Endocrine Practice最新文献

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Neck Ultrasound in Older Adults With Thyroid Nodules: Considering Risk of Death From Other Causes 老年人甲状腺结节的颈部超声检查:考虑其他原因导致的死亡风险。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.06.007
Nina Francis-Levin PhD , Edward Shao BS , Jacob Ortlieb MHI , Brittany Gay BA , Mousumi Banerjee PhD , Maria Papaleontiou MD , Megan R. Haymart MD
{"title":"Neck Ultrasound in Older Adults With Thyroid Nodules: Considering Risk of Death From Other Causes","authors":"Nina Francis-Levin PhD ,&nbsp;Edward Shao BS ,&nbsp;Jacob Ortlieb MHI ,&nbsp;Brittany Gay BA ,&nbsp;Mousumi Banerjee PhD ,&nbsp;Maria Papaleontiou MD ,&nbsp;Megan R. Haymart MD","doi":"10.1016/j.eprac.2025.06.007","DOIUrl":"10.1016/j.eprac.2025.06.007","url":null,"abstract":"<div><h3>Objective</h3><div>Thyroid nodules are common in older adults with the majority being benign. Optimal use of neck ultrasound for nodule surveillance in older adults, particularly in the setting of comorbidities and competing causes of death, remains unknown. We aimed to evaluate the use of neck ultrasound for thyroid nodule surveillance in older adults and to assess subsequent cause of death.</div></div><div><h3>Methods</h3><div>We used a dataset that combines the Centers for Medicare &amp; Medicaid Services data with the health data of University of Michigan Medicine patients between 2016 and 2021. We identified patients aged ≥ 65 with thyroid nodule(s) (median follow-up 2 years, range 0-6 years). Demographic characteristics, number of comorbidities (range 0-6), frequency of neck ultrasound, and cause of death were analyzed.</div></div><div><h3>Results</h3><div>Of the 18 001 patients diagnosed with thyroid nodules, median age was 75 years (range 65-105), and 71.2% were female. Only 29 (0.2%) died of thyroid cancer and 2387 (13.3%) died of other causes. Patients who died of other causes had more comorbidities (mean comorbidities 1.73, range 0-5 vs mean comorbidities in entire cohort 1.2, range 0-6). During the study period, those who died of other causes received a mean of 1.31 neck ultrasounds (range 0-12) whereas the rest of the cohort received a mean of 2.41 neck ultrasounds (range 0-26), <em>P</em> &lt; .001.</div></div><div><h3>Conclusions</h3><div>Older adults with thyroid nodules are more likely to die of causes other than thyroid cancer. Neck ultrasound for surveillance should be tailored to the patient, with consideration for comorbidities and life expectancy.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1105-1109"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Glucose Monitoring–Guided Insulin Infusion in Critically Ill Patients Promotes Safety, Improves Time Efficiency, and Enhances Provider Satisfaction cgm引导下危重患者胰岛素输注可提高安全性、时间效率和提供者满意度。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.05.751
Erin R. Giovannetti MSN, FNP-C , Rachael O. Lee MSN , Robert L. Thomas MD, PhD , Tamar Wolinsky MD , Adrianne V. Talbot MSN , Rabia S. Ali MSN , Tricia Santos Cavaiola MD , Kristen Kulasa MD , Schafer C. Boeder MD
{"title":"Continuous Glucose Monitoring–Guided Insulin Infusion in Critically Ill Patients Promotes Safety, Improves Time Efficiency, and Enhances Provider Satisfaction","authors":"Erin R. Giovannetti MSN, FNP-C ,&nbsp;Rachael O. Lee MSN ,&nbsp;Robert L. Thomas MD, PhD ,&nbsp;Tamar Wolinsky MD ,&nbsp;Adrianne V. Talbot MSN ,&nbsp;Rabia S. Ali MSN ,&nbsp;Tricia Santos Cavaiola MD ,&nbsp;Kristen Kulasa MD ,&nbsp;Schafer C. Boeder MD","doi":"10.1016/j.eprac.2025.05.751","DOIUrl":"10.1016/j.eprac.2025.05.751","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate the integration of real-time CGM (rtCGM) into an insulin infusion computer calculator (IICC) to improve glycemic control, time efficiency, safety, and clinician workflow in the intensive care unit (ICU).