Endoscopy International Open最新文献

{"title":"Interval colorectal cancer: Lesson from looking back.","authors":"Giovanni Aldinio, Helmut Neumann, Luigi Boni, Emanuele Dabizzi, Luca Elli, Marco Maggioni, Gian Eugenio Tontini","doi":"10.1055/a-2638-6322","DOIUrl":"10.1055/a-2638-6322","url":null,"abstract":"","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26386322"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided gallbladder drainage for distal malignant biliary obstruction: Outcomes from a multicenter cohort.","authors":"Michael Chieng, Tara Fox, Jerry Yung-Lun Chin, Estella Johns, Rees Cameron, Frank Weilert","doi":"10.1055/a-2631-7857","DOIUrl":"10.1055/a-2631-7857","url":null,"abstract":"<p><strong>Background and study aims: </strong>Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is described as salvage therapy for patients with distal malignant biliary obstruction (DMBO). However, there is a paucity of data reporting on clinical outcomes for this indication.</p><p><strong>Patients and methods: </strong>A multicenter retrospective review of 26 EUS-GBD cases was performed between 2017 and 2023 at two centers in New Zealand. Efficacy outcomes of technical success (TS), clinical success (CS), length of stay (LOS), and resumption of cancer therapy were recorded. Adverse events (AEs), reinterventions, time to reintervention, and survival also were examined. Reinterventions were categorized into early (< 7 days) or delayed procedures (≥ 7 days).</p><p><strong>Results: </strong>Mean age was 74 years. Pancreatic cancer was the most common diagnosis. All included cases were unresectable and eight of 26 (30.8%) were chemotherapy candidates. TS and CS were achieved in all patients. At 14 days, bilirubin decreased from a mean of 139 to 55 μmol/L, a 60.4% reduction from baseline value. Mean LOS was 3 days. Of eligible patients, 87.5% were able to resume chemotherapy post-procedure. There were no intra-procedural complications nor early reinterventions. Four serious AEs (15.4%) required reintervention; the remaining nine were treated conservatively. Median survival was 103 days.</p><p><strong>Conclusions: </strong>EUS-GBD is a clinically effective salvage therapy for DMBO that may be positioned after unsuccessful endoscopic retrograde cholangiopancreatography or EUS-BD in a single anesthetic session. Most patients have a short LOS and few serious AEs. Furthermore, oncologic therapy can be successfully resumed post-procedure. EUS-GBD, therefore, should be considered an effective, safe, and durable addition to the treatment armamentarium for DMBO.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26317857"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minor papilla approach improves technical success of nasopancreatic drainage-based pancreatic juice cytology for early pancreatic cancer diagnosis.","authors":"Tatsunori Satoh, Shinya Kawaguchi, Haruna Takahashi, Yuichi Masui, Masanori Matsuda, Asami Kawai, Shinya Endo, Takafumi Kurokami, Naofumi Shirane, Kazuya Ohno","doi":"10.1055/a-2631-7957","DOIUrl":"10.1055/a-2631-7957","url":null,"abstract":"<p><strong>Background and study aims: </strong>Early detection of pancreatic cancer (PC) is vital for improving survival, yet it often relies on indirect imaging findings rather than detection of distinct masses. Recently, pancreatic juice cytology obtained via nasopancreatic drainage (NPD-PJC) has emerged as a valuable diagnostic approach for early-stage disease. However, technical challenges associated with NPD placement remain a significant limitation. This study aimed to assess whether incorporating a minor papilla approach improves the technical success rate for NPD-PJC in patients with suspected early-stage PC.</p><p><strong>Patients and methods: </strong>We conducted a retrospective study of patients scheduled for NPD placement for NPD-PJC between January 2015 and November 2024. Demographic and procedural data were collected, including endoscopic retrograde pancreatography (ERP) findings and outcomes associated with major and minor papilla approaches. Potential risk factors for technical failure and post-ERP pancreatitis (PEP) were evaluated.