Paediatric asthma and allergy最新文献_第7页

Characterization of severe asthma in the pediatric population of Tarragona. Observational study 塔拉戈纳儿童重症哮喘的特征分析。观察性研究

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa956

A. Bobe, Amalui Vásquez, E. Rua, M. García, A. Gómez, M. Pascual, M. Bosque-García

引用次数: 0

Infant RSV prophylaxis, RSV infection, and nasopharyngeal microbiota at age six years 6岁时婴儿RSV预防、RSV感染和鼻咽微生物群

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa4939

W. H. Man, Nienke M. Scheltema, M. Houten, Elisabeth E. Nibbelke, N. Achten, K. Arp, E. Sanders, L. Bont, D. Bogaert

{"title":"Infant RSV prophylaxis, RSV infection, and nasopharyngeal microbiota at age six years","authors":"W. H. Man, Nienke M. Scheltema, M. Houten, Elisabeth E. Nibbelke, N. Achten, K. Arp, E. Sanders, L. Bont, D. Bogaert","doi":"10.1183/13993003.congress-2019.oa4939","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa4939","url":null,"abstract":"Background: Respiratory syncytial virus (RSV) infection during infancy is suggested to cause long-term wheeze. In turn, wheeze has been associated with bacterial dysbiosis of the respiratory tract. We investigated the effects of RSV prophylaxis by palivizumab during infancy on respiratory microbiota composition at six years of age in participants of an RCT. Methods: 429 infants born between 32-35 weeks of gestation randomly received palivizumab or placebo during the RSV season of their first year of life. Children were followed for clinical symptoms until 6 years of age. At age six, nasopharyngeal swabs were collected and reversible airway obstruction was determined. Samples of 395 children were available for 16S-rRNA sequencing. Findings: We observed that RSV prophylaxis in infancy was associated with a higher abundance of Haemophilus and lower abundance of Moraxella and Neisseria, at age six years. Stratified analysis comparing microbiota at age six of children with PCR-confirmed RSV infection to children without proven RSV infection in infancy showed similar microbiota associations compared to those found with RSV prophylaxis. PCR-confirmed rhinovirus infection in infancy partly negated the impact of PCR-confirmed RSV infection on respiratory microbiota at age six. Reversible airway obstruction at age six was positively associated with Haemophilus and Streptococcus abundance and negatively associated with the abundance of health-associated spp., e.g. Moraxella, Neisseria, Corynebacterium and Dolosigranulum. Interpretation: Together, our results warrant further studies to shed light on the long-term ecological effects of viral infections and (RSV) prophylaxis in infancy.","PeriodicalId":114886,"journal":{"name":"Paediatric asthma and allergy","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134185659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of knowledge, attitude and perceptions on medication adherence in children with asthma 知识、态度和观念对哮喘患儿服药依从性的影响

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5430

Andrea Shu Xian Chiang, Ai Huay Teo, Guan Tain Lee, Soh Yan Tan, Mary Hoon, O. Chay, A. Goh, Yi Hua Tan, Z. Cheng, A. Pugalenthi, O. Teoh, B. Thomas

{"title":"Impact of knowledge, attitude and perceptions on medication adherence in children with asthma","authors":"Andrea Shu Xian Chiang, Ai Huay Teo, Guan Tain Lee, Soh Yan Tan, Mary Hoon, O. Chay, A. Goh, Yi Hua Tan, Z. Cheng, A. Pugalenthi, O. Teoh, B. Thomas","doi":"10.1183/13993003.congress-2019.pa5430","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5430","url":null,"abstract":"Introduction: Poor medication adherence is a common cause of persistent poor control in children with asthma. Aim: To assess the impact of knowledge, attitude and perceptions about asthma, on medication adherence in children with asthma. Methods: In this prospective study, children aged 7-18 years with asthma had comprehensive clinical assessment and spirometry. A 31 item questionnaire to assess the knowledge, attitude and perceptions (KAP questionnaire) about asthma was administered. Medication adherence was assessed by a combination of self reporting, pharmacy records review, inhaler check, and tablet counting, as appropriate; and was classified into 3 groups (good, average and poor). Asthma control was assessed as controlled, partly controlled or uncontrolled based on the GINA criteria. Results: 180 children (mean [SD] age=11.4 [2.8] years, 59.4% males) were studied. Adherence was good in 101 (56.1%), average in 56 (31.1%) and poor in 23 (12.8) children. The proportion (mean [95% CI]) of appropriate responses on the KAP questionnaire in those with poor adherence (47.7 [41.2-54.2]%) was significantly lower compared to those with good (57.2 [53.4-60.9]%) and average (52.5 [49.1-55.8]%) adherence (p=0.0433). Asthma control was good in 47.5% with good adherence, compared to 33.8% with average or poor adherence (p=0.0031). Significant bronchodilator reversibility in FEV1 (≥12%) was observed in 23.7% with good adherence, compared to 39.2% with average or poor adherence (p=0.0338). Conclusions: Our data suggest that knowledge, attitudes, and perceptions about asthma affect medication adherence and asthma control. Hence, improving these should be a key focus in the management of asthma.","PeriodicalId":114886,"journal":{"name":"Paediatric asthma and allergy","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123234431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Forced oscillation technique (FOT) and Impulse Oscillometry (IOS) depict longer duration of disease in children with Sickle cell disease (SCD) while N2-Multiple-breath-washout (N2MBW) provides new insight on respiratory pattern 强迫振荡技术(FOT)和脉冲振荡法(IOS)描述了镰状细胞病(SCD)儿童疾病持续时间更长，而n2 -多次呼吸冲洗(N2MBW)提供了呼吸模式的新见解