</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 35 critically ill adult patients requiring insulin infusion in the surgical and medical ICUs. Dexcom G7 rtCGM values were integrated into an institution-developed IICC using an ongoing validation protocol, allowing for nonadjunctive CGM use. The accuracy of rtCGM was assessed by comparing matched CGM and point-of-care (POC) glucose values using mean absolute relative difference (MARD), surveillance error grid, and Parkes Error Grid analyses. CGM time-in-range metrics, clinician turnaround time for glucose monitoring, and nurse satisfaction were also evaluated.</div></div><div><h3>Results</h3><div>A total of 1291 matched glucose pairs were analyzed. The rtCGM system demonstrated a MARD of 12.5%, with 99.6% of the values falling within clinically acceptable error zones (A+B) on the Parkes Error Grid. Patients in the rtCGM-IICC protocol had mean glucose 141.9 mg/dL, with mean time in range (70-180 mg/dL) 82.8%, time above range (&gt; 180 mg/dL) 14.5%, and time below range (&lt; 70 mg/dL) 0.5%. Clinician time efficiency improved significantly, with POC testing requiring a mean turnaround time of nearly 5 minutes compared to 3-second CGM retrieval. All surveyed nurses (<em>n</em> = 20) reported rtCGM increased efficiency and improved safety and preferred rtCGM with POC over POC testing alone.</div></div><div><h3>Conclusion</h3><div>Integrating rtCGM with an IICC protocol in the ICU enhances glycemic control, improves workflow efficiency, and reduces clinician workload while maintaining high accuracy.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1143-1149"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perineural Invasion Is Not an Independent Risk Factor for Recurrence and Lateral Neck Metastasis in Thyroid Cancer: A Propensity Score Matching Analysis 围神经侵犯不是甲状腺癌复发和侧颈转移的独立危险因素:倾向评分匹配分析。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.05.747
Joonseon Park MD, PhD , Sue Youn Kim MD , Chan Kwon Jung MD, PhD , Solji An MD , Ja Seong Bae MD, PhD , Kwangsoon Kim MD, PhD
{"title":"Perineural Invasion Is Not an Independent Risk Factor for Recurrence and Lateral Neck Metastasis in Thyroid Cancer: A Propensity Score Matching Analysis","authors":"Joonseon Park MD, PhD ,&nbsp;Sue Youn Kim MD ,&nbsp;Chan Kwon Jung MD, PhD ,&nbsp;Solji An MD ,&nbsp;Ja Seong Bae MD, PhD ,&nbsp;Kwangsoon Kim MD, PhD","doi":"10.1016/j.eprac.2025.05.747","DOIUrl":"10.1016/j.eprac.2025.05.747","url":null,"abstract":"<div><h3>Objectives</h3><div><span><span>Perineural invasion<span> (PNI) in thyroid cancer is a relatively rare but significant pathologic feature with crucial implications for prognosis and management. This study investigates the impact of PNI on recurrence and lateral </span></span>neck lymph node metastasis (</span><em>N</em><span>1b) in patients with thyroid cancer.</span></div></div><div><h3>Methods</h3><div><span>This retrospective analysis included 8572 patients with thyroid cancer who underwent surgery from January 2000 to December 2020 at Seoul St. Mary’s Hospital. Clinicopathologic characteristics and outcomes were compared between the patients with and without PNI before and after propensity score matching<span> (PSM). The logistic regression analysis identified the risk factors for </span></span><em>N</em><span>1b, whereas the Cox regression analysis determined the risk factors for recurrence.</span></div></div><div><h3>Results</h3><div>Of the 8572 patients, 144 (1.7%) presented with PNI. The PNI group had higher rates of gross extrathyroidal extension, vascular and lymphatic invasion, and advanced TNM stage. The recurrence rates were higher in the PNI group both before (11.1% vs 5.6%) and after PSM (11.3% vs 5.6%). PNI was a significant risk factor for <em>N</em><span>1b in the univariate logistic regression analysis but not in the multivariate analysis before and after PSM. The Cox regression analysis revealed that PNI is a significant risk factor for recurrence before PSM but not after PSM.</span></div></div><div><h3>Conclusions</h3><div>The PNI in thyroid cancer was associated with higher recurrence rates and increased <em>N</em>1b. However, it was not considered a significant independent risk factor for recurrence or <em>N</em>1b. Further research is needed to refine the management strategies for patients with PNI to improve prognosis.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1095-1104"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Info for Readers/Subscription page 读者信息/订阅页面
