Comparative Characteristics of Morphological Changes in Neurons of The Parietal Cortex of Rats with Anoxia of Ischemic and Respiratory Genesis

Acute oxygen deficiency is the basis of a variety of pathological processes in many diseases and environmental factors. When studying the rat brain under conditions of its total ischemia and mechanical asphyxia, the presence of structural changes in both studied periods (after 30 and 60 minutes) was revealed: a decrease in the area and a change in shape (loss of sphericity and an increase in elongation) of cells, as well as a change in the degree of chromatophilia, which was manifested by a decrease in normochromic neurons with a simultaneous increase in hyperchromic shriveled neurons. At the same time, total cerebral ischemia led to more pronounced changes in the studied neurons of the parietal cortex, which was manifested by a more significant decrease in the area of neurons after 30 minutes of anoxia, while shape changes in the form of loss of sphericity and increased elongation were noted to a greater extent with mechanical asphyxia. These differences may be due to the preservation of cardiac activity during mechanical asphyxia for a short time.