Archives of Immunology Research and Therapy最新文献

Prevalence of rs11385942 and rs657152 single nucleotide polymorphisms in the world population susceptible to severe COVID-19 rs11385942和rs657152单核苷酸多态性在全球严重COVID-19易感人群中的流行情况

Archives of Immunology Research and Therapy Pub Date : 2023-02-06 DOI: 10.58489/2836-5003/006

M. Biswas

{"title":"Prevalence of rs11385942 and rs657152 single nucleotide polymorphisms in the world population susceptible to severe COVID-19","authors":"M. Biswas","doi":"10.58489/2836-5003/006","DOIUrl":"https://doi.org/10.58489/2836-5003/006","url":null,"abstract":"Aims: This study was aimed to investigate predictive prevalence of rs11385942 and rs657152 single nucleotide polymorphisms (SNPs) in the world populations since these were associated with severe COVID-19. Methods: Genetic data of rs11385942 and rs657152 SNPs of the 26 populations were obtained from the 1000 Genomes project. Phenotypes were assigned as high-risk, medium-risk or no-risk based on the carrying of characteristics risk alleles. Results: It was demonstrated that the prevalence of risk allele associated with rs11385942 SNP for developing severe COVID-19 was significantly different in various ethnic groups (Chi-square test, p<0.00001) with highly prevalent in South Asia (29.6%; 95% CI 27%-32%), followed by Europe (8.1%; 95% CI 6%-10%), Africa (5.3%; 95% CI 4%-7%), America (4.6%; 95% CI 3%-6%) and East Asia (0.5%; 95% CI 0%-1%), respectively. However, prevalence of risk allele associated with rs657152 SNP was not significantly different in various ethnic groups (Chi-square test, p=0.06) but was highly prevalent in South Asia (46.1%; 95% CI 44%-48%), followed by Africa (43.6%; 95% CI 43%-44%), Europe (36.8%; 95% CI 36%-37%), East Asia (36.3%; 95% CI 35%-38%) and America (30.5%; 95% CI 30%-31%), respectively. High-risk phenotypes associated with carrying two copies of rs11385942 variant alleles were significantly different in various ethnic groups (Chi-square test, p=0.005) with highly prevalent in South Asia (9.4%; 95% CI 7%-12%), followed by Africa (0.6%; 95% CI 0%-1%) and America (0.3%; 95% CI 0%-1%), respectively. Conclusion: Genetic associations of rs11385942 and rs657152 with severe COVID-19 should urgently assess in different ethnicities for pathogenesis of this pandemic disease.","PeriodicalId":115259,"journal":{"name":"Archives of Immunology Research and Therapy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122107497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Changes in Neurons of The Parietal Cortex and Hippocampus of Rats with Partial Cerebral Ischemia 脑局部缺血大鼠顶叶和海马神经元形态学变化

Archives of Immunology Research and Therapy Pub Date : 2023-02-06 DOI: 10.58489/2836-5003/009

E. Bon'

引用次数: 0

General Characteristics of Brain Immunohistochemical Markers 脑免疫组织化学标志物的一般特征

Archives of Immunology Research and Therapy Pub Date : 2023-02-06 DOI: 10.58489/2836-5003/007

Bon L.I.

引用次数: 0

Transmitting, mutational and pandemic nature of corona: the role of transposons, is1: tn:is1 and crispr- cas-9 冠状病毒的传播、突变和大流行性质:转座子、is1: tn:is1和crispr- cas-9的作用

Archives of Immunology Research and Therapy Pub Date : 2023-02-06 DOI: 10.58489/2836-5003/008

