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Roles of the PI3K/AKT Signalling Pathway in Cholangiocarcinoma: A Mini Review PI3K/AKT信号通路在胆管癌中的作用:综述
Earth Science Frontiers Pub Date : 2023-08-31 DOI: 10.11648/j.sf.20230403.12
Teng Fei Zhang, Hai Tao Lv, Yue Ting Jin, Wen x Ting Jin, Hai Bo Wu, Qiu Sheng Li, Peng Xiang Liu, Zi Qiang Wu, Yao Zheng Zhang
{"title":"Roles of the PI3K/AKT Signalling Pathway in Cholangiocarcinoma: A Mini Review","authors":"Teng Fei Zhang, Hai Tao Lv, Yue Ting Jin, Wen x Ting Jin, Hai Bo Wu, Qiu Sheng Li, Peng Xiang Liu, Zi Qiang Wu, Yao Zheng Zhang","doi":"10.11648/j.sf.20230403.12","DOIUrl":"https://doi.org/10.11648/j.sf.20230403.12","url":null,"abstract":": Cholangiocarcinoma (CCA) is a diverse group of malignant tumors originating from the bile duct and other sites in the biliary tree. Effective treatment methods for CCA are currently lacking. Therefore, understanding the genetic mechanisms and therapeutic targets is crucial for improving treatment outcomes and survival rates. This review focuses on the key roles of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in CCA tumor initiation and progression. Potential therapeutic approaches based on this pathway were also discussed. Results showed increased activation of the PI3K/AKT pathway in CCA tissues and proteins like p85α, mTOR","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76753328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of Major Diseases of Bread Wheat (Triticum aestivum L.) and Their Association with Altitude in the Central Part of Ethiopia 埃塞俄比亚中部面包小麦主要病害的重要性及其与海拔的关系
Earth Science Frontiers Pub Date : 2023-08-28 DOI: 10.11648/j.sf.20230403.11
Yitagesu Tadesse, Asela Kesho, Dereje Amare
{"title":"Importance of Major Diseases of Bread Wheat (<i>Triticum aestivum</i> L.) and Their Association with Altitude in the Central Part of Ethiopia","authors":"Yitagesu Tadesse, Asela Kesho, Dereje Amare","doi":"10.11648/j.sf.20230403.11","DOIUrl":"https://doi.org/10.11648/j.sf.20230403.11","url":null,"abstract":": A study of the wheat diseases importance in different locations and associated factors has been limited in Ethiopia. As a result","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83520739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuber Yield Loss Assessment of Potato (Solanum tuberosum) Due to Late Blight (Phytophthora infestans) Disease in Central Highland Parts of Ethiopia 埃塞俄比亚中部高原地区马铃薯晚疫病(疫霉)致块茎产量损失评估
Earth Science Frontiers Pub Date : 2023-08-22 DOI: 10.11648/j.sf.20230402.12
Asela Kesho, Yitagesu Tadesse
{"title":"Tuber Yield Loss Assessment of Potato (<i>Solanum tuberosum</i>) Due to Late Blight (<i>Phytophthora infestans</i>) Disease in Central Highland Parts of Ethiopia","authors":"Asela Kesho, Yitagesu Tadesse","doi":"10.11648/j.sf.20230402.12","DOIUrl":"https://doi.org/10.11648/j.sf.20230402.12","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75552521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs 液体固体:一种提高难水溶性药物溶解度和生物利用度的新技术
Earth Science Frontiers Pub Date : 2023-07-06 DOI: 10.11648/j.sf.20230402.11
Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule
{"title":"A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs","authors":"Andrew Chekwube Ezegbe, Grace Amarachi Ezegbe, Josephat Ikechukwu Ogbonna, Sabinus Ifeanyi Ofoefule","doi":"10.11648/j.sf.20230402.11","DOIUrl":"https://doi.org/10.11648/j.sf.20230402.11","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77452853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Sign-Detection-Scheme Using Modular Computation Technique for the Moduli Set {2n-1, 2n, 2n+1, 2(n+1)-1, 22n-5} 基于模集{2n- 1,2n, 2n+ 1,2 (n+1)- 1,22n -5}的高效符号检测方法
Earth Science Frontiers Pub Date : 2023-05-31 DOI: 10.11648/j.sf.20230401.12
Mohammed Ibrahim Daabo, Valentine Aveyom
{"title":"Efficient Sign-Detection-Scheme Using Modular Computation Technique for the Moduli Set {2<sup>n</sup>-1, 2<sup>n</sup>, 2<sup>n</sup>+1, 2<sup>(n+1)</sup>-1, 2<sup>2n</sup>-5}","authors":"Mohammed Ibrahim Daabo, Valentine Aveyom","doi":"10.11648/j.sf.20230401.12","DOIUrl":"https://doi.org/10.11648/j.sf.20230401.12","url":null,"abstract":": In computer arithmetic, one of the most important things to consider in hardware design is the ability of the system to detect and display numbers with their signs. This when properly managed will reduce errors and ensure hardware reliability. But interestingly, detecting and knowing the sign of a residue number during arithmetic operation is very difficult. Magnitude Comparison, Scaling and Number conversions are some of the other difficult operations in Residue Number System (RNS). Unlike the weighted number