Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing最新文献

筛选
英文 中文
Review of the Pathology, Diagnosis and Treatment for Alzheimer's Disease 阿尔茨海默病的病理、诊断和治疗进展
Xian-Guo Liu
{"title":"Review of the Pathology, Diagnosis and Treatment for Alzheimer's Disease","authors":"Xian-Guo Liu","doi":"10.1145/3448748.3448767","DOIUrl":"https://doi.org/10.1145/3448748.3448767","url":null,"abstract":"Alzheimer's disease (AD), the leading cause of dementia--a continuous decline in thinking, behavioral and social skills--worldwide in the late ages, is becoming increasingly serious due to the fact that the global population is aging. However it is not a normal part of aging. It is now threatening public health systems. Countless families are suffering from older members' cognitive decline. Memory loss is typical of the symptoms. Although there are some medications that relieve the symptoms for AD patients, further research on a definitive cure of this disease is still in urgent necessity. This review is talking about updates on AD's pathology, diagnosis and treatment.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126016786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Diagnosis of Parkinson's Disease Based on Gait, Speech Analysis and Machine Learning Techniques 基于步态、语音分析和机器学习技术的帕金森病诊断
Yuyang Miao, X. Lou, H. Wu
{"title":"The Diagnosis of Parkinson's Disease Based on Gait, Speech Analysis and Machine Learning Techniques","authors":"Yuyang Miao, X. Lou, H. Wu","doi":"10.1145/3448748.3448804","DOIUrl":"https://doi.org/10.1145/3448748.3448804","url":null,"abstract":"Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system. The common symptoms are tremor, rigidity, slowness of movement, and difficulty with walking at early stages. Currently, PD can't be cured. And there are not really effective methods to diagnose it. However, machine learning is a new way for the diagnosis of PD. It can build a model from PD patients' dataset, which can help classify PD and healthy people. In this review, the applications of machine learning for PD diagnosis by algorithms and data are analyzed. Several machine learning classifiers are briefly introduced, including artificial neural network (ANN), support vector machine (SVM), Naive Bayes (NB), K-Nearest Neighbor (k-NN). Next, the basis of gait analysis is introduced, including gait circle and gait data, and then, each step of the machine learning processing is focused on. Two ways are concentrated to analyze speech signals - support vector machine (SVM) and artificial neural network (ANN). This review presents that machine learning has good performances for the diagnosis of PD. However, it can only be a diagnosis tool to help doctors because of its limited generalization. In the future, people should explore more effective algorithms with better generalization.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123342044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Decoding Categories from Human Brain Activity in the Human Visual Cortex Using the Triplet Network 利用三重网络解码人类视觉皮层中人脑活动的分类
Lulu Hu, Jingwei Li, Chi Zhang, Li Tong
{"title":"Decoding Categories from Human Brain Activity in the Human Visual Cortex Using the Triplet Network","authors":"Lulu Hu, Jingwei Li, Chi Zhang, Li Tong","doi":"10.1145/3448748.3448769","DOIUrl":"https://doi.org/10.1145/3448748.3448769","url":null,"abstract":"Decoding visual stimuli from functional magnetic resonance imaging (fMRI) is of great significance for understanding the neural mechanism of the visual information processing in the human brain. How to extract effective information from massive voxel data in the brain to predict the brain state is a problem worth discussing in fMRI. However, the inherent characteristics of small quantity and high dimensionality in fMRI data limited the performance of brain decoding. As an effective way to acquire visual information, people usually compare with the prior knowledge learned when recognizing objects, and does not need to have a complete understanding of visual information. In this paper, we proposed a new visual classification model to decode the stimulus categories from the visual information of the brain based on the triplet network. The triplet network is a model framework with a comparison mechanism similar to that of human visual recognition objects, contains three-branches weight sharing subnetworks, which are composed of fully connected networks in our model. Our results showed that the decoding accuracy is 57.5±1.86% and 44.17±1.31% for S1 and S2, respectively. S1 was about 6% higher than the best traditional machine learning classifier SVM, while S2 was nearly 3.5% higher than SVM. Our results fully confirmed the validity of comparing the differences between samples in fMRI data with small quantity.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121673231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Frequency-constrained Spectrum Difference Mapping Framework for Decoding Brain Activity from Functional Magnetic Resonance Imaging Data 从功能磁共振成像数据解码脑活动的频率约束频谱差分映射框架
Qin Yu, Yulong Xiong, Haitong Tang, Shuang He, Kaiyue Liu, Ni-zhuan Wang