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa964

F. Lucca, M. Piazza, L. Tenero, E. Bonetti, S. Cesaro, G. Piacentini

引用次数: 0

Mepolizumab eligibility in children with severe asthma – do we need paediatric specific criteria? 重度哮喘患儿Mepolizumab的适格性——我们是否需要儿科特定标准?

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa950

B. Davies, Deevena Chinthala, S. Frost, Isobel Brookes, P. Kenia, S. Rao, P. Nagakumar

{"title":"Mepolizumab eligibility in children with severe asthma – do we need paediatric specific criteria?","authors":"B. Davies, Deevena Chinthala, S. Frost, Isobel Brookes, P. Kenia, S. Rao, P. Nagakumar","doi":"10.1183/13993003.congress-2019.pa950","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa950","url":null,"abstract":"Background: Children > 6yr with poor asthma control despite maximally prescribed treatment have Problematic Severe Asthma. Detailed multidisciplinary team (MDT) assessment is key to phenotype children for identification of modifiable factors and consideration of licensed biological therapies (Omalizumab, Mepolizumab). We reviewed eligibility for biologics in a regional paediatric severe asthma centre in the UK. Methods: 67 patients on Steps 4-5 of GINA guideline therapies underwent protocol-based hospital, school and home MDT asthma assessment between 2015-2018. Medication adherence was assessed by electronic monitoring device (EMD). Spirometry, fractional exhaled nitric oxide (FeNO), blood tests for full blood count, IgE and aeroallergen sensitisation were performed. Results: Median age at assessment was 10.9 yr (range 6.0-15.8 yr). Male:Female - 40:27. Median inhaled steroid dose was 1000mcg Beclomethasone equivalent (range 400-2000mcg). 44 (66%) were on long-term oral steroids. Median FEV1 was 81% predicted (range 45-115%). Median FeNO was 37ppb (range 7-210ppb). 42 (63%) had adherence assessed by EMD. 35 (52%) were eligible for Omalizumab; 54 (80%) were eligible for Mepolizumab; 27 (40%) were eligible for both. There was no correlation between FeNO and peripheral eosinophil count in patients eligible for Mepolizumab (p=0.23). Conclusions: Surprisingly 80% children in our cohort fulfilled the criteria for Mepolizumab. The effect of interventions including improved medication adherence on peripheral eosinophil count is unknown. Due to resource implications, robust studies to identify paediatric-specific eligibility criteria and biomarkers predicting response to Mepolizumab should be explored.","PeriodicalId":114886,"journal":{"name":"Paediatric asthma and allergy","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125529276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Use of mouthpiece with the VR647 inhalation system in children aged 1 to 4 years 1至4岁儿童使用VR647吸入系统的吸口

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa962

L. Bacharier, G. Burgess, B. Müllinger, S. Snape

引用次数: 0

Understanding the relationship between breastfeeding and childhood asthma: A systematic review and meta-analysis 了解母乳喂养与儿童哮喘之间的关系:一项系统回顾和荟萃分析

