IF 6.4 1区生物学

eLife Pub Date : 2025-01-13 DOI: 10.7554/eLife.96303

Claire Meissner-Bernard, Friedemann Zenke, Rainer W Friedrich

{"title":"Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.","authors":"Claire Meissner-Bernard, Friedemann Zenke, Rainer W Friedrich","doi":"10.7554/eLife.96303","DOIUrl":"10.7554/eLife.96303","url":null,"abstract":"Biological memory networks are thought to store information by experience-dependent changes in the synaptic connectivity between assemblies of neurons. Recent models suggest that these assemblies contain both excitatory and inhibitory neurons (E/I assemblies), resulting in co-tuning and precise balance of excitation and inhibition. To understand computational consequences of E/I assemblies under biologically realistic constraints we built a spiking network model based on experimental data from telencephalic area Dp of adult zebrafish, a precisely balanced recurrent network homologous to piriform cortex. We found that E/I assemblies stabilized firing rate distributions compared to networks with excitatory assemblies and global inhibition. Unlike classical memory models, networks with E/I assemblies did not show discrete attractor dynamics. Rather, responses to learned inputs were locally constrained onto manifolds that 'focused' activity into neuronal subspaces. The covariance structure of these manifolds supported pattern classification when information was retrieved from selected neuronal subsets. Networks with E/I assemblies therefore transformed the geometry of neuronal coding space, resulting in continuous representations that reflected both relatedness of inputs and an individual's experience. Such continuous representations enable fast pattern classification, can support continual learning, and may provide a basis for higher-order learning and cognitive computations.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG. 通过脑电图非周期成分评估慢性疼痛的兴奋和抑制之间的平衡。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-13 DOI: 10.7554/eLife.101727

Cristina Gil Avila, Elisabeth S May, Felix S Bott, Laura Tiemann, Vanessa Hohn, Henrik Heitmann, Paul Theo Zebhauser, Joachim Gross, Markus Ploner

{"title":"Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG.","authors":"Cristina Gil Avila, Elisabeth S May, Felix S Bott, Laura Tiemann, Vanessa Hohn, Henrik Heitmann, Paul Theo Zebhauser, Joachim Gross, Markus Ploner","doi":"10.7554/eLife.101727","DOIUrl":"10.7554/eLife.101727","url":null,"abstract":"Chronic pain is a prevalent and debilitating condition whose neural mechanisms are incompletely understood. An imbalance of cerebral excitation and inhibition (E/I), particularly in the medial prefrontal cortex (mPFC), is believed to represent a crucial mechanism in the development and maintenance of chronic pain. Thus, identifying a non-invasive, scalable marker of E/I could provide valuable insights into the neural mechanisms of chronic pain and aid in developing clinically useful biomarkers. Recently, the aperiodic component of the electroencephalography (EEG) power spectrum has been proposed to represent a non-invasive proxy for E/I. We, therefore, assessed the aperiodic component in the mPFC of resting-state EEG recordings in 149 people with chronic pain and 115 healthy participants. We found robust evidence against differences in the aperiodic component in the mPFC between people with chronic pain and healthy participants, and no correlation between the aperiodic component and pain intensity. These findings were consistent across different subtypes of chronic pain and were similarly found in a whole-brain analysis. Their robustness was supported by preregistration and multiverse analyses across many different methodological choices. Together, our results suggest that the EEG aperiodic component does not differentiate between people with chronic pain and healthy individuals. These findings and the rigorous methodological approach can guide future studies investigating non-invasive, scalable markers of cerebral dysfunction in people with chronic pain and beyond.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins. 感觉经验通过涉及退化素的不同途径控制树突结构和行为。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.83973

Sharon Inberg, Yael Iosilevskii, Alba Calatayud-Sanchez, Hagar Setty, Meital Oren-Suissa, Michael Krieg, Benjamin Podbilewicz