{"title":"A Frequency-constrained Spectrum Difference Mapping Framework for Decoding Brain Activity from Functional Magnetic Resonance Imaging Data","authors":"Qin Yu, Yulong Xiong, Haitong Tang, Shuang He, Kaiyue Liu, Ni-zhuan Wang","doi":"10.1145/3448748.3448792","DOIUrl":"https://doi.org/10.1145/3448748.3448792","url":null,"abstract":"Many studies have shown that spontaneous low-frequency oscillation is an intrinsic attribute of human brain activity based on the resting-state blood oxygen level-dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) technology. Amplitude of low-frequency fluctuations (ALFF) is an effective way to capture the low-frequency fluctuation and has a hugely wide range of applications in mental disorders, neurological diseases, occupational neuroplasticity, etc. Such approaches, however, needs further improvement in two problems: low sensitivity to low-frequency signals; noise signal interference. Based on this, this paper proposes a frequency-constrained spectrum difference mapping framework (SDMF). A frequency domain is transformed through fast Fourier transform (FFT) and divided by designating Frequency(low), Frequency(mid), and Frequency(high). Then, spectrum difference value (SDV) is calculated between the two regions as the characterization value of brain activity state. Through our experimental results, we propose that SDMF can achieve the noise reduction effect, and it is the same as the region of the spontaneous active state in the traditional ALFF. In our method, it also showed that SDMF with different metrics has achieved the suppression of the Temporal, Lingual, and enhancement of the Occipital region. All in all, SDMF is a basic framework to analyze the band constraints, and the traditional ALFF can also be included as a special mode.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131193806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cooperative Co-evolution Algorithm for Fuzzy Production Planning and Scheduling in Prefabricated Building Construction 装配式建筑施工中模糊生产计划与调度的协同进化算法
Yisong Yuan, S. Ye, Hang Yang, Lin Lin
{"title":"A Cooperative Co-evolution Algorithm for Fuzzy Production Planning and Scheduling in Prefabricated Building Construction","authors":"Yisong Yuan, S. Ye, Hang Yang, Lin Lin","doi":"10.1145/3448748.3448791","DOIUrl":"https://doi.org/10.1145/3448748.3448791","url":null,"abstract":"This paper formulates a fuzzy production planning and scheduling (FPPS) model in prefabricated building (PB) construction. FPPS will help improve operation efficiency and stability of PB components manufacturing. This paper also focuses on the uncertainty of the execution time of the operations, and constructs the interval value of the execution time to express it through fuzzy theory. This paper proposes a cooperative co-evolution algorithm (CCEA) to solve this NP-hard combinatorial optimization problem with complex system constrains. This paper designs a multi-stage representation for FPPS, and improves CCEA with a self-adaptive mechanism and a self-adaptive selection process. The benchmarks and extended datasets with fuzzy processing time, and an example of practical prefabricated building construction project is adopted to test our CCEA. Computational results show that the CCEA performs better than the existing state-of-the-art methods.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131535495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Study on Dispatching Model of Block Economy Based-Data Mining 基于数据挖掘的块经济调度模型研究
Xiaohan Gao, Qiang Lin
{"title":"Study on Dispatching Model of Block Economy Based-Data Mining","authors":"Xiaohan Gao, Qiang Lin","doi":"10.1145/3448748.3448990","DOIUrl":"https://doi.org/10.1145/3448748.3448990","url":null,"abstract":"Economic dispatch plays the most important role in the economic and stability of financial system operation. With the introduction of many intelligent management models in economic construction, the scale of collectible financial system data has shown an explosive growth trend. In the paper, a PSO-LSSVM data mining prediction model based on big data is established, and a block-based economic dispatch method is proposed to deal with financial risks. In the experiment, financial data is used as a sample to predict the actual risk curve. The results show that the risk prediction result obtained by the proposed prediction algorithm is closer to the actual risk. The validity of the model is explained, and the experimental results provide a decision-making basis for the economic dispatch of the financial system.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114404147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome analysis and identification of key pathway in visceral adipose tissue from obesity-related diabetes 肥胖相关糖尿病内脏脂肪组织关键通路的基因组分析和鉴定
Yue Shi, Wentao Han, Huagen Wei, Siwei Zhou, Weizheng Kong, Li-ping Shi, Huiqun Wu
