":"T. Sundari, N. Mariana, Debby Intan Permatasari, A. Rusli, Pompini Agustina Sitompul, Rosamarlina Rosamarlina, Aninda Dinar Widiantari, S. Maemun, V. Lisdawati","doi":"10.36408/mhjcm.v10i2.867","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.867","url":null,"abstract":"BACKGROUND: Fixed Dose Combination (FDC) was aimed to simplify TB therapy and facilitate physician and patient compliance.\u0000OBJECTIVE: We aimed to evaluate the effect of FDC antituberculosis and separate formulations (SF) on clinical symptoms, weight gain, adverse effect and plasma concentration in TB/HIV cases during the intensive phase.\u0000METHOD: Prospective cohort study was conducted in public hospital, Jakarta. We recruited TB-HIV patients in May 2018-May 2019. Patients (over than 18 years old) diagnosed with TB-HIV who consumed either FDC or SF and had not received antiretroviral. A total of 36 subjects were included in this study, 20 subjects in FDC group and 16 subjects in SF group.\u0000RESULT:  There was not significant different between FDC and SF groups with an improvement of clinical symptoms (P = 0.70) and weight gain (P = 1.00). Gastrointestinal syndrome was 75% in FDC group; 62.5 % in SF group. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration after 2 weeks therapy in FDC group were 5.49 mg/L (±3.40 mg/L), 1.35 mg/L (±1.20 mg/L), 19.87 mg/L (±17.00 mg/L), respectively. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration in SF group were 6.42 mg/L (±4.80mg/L), 0.87 mg/L (±0.70 mg/L), 5.03 mg/L (±7.60 mg/L), respectively.\u0000CONCLUSION: There was not significant different between FDC and SF groups on improvement of clinical symptoms and weight gain in intensive phase of therapy, the highest of adverse effects was gastrointestinal syndrome, and all subjects had normal reference ranges of rifampicin concentrations, and isoniazid and pyrazinamide below the normal range.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121494878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Growth Cut-Off Point To Predict Neonatal Outcome In Pregnancy With Normal And Deficient Vitamin D Levels: Intergrowth-21, World Health Organization Fetal Growth Curve, And Hadlock’s Estimated Fetal Weight 预测正常和缺乏维生素D妊娠期新生儿结局的胎儿生长分界点:Intergrowth-21、世界卫生组织胎儿生长曲线和哈德洛克胎儿估计体重
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.877
J. Dewantiningrum, H. Kristanto, D. Pudjonarko, M. Mexitalia, A. Ediati, A. Soejoenoes, S. Hadisaputro
{"title":"Fetal Growth Cut-Off Point To Predict Neonatal Outcome In Pregnancy With Normal And Deficient Vitamin D Levels: Intergrowth-21, World Health Organization Fetal Growth Curve, And Hadlock’s Estimated Fetal Weight","authors":"J. Dewantiningrum, H. Kristanto, D. Pudjonarko, M. Mexitalia, A. Ediati, A. Soejoenoes, S. Hadisaputro","doi":"10.36408/mhjcm.v10i2.877","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.877","url":null,"abstract":"Purpose : Analyze the cut-off point of fetal growth based on the Intergrowth-21, World Health Organization (WHO), and Hadlock’s estimated fetal weight (EFW) in pregnant women with normal or deficient vitamin D levels to predict neonatal outcomes.\u0000Method: This cross sectional study to develop a diagnostic test, included 120 of pregnant women who completed follow up until children aged 2 years, divided into normal and deficient vitamin D group. Ultrasound and maternal vitamin D level examined during the second trimester of pregnancy. EFW was calculated using Hadlock’s formula and plotted on the Intergrowth-21 and WHO curves. The reference standards were the neonatal outcome, LBW, stunting, and neurocognitive impairment. Significant odds ratio (OR) value and area under the curve (AUC) of 0.6 are used to determine the cut-off point to be used.\u0000Result: Fetal growth curve was based on the WHO at the 5th percentile to predict LBW to have an AUC of 0.6 and OR of 6, 95% confidence interval (CI) of 1.36–26.45. The AUC for predicting LBW based on Intergrowth and Hadlock were 0.45 and OR not significant. As well as the AUC estimated stunting based on Hadlock, the Intergrowth-21 and the WHO fetal growth curves is <0.6 with OR not statistically significant. The AUC predicted neurocognitive impairment based on WHO’s chart was 0.6 but OR not statistically significant.\u0000Conclusion: The WHO fetal growth curve can be used to predict LBW. The cut-off point of the fetal growth curve and which percentile is determined by the neonatal outcome.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123213402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efek Nefrotoksik Gentamisin Terhadap Tikus Wistar 对树懒老鼠的新毒性影响
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.909
Evi Lusiana, Irsan Saleh, E. Sinaga, Zen Hafy
{"title":"Efek Nefrotoksik Gentamisin Terhadap Tikus Wistar","authors":"Evi Lusiana, Irsan Saleh, E. Sinaga, Zen Hafy","doi":"10.36408/mhjcm.v10i2.909","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.909","url":null,"abstract":"LATAR BELAKANG : Gentamisin merupakan antibiotik golongan aminoglikosida yang digunakan sebagai pengobatan untuk berbagai infeksi. Salah satu efek samping yang dilaporkan pada penggunaan  gentamisin adalah nefrotoksik. \u0000  \u0000TUJUAN : Untuk mengidentifikasi efek nefrotoksik yang mengarah ke fibrosis ginjal akibat induksi gentamisin terhadap tikus wistar. \u0000  \u0000METODE : Penelitian ini merupakan penelitian eksperimental  in vivo, pre and post tes control group design, di Laboratorium Animal House Fakultas Kedokteran, Universitas Sriwijaya dan Balai Besar Laboratorium Kesehatan Palembang pada bulan September–Oktober 