Egyptian Journal of Radiation Sciences and Applications最新文献_第2页

Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway 酿酒酵母发酵大蒜通过调节NF-κ b和STAT3信号通路减轻γ辐照诱导的脑和肝毒性

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-10-30 DOI: 10.21608/ejrsa.2023.236135.1161

Sawsan M. El-Sonbaty, Hanan F. Abd Elhameed, Amel F.M. Ismail

引用次数: 0

Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays 聚乙烯醇/明胶/银纳米复合材料对γ射线辐照大鼠皮肤创面的治疗作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-10-02 DOI: 10.21608/ejrsa.2023.212588.1154

Gh. K. El Khalafawy, A. A. Elkady, A. F. El Bedewi, M. Salah

引用次数: 0

Discharge Simulation of an MTR Pool Type RR due to a Break in the Reactor Tank MTR池型RR型反应器罐内破裂后的放电模拟

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-10-02 DOI: 10.21608/ejrsa.2023.225847.1157

Neama M. El-Sahlamy, Ahmed S. Khedr

引用次数: 0

Eugenol Mitigates γ-rays-induced Acute Renal Destructive Impacts in Rats 丁香酚减轻γ射线引起的大鼠急性肾破坏作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-08-15 DOI: 10.21608/ejrsa.2023.213316.1155

A. Elkady, R. Ebrahim, W. A. El khouly

{"title":"Eugenol Mitigates γ-rays-induced Acute Renal Destructive Impacts in Rats","authors":"A. Elkady, R. Ebrahim, W. A. El khouly","doi":"10.21608/ejrsa.2023.213316.1155","DOIUrl":"https://doi.org/10.21608/ejrsa.2023.213316.1155","url":null,"abstract":"A CUTE renal injury is a common and hazardous distress of γ-rays’ exposure. The aim of the current study is to explore the role of eugenol on γ-rays-induced acute kidney lesions in rats. The rats were separated into four groups (n=6). The control group received saline for two weeks. The eugenol group received i.p. 20 mg/kg Eugenol for two weeks. The γ-rays group was pretreated with saline for a week, then whole-body exposed to 8 Gy γ-rays and saline treatment continued for another week. The rats in γ-rays+ eugenol group received Eugenol for a week pre-irradiation, then were exposed to γ-rays and eugenol treatment continued for another week. The blood and kidney samples were collected for histopathological and biochemical investigations. It was observed that exposure to γ-rays induced atrophy of glomeruli with increasing capsular space, expanded renal tubules and congested inter tubular blood vessels. Histological changes were accompanied by significant decreases in the level of antioxidants: reduced glutathione content (GSH), and superoxide dismutase (SOD), and catalase (CAT) activities with a significant increase of malondialdehyde (MDA; end-product of lipid peroxidation), indicating oxidative stress. Significant increases in the levels of inflammatory markers, tumor necrosis factor-alpha (TNF-α) and interleukin-1 Beta (IL-1β) levels were recorded also. Kidney damage was substantiated by significant increases in urea, creatinine, lactate dehydrogenase (LDH), γ-glutamyltransferase (γGT), and disturbance of electrolytes balance; elevated sodium (Na + ), and decreased potassium (K + ). Eugenol treatment has significantly improved histological damage oxidative stress and inflammatory-biomarkers, which was accompanied by significant amelioration of kidney functions. It could be concluded that eugenol may alleviate acute kidney injury resulting from γ -rays exposure through its antioxidant and anti-inflammatory properties.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84705018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short Term Effect of Gamma-Irradiation on Cytokeratin 17 and Calponin Expression in Submandibular Glands of Rats γ辐照对大鼠颌下腺细胞角蛋白17和钙钙蛋白表达的短期影响

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-04-27 DOI: 10.21608/ejrsa.2023.191299.1149

S. Ahmed, Amr H Rasmy

{"title":"Short Term Effect of Gamma-Irradiation on Cytokeratin 17 and Calponin Expression in Submandibular Glands of Rats","authors":"S. Ahmed, Amr H Rasmy","doi":"10.21608/ejrsa.2023.191299.1149","DOIUrl":"https://doi.org/10.21608/ejrsa.2023.191299.1149","url":null,"abstract":"D ESPITE the tremendous development in radiotherapy techniques, salivary glands among tissue are unintentionally exposed to radiation during head and neck cancer radiotherapy due to anatomical issue. Therefore, the purpose of the present study is to evaluate the histopathological consequence of gamma radiation (15 Gy) on submandibular glands as well as cytokeratin (CK) 17 and calponin expressions for deeper understanding of the mechanism of radiation –induced salivary gland injury. Rats were divided into control and irradiated groups. Rats’ heads in irradiated group were subjected to a single dose of gamma radiation (15Gy). The specimens of submandibular gland were examined for the histological changes and CK 17 and calponin expression. The intensity of CK 17 expression and also the area percent of CK 17 and calponin expression were measured. Data revealed acinar cytoplasmic vacuoles, loss of architecture and shrinkage in irradiated glands. Some areas showed degranulation of granular convoluted tubules and duct degeneration. The intensity of previously mentioned changes was increased by time. The intensity of CK 17 expression rose with time for both ductal and acinar cells while the area percent of expression decreased. The area of calponin expression decreased up to seven days after radiation and then increased at fourteen days. In conclusion, the obtained results about the histological changes as well as intensity and area of CK 17 and calponin expression indicate the deleterious acute effect of single dose (15Gy) of gamma radiation on the submandibular gland parenchyma that may hinder salivary production and secretion.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88317825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Novel Modified 5-Fluorouracil with Zinc Oxide Nano-Particles and its Combined Effect with Gamma Radiations on Human Cancer Cell Lines 纳米氧化锌修饰5-氟尿嘧啶及其与γ射线联合作用对人癌细胞的影响