</p><p><strong>Results: </strong>A total of 81 cases were planned for NPD-PJC within the study period to differentiate early-stage PC. The success rate of the major papilla approach alone was 81.5%, which significantly increased to 93.8% ( <i>P</i> = 0.00157) with the addition of the minor papilla approach. Abnormal ductal configurations were associated with failure of the conventional approach (odds ratio 23.4). The minor papilla approach was not a significant risk factor for PEP, whereas younger age (≤ 70 years) and high body mass index (≥ 25) were identified as PEP risk factors.</p><p><strong>Conclusions: </strong>Incorporating the minor papilla approach substantially improves technical success of NPD-PJC without increasing PEP risk, underscoring the importance of individualized ERP strategies for early-stage PC diagnosis.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26317957"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a novel tapered-tip sheath system for preoperative mapping biopsy of biliary tract cancers.","authors":"Tomoaki Matsumori, Norimitsu Uza, Kazuhiro Okada, Masahiro Shiokawa, Takahisa Maruno, Yoshihiro Nishikawa, Takeshi Kuwada, Yuya Muramoto, Muneji Yasuda, Hajime Yamazaki, Kojiro Taura, Etsuro Hatano, Yuzo Kodama, Hiroshi Seno","doi":"10.1055/a-2631-7538","DOIUrl":"10.1055/a-2631-7538","url":null,"abstract":"<p><strong>Background and study aims: </strong>Preoperative evaluation of biliary tract cancer progression plays a critical role in assessing resectability and in selecting the appropriate surgical procedure. This study aimed to evaluate the utility of a novel tapered-tip sheath system for mapping biopsy to assess the extent of biliary tract cancer.</p><p><strong>Patients and methods: </strong>This observational, comparative study included 32 patients who were diagnosed with biliary tract cancers and underwent mapping biopsies with the novel tapered-tip sheath system and 21 patients using the conventional methods before the period. Technical success, total biopsy time, number of biopsy specimens, appropriate tissue sampling, adverse events (AEs), and negative surgical margin in case of surgical resection were evaluated.</p><p><strong>Results: </strong>The following were the respective results for the novel system and conventional methods groups: technical success rates, 73.3% and 48.4% ( <i>P</i> = 0.027); total biopsy times, 11.4 and 23.5 minutes ( <i>P</i> = 0.043); median number of specimens obtained per procedure, 6 and 3 ( <i>P</i> < 0.001); appropriate tissue sampling rates, 86.1% and 67.2% ( <i>P</i> < 0.001); AE rates, 2.1% and 0%; and negative surgical margin rates, 90.4% and 78.6%.</p><p><strong>Conclusions: </strong>Preoperative mapping biopsy using the novel tapered-tip sheath system is a promising option for assessing the extent of biliary tract cancers.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26317538"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathologic complete response after neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Endoscopic characteristics and implications.","authors":"Peng Yuan, Zongchao Liu, Liang Dai, Yan Yan, Yaya Wu, Keneng Chen, Wenqing Li, Qi Wu","doi":"10.1055/a-2625-5884","DOIUrl":"10.1055/a-2625-5884","url":null,"abstract":"<p><strong>Background and study aims: </strong>This study aimed to identify endoscopic characteristics and develop predictive models for detecting a pathologic complete response (pCR) after neoadjuvant therapy in patients with esophageal squamous cell carcinoma (ESCC).</p><p><strong>Patiens and methods: </strong>This study enrolled 220 patients including a retrospective cohort (n = 158) and a prospective cohort (n = 62), from May 2018 to March 2023 with ESCC who received neoadjuvant chemoimmunotherapy (nCIT) or neoadjuvant chemotherapy (nCT) followed by surgery. Predictive capability of the endoscopic characteristics for pCR was developed and validated using machine learning.