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/S1530-891X(25)00985-1
{"title":"Info for Readers/Subscription page","authors":"","doi":"10.1016/S1530-891X(25)00985-1","DOIUrl":"10.1016/S1530-891X(25)00985-1","url":null,"abstract":"","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages A1-A2"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing Inpatient Hypoglycemia: A Diversified Approach to a Complex Problem 降低住院低血糖:一个复杂问题的多样化方法。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.05.744
Audrey Lane MD , Melissa McKnight PharmD, BCPS , Kaeli Samson MA, MPH , Mitchell Nohner MD , Andjela Drincic MD
{"title":"Reducing Inpatient Hypoglycemia: A Diversified Approach to a Complex Problem","authors":"Audrey Lane MD ,&nbsp;Melissa McKnight PharmD, BCPS ,&nbsp;Kaeli Samson MA, MPH ,&nbsp;Mitchell Nohner MD ,&nbsp;Andjela Drincic MD","doi":"10.1016/j.eprac.2025.05.744","DOIUrl":"10.1016/j.eprac.2025.05.744","url":null,"abstract":"<div><h3>Objective</h3><div><span>Hypoglycemia in hospitalized patients is a persistent adverse event. Three </span>quality improvement interventions were implemented with the aim of reducing hypoglycemia. Each intervention was targeted at one component of typical inpatient insulin management (basal, prandial, and correction) to attempt to achieve this singular quality improvement aim.</div></div><div><h3>Methods</h3><div>Incidence of hypoglycemia in nonobstetrics patients ≥ 19 years of age at a tertiary hospital<span> receiving scheduled insulin before and after the implementation of quality improvement initiatives was compared. Incidence was defined as the number of unique patients with a hypoglycemic<span> event in each month, divided by all admissions for that month. The interventions included integrating weight-based insulin guidance into the electronic medical record, the addition of a carbohydrate-limited diet, and increasing the threshold for correction insulin administration from 150 mg/dL to 180 mg/dL.</span></span></div></div><div><h3>Results</h3><div>After implementation of the interventions, there was a significantly lower incidence of hypoglycemia associated with prandial insulin (<em>P</em> = .02) and correction insulin (<em>P</em> &lt; .001). There was not a significant decrease in hypoglycemia associated with basal insulin in the overall sample (<em>P</em><span> = .25). There was a significant decrease in a subgroup analysis focused on hospital-associated hyperglycemia<span> and type 2 diabetes<span> (via exclusion of patients with type 1 diabetes or cystic fibrosis-related diabetes) (</span></span></span><em>P</em><span> = .005). Notably, following the interventions, there was a reduction in institutional blood glucose<span> readings within goal range (71-179 mg/dL), which presumably translates to an increase in hyperglycemia, given the known decrease in hypoglycemia (</span></span><em>P</em> value &lt; .0001).</div></div><div><h3>Conclusion</h3><div>Through a multipronged approach consisting of three unique QI interventions – each targeting one aspect of inpatient insulin management – our academic institution was able to significantly reduce the number of inpatient hypoglycemic events.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1110-1115"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pituitary Stalk Lesions: Causes and Diagnostic Challenges 垂体柄病变:原因和诊断挑战。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.05.750
Roberto Salvatori MD
