Epidemiology and Vaccinal Prevention最新文献

{"title":"Possibilities of Using Geoinformation Technologies in Epidemiological Surveillance of COVID-19 Infection at the Regional Level","authors":"E. I. Kravchenko, A. I. Blokh, O. Pasechnik","doi":"10.31631/2073-3046-2024-23-1-33-40","DOIUrl":"https://doi.org/10.31631/2073-3046-2024-23-1-33-40","url":null,"abstract":"Relevance. The spread of the new coronavirus infection throughout the world has led to expressed interest in studying, among other things, the patterns of territorial distribution of cases of the disease. Aim. To investigate the spatial distribution of cases of COVID-19 infection and develop proposals for the use of GIS technologies in the epidemiological supervision system for the new coronavirus infection at the regional level. Materials and methods. The study was conducted on the territory of the closed administrative- territorial entity of Zelenogorsk, Krasnoyarsk Territory. 4176 cases of COVID-19 infection were reported during the study period of 57 weeks (04/12/2020 to 06/18/2021). Each case of the disease was geocoded by the residence of the sick person using a projection coordinate system from the open data of the Open Street Map resource. The spatial distribution of COVID-19 cases was studied with geographic information system QGIS Desktop version 3.28.0. Spatial autocorrelation analysis was carried out using the Getis-Ord index. Results. During the application of GIS technologies, the density of distribution of COVID-19 infection cases was estimated, six zones with an average core density were discovered, the outbreaks in the northern part of the city had the greatest epidemiological significance. When assessing the clustering of cases within the specified territorial zones, eleven clusters were identified, three of which were characterized by the highest density of cases - 1210.1 cases per 1 sq. km, 1155.9 and 1116.7 cases per 1 sq. km. The Getis-Ord index value ranged from 0.00 to 2.576, the majority of cases was recorded in territorial clusters located in the northern part of the city. Conclusions. New knowledge obtained on the basis of modern GIS technologies about the presence of “hot spots” or clusters in the administrative territory will make the adjustment of preventive measures in micro-areas with a high prevalence of infection possible and develop strategies for more effective control of COVID-19 infection.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics of Inflammatory Demyelinating Diseases of the Central Nervous System Including Multiple Sclerosis","authors":"A. V. Svetlichnaya","doi":"10.31631/2073-3046-2024-23-1-21-32","DOIUrl":"https://doi.org/10.31631/2073-3046-2024-23-1-21-32","url":null,"abstract":"Relevance. Demyelinating diseases of the central nervous system and multiple sclerosis, in particular, make their debut at a young age and can lead to profound disability and death within a few years. In the last decade, there has been an increase in the number of cases of demyelinating diseases in Russia and in the world, which necessitates an in-depth study of these pathologies. Goal. To study the dynamics and features of the formation of morbidity, prevalence and mortality from demyelinating diseases of the central nervous system, including multiple sclerosis in various population groups in the Russian Federation. Materials and methods. The study design is a descriptive retrospective epidemiological study (continuous). The data was sampled from the forms of the federal state statistical observation on the distribution of the deceased by gender, age groups and causes of death of Rosstat (FSN S-51), as well as from the statistical collections of the Federal State Budgetary Institution \"Central Research Institute of the Ministry of Health of the Russian Federation \"Morbidity of the population\" from 2009 to 2021. Results. The analysis of the data showed that in 2009-2021 in Russia there was an increase in idiopathic inflammatory demyelinating diseases (IDD) and multiple sclerosis (MS) among the adult population and adolescents aged 15 to 17 years. There is no tendency to increase or decrease the incidence among children under 14 years of age. The highest average long–term incidence rates of IDD and MS among adults are observed in the Ufa region (7.13 ± 0.27 and 5.31 ± 0.23 per 100 thousand adults, respectively), among children under 14 - IDD in the Central Federal District (1.88 ± 0.18 per 100 thousand contingent) and MS in the Central Federal District and Volga Federal District (0.22 ± 0.07 per 100 thousand contingent). Among children from 15 to 17 years of age, the highest incidence of IDD is noted in the Northwestern Federal District (4.41 ± 1.10 per 100 thousand contingent) and the Ural Federal District (4.40 ± 1.09 per 100 thousand contingent), RS – in the Central Federal District (2.67 ± 0.51 per 100 thousand contingent). IDD and MS are the least common among all age groups in the Far Eastern Federal District. Over the period from 2000 to 2020, there has been a decrease in MS mortality in the Russian Federation by 34%, from 0.72 to 0.48 per 100,000 population. The average annual mortality rate from MS among men was 0.4 ± 0.021 cases per 100 thousand of the contingent, among women 0.5 ± 0.023 cases per 100 thousand of the contingent. Conclusion. The increase in the incidence of demyelinating diseases and MS, in particular, is an important medical and social problem. These pathologies significantly reduce the quality of life and shorten the duration of work, due