</p><p><strong>Results: </strong>All patients underwent endoscopic examinations before surgery but after neoadjuvant therapy. Cohort I was divided into a training set (n = 112) and an internal validation set (n = 46) at a 7:3 ratio. Seven endoscopic features were assessed: scarring; intraepithelial papillary capillary loop (IPCL) type B; depressed mucosa post-tumor disappearance; eroding mucosal changes with an uneven surface; nonsuperficial neoplastic lesions; protruded changes; and presence of cancer cells in biopsy specimens. Using these characteristics as predictors, a multivariate logistic regression model was trained to predict pCR. For further validation, data from prospective Cohorts II and III were incorporated. The model achieved 96.43% accuracy (95% confidence interval [CI] 91.11%-99.02%) in the training set, 93.48% (95% CI 82.10%-98.63%) for internal validation of Cohort I, and 96.77% (95% CI 88.83%-99.61%) in the prospective validation set.</p><p><strong>Conclusions: </strong>Endoscopic characteristics are significant predictors of pCR in patients with ESCC receiving nCIT or nCT. The predictive model demonstrated high accuracy in both derivation and validation cohorts.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26255884"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial buy-in does not affect outcomes of endoscopic sleeve gastroplasty: Retrospective cohort.","authors":"Lea Sayegh, Karl Akiki, Karim Al Annan, Yara Salameh, Khushboo Gala, Kamal Abi Mosleh, Manpreet Mundi, Omar Ghanem, Barham K Abu Dayyeh, Andrew C Storm","doi":"10.1055/a-2631-7439","DOIUrl":"10.1055/a-2631-7439","url":null,"abstract":"<p><strong>Background and study aims: </strong>Endoscopic sleeve gastroplasty (ESG) is an effective treatment for obesity but typically is not covered by insurance. It is not known whether patients with financial investment in their endoscopic procedure are more likely to achieve and/or maintain weight loss as compared with those who have no financial buy-in. We aimed to compare treatment adherence and outcomes between patients paying out-of-pocket (OOP) and those who underwent ESG as part of any clinical trial where costs were covered by a study protocol (no payment; NP).</p><p><strong>Patients and methods: </strong>Data were collected via retrospective chart review. One hundred sixty-four patients who had an ESG with at least 6 months of follow-up were included. Repeated measures with generalized linear model were used to evaluate weight loss at different time points after ESG and labs values at baseline and 1-year follow-up to assess for comorbidity improvement between cohorts. Compliance was evaluated by comparing exercise adherence rates.</p><p><strong>Results: </strong>The pattern of weight loss and change in laboratory values was not different over time between the OOP group (n = 139) and NP group (n = 25). Patients lost an average of 14% (12.2-15.9) and 12.9% (9.3-16.5) of total body weight over all time points, respectively, in both groups (6, 12 and 24 months). Treatment adherence also did not differ between the groups.</p><p><strong>Conclusions: </strong>Having \"skin in the game\" by paying for ESG OOP does not correlate with better outcomes or treatment adherence, which further supports broad insurance coverage for this procedure.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26317439"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Green endoscopy, one step toward a sustainable future: Literature review.","authors":"Marcello Maida, Alessandro Vitello, Endrit Shahini, Roberto Vassallo, Emanuele Sinagra, Socrate Pallio, Giuseppinella Melita, Daryl Ramai, Marco Spadaccini, Cesare Hassan, Antonio Facciorusso","doi":"10.1055/a-2649-7488","DOIUrl":"https://doi.org/10.1055/a-2649-7488","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2303-8621.].</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"12 8","pages":"C5"},"PeriodicalIF":2.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel preparation assessment using artificial intelligence: Systematic review.","authors":"Kristoffer Mazanti Cold, Amaan Ali, Lars Konge, Flemming Bjerrum, Laurence Lovat, Omer Ahmad","doi":"10.1055/a-2625-6327","DOIUrl":"10.1055/a-2625-6327","url":null,"abstract":"<p><strong>Background and study aims: </strong>Insufficient bowel preparation is the leading cause of missed adenomas in colonoscopy. The Boston Bowel Preparation Scale (BBPS) is the most thoroughly validated and widely used scale to estimate risk of missed adenomas. Artificial intelligence (AI) could automatically quantify bowel preparation, thus reducing bias and limitations inherent in human rating. This systematic review aimed to identify, describe, and evaluate all AI-BPS systems for colonoscopy.