Drug Research最新文献_第5页

Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis. 双氯芬酸诱导的正常血压大鼠和高血压大鼠肾损伤的特征：比较分析

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI: 10.1055/a-2277-8458

Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza

{"title":"Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis.","authors":"Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza","doi":"10.1055/a-2277-8458","DOIUrl":"10.1055/a-2277-8458","url":null,"abstract":"Background: Diclofenac is the non-steroidal anti-inflammatory drug (NSAID) mostly prescribed worldwide, but it is highly associated with hypertension and acute kidney injury. Despite that, little information is available about the renal effects of diclofenac in hypertensive individuals, which led us to carry out this comparative study between the renal effects of this NSAID in normotensive (NTR) and spontaneously hypertensive rats (SHR).Methods: Male Wistar NTR and SHR were orally treated with vehicle (V: 10 mL/kg) or diclofenac sodium (D: 100 mg/kg) once a day for 3 days. Urine volume, electrolytes excretion (Na+, K+, Cl-, and Ca2+), urea, creatinine, pH, and osmolarity were evaluated. Furthermore, blood samples and renal tissue were collected to perform biochemical and histological analysis.Results: Diclofenac increased the renal corpuscle and bowman's space in the SHR, while no microscopic changes were observed in the renal tissue of NTR. Regarding the urinary parameters, diclofenac reduced urine volume, pH, osmolarity, and all electrolytes excretion, followed by decreased urea and creatinine levels in both lineages. Moreover, it also induced hyponatremia, hypokalemia, and hypocalcemia in SHR, while reduced glutathione-S-transferase activity, lipid hydroperoxides, and nitrite levels in renal tissue.Conclusions: The data presented herein demonstrated that diclofenac induces renal damage and impaired renal function in both NTR and SHR, but those effects are exacerbated in SHR, as seen by the histological changes and electrolytes balance disturbance, therefore, reinforcing that diclofenac may increase the risks of cardiovascular events in hypertensive patients.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"171-179"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury. 薯蓣皂苷在改善四氯化碳诱发的小鼠肝损伤中的治疗潜力

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI: 10.1055/a-2263-1329

Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghani

{"title":"Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury.","authors":"Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghani","doi":"10.1055/a-2263-1329","DOIUrl":"10.1055/a-2263-1329","url":null,"abstract":"Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory properties. The current study investigated whether diosgenin could ameliorate carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4 was injected intraperitoneally twice a week for 8 weeks. Daily oral administration of diosgenin at doses of 20, 40, and 80 mg/kg was started one day before CCL4 injection and continued for 8 weeks. Finally, serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also albumin were assessed. Catalase and superoxide dismutase (SOD) activities in addition to glutathione (GSH) and malondialdehyde (MDA) levels were also quantified in the liver homogenate and routine histological evaluation was also conducted. Elevated serum levels of liver enzymes and decreased serum level of albumin caused by CCL4 were significantly restored following diosgenin administration at doses of 40 and 80 mg/kg. Long-term administration of CCL4 increased inflammatory and apoptotic factors such as IL-1β, caspase 3, TNF-α, and IL-6 and decreased SOD and catalase activities as well as GSH level in liver homogenates; while MDA level was increased. Treatment with diosgenin increased SOD and catalase activities and GSH levels in the liver of injured animals. In addition, liver MDA, IL-1β, caspase 3, TNF-α, and IL-6 level or activity decreased by diosgenin treatment. Additionally, diosgenin aptly prevented aberrant liver histological changes. According to obtained results, diosgenin can dose-dependently diminish CCl4-induced liver functional deficits and histological changes in a dose-dependent manner, possibly due to its antioxidant and anti-inflammation properties, and its beneficial effect is comparable to known hepatoprotective agent silymarin.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"156-163"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day. 化妆品使用相关不良反应的观察研究：当今化妆品警戒的需要。

IF 2.2

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-11 DOI: 10.1055/a-2251-6655