to the development of persistent disability in the young population. The study showed the uneven distribution of the disease across the territories of the Russian Federation, which in ","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence to Hepatitis B Virus among Prisoners Taking into Account Age, HIV Status, and Injection Drug Use","authors":"M. Piterskiy, A. A. Storozhev, Yuliya A. Zakharova, I. A. Zakharov, A. V. Semenov","doi":"10.31631/2073-3046-2024-23-1-14-20","DOIUrl":"https://doi.org/10.31631/2073-3046-2024-23-1-14-20","url":null,"abstract":"Relevance. Prisoners have a high risk of contracting hemocontact viral infections (including HIV, viral hepatitis B and C, etc.), which creates an additional infectious burden on the entire population living in the territory. Aims. To study the level of immune protection to viral hepatitis B in risk groups (age, HIV status, and injection drug use) of persons held in places of detention to identify those in need of vaccine prophylaxis. Materials & Methods. 343 blood serum samples obtained in 2021 from males with negative HBsAg status were studied. Anti-HBs antibodies to HBsAg were determined using a set of reagents “VectoHBsAg-antibodies” (Vector-Best, Russia). Results and discussion. The protective titer of anti-HBs antibodies was detected in 44.0% (n = 151) of cases, and was absent in 56.0% of the subjects. At the same time, anti-HBs was significantly more often detected in people living with HIV/AIDS (p = 0.038), injecting drug users (p = 0.002), as well as young people born after 1984 (p = 0.019). Conclusion. The lack of a significant level of collective immunity among prisoners, primarily the older age group before 1984, their risky behaviors (sexual, injection) indicate the need for active identification of seronegative persons serving sentences in places of detention and specific immunoprophylaxis.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criteria for Assessing the Epidemiological Situation of Pertussis in Russian Federation","authors":"A. A. Basov, S. O. Vysochanskaya, O. V. Tsvirkun, T. R. Belova, S. E. Aduguzelov, Yury V. Zhernov, K. A. Yatskovsky","doi":"10.31631/2073-3046-2024-23-1-4-13","DOIUrl":"https://doi.org/10.31631/2073-3046-2024-23-1-4-13","url":null,"abstract":"Relevance. Differences in case definition criteria and diagnostic recommendations of pertussis between different countries, pose challenges in the analysis and effective control of disease. An important component of successful surveillance is laboratory diagnostics, which, if used in a timely and quality manner, can influence the rate of reported cases. In addition, current criteria for epidemiological surveillance do not sufficiently take into account the severity of the disease and the vaccination status of the patient, which makes it difficult to take effective preventive measures. Aims. Assess the epidemiological situation regarding pertussis infection in Russia to propose criteria for epidemiological surveillance. Materials and methods. The data was obtained from official state statistics (form No. 2 «Information on infectious and parasitic diseases», No. 5 «Information on preventive vaccinations», No. 6 «Information on the contingents of children and adults vaccinated against infectious diseases») and analytical tables developed at G.N. Gabrichevsky Research Institute of Epidemiology and Microbiology, including information on each case of pertussis and collected from the Rospotrebnadzor Directorates in the Russian Federation (in 2017–2022). Statistical data processing and plotting were carried out with R version 4.1.2. Results. From 2002 to 2017, the incidence of pertussis in Russia did not exceed the established norms. However, in 2019 there was an increase in incidence. In 2023, the incidence of pertussis reached record levels over the past 22 years – 19.0 per 100 thousand population. Vaccination rates against pertussis have remained high since 2003. The structure of cases shows that the majority of pertussis cases occur among unvaccinated children in the first year of life; deaths from pertussis are recorded annually, mainly among unvaccinated children under 2 years of age. From 2017 to 2019, the incidence among the unvaccinated was significantly higher than among the vaccinated; in 2020-2022, incidence among the unvaccinated decreased, but remained higher than among the vaccinated during the period of COVID-19 restrictive measures. There was no statistically significant difference in the distribution of pertussis severity in the periods before and after the COVID19 pandemic. Outbreaks of infection are mostly without spread, and in 2020-2022 the proportion of such outbreaks has increased. Schools remain the main site of infection, but the proportion of cases in kindergartens has increased. Conclusions. The following criteria for epidemiological well-being are proposed: subject to the achievement of timely vaccination coverage in 95% of people of decreed ages and timely implementation of anti-epidemic measures, there should be no deaths from pertussis, the incidence of pertussis should be sporadic and registered predominantly (more than 50% of cases) in the form of mild forms, the majority of pertussis cases occur among unvaccinated child","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of COVID-19 among Vaccinated with Sputnik V and CoviVac Vaccines (Results of the Telephone Survey for the Epidemic Season 2021–2022 in