2022. Terdapat 4 kelompok perlakuan yaitu  Kelompok I plasebo; kelompok II diinduksi gentamisin (KIG I) sebesar 80 mg/kgBB; kelompok III diinduksi gentamisin (KIG II) sebesar 120 mg/kgBB; kelompok IV diinduksi gentamisin (KIG III) sebesar 240 mg/kgBB. Gentamisin diberikan selama 7 hari secara intraperitoneal, masing-masing 8 ekor tikus wistar tiap kelompok. Semua tikus wistar setiap kelompok diambil  darah pada hari ke-0,3,7, dan 14. Hasil penelitian, diuji normalitas dengan uji Saphiro-Wilk dan homogenitas dengan uji levene‘s. Dilakukan analisa dengan uji Anova dan dilanjutkan dengan uji Post-Hoc \u0000  \u0000HASIL :  Induksi gentamisin pada kelompok KIG I dan KIG II signifikan dalam menaikkan rerata kadar kreatinin dan ureum pada hari   ke-0 dan hari ke-14 perlakuan (p<0,05). Pada kelompok KIG III teradapat kematian 50% pada hewan coba yang menunjukkan Letal dose 50 (LD50) pada dosis tersebut.  \u0000  \u0000KESIMPULAN : KIG I dan KIG II memiliki efek nefrotoksik yang bermakna dalam menaikkan kadar kreatinin dan ureum yang mengarah pada fibrosis ginjal.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131242381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of ROX Index and Surfactant Protein-D with HFNC Outcome in COVID-19 Patients ROX指数和表面活性蛋白d与COVID-19患者HFNC预后的比较
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.924
Achmad Syamsufandi Rozi, Ngakan Putu Parsama Putra, U. Setyawan, A. Listyoko
{"title":"Comparison of ROX Index and Surfactant Protein-D with HFNC Outcome in COVID-19 Patients","authors":"Achmad Syamsufandi Rozi, Ngakan Putu Parsama Putra, U. Setyawan, A. Listyoko","doi":"10.36408/mhjcm.v10i2.924","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.924","url":null,"abstract":"Background: In COVID-19, severe clinical deterioration can lead to respiratory distress. High Flow Nasal Cannula (HFNC) is an oxygenation treatment recommended in severe COVID-19 patients, with various studies showing decreased recovery time and intensive care needed. However, instruments to predict HNFC outcomes, specifically in COVID-19, are not yet widely studied. ROX index is a practical instrument proven effective in predicting HFNC outcome in pneumonia while showing high variabilities of optimum time of assessments and cut-off values in COVID-19. Surfactant Protein-D (SP-D) is an alveolar protein showing potential as a biomarker in acute lung injury and respiratory distress. In this study, we analyzed ROX index and SP-D potential as HFNC outcome predictors in COVID-19 patients.\u0000Methods: This prospective study recruited severe and critical COVID-19 patients treated with HFNC. Patient characteristics, laboratory values including initial serum SP-D values, and ROX index were recorded. Significant differences were analyzed using Chi-Square and Mann-Whitney tests. Receiver operating characteristic (ROC) analysis was used to determine HFNC outcome predictive abilities of ROX index and serum SP-D.\u0000Result: 31 subjects with successful HFNC outcomes in 19 subjects and failed HFNC outcomes in 12 subjects were included in this study. ROX index and SP-D value were significantly higher in subjects with successful HFNC compared to failed HFNC (p < 0.05). ROX index at 6, 12, and 24 hours showed good HFNC outcome predictive ability (AUC > 0.7, p < 0.05).\u0000Conclusion: Successful HFNC outcome in COVID-19 was significantly related to higher ROX index and serum SP-D values. ROX index also showed good potential as an HFNC outcome predictor in COVID-19 patients.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116466346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Of Serum Hemoglobin And Vitamin D Levels With Posutral Balance 血清血红蛋白和维生素D水平与血电位平衡的关系
Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2023-07-31 DOI: 10.36408/mhjcm.v10i2.948
D. Ngestiningsih, M. Wicaksono, Muhammad Agung Wibowo Wicaksono, Probosuseno Probosuseno, Yuswo Supatmo, Banundari Rachmawati
{"title":"Relationship Of Serum Hemoglobin And Vitamin D Levels With Posutral Balance","authors":"D. Ngestiningsih, M. Wicaksono, Muhammad Agung Wibowo Wicaksono, Probosuseno Probosuseno, Yuswo Supatmo, Banundari Rachmawati","doi":"10.36408/mhjcm.v10i2.948","DOIUrl":"https://doi.org/10.36408/mhjcm.v10i2.948","url":null,"abstract":"Background: The population of the elderly in Indonesia has increased significantly in recent years. The incidence of falls is influenced by postural balance. Vitamin D and hemoglobin deficiency are associated with decreased muscle function and postural balance. This study is to investigate the relationship between vitamin D and hemoglobin levels with postural balance in the elderly.\u0000Methods: The study used a cross-sectional design with the participation of 33 patients (aged 64.94±5.42 years). The study sample was elderly individuals who fulfilled the inclusion criteria at Semarang Elderly Posyandu. Patients performed postural balance test, with Sharpened romberg and tandem gait test. The examination of vitamin D and hemoglobin was taken from the patient's venous blood. Vitamin D was measured using ELISA.\u0000Results: The results of the independent sample t-test analytic test revealed a P value of vitamin D (0.007) and a P value of hemoglobin of (0.021) (p<0.05). There is a meaningful relationship between vitamin D and hemoglobin levels with postural balance in the elderly..\u0000Conclusion: Decreasing Haemoglobine and Vitamin D impair the postural balance.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121389936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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