{"title":"Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.","authors":"Sharon Inberg, Yael Iosilevskii, Alba Calatayud-Sanchez, Hagar Setty, Meital Oren-Suissa, Michael Krieg, Benjamin Podbilewicz","doi":"10.7554/eLife.83973","DOIUrl":"10.7554/eLife.83973","url":null,"abstract":"Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the Caenorhabditis elegans' arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals. We found that mechanosensory signals induced by conspecifics and by glass beads affect the dendritic structure of the PVD. Moreover, developmentally isolated animals show a decrease in their ability to respond to harsh touch. The structural and behavioral plasticity following sensory deprivation are functionally independent of each other and are mediated by an array of evolutionarily conserved mechanosensory amiloride-sensitive epithelial sodium channels (degenerins). Calcium imaging of the PVD neurons in a micromechanical device revealed that controlled mechanical stimulation of the body wall produces similar calcium dynamics in both isolated and crowded animals. Our genetic results, supported by optogenetic, behavioral, and pharmacological evidence, suggest an activity-dependent homeostatic mechanism for dendritic structural plasticity, that in parallel controls escape response to noxious mechanosensory stimuli.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat. 臂旁CGRP神经元在自然威胁下调节主动防御行为。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.101523

Gyeong Hee Pyeon, Hyewon Cho, Byung Min Chung, June-Seek Choi, Yong Sang Jo

{"title":"Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.","authors":"Gyeong Hee Pyeon, Hyewon Cho, Byung Min Chung, June-Seek Choi, Yong Sang Jo","doi":"10.7554/eLife.101523","DOIUrl":"https://doi.org/10.7554/eLife.101523","url":null,"abstract":"Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons serve as a true general alarm, their activation would modulate both passive nad active defensive behaviors depending on the magnitude and context of the threat. However, most prior research has focused on the role of CGRP neurons in passive freezing responses, with limited exploration of their involvement in active defensive behaviors. To address this, we examined the role of CGRP neurons in active defensive behavior using a predator-like robot programmed to chase mice. Our electrophysiological results revealed that CGRP neurons encode the intensity of aversive stimuli through variations in firing durations and amplitudes. Optogenetic activation of CGRP neuron during robot chasing elevated flight responses in both conditioning and retention tests, presumably by amyplifying the perception of the threat as more imminent and dangerous. In contrast, animals with inactivated CGRP neurons exhibited reduced flight responses, even when the robot was programmed to appear highly threatening during conditioning. These findings expand the understanding of CGRP neurons in the PBN as a critical alarm system, capable of dynamically regulating active defensive behaviors by amplifying threat perception, ensuring adaptive responses to varying levels of danger.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging. 活细胞单分子成像揭示核受体相互作用网络的惊人特征。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.92979

Liza Dahal, Thomas G W Graham, Gina M Dailey, Alec Heckert, Robert Tjian, Xavier Darzacq

{"title":"Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging.","authors":"Liza Dahal, Thomas G W Graham, Gina M Dailey, Alec Heckert, Robert Tjian, Xavier Darzacq","doi":"10.7554/eLife.92979","DOIUrl":"10.7554/eLife.92979","url":null,"abstract":"Type II nuclear receptors (T2NRs) require heterodimerization with a common partner, the retinoid X receptor (RXR), to bind cognate DNA recognition sites in chromatin. Based on previous biochemical and overexpression studies, binding of T2NRs to chromatin is proposed to be regulated by competition for a limiting pool of the core RXR subunit. However, this mechanism has not yet been tested for endogenous proteins in live cells. Using single-molecule tracking (SMT) and proximity-assisted photoactivation (PAPA), we monitored interactions between endogenously tagged RXR and retinoic acid receptor (RAR) in live cells. Unexpectedly, we find that higher expression of RAR, but not RXR, increases heterodimerization and chromatin binding in U2OS cells. This surprising finding indicates the limiting factor is not RXR but likely its cadre of obligate dimer binding partners. SMT and PAPA thus provide a direct way to probe which components are functionally limiting within a complex TF interaction network providing new insights into mechanisms of gene regulation in vivo with implications for drug development targeting nuclear receptors.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"12 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The NeuroML ecosystem for standardized multi-scale modeling in neuroscience. 神经科学中标准化多尺度建模的NeuroML生态系统。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.95135

Ankur Sinha, Padraig Gleeson, Bóris Marin, Salvador Dura-Bernal, Sotirios Panagiotou, Sharon Crook, Matteo Cantarelli, Robert C Cannon, Andrew P Davison, Harsha Gurnani, Robin Angus Silver