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-04-08 DOI: 10.21608/ejrsa.2023.193748.1150

N. Hassan,, M. El-Dessouky, A. salah eldin, E. Elgazzar, A. M. Badawi

引用次数: 1

Evaluation of Efficacy of Bioactive Compounds Produced by Streptomyces sp. in Comparison with Commercial Antibiotics against Urinary Tract Infection Bacterial Pathogens 链霉菌产生物活性化合物与市售抗生素对尿路感染病原菌的疗效比较

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-03-28 DOI: 10.21608/ejrsa.2023.181582.1146

M. Soliman, E. Araby

引用次数: 0

Prophylactic Effects of DL-β Hydroxybutyrate against Hepatic Cellular Senescence Induced by D-galactose or γ-irradiation via Partial Modulation of Antioxidants and Trace Elements in Male Rats DL-β羟基丁酸通过部分调节抗氧化剂和微量元素对d -半乳糖或γ辐照诱导的雄性大鼠肝细胞衰老的预防作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-03-27 DOI: 10.21608/ejrsa.2023.187973.1148

M. E. Habieb, M. Mohamed, Doaa M. El Gamal, A. M. Hawas, Tarek M. Mohamed

引用次数: 0

Modulation of Sirtuin-1, Apoptosis and Redox Signaling Pathways by Astringenin: A Potential Parkinsonism Therapeutic Effect 黄芪素对Sirtuin-1、细胞凋亡和氧化还原信号通路的调节:一种潜在的帕金森治疗作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-03-13 DOI: 10.21608/ejrsa.2023.194141.1152

R. R. Rashed, E. Moustafa, E. Rashed

{"title":"Modulation of Sirtuin-1, Apoptosis and Redox Signaling Pathways by Astringenin: A Potential Parkinsonism Therapeutic Effect","authors":"R. R. Rashed, E. Moustafa, E. Rashed","doi":"10.21608/ejrsa.2023.194141.1152","DOIUrl":"https://doi.org/10.21608/ejrsa.2023.194141.1152","url":null,"abstract":"V ARIETIES of cellular stressors are reported to disrupt brain circuits or neuronal pathways that distribute neurotransmitter signals, resulting in subsequent genetic abnormalities, behavioral impairments, and/or mood disorders. For example, unfolded proteins accumulation in the endoplasmic reticulum (ER) induces ER stress-mediated cell death. Astringenin (AST) flavonoid functions as a neuroprotective agent and rescues neurons from various insults. However, the molecular mechanisms underlying the neuroprotective effects of Astringenin are still unclear. Rats received a single intraperitoneal (i.p.) injection of reserpine (RES) (5mg/kg) or exposed to a single dose of 10Gy head ionizing radiation (RAD) followed by AST treatment and sustained for 7 days. The expression of α-synuclein increased following head irradiation or reserpine administration, and endoplasmic reticulum stress factors were increased in brain tissue. AST administration results in upregulation of expression of AMPK and SIRT1, resulting in the inactivation of NF-κB p-65, FOXO1, and caspase-3. In addition, reduction of α-synuclein by AST improved the mobility-deficient behavior in rats. AST has also attenuated the decrease of dopamine, serotonin and BDNF levels. Moreover, AST upregulation of NRF2/HO1 levels was accompanied by enhancements of GSH content and SOD activity, and decreased inflammatory cytokines (TNF-α, IL-1β and IL-6). Such findings suggest that AST could be considered a promising agent that alleviates neuroinflammation by inhibiting ERs-mediated apoptosis signaling, and might possess a parkinsonism therapeutic effect.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82604098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung Ultrasound in ICU Admitted COVID-19 Patients; Can LUS Replace CT Chest ICU住院COVID-19患者的肺部超声检查LUS能代替胸部CT吗

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2023-03-06 DOI: 10.21608/ejrsa.2023.176921.1144

H. Salem, Jihan M. Saleh

引用次数: 0