{"title":"Genome analysis and identification of key pathway in visceral adipose tissue from obesity-related diabetes","authors":"Yue Shi, Wentao Han, Huagen Wei, Siwei Zhou, Weizheng Kong, Li-ping Shi, Huiqun Wu","doi":"10.1145/3448748.3448757","DOIUrl":"https://doi.org/10.1145/3448748.3448757","url":null,"abstract":"Obesity increases the risk of diabetes; however, not everyone who is obese develops diabetes. In this study, the dataset GSE54350 was downloaded from the Gene Expression Omnibus database (GEO), including obese diabetic and non-diabetic samples as control. Differentially expressed genes (DEGs) between obese diabetic and non-diabetic samples were selected using GEO2R plugin. Gene ontology (GO) enrichment and protein-protein interaction (PPI) analysis of these DEGs were performed using Metascape. The results showed 1073 DEGs, including 496 up-regulated genes and 577 down-regulated genes. These DEGs were enriched in biological pathways involved in hemostasis, regulation of organelle assembly, apoptotic signaling, myeloid leukocyte activation, apoptosis, etc. We revealed that Caspase 3 (CASP3) and tissue inhibitor of metalloproteinase 3 (TIMP3) might serve as marker genes and potential therapeutic targets for obesity-related diabetes, which deserves further investigations for validation.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123204721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid multiplexed detection of cytokines with microfluidic chip 微流控芯片快速多路检测细胞因子
Q. Lin, Shih-Mo Yang, Wenjun Zhang
{"title":"Rapid multiplexed detection of cytokines with microfluidic chip","authors":"Q. Lin, Shih-Mo Yang, Wenjun Zhang","doi":"10.1145/3448748.3448754","DOIUrl":"https://doi.org/10.1145/3448748.3448754","url":null,"abstract":"We report an immunological method that integrates microfluidic chip and encoded beads to improve the accuracy and rapidity of molecules detection. The microfluidic chip for isolating individual beads in array can detect multiple cytokines simultaneously. The different kinds of encoded beads ware generated via two different polymers mixed at specific ratios. The surface of the beads was chemically modified to obtain sandwich-beads, making it capture specific cytokines. Two emission light were combined to excite encoded beads and anti-body simultaneously. Then we used CCD camera to take images. Finally, the images was analyzed by image processing algorithm to drew standard curves. We applied it to detect the concentration of IL-2, IL-10 and IL-6 cytokines in one sample simultaneously, and the results reach the level of pg/ml. The method used in this article for detecting the rare concentration of multi-cytokine raises the efficiency of immunology.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125393508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High electric conducting 1D nanomaterial/polymer composite fibers for wearable biomedical sensing system 用于可穿戴生物医学传感系统的高导电性一维纳米/聚合物复合纤维
Haiyang Lu, Zhihao Yang, Long Ba
{"title":"High electric conducting 1D nanomaterial/polymer composite fibers for wearable biomedical sensing system","authors":"Haiyang Lu, Zhihao Yang, Long Ba","doi":"10.1145/3448748.3448750","DOIUrl":"https://doi.org/10.1145/3448748.3448750","url":null,"abstract":"As a fundamental material for smart biomedical suit with multicomponent sensors and signal transmission, high electric conducting polymer fibers with excellent strain durability have gained extensive interesting for years. We have developed a robust protocol for the fabrication of high conducting 1D nanomaterial/polymer composite fibers. The silver nanowires (AgNWs) and single wall carbon nanotubes (SWCNTs) were used as electric conducting elements. By using multiple coating procedure through coaxial nozzle, the 1D materials were uniformly enveloped on commercial polyamide 6 (PA6) fiber surface. The conductivity of the fibers and its stability under tensile strain were measured. It was found that AgNWs coated fiber has length resistance about 12 &OHgr;/cm and SWCNTs coated fiber has length resistance about 3600 &OHgr;/cm. Both fibers have excellent flexibility and strain stability, while the strain stability of SWCNT coated fiber is much higher that of AgNW coated fiber. The analysis indicates that the higher strain stability of SWCNTs coated fiber is attributed to the high tensile strength of carbon nanotube and mutual slip of cross covered network. The stable conductivity of both fibers enables them be used as wide varieties human wearable biomedical sensors and signal transmission lines compatible with textile technologies.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"GE-23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126565378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research on Crisis Warning Model of Enterprise Finance Based on Deep Learning 基于深度学习的企业财务危机预警模型研究
Yeming Chen, Xinyuan Han
{"title":"Research on Crisis Warning Model of Enterprise Finance Based on Deep Learning","authors":"Yeming Chen, Xinyuan Han","doi":"10.1145/3448748.3448775","DOIUrl":"https://doi.org/10.1145/3448748.3448775","url":null,"abstract":"Looking for an effective financial crisis early warning method is of great significance to China's economy and company development. This paper fully considers the internal factors that affect the financial situation of enterprises, and establishes a financial early warning index system composed of eighteen secondary indicators. This paper uses LSTM neural network in deep learning to establish an early warning model. The results show that the prediction accuracy of the early warning model based on deep learning can reach more than 85%.","PeriodicalId":115821,"journal":{"name":"Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123917447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信