system, it is even extremely difficult to determine the sign of a number in an RNS architecture thereby hampering the full implementation RNS in general purpose computing. In this paper, an efficient sign detection algorithm for detecting the sign of a number in an RNS architecture is presented. In formulating the algorithms, X maximum, (X max ) is computed from the Dynamic Range, M=∏ ki=1 (m i ). Modular Computation Technique is employed as a converter to compute X from the residues (r 1 , r 2 , r 3 ) with respect to a given moduli set, say (cid:1) = { (cid:2) 1 , (cid:2) 2 …, (cid:2) n }. X is positive if X-X max <0 otherwise X is negative and the actual value is this case is computed as X-M. The moduli set {2 n -1, 2 n , 2 n +1, 2 (n+1) -1, 2 2n -5} is used for the system design implementation and for numerical illustrations. It is observed that the scheme effectively detects the sign of RNS numbers and theoretical analysis showed that simple hardware resources and low-power modular adders are used in the design. It is also observed that the scheme when implemented practically can help project RNS to be used in general purpose computing.","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84775350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essentials for soil and water conservation in ecosystem management 生态系统管理中的水土保持要点
Earth Science Frontiers Pub Date : 2021-07-25 DOI: 10.13745/J.ESF.SF.2020.10.4
Jia Dewen
{"title":"Essentials for soil and water conservation in ecosystem management","authors":"Jia Dewen","doi":"10.13745/J.ESF.SF.2020.10.4","DOIUrl":"https://doi.org/10.13745/J.ESF.SF.2020.10.4","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"17 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89242751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A technical framework for ecosystem conservation and restoration 生态系统保护与恢复的技术框架
Earth Science Frontiers Pub Date : 2021-07-25 DOI: 10.13745/J.ESF.SF.2020.10.23
Zhou Yan, Chendan Yan, Ying Lingxiao, Yang Chongyao
{"title":"A technical framework for ecosystem conservation and restoration","authors":"Zhou Yan, Chendan Yan, Ying Lingxiao, Yang Chongyao","doi":"10.13745/J.ESF.SF.2020.10.23","DOIUrl":"https://doi.org/10.13745/J.ESF.SF.2020.10.23","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"104 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78187934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Characteristics and tectonic significance of the early Paleozoic syenite granite from Jinchuan, Gansu Province 甘肃金川早古生代正长花岗岩特征及构造意义
Earth Science Frontiers Pub Date : 2021-07-25 DOI: 10.13745/J.ESF.SF.2020.7.7
Zhang Xiaoxu, Su Shangguo, Li Meiyu, Wang Weizhu
{"title":"Characteristics and tectonic significance of the early Paleozoic syenite granite from Jinchuan, Gansu Province","authors":"Zhang Xiaoxu, Su Shangguo, Li Meiyu, Wang Weizhu","doi":"10.13745/J.ESF.SF.2020.7.7","DOIUrl":"https://doi.org/10.13745/J.ESF.SF.2020.7.7","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"27 1","pages":"283"},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91083478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporospatial distribution and influencing factor analysis of dust concentration in Wuhai, Inner Mongolia 内蒙古乌海地区粉尘浓度时空分布及影响因素分析
Earth Science Frontiers Pub Date : 2021-07-25 DOI: 10.13745/J.ESF.SF.2020.10.5
Zhang Minghao, Zhao Tingning, Xiao Huijie
{"title":"Temporospatial distribution and influencing factor analysis of dust concentration in Wuhai, Inner Mongolia","authors":"Zhang Minghao, Zhao Tingning, Xiao Huijie","doi":"10.13745/J.ESF.SF.2020.10.5","DOIUrl":"https://doi.org/10.13745/J.ESF.SF.2020.10.5","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"9 1","pages":"118"},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87551775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Iron and manganese in shallow groundwater in Shijiazhuang: Distribution characteristics and a cause analysis 石家庄市浅层地下水中铁、锰的分布特征及成因分析
Earth Science Frontiers Pub Date : 2021-07-25 DOI: 10.13745/J.ESF.SF.2020.7.4
Zhang Xiaowen, He Jiangtao, Huang Guanxing
{"title":"Iron and manganese in shallow groundwater in Shijiazhuang: Distribution characteristics and a cause analysis","authors":"Zhang Xiaowen, He Jiangtao, Huang Guanxing","doi":"10.13745/J.ESF.SF.2020.7.4","DOIUrl":"https://doi.org/10.13745/J.ESF.SF.2020.7.4","url":null,"abstract":"","PeriodicalId":11503,"journal":{"name":"Earth Science Frontiers","volume":"98 1","pages":"206"},"PeriodicalIF":0.0,"publicationDate":"2021-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74563868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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