St. Petersburg)","authors":"M. K. Erofeeva, O. V. Gashinskaya, Z. V. Buzitskaya, T. G. Zubkova, E. V. Shakhlanskaya, M. A. Stukova, D. Lioznov","doi":"10.31631/2073-3046-2023-22-6-81-89","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-81-89","url":null,"abstract":"Relevance. The emergence of a new SARS-COV-2 coronavirus in early 2020 radically changed the seasonal pattern of influenza and other acute respiratory infections worldwide. Along with a decrease in the frequency of RSV infection, the number of diagnosed cases of influenza virus infection decreased by 99% during the COVID-19 pandemic. Vaccines are known to be the best tool at our disposal for preventing infectious diseases and reducing the risk of serious complications and deaths. The Russian Federation has great experience in developing vaccines against viral and bacterial infections and is constantly improving the technology of their production putting new vaccine preparations into circulation. Domestic vaccines against a new coronavirus infection caused by SARS-CoV-2 virus were developed in the shortest possible time. This work evaluated the efficacy of Gam-Covid-Vac (Sputnik V) and CoviVac vaccines during periods of circulation of different variants of SARS-CoV-2 «Delta» and «Omicron» in St. Petersburg.Aims. To evaluate the prophylactic efficacy of domestic vaccines Gam-Covid-Vac (Sputnik V) and CoviVac in the epidemic season 2021–2022 in the periods of SARS-CoV-2 «Delta» and «Omicron» variants circulation in Saint-Petersburg.Materials and Methods. Vaccination and follow-up of vaccinated subjects was initiated in February 2021, with the arrival of the Gam-Covid-Vac (Sputnik V) and CoviVac vaccines at the specialized clinic of Smorodintsev Research Institute of Influenza. Follow-up of vaccinated subjects for one year after vaccination included 346 men and women aged 19-85 years, who were interviewed in two telephone surveys.Results. Telephone interviews among individuals vaccinated with Gam-Covid-Vaс (Sputnik V) and CoviVac vaccines revealed that during the circulation of «Delta» variant, 2nd half of 2021, COVID-19 disease occurred in 16.3% of people vaccinated with the CoviVac vaccine and in 15.8% of those vaccinated with Sputnik V vaccine – differences between groups were not statistically significant (p > 0.05). COVID-19 disease in both vaccine groups was predominantly mild with 61.95% of observed falling ill in the CoviVac vaccine group and 84.4% (slightly more, 1.4-fold) in Sputnik V vaccine group. At the same time, moderate and severe diseases were slightly more in absolute value among those vaccinated with \"CoviVac\" vaccine. Cough, lung damage from 30% to 80%, loss of sense of smell and taste dominated among the symptoms in both groups of patients. During the second observation period (January-April 2022), when «Omicron» variant were actively circulating, the number of cases among CoviVac and Sputnik V vaccines was 37.5% and 43.8%, respectively; the differences between the vaccine groups were not statistically significant (p > 0.05). During this period, diseases in CoviVac and Sputnik V vaccine groups were predominantly mild in 84.4% and 90.5%, respectively, with statistically insignificant differences. There were also no significant dif","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemic Situation of Tularemia in Karelia at the Present Time","authors":"T. N. Demidova, L. Rubis, A. Semikhin, E. A. Gurina, A. V. Amirkhanyan, N. V. Sheenkov, V. V. Gorshenko, Yu. A. Birkovskay","doi":"10.31631/2073-3046-2023-22-4-175-182","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-4-175-182","url":null,"abstract":"Tularemia is a natural focal infection, characterized by the ability to maintain epizootic and epidemic potential for decades and periodically become more active. Since 2016, an increase in the incidence of tularemia has been observed in the Republic of Karelia.Aims. To evaluate the epidemiological situation with tularemia in the Republic of Karelia to determine the directions of preventive work in modern conditions.Conclusions. Analysis of the epizootic and epidemiological situation regarding tularemia in the Republic of Karelia demonstrates the possibility of intensifying the epizootic process after decades of relative prosperity. The increase in the incidence of the population was not only the result of the activation of natural foci of infection, but also of improved diagnosis of the disease and change in tactics for using vaccines in areas enzootic for tularemia.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of Genetically Determined Resistance against Human Norovirus Infection through Polymorphism of the FUT2 gene: a Review of the Literature","authors":"R. O. Bykov, A. V. Semenov, P. K. Starikova, T. M. Itani","doi":"10.31631/2073-3046-2023-22-6-148-154","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-148-154","url":null,"abstract":"Relevance. Human Noroviruses (HuNoV) are highly contagious pathogens responsible of acute human norovirus infection. HuNoV is the cause of every fifth case of acute non-bacterial gastroenteritis, annually causing about 699 million cases of the disease and more than 200 thousand deaths worldwide. Controlled expression of the HBGA antigens by the FUT2 gene causes resistance to human norovirus. Polymorphisms of the FUT family genes contribute to partial or complete immunity to certain genogroups/ genotypes of norovirus.Aims. To characterize the effect of FUT2 gene polymorphisms on susceptibility to HuNoV.Results. Nonsensemutations of G428A in two homologous alleles contribute to the formation of a secretory-negative phenotype (se), which is a factor determining immunity to noroviruses. Some missense-mutations in the nucleotide positions se385,571 form partial resistance against certain genotypes. People with a secretory-negative phenotype are immune to infection by the GII.4 genotype and its genovariants.Conclusions. The expression of HLA antigens by the functionally inactive FUT2 gene plays a key role in the resistance of the human population to HuNoV. Susceptibility to HuNoV largely depends on the prevalence of HBGA phenotypic diversity among ethnic populations around the world. Targeted screening aimed at identifying polymorphisms of the FUT family will allow identifying risk groups more susceptible to HuNoV.