Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences最新文献_第5页

[The human chorionic gonadotrophin reference standard (Control 941) of the National Institute of Health Sciences]. [国家卫生科学研究所人绒毛膜促性腺激素参考标准(Control 941)]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

M Ema, R Kurosaka, H Amano, Y Nakagawa, T Murai, Y Ogawa

引用次数: 0

[Twenty-eight days repeated dose toxicity test of N-(fluorodichloromethylthio)phthalimide in rats]. [N-(氟二氯甲基硫)邻苯二酰亚胺对大鼠28天重复剂量毒性试验]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

Y Matsushima, M Tsuda, K Naito, M Saitoh, K Isama, Y Ikarashi, Y Kawasaki, J Momma, S Kitajima, M Kaniwa

{"title":"[Twenty-eight days repeated dose toxicity test of N-(fluorodichloromethylthio)phthalimide in rats].","authors":"Y Matsushima, M Tsuda, K Naito, M Saitoh, K Isama, Y Ikarashi, Y Kawasaki, J Momma, S Kitajima, M Kaniwa","doi":"","DOIUrl":"","url":null,"abstract":"N-(Fluorodichloromethylthio)phthalimide (Fluor-folpet) has been widely used as an anti-mold and anti-bacterial agent. In this study, 28 days repeated-dose oral toxicity study of fluor-folpet was carried out in Slc:Wistar rats. An oral toxicity study for fluor-folpet, the twenty-eight days test, repeated-dose, oral administration, was performed as follows: Five week-old rats, male and female, 10 rats, each/group, were treated with intragastric administration of fluor-folpet with a dose of 0 (1% Sodium CMC, control), 20, 80 and 320 mg/kg, body weight. Recovery test, for 14 days after the last treatment, was examined for the control and the 320 mg/kg groups. The 320 mg/kg groups, both males and females, showed significantly reduced their body-weight gain compared with the control group. In the 320 mg/kg group, five out of 20 male rats and four out of 20 female rats died from dyspnea during the treatment period. In the female rats in the 320 mg/kg group, serum ChE level was decreased to 50% of control level and gamma-GT was increased in a dose-dependent manner, but these serum levels recovered after 14 days non-treatment period. No histopathological change, relating to the treatment, in liver was observed. Increased weight of the kidney and vacuolation in renal tubules were found in both sexes of 320 mg/kg group. Hyperkeratosis and hyperplasia of the stomach epithelium were observed at the dose more than 80 mg/kg in male, and more than 20 mg/kg in female. A supplemental study, repeated-dose, oral administration in rats carried out to examine the dyspnea revealed that severe acute toxic damages in epithelium of nasal cavity and meatus nasopharyngeus were induced by intragastric administration of fluor-folpet. Fluor-folpet is shown to be cytotoxic. In conclusion, the no-observed-effect level (NOEL) for fluor-folpet was not found under the experimental conditions employed in this repeated-dose toxicity study.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19690364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Teratogenicity study of stevioside in rats]. 甜菊糖苷对大鼠致畸性的研究。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

M Usami, K Sakemi, K Kawashima, M Tsuda, Y Ohno

引用次数: 0

[Cell proliferative activities of cholangiofibrosis induced in rats treated with bromodichloromethane]. [溴二氯甲烷诱导大鼠胆管纤维化的细胞增殖活性]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

K Yasuhara, K Mitsumori, Y Aida, H Onodera, M Takahashi

{"title":"[Cell proliferative activities of cholangiofibrosis induced in rats treated with bromodichloromethane].","authors":"K Yasuhara, K Mitsumori, Y Aida, H Onodera, M Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"To clarify whether bromodichloromethane (BDCM)-induced cholangiofibrosis progresses to cholangiocarcinoma, further morphological examinations were performed on the livers obtained from our previous experiment. The livers of Wistar rats fed diet containing 2200, 550, 140 or 0 ppm of microencapsulated BDCM up to 24 months were examined at months 6, 12, 18, and 24. The liver sections were stained with H-E, PAS and Azan, and were subjected to immunostaining using antiproliferating cell nuclear antigen (PCNA) monoclonal antibody for determination of the PCNA labeling index of bile duct epithelia, as well as silver staining for nucleolar organizer regions (AgNORs). At month 6, the severity of hyperplasia of atypical bile duct epithelia in the 2200 ppm group was marked, their PCNA labeling index being highest (68.5). The number of bile ducts gradually decreased, and the severity of fibrosis became more marked, with prolongation of the treatment. The PCNA labeling index in hyperplastic bile ducts in this group also decreased to 31.5 at month 24. The number of AgNORs in the nuclei of bile duct epithelia in the 2200 ppm group was highest at month 6, but decreased thereafter. The present study suggests that the possibility of the progression from cholangiofibrosis to neoplastic lesions is extremelly low.","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19690368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Toxicity in rats fed diet containing iron lactate for 26 weeks]. [饲喂含乳酸铁饲料26周大鼠的毒性研究]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

K Takegawa, K Yasuhara, K Mitsumori, H Onodera, T Shimo, M Takahashi

引用次数: 0

[A study on the establishment of the specification of polyvinylpolypyrroridone as a food additive]. 【关于建立聚乙烯聚吡咯烷酮食品添加剂规范的研究】。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

Y Kawasaki, Y Takeda, H Ishiwata, T Yamada

引用次数: 0

[Migration of lead and cadmium from lacquered tableware]. [漆餐具中铅和镉的迁移]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

Y Kawamura, T Sugita, I Tuji, T Yamada

引用次数: 0

[First drafts of the Environmental Health Criteria (EHC) circulated for comments by IPCS in 1994-1995]. [环境卫生标准初稿于1994-1995年分发，供ipcc提出意见]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

C Ohtake

引用次数: 0

[Technical implications on the quality standard of new drugs]. [对新药质量标准的技术影响]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

M Uchiyama

引用次数: 0

[Globalization of herbal medicines]. [草药的全球化]。

Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences Pub Date : 1995-01-01

M Satake

引用次数: 0