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4516

Mike Xue, E. Dehaas, O. Kurmi

{"title":"Understanding the relationship between breastfeeding and childhood asthma: A systematic review and meta-analysis","authors":"Mike Xue, E. Dehaas, O. Kurmi","doi":"10.1183/13993003.congress-2019.pa4516","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4516","url":null,"abstract":"Background: Despite breastfeeding being widely recommended, its relationship with asthma continues to be debated. Aims: To carry out a systematic review and meta-analysis of cohort studies to understand if breastfeeding (BF) is inversely associated with physician diagnosed asthma in children. Methods: A comprehensive search was conducted on cohort studies published until June 2018 in any of MEDLINE, EMBASE, Cochrane, CINAHL and ProQuest Nursing and Allied Health Source databases. A manual search of references was conducted for additional resources. Data extraction were restricted to cohort studies or randomized controlled trials that reported physician diagnosed asthma in children aged Results: Out of 46 articles, the meta-analysis of 26 studies indicated that BF compared to no BF was associated with a 21% lower risk of asthma (Pooled effect size, 95% CI=0.79, 0.76-0.83) on asthma and BF. Similarly, children who had been exclusively BF had 28% lower risk (0.72, 0.64-0.80) of asthma and those who had partially breastfed had 17% lower risk (0.83, 0.76-0.90). The heterogeneity among studies that reported any, exclusive and partial BF were 46%, 30% and 45% respectively. Conclusions: The findings suggests that there is 17 to 28% lower risk of asthma in children who are breastfed more, strongly supporting the advocacy for breastfeeding.","PeriodicalId":114886,"journal":{"name":"Paediatric asthma and allergy","volume":"313 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129749704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

By how much can exhaled nitric oxide vary over three months in children with stable asthma? 在患有稳定哮喘的儿童中，呼出的一氧化氮在三个月内会变化多少?

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5419

S. Turner, S. Fielding, M. Pijnenburg, J. D. Jongste, K. Pike, G. Roberts, H. Petsky, A. Chang, M. Fritsch, T. Frischer, P. Gergen, S. Szefler, F. Vermeulen, R. Vael

引用次数: 1

Transition to independent self-management among children with asthma 哮喘儿童向独立自我管理过渡

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa932

S. N. Ramdzan, H. Pinnock, S. Liew, Syuhada Sukri, H. Salim, N. Hanafi, N. Hussein, Julia Suhaimi, P. Lee, Ai Theong Cheong, Azainorsuzilha Ahad, S. Cunningham, M. Kendall, E. Khoo

引用次数: 0

Allergic sensitisation and relationship with asthma and other allergic diseases in children in the province of Bengo, Angola 安哥拉本戈省儿童的过敏性致敏及其与哮喘和其他过敏性疾病的关系

Paediatric asthma and allergy Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4500

M. Arrais, Ofélia Lulua, Francisca Quifica, J. Gama, L. Taborda-Barata, M. Brito

{"title":"Allergic sensitisation and relationship with asthma and other allergic diseases in children in the province of Bengo, Angola","authors":"M. Arrais, Ofélia Lulua, Francisca Quifica, J. Gama, L. Taborda-Barata, M. Brito","doi":"10.1183/13993003.congress-2019.pa4500","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4500","url":null,"abstract":"Background: In recent decades, the prevalence of allergies has increased, especially in children. In Africa, few studies have evaluated allergic sensitisation and in Angola, none. The aim of this study was to evaluate the profile of allergic sensitisation in children with asthma and other allergic diseases. Method: This was a cross sectional study, using the methodology of the International Study of Asthma and Allergic Diseases in Children (ISAAC), conducted from September to November 2017 in 5 to 14 year-old children in the Bengo Province, Angola. Out of total of 33 public schools, 5 (15%) were randomly selected, 3 in urban and 2 in rural areas. Allergic sensitisation was defined by positive skin prick tests (SPT) and/or positive inhalant Phadiatop. Data were analysed with SPSS Statistics v25.0. Results: The sample consisted of 1023 children, 48% girls, 58% 10-14 year-old, 61% living in urban areas. Of these children, 8% had positive SPT with most frequent sensitisation being to mites (B.tropicalis, D.farinae, D.pteronyssinus) and cockroach mix, without statistically significant differences between sexes, age and urban or rural area residents. About 56% children were monosensitised, 44% were polysensitized, and most sensitized children (55%) were asymptomatic. No significant differences in allergen sensitisation patterns were observed among atopic children who were asymptomatic, had asthma, rhinitis or eczema. Conclusion: Allergic sensitisation to dust mites, cockroach mix and fungi is the most frequent pattern observed in 5-14 year old Angolan children in Bengo but this was not different between sensitised children with and without allergic diseases.","PeriodicalId":114886,"journal":{"name":"Paediatric asthma and allergy","volume":"236 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125706358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0