{"title":"The NeuroML ecosystem for standardized multi-scale modeling in neuroscience.","authors":"Ankur Sinha, Padraig Gleeson, Bóris Marin, Salvador Dura-Bernal, Sotirios Panagiotou, Sharon Crook, Matteo Cantarelli, Robert C Cannon, Andrew P Davison, Harsha Gurnani, Robin Angus Silver","doi":"10.7554/eLife.95135","DOIUrl":"10.7554/eLife.95135","url":null,"abstract":"Data-driven models of neurons and circuits are important for understanding how the properties of membrane conductances, synapses, dendrites, and the anatomical connectivity between neurons generate the complex dynamical behaviors of brain circuits in health and disease. However, the inherent complexity of these biological processes makes the construction and reuse of biologically detailed models challenging. A wide range of tools have been developed to aid their construction and simulation, but differences in design and internal representation act as technical barriers to those who wish to use data-driven models in their research workflows. NeuroML, a model description language for computational neuroscience, was developed to address this fragmentation in modeling tools. Since its inception, NeuroML has evolved into a mature community standard that encompasses a wide range of model types and approaches in computational neuroscience. It has enabled the development of a large ecosystem of interoperable open-source software tools for the creation, visualization, validation, and simulation of data-driven models. Here, we describe how the NeuroML ecosystem can be incorporated into research workflows to simplify the construction, testing, and analysis of standardized models of neural systems, and supports the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles, thus promoting open, transparent and reproducible science.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping patterns of thought onto brain activity during movie-watching. 在看电影时将思维模式映射到大脑活动。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.97731

Raven Star Wallace, Bronte Mckeown, Ian Goodall-Halliwell, Louis Chitiz, Philippe Forest, Theodoros Karapanagiotidis, Bridget Mulholland, Adam Turnbull, Tamara Vanderwal, Samyogita Hardikar, Tirso R J Gonzalez Alam, Boris C Bernhardt, Hao-Ting Wang, Will Strawson, Michael Milham, Ting Xu, Daniel S Margulies, Giulia L Poerio, Elizabeth Jefferies, Jeremy I Skipper, Jeffrey D Wammes, Robert Leech, Jonathan Smallwood

{"title":"Mapping patterns of thought onto brain activity during movie-watching.","authors":"Raven Star Wallace, Bronte Mckeown, Ian Goodall-Halliwell, Louis Chitiz, Philippe Forest, Theodoros Karapanagiotidis, Bridget Mulholland, Adam Turnbull, Tamara Vanderwal, Samyogita Hardikar, Tirso R J Gonzalez Alam, Boris C Bernhardt, Hao-Ting Wang, Will Strawson, Michael Milham, Ting Xu, Daniel S Margulies, Giulia L Poerio, Elizabeth Jefferies, Jeremy I Skipper, Jeffrey D Wammes, Robert Leech, Jonathan Smallwood","doi":"10.7554/eLife.97731","DOIUrl":"10.7554/eLife.97731","url":null,"abstract":"Movie-watching is a central aspect of our lives and an important paradigm for understanding the brain mechanisms behind cognition as it occurs in daily life. Contemporary views of ongoing thought argue that the ability to make sense of events in the 'here and now' depend on the neural processing of incoming sensory information by auditory and visual cortex, which are kept in check by systems in association cortex. However, we currently lack an understanding of how patterns of ongoing thoughts map onto the different brain systems when we watch a film, partly because methods of sampling experience disrupt the dynamics of brain activity and the experience of movie-watching. Our study established a novel method for mapping thought patterns onto the brain activity that occurs at different moments of a film, which does not disrupt the time course of brain activity or the movie-watching experience. We found moments when experience sampling highlighted engagement with multi-sensory features of the film or highlighted thoughts with episodic features, regions of sensory cortex were more active and subsequent memory for events in the movie was better-on the other hand, periods of intrusive distraction emerged when activity in regions of association cortex within the frontoparietal system was reduced. These results highlight the critical role sensory systems play in the multi-modal experience of movie-watching and provide evidence for the role of association cortex in reducing distraction when we watch films.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valence and salience encoding in the central amygdala. 中央杏仁核的价态和显著性编码。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.101980