</p><p><strong>Methods: </strong>A systematic literature review was conducted using MEDLINE, EMBASE, and SCOPUS based on three sets of terms aligned with the inclusion criteria: colonoscopy, BPS, and AI. Two reviewers independently evaluated and completed data extraction from the articles.</p><p><strong>Results: </strong>A total of 1,449 studies were identified, with eight meeting the eligibility criteria. Six AI-BPS systems were trained on expert BBPS ratings, and two studies used a fecal-mucosal ratio. All studies compared their AI-BPS with expert BBPS ratings; two showed that their AI-BPS outperformed expert BBPS ratings, and six showed comparable performances. Three studies also demonstrated correlations with adenoma detection rates (ADRs), adenoma miss rates (AMRs), or polyp detection rates (PDRs). Only one prospective study implemented its AI-BPS, finding lower AMR in adequately prepared compared with inadequately prepared bowels.</p><p><strong>Conclusions: </strong>AI-BPS can standardize and outperform human bowel preparation evaluation by better correlating with expert BBPS ratings, AMR, ADR, and PDR. Further research following recommended reporting guidelines is needed to allow for cross-study comparisons and meta-analysis, which was not possible in this study due to heterogonous study design and reporting metrics.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26256327"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-insufflation endoscopic intermuscular dissection in the management of a rectal neuroendocrine tumor.","authors":"Xiangji Liu, Jingjing Yao, Jing Wang, Taiping Wang, Haiyan Zhang, Ling Wang, Jindong Fu","doi":"10.1055/a-2616-6799","DOIUrl":"10.1055/a-2616-6799","url":null,"abstract":"","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26166799"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance and agreement of auditors for evaluation of computer-aided optical polyp diagnosis: Prospective study.","authors":"Felix Huang, Thea Iulia Dimbu, Douglas K Rex, Heiko Pohl, Cesare Hassan, Roupen Djinbachian, Victoire Michal, Dong Hyun Kim, Bilal Amani, Nahlah Haddouch, Sofie Fournier, Daniel von Renteln","doi":"10.1055/a-2631-8030","DOIUrl":"10.1055/a-2631-8030","url":null,"abstract":"<p><strong>Background and study aims: </strong>Guidelines recommend independent auditing of diagnostic performance for clinical implementation of computer-aided optical polyp diagnosis (CADx). This study evaluated diagnostic performance and interobserver agreement of auditors and offered guidance on conducting CADx audits.</p><p><strong>Methods: </strong>Images and videos of all ≤ 5-mm polyps from a large, prospective study with systematic activation of CADx were audited by three expert endoscopists. Experts performed independent, blinded diagnostic review including documentation of confidence level. The primary outcome was sensitivity of audit by three experts for high-confidence adenomas compared with pathology. Secondary outcomes included number of reviewers for optimal CADx auditing and interobserver agreement.</p><p><strong>Results: </strong>Four hundred eighty-seven diminutive polyps were audited (510 patients). Sensitivity was 99.4% (95% confidence interval [CI] 96.0-100) using three experts (Strategy A); 88.7% (95% CI 84.1-92.1) using two experts and one referee (Strategy B); 99% (95% CI 96-99.8), 98.8% (95% CI 95.4-99.8), and 99.4% (95% CI 96.3-100) using two-expert combinations (Strategy C); and 98.2% (95% CI 95.1-99.4), 97.3% (95% CI 94.0-98.9), and 88.9% (95% CI 83.6-92.7) for each expert individually (Strategy D). Among 266 pathology-based adenomas, Strategy A evaluated 160 polyps versus 196, 172, and 170 in Strategy C; and 220, 223, and 207 in Strategy D. Strategy B evaluated all 266 adenomas. Overall interobserver agreement was moderate (kappa 0.52), but very high for high-confidence adenomas (kappa 0.89).</p><p><strong>Conclusions: </strong>Expert audit for evaluating CADx resulted in high sensitivity and interobserver agreement for high-confidence adenomas. Audit by two experts, with a third expert for arbitration, permitted audit of all polyps and effective assessment of CADx within clinical studies.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a26318030"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}