{"title":"Pituitary Stalk Lesions: Causes and Diagnostic Challenges","authors":"Roberto Salvatori MD","doi":"10.1016/j.eprac.2025.05.750","DOIUrl":"10.1016/j.eprac.2025.05.750","url":null,"abstract":"<div><div><span>The pituitary stalk<span> (PS) is a funnel-shaped structure that connects the hypothalamus to the </span></span>pituitary gland<span><span>. It contains some anterior pituitary cells, the hypophyseal vessels, and the axons of neurons whose bodies are located in the hypothalamus and terminate in the posterior pituitary<span> gland, where they store and release arginine vasopressin and oxytocin. The PS is best visualized by magnetic resonance imaging. PS thickening (PST) is often associated with arginine vasopressin deficiency, but it can also present with </span></span>anterior pituitary hormones<span><span><span> deficits or normal pituitary function. PST can be an isolated finding, or be expression of a multisystem infectious, inflammatory, or </span>neoplastic process. Accordingly, these cases are best managed with the input of pituitary specialists from different disciplines. Although PS biopsy can provide a pathologic diagnosis, this is an invasive procedure that requires an experienced neurosurgeon and carries significant risks. This review discusses the causes and symptoms of PST, and addresses the demographic, history, physical examination, biochemical and radiological features that can help the </span>endocrinologist in identifying the most likely cause of PST in any given patient, and to decide when biopsy is needed.</span></span></div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1171-1176"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Effectiveness of Glucagon-like Peptide-1- Receptor Agonists in Patients With Heart Failure With Preserved or Minimally Reduced Ejection Fraction: A Comprehensive Bayesian Network Meta-Analysis and Network Meta-Regression GLP-1受体激动剂对射血分数保持或最低限度降低的心力衰竭患者的比较疗效:综合贝叶斯网络荟萃分析和网络荟萃回归
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.06.005
Ibrahim Khalil MBBS , M Rafiqul Islam MBBS , A.B.M. Kamrul-Hasan MBBS, MD , Lakshmi Nagendra MBBS, MRCP, MD, DM, DrNB, FRCP , Sunjida Amin Promi MBBS , Md Abu Sayed MBBS , Mohd Turzo Rahman MD , Nowrin Sultana MBBS , Noshin Anjum Tasmi MBBS , Manisha Das MBBS , Salsabil Tarannum MBBS , Rajendronath Dey MBBS , Deep Dutta MBBS, MD, DM, DNB, FRCP
{"title":"Comparative Effectiveness of Glucagon-like Peptide-1- Receptor Agonists in Patients With Heart Failure With Preserved or Minimally Reduced Ejection Fraction: A Comprehensive Bayesian Network Meta-Analysis and Network Meta-Regression","authors":"Ibrahim Khalil MBBS ,&nbsp;M Rafiqul Islam MBBS ,&nbsp;A.B.M. Kamrul-Hasan MBBS, MD ,&nbsp;Lakshmi Nagendra MBBS, MRCP, MD, DM, DrNB, FRCP ,&nbsp;Sunjida Amin Promi MBBS ,&nbsp;Md Abu Sayed MBBS ,&nbsp;Mohd Turzo Rahman MD ,&nbsp;Nowrin Sultana MBBS ,&nbsp;Noshin Anjum Tasmi MBBS ,&nbsp;Manisha Das MBBS ,&nbsp;Salsabil Tarannum MBBS ,&nbsp;Rajendronath Dey MBBS ,&nbsp;Deep Dutta MBBS, MD, DM, DNB, FRCP","doi":"10.1016/j.eprac.2025.06.005","DOIUrl":"10.1016/j.eprac.2025.06.005","url":null,"abstract":"<div><h3>Objectives</h3><div><span><span>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown beneficial effects on clinical outcomes in patients with heart failure (HF) with preserved ejection fraction (HFpEF) or minimally reduced ejection fraction (HFmrEF). This network meta-analysis (NMA) aimed to consolidate evidence from </span>RCTs assessing the effects of GLP-1 RAs in HFpEF and </span>HF with reduced ejection fraction.</div></div><div><h3>Methods</h3><div>Several databases were searched comprehensively for relevant RCTs. A Bayesian NMA was conducted using R, and meta-regression was employed to investigate potential sources of heterogeneity. Statistical significance was evaluated using 95% credible intervals (CrIs) and surface under the cumulative ranking curve to rank treatment effectiveness. The primary outcome was hospitalization for HF (HHF).</div></div><div><h3>Results</h3><div>Eight reports from 6 Phase 3 RCTs (<em>N</em><span><span> = 24 099), mostly with low risks of bias, were included. Compared to placebo, semaglutide reduced the risk of HHF (HR 0.52, 95% CrI [0.25, 0.87]), while </span>tirzepatide<span> (HR 0.51, 95% CrI [0.16, 1.24]) and exenatide<span><span> (HR 0.82, 95% CrI [0.33, 1.73]) demonstrated no effect. Semaglutide and exenatide<span>, but not tirzepatide, reduced the risk of all-cause mortality. None affected </span></span>cardiovascular mortality<span>. Semaglutide decreased the risk of worsening of HF events; tirzepatide did not. Tirzepatide and semaglutide<span> enabled weight loss; however, only semaglutide notably enhanced the 6-minute walk distance. According to the surface under the cumulative ranking curve values, tirzepatide ranked highest for reducing HHF and body weight, semaglutide for decreasing cardiovascular mortality and worsening of HF events and improving the 6-minute walk distance, and exenatide for reducing all-cause mortality.