Mi-Seon Kong, Ethan Ancell, Daniela M Witten, Larry S Zweifel

引用次数: 0

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis. 过大的细胞激活全局蛋白酶体介导的蛋白质降解来维持细胞大小的稳态。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-10 DOI: 10.7554/eLife.75393

Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri

{"title":"Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.","authors":"Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri","doi":"10.7554/eLife.75393","DOIUrl":"https://doi.org/10.7554/eLife.75393","url":null,"abstract":"Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell size checkpoints, which delay cell cycle progression in small cells, and size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018). While we previously identified the p38 MAPK pathway as a key regulator of the mammalian cell size checkpoint (S. Liu et al., 2018), the mechanism of size-dependent growth rate regulation has remained elusive. Here, we quantified global rates of protein synthesis and degradation in cells of varying sizes, both under unperturbed conditions and in response to perturbations that trigger size-dependent compensatory growth slowdown. We found that protein synthesis rates scale proportionally with cell size across cell cycle stages and experimental conditions. In contrast, oversized cells that undergo compensatory growth slowdown exhibit a superlinear increase in proteasome-mediated protein degradation, with accelerated protein turnover per unit mass, suggesting activation of the proteasomal degradation pathway. Both nascent and long-lived proteins contribute to the elevated protein degradation during compensatory growth slowdown, with long-lived proteins playing a crucial role at the G1/S transition. Notably, large G1/S cells exhibit particularly high efficiency in protein degradation, surpassing that of similarly sized or larger cells in S and G2, coinciding with the timing of the most stringent size control in animal cells. These results collectively suggest that oversized cells reduce their growth efficiency by activating global proteasome-mediated protein degradation to promote cell size homeostasis.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"14 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-resolution awake mouse fMRI at 14 tesla. 高分辨率清醒小鼠fMRI在14特斯拉。

IF 6.4 1区生物学

eLife Pub Date : 2025-01-09 DOI: 10.7554/eLife.95528

David Hike, Xiaochen Liu, Zeping Xie, Bei Zhang, Sangcheon Choi, Xiaoqing Alice Zhou, Andy Liu, Alyssa Murstein, Yuanyuan Jiang, Anna Devor, Xin Yu

{"title":"High-resolution awake mouse fMRI at 14 tesla.","authors":"David Hike, Xiaochen Liu, Zeping Xie, Bei Zhang, Sangcheon Choi, Xiaoqing Alice Zhou, Andy Liu, Alyssa Murstein, Yuanyuan Jiang, Anna Devor, Xin Yu","doi":"10.7554/eLife.95528","DOIUrl":"10.7554/eLife.95528","url":null,"abstract":"High-resolution awake mouse functional magnetic resonance imaging (fMRI) remains challenging despite extensive efforts to address motion-induced artifacts and stress. This study introduces an implantable radio frequency (RF) surface coil design that minimizes image distortion caused by the air/tissue interface of mouse brains while simultaneously serving as a headpost for fixation during scanning. Furthermore, this study provides a thorough acclimation method used to accustom animals to the MRI environment minimizing motion-induced artifacts. Using a 14 T scanner, high-resolution fMRI enabled brain-wide functional mapping of visual and vibrissa stimulation at 100 µm×100 µm×200 µm resolution with a 2 s per frame sampling rate. Besides activated ascending visual and vibrissa pathways, robust blood oxygen level-dependent (BOLD) responses were detected in the anterior cingulate cortex upon visual stimulation and spread through the ventral retrosplenial area (VRA) with vibrissa air-puff stimulation, demonstrating higher-order sensory processing in association cortices of awake mice. In particular, the rapid hemodynamic responses in VRA upon vibrissa stimulation showed a strong correlation with the hippocampus, thalamus, and prefrontal cortical areas. Cross-correlation analysis with designated VRA responses revealed early positive BOLD signals at the contralateral barrel cortex (BC) occurring 2 s prior to the air-puff in awake mice with repetitive stimulation, which was not detected using a randomized stimulation paradigm. This early BC activation indicated a learned anticipation through the vibrissa system and association cortices in awake mice under continuous exposure of repetitive air-puff stimulation. This work establishes a high-resolution awake mouse fMRI platform, enabling brain-wide functional mapping of sensory signal processing in higher association cortical areas.","PeriodicalId":11640,"journal":{"name":"eLife","volume":"13 ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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