Geetika Mehta, Daksh Raj Tyagi, Monika Sachdeva, Rashmi Tripathi, Himanshu Tyagi

{"title":"An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day.","authors":"Geetika Mehta, Daksh Raj Tyagi, Monika Sachdeva, Rashmi Tripathi, Himanshu Tyagi","doi":"10.1055/a-2251-6655","DOIUrl":"10.1055/a-2251-6655","url":null,"abstract":"Introduction: The pursuit of aesthetic attractiveness and increased awareness have contributed significantly to the growth of the cosmetic industry. However, it is crucial to recognize that even the minimal use of cosmetics may have harmful consequences for both the overall well-being and the broader community, an issue that has yet to be adequately recognized or addressed.Objective: This study is aimed at providing insights into the usage pattern of consumer behavior regarding skin care products and to assess the prevalence and determinants of cosmetic-related adverse events among the general populace.Materials and methods: A community-based cross-sectional study was carried out for four months in a satellite city of the National Capital Region (NCR) of India. The data from 435 respondents was collected using a self-administered questionnaire and analyzed using frequencies and percentages.Results: Among 435 participants, 32.9% experienced one or more adverse effects owing to the use of skincare products; the prevalence was higher in females (36.3%). Hair loss, allergies, and dry skin were the most frequently reported adverse effects. The majority of the adverse reactions were reported with soap (21%), followed by shampoo (17%). The gender-wise difference between adverse effects of skin care products was found to be statistically significant.Conclusion: To improve the system's efficiency, a comprehensive review of the current regulatory protocols for cosmetics is crucial. Additionally, it is essential to widely disseminate information on Cosmetovigilance and promote the reporting of any adverse effects of cosmetics within the community; this is the demand of the present time.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"164-170"},"PeriodicalIF":2.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Potential of mRNA as Biomarker to Revolutionize Diagnosis of Colorectal Cancer. 了解 mRNA 作为生物标记物的潜力，彻底改变结直肠癌诊断。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1055/a-2244-6572

Rina Das, Dinesh Kumar Mehta, Nidhi Gupta

{"title":"Understanding the Potential of mRNA as Biomarker to Revolutionize Diagnosis of Colorectal Cancer.","authors":"Rina Das, Dinesh Kumar Mehta, Nidhi Gupta","doi":"10.1055/a-2244-6572","DOIUrl":"10.1055/a-2244-6572","url":null,"abstract":"MicroRNA as potential biomarker for early diagnosis, differentiating various stages, interpreting the success of postoperative curative surgery and predicting early relapse of Colorectal cancer.In the realm of medical research, the quest to find effective biomarkers for various diseases has always been a top priority. Colorectal cancer (CRC), one of the leading causes of cancer-related deaths worldwide, is no exception. The emergence of microRNA (mRNA) as a potential biomarker for CRC has sparked immense interest among scientists and clinicians alike. mRNA, a molecule responsible for translating genetic information into functional proteins, presents a promising avenue for early detection and personalized treatment of this deadly disease. By analyzing the specific patterns and levels of mRNA expression in CRC cells, researchers have the ability to identify signatures that can aid in accurate diagnosis, predict patient prognosis, and even guide targeted therapies. This breakthrough in molecular biology not only enhances our understanding of CRC but also holds the potential to revolutionize the field of cancer diagnostics and treatment. In this article, we will delve deeper into the potential of mRNA as a biomarker for CRC, exploring its benefits and challenges in the field of cancer research.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"102-112"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status. 格列吡嗪临床前和临床现状百科全书。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-26 DOI: 10.1055/a-2237-8566

Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh

{"title":"Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status.","authors":"Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh","doi":"10.1055/a-2237-8566","DOIUrl":"10.1055/a-2237-8566","url":null,"abstract":"Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used in concert with TRAIL to treat cancer cells; in vitro studies have shown that it suppresses angiogenesis and vasculogenesis while shielding cells from glycation-induced damage. Anticonvulsant effects and modifications in the pharmacokinetics of other medications, such as Divalproex Sodium, were seen in glipizide in vivo experiments. Propranolol amplifies glipizide's hypoglycemic effect briefly in normal animals but consistently enhances it in diabetic ones. In the treatment of cancer and neurodegenerative poly(Q) illnesses, glipizide has demonstrated to offer potential therapeutic advantages. It is ineffective in preventing DENA-induced liver cancer and may cause DNA damage over time. The way glipizide interacts with genetic variants may increase the risk of hypoglycemia. Combining Syzygium cumini and ARBE to glipizide may enhance glycemic and lipid control in type 2 diabetes. Individuals with coronary artery disease who take glipizide or glyburide have an increased risk of death. The risk of muscular responses and acute pancreatitis is minimal when glipizide and dulaglutide are combined. In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"123-132"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Hypertension to Beyond: Unraveling the Diverse Mechanisms of Olmesartan in Disease Modulation. 从高血压到其他疾病：揭示奥美沙坦在疾病调节中的多种机制。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1055/a-2244-3136

Laiba Rind, Tarique Mahmood, Mohammed Haris Siddiqui, Farogh Ahsan, Arshiya Shamim, Aamir Anwar, Rajnish Kumar Yadav

{"title":"From Hypertension to Beyond: Unraveling the Diverse Mechanisms of Olmesartan in Disease Modulation.","authors":"Laiba Rind, Tarique Mahmood, Mohammed Haris Siddiqui, Farogh Ahsan, Arshiya Shamim, Aamir Anwar, Rajnish Kumar Yadav","doi":"10.1055/a-2244-3136","DOIUrl":"10.1055/a-2244-3136","url":null,"abstract":"Olmesartan, originally known for its antihypertensive properties, exhibits promising potential in addressing inflammation-mediated diseases. As an angiotensin II receptor blocker (ARB), Olmesartan influences pivotal pathways, including reactive oxygen species, cytokines, NF-κB, TNF-α, and MAPK. This suggests a viable opportunity for repurposing the drug in conditions such as ulcerative colitis, neuropathy, nephropathy, and cancer, as supported by multiple preclinical studies. Ongoing clinical trials, particularly in cardiomyopathy and nephropathy, suggest a broader therapeutic scope for Olmesartan. Repurposing efforts would entail comprehensive investigations using disease-specific preclinical models and dedicated clinical studies. The drug's established safety profile, wide availability, and well-understood ARB mechanism of action offer distinct advantages that could facilitate a streamlined repurposing process. In summary, Olmesartan's versatile impact on inflammation-related pathways positions it as a promising candidate for repurposing across various diseases. Ongoing clinical trials and the drug's favorable attributes enhance its appeal for further exploration and potential application in diverse medical contexts.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"93-101"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Xanthine Derivatives Against Arsenic Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal Tissues. 黄嘌呤衍生物对三氧化二砷诱导的小鼠肝脏和肾脏组织氧化应激的保护作用

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1055/a-2247-5232

Navid Omidifar, Ahmad Gholami, Mansoureh Shokripour, Mohammad Ali Nourani, Milad Mohkam, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Bagher Khorram, Amir Nili Ahmadabadi, Mahintaj Dara

