Roles of the PI3K/AKT Signalling Pathway in Cholangiocarcinoma: A Mini Review

Q3 Earth and Planetary Sciences

地学前缘 Pub Date : 2023-08-31 DOI:10.11648/j.sf.20230403.12

Teng Fei Zhang, Hai Tao Lv, Yue Ting Jin, Wen x Ting Jin, Hai Bo Wu, Qiu Sheng Li, Peng Xiang Liu, Zi Qiang Wu, Yao Zheng Zhang

引用次数: 0

Abstract

: Cholangiocarcinoma (CCA) is a diverse group of malignant tumors originating from the bile duct and other sites in the biliary tree. Effective treatment methods for CCA are currently lacking. Therefore, understanding the genetic mechanisms and therapeutic targets is crucial for improving treatment outcomes and survival rates. This review focuses on the key roles of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in CCA tumor initiation and progression. Potential therapeutic approaches based on this pathway were also discussed. Results showed increased activation of the PI3K/AKT pathway in CCA tissues and proteins like p85α, mTOR

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PI3K/AKT信号通路在胆管癌中的作用:综述

胆管癌(CCA)是一组起源于胆管和其他胆道部位的恶性肿瘤。目前缺乏有效的治疗方法。因此，了解遗传机制和治疗靶点对改善治疗效果和生存率至关重要。本文就磷脂酰肌醇3-激酶(PI3K)信号通路在CCA肿瘤发生和发展中的关键作用进行综述。基于这一途径的潜在治疗方法也进行了讨论。结果显示，CCA组织中PI3K/AKT通路和p85α、mTOR等蛋白的激活增加

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

地学前缘 Earth and Planetary Sciences-Geology

CiteScore

2.70

自引率

0.00%

发文量

6050

期刊介绍： Earth Science Frontiers is a bimonthly Chinese academic journal co-sponsored by China University of Geosciences (Beijing) and Peking University. Academician Deng Jun has been the editor-in-chief since its founding in 1994. Each issue of the journal invites special editors to compile theme albums, supplemented by selected free submissions, to fully display the cutting-edge, innovative and basic research results in the field of earth sciences, and publish academic debate articles. With its academic influence and excellent performance, Earth Science Frontiers has won honors such as "China's Most Internationally Influential Academic Journal" and "One Hundred Outstanding Chinese Academic Journals", and has been selected into China's "Excellence Action Plan" project.