</span></span></span></span></span></div></div><div><h3>Conclusion</h3><div>GLP-1 RAs provide significant benefits for patients with HFpEF or HFmrEF, with semaglutide offering more advantages than tirzepatide and exenatide.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1133-1142"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth Hormone and Bone: Preclinical and Clinical Perspectives 生长激素和骨骼:临床前和临床观点。
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-09-01 DOI: 10.1016/j.eprac.2025.07.005
Kevin C.J. Yuen MD, FRCP, FACE, FEAA
{"title":"Growth Hormone and Bone: Preclinical and Clinical Perspectives","authors":"Kevin C.J. Yuen MD, FRCP, FACE, FEAA","doi":"10.1016/j.eprac.2025.07.005","DOIUrl":"10.1016/j.eprac.2025.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>Growth hormone (GH) is essential for growth and bone metabolism. This article reviews preclinical data that has shaped our understanding of the mechanisms underpinning the effects of GH on bone beyond the downstream activation of insulin-like growth factor-I (IGF-I) generation and summarizes the clinical data of GH deficiency (GHD) and acromegaly on bone health parameters and fracture risk.</div></div><div><h3>Methods</h3><div>A literature search was conducted on PubMed using the following key words: GH, IGF-I, bone, GHD, and acromegaly. The discussion of therapy in GHD and patients with acromegaly, and their fracture risk assessment was based on evidence derived from previously published preclinical and clinical studies.</div></div><div><h3>Results</h3><div>Preclinical and clinical data have demonstrated important pleiotropic effects of GH and IGF-I on bone formation and resorption. GH exerts direct and IGF-dependent and independent effects on bone, while IGF-I acts in an endocrine and autocrine/paracrine manner. In GHD, decreased bone turnover, delayed statural growth, low bone mass, and increased fracture risk are observed, whereas acromegaly is associated with increased bone turnover but decreased lumbar bone mineral density and increased vertebral fracture and osteoarthritis risk. Treatment aimed at normalizing the GH/IGF-I axis decreases the fracture risk in GHD, but not acromegaly.</div></div><div><h3>Conclusion</h3><div>Preclinical and clinical studies have improved our understanding of the role of GH in bone in healthy individuals and in disease states. More research is needed to identify the effects of GH on bone and to determine how best to treat patients with GHD and acromegaly, so that their bone health is optimized.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages 1197-1206"},"PeriodicalIF":4.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Large Metastatic Pheochromocytoma in a Hypertensive Patient 高血压患者的大转移性嗜铬细胞瘤
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-08-29 DOI: 10.1016/j.eprac.2025.05.086
{"title":"A Large Metastatic Pheochromocytoma in a Hypertensive Patient","authors":"","doi":"10.1016/j.eprac.2025.05.086","DOIUrl":"10.1016/j.eprac.2025.05.086","url":null,"abstract":"","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Pages S28-S29"},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Diabetes on the Age of Natural Menopause 糖尿病对自然绝经年龄的影响
IF 4.6 3区 医学
Endocrine Practice Pub Date : 2025-08-29 DOI: 10.1016/j.eprac.2025.05.062
{"title":"Effect of Diabetes on the Age of Natural Menopause","authors":"","doi":"10.1016/j.eprac.2025.05.062","DOIUrl":"10.1016/j.eprac.2025.05.062","url":null,"abstract":"","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 9","pages":"Page S20"},"PeriodicalIF":4.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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