N. Brahma

{"title":"Transmitting, mutational and pandemic nature of corona: the role of transposons, is1: tn:is1 and crispr- cas-9","authors":"N. Brahma","doi":"10.58489/2836-5003/008","DOIUrl":"https://doi.org/10.58489/2836-5003/008","url":null,"abstract":"Corona/ Covid19/Omicron / SARS/ MARS similar viruses have no individual genetic mechanism to make them encapsulated spore forming microbes similar to bacteria, fungi, algal blooms involved spreading allergy. Transmission in all such cases need fluid dynamics of water and air. This flow does not require any support of matrix, i.e., nano particles of carbon, silicates and dust of animate inanimate molecules. They enter into lung alveoli surface epithelial cell, adhere on the surface of body saliva, originated due to cold and other infections. In support of ACE-I and II (Angiotensin Converting Enzyme I and II). So, there are two releasing mechanisms are existing in corona infection; one is the release of corona virus from the alveoli cells with matrix binds of one co-morbid patients directly to other healthy recipient at the distance of 6 m in a closed environment by its self-development irritation and allergy, as received by sudden irritating smoke developed from kitchen, pollen, that grows during grass cutting, cleaning and sanitization. Transcription of m-RNA, in a matrix based single corona after entering into lung alveoli starts to transcribe and translate to many molecules of corona viruses, damages alveoli cells of lung, caused due to individual physiological conditions, old (above 70 years) and young (below 40), co-morbid(sick) and healthy people at similar age groups. IS: Tn:IS), Crispr/Cas-9 DNA transposons existing in corona m-RNA starts to act during transcription, and translation","PeriodicalId":115259,"journal":{"name":"Archives of Immunology Research and Therapy","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124437688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological Disorders in Men Patients with Anogenital Warts 男性生殖器疣患者的免疫功能紊乱

Archives of Immunology Research and Therapy Pub Date : 2022-12-27 DOI: 10.58489/2836-5003/004

Munieva S.H

引用次数: 0

Existence of At Least 2 Classes of Ipa in Sea Star Immune System. Comparisons Between Asterias Rubens and Other Asterids 海星免疫系统中存在至少2类Ipa。鲁本斯星与其他小行星的比较

Archives of Immunology Research and Therapy Pub Date : 2022-12-27 DOI: 10.58489/2836-5003/005

M. Leclerc

引用次数: 0

Comparative Characteristics of Morphological Changes in Neurons of The Parietal Cortex of Rats with Anoxia of Ischemic and Respiratory Genesis 缺血性缺氧和呼吸性缺氧大鼠顶叶皮层神经元形态变化的比较特征

Archives of Immunology Research and Therapy Pub Date : 2022-12-27 DOI: 10.58489/2836-5003/003

M.A. Feduto

引用次数: 0

Pulmonology And Immunology; A Brief Overview 肺脏学与免疫学;简介

Archives of Immunology Research and Therapy Pub Date : 2022-12-27 DOI: 10.58489/2836-5003/002

Mirici Nihal Arzu

引用次数: 0

Perspective of Human Leukocyte Antigen testing 人白细胞抗原检测的展望

Archives of Immunology Research and Therapy Pub Date : 2022-12-27 DOI: 10.58489/2836-5003/001

N. Johnkennedy

{"title":"Perspective of Human Leukocyte Antigen testing","authors":"N. Johnkennedy","doi":"10.58489/2836-5003/001","DOIUrl":"https://doi.org/10.58489/2836-5003/001","url":null,"abstract":"Most of the cells in the body have proteins or markers called human leukocyte antigens (HLA). To determine which cells, belong in the body and which do not, the immune system uses HLA. Human leukocyte antigen (HLA) typing is used to match recipients and donors for bone marrow or cord blood transplants. The human major histocompatibility complex (HLA) is located on the short arm of chromosome 6, and it is a complex of genes that encode cell-surface proteins necessary for immune system regulation. It is well known that this human genetic system is the most polymorphic. HLA class I and class II molecules' biological function is to present antigens that have been processed into peptides. HLA was initially just a list of antigens discovered as a result of transplant rejection. HLAs are alloantigen’s that range from person to person due to genetic variance. In essence, every person's immune system is tailored to the distinct HLA and self-proteins produced by that person; when tissues are transferred to another person, however, things go wrong. Individuals almost always have different \"banks\" of HLAs, which causes transplant rejection because the recipient's immune system mistakes the transplanted tissue for non-self and kills the foreign tissue. HLAs were found as a result of this realization.","PeriodicalId":115259,"journal":{"name":"Archives of Immunology Research and Therapy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115310775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0