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophilus meningitis – Current Aspects of Epidemiology and Prevention: a Descriptive Review","authors":"M. I. Gritsay, I. Koroleva, M. A. Koroleva","doi":"10.31631/2073-3046-2023-22-6-162-174","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-162-174","url":null,"abstract":"Relevance. H. influenzae is a common cause of bacterial meningitis in children worldwide. Significant data have been accumulated worldwide on the use of H. influenzae type b conjugate vaccines over the past three decades. In the Russian Federation, constant monitoring of hemophilic meningitis is carried out, but data on the incidence of hemophilic infection are limited.Target. To consider global changes in the epidemiology of invasive forms of H. influenzae in the world and in the Russian Federation.Conclusions. The use of conjugate vaccines has resulted in a steady decline in invasive Hib infections. However, there has been a significant increase in invasive infections with non-typeable H. influenzae and non-b serotypes. In the Russian Federation, the incidence of meningitis caused by H. influenzae does not tend to increase or decrease; the majority of cases occur in children under 5 years of age.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Burden of Invasive Meningococcal Infection in Children in the Republic of Belarus","authors":"E. N. Sergienko, I. N. Kozhanova, O. Romanova, A. D. Solodov, P. A. Sсutova","doi":"10.31631/2073-3046-2023-22-6-99-107","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-99-107","url":null,"abstract":"Relevance Invasive meningococcal infection (IMI) is a significant clinical problem and is associated with a high probability of severe complications and death. Vaccination programs against meningococcus can achieve significant clinical effectiveness and require significant financial costs. This makes it relevant to study the economic burden of meningococcal infection in the conditions of modern healthcare in order to obtain basic data for subsequent research in the field of evaluation of medical technologies.Aims. To assess the economic burden of IMI in children in the conditions of healthcare in the Republic of BelarusMaterial and methods: a retrospective study using the \"cost of illness\" method was conducted for 22 children hospitalized in the city children's infectious clinical diseases hospital in 2018-2019. All values are presented in belarusian rubles. The average ± standard deviation, minimum – maximum values, median [Q1, Q3], cost shares (%) are calculated for the cost values. The minimum– maximum values and median [Q1, Q3] were calculated for the age of the patients.Results: taking into account the costs of treatment in healthcare organizations of all patients studied, the share of direct costs of hospitalization was 29.0%, the share of direct costs of diagnosis – 7.2%, the share of direct costs of pharmacotherapy - 8.3%. A significant part of the costs accounted for observations after discharge and amounted to 55.4%.Conclusion: a retrospective study of the economic burden of MI in the Republic of Belarus using the \"cost of illness\" method in patients hospitalized in a public health organization demonstrates a significant economic burden of this disease, which in the long term is primarily due to the presence of complications in the patient, as well as the impact of the patient's death on the value of total costs. The data obtained can be used in conducting national research on the evaluation of medical technologies.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Surveillance of Tuberculosis: from Molecular Methods to Genomic Studies","authors":"O. Ogarkov, E. Savilov, S. Zhdanova","doi":"10.31631/2073-3046-2023-22-6-155-161","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-155-161","url":null,"abstract":"Relevance. The globalization of the epidemic process requires improved surveillance of infectious diseases, in particular tuberculosis.Methods of molecular and genomic analysis are the most informative approaches that can radically change the management of this disease.Aims. To substantiate the necessary and sufficient volume of molecular studies for the exhaustive detection of most epidemic genotypes of Mycobacterium tuberculosis in Russia and the countries of the former USSR.Conclusions. Genetic lines L2 (Beijing) and L4 (Euro-American) cover more than 95% of all epidemic genotypes of M. tuberculosis in Russia and the countries of the former USSR. The development of rapid tests compatible with global data on genomic polymorphism will make it possible to conduct an epidemiological analysis of tuberculosis outbreaks within the country and to differ from cases of transbordern transmission of new genotypes outside.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}