{"title":"Protective Effects of Xanthine Derivatives Against Arsenic Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal Tissues.","authors":"Navid Omidifar, Ahmad Gholami, Mansoureh Shokripour, Mohammad Ali Nourani, Milad Mohkam, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Bagher Khorram, Amir Nili Ahmadabadi, Mahintaj Dara","doi":"10.1055/a-2247-5232","DOIUrl":"10.1055/a-2247-5232","url":null,"abstract":"In this study, the protective efficacy of pentoxifylline (PTX) as a xanthine derivative against arsenic trioxide (ATO)-induced kidney and liver damage in mice was investigated. Thirty-six mice were divided into six groups, receiving intraperitoneal injections of saline, ATO, PTX, or a combination for four weeks. Blood samples were analyzed for serum biochemistry, while hepatic tissue underwent examination for histopathological changes and assessment of oxidative stress markers and antioxidant gene expression through Real-Time PCR. ATO exposure significantly increased serum markers (creatinine, ALT, BUN, ALP, AST) and induced histopathological changes in the liver. Moreover, it elevated renal and hepatic nitric oxide (NO) and lipid peroxidation (LPO) levels, and reduced antioxidant enzyme expression (CAT, GSR, GPx, MPO, SOD), total thiol groups (TTGs), and total antioxidant capacity (TAC). Conversely, PTX treatment effectively lowered serum hepatic and renal markers, improved antioxidant markers, and induced histopathological alterations. Notably, PTX did not significantly affect renal and hepatic NO levels. These findings suggest that PTX offers therapeutic potential in mitigating liver and acute kidney injuries induced by various insults, including exposure to ATO.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"133-144"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Perspective of Using Flow Cytometry for Unpuzzling Hypoxia-Inducible Factors Signalling. 使用流式细胞仪揭示缺氧诱导因子信号的视角。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.1055/a-2248-9180

Vishal J Patel, Amit Joharapurkar, Mukul R Jain

引用次数: 0

Correction: Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status. 更正：格列吡嗪临床前和临床状态百科全书。

IF 2.2

Drug Research Pub Date : 2024-03-01 Epub Date: 2024-05-15 DOI: 10.1055/a-2321-8886

Saad Mohammed, Tarique Mahmood, Arshiya Shamim, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Rufaida Waseem, Aditya Singh

引用次数: 0

Therapeutic Effects of Tamsulosin in Nightmare Disorder: A Randomized, Double Blind, Placebo-Controlled, Cross-Over, Pilot Study. 坦索罗辛对梦魇症的治疗效果：一项随机、双盲、安慰剂对照、交叉试验研究。

IF 2.2

Drug Research Pub Date : 2024-02-01 Epub Date: 2024-01-18 DOI: 10.1055/a-2226-3604

Negin Naderifar, Elnaz Roohi, Ali Sharifi, Nemat Jaafari, Farshad Hashemian

{"title":"Therapeutic Effects of Tamsulosin in Nightmare Disorder: A Randomized, Double Blind, Placebo-Controlled, Cross-Over, Pilot Study.","authors":"Negin Naderifar, Elnaz Roohi, Ali Sharifi, Nemat Jaafari, Farshad Hashemian","doi":"10.1055/a-2226-3604","DOIUrl":"10.1055/a-2226-3604","url":null,"abstract":"Nightmare disorder is associated with functional impairment, distress, and low quality of life; however, studies on pharmacotherapy of this debilitating disorder yielded mixed results. Prazosin, a non-selective α1 blocker is reported to be effective in treatment of post-traumatic stress disorder-related nightmares. We aimed at investigating therapeutic effects of tamsulosin which has higher affinity for blocking α1A and α1D adrenoceptors in treatment of nightmare disorder. A randomized, double blind, cross-over, placebo-controlled pilot study was conducted. Patients were randomly assigned to receive Tamsulosin 0.4 mg once daily or placebo for period of four weeks. Following a 2-week wash-out period, they were crossed over to the other group and received drug or placebo for duration of 4 additional weeks. Nightmare frequency and intensity measurements were carried out using Disturbing Dreams and Nightmares Severity Index (DDNSI). Blood pressure measurements were also performed. According to per protocol analysis, mean DDNSI scores decreased following administration of tamsulosin and a statistical trend towards significance was reported (p=0.065, d=0.236). Results of intention to treat analysis showed significant difference in DDNSI scores after drug use (p=0.030, d=0.651). Additionally, DDNSI scores dropped significantly following placebo use. However, intention to treat analysis showed no statistically significant difference pre and post placebo period (0.064, d=0.040). Tamsulosin may be effective in treatment of nightmare disorder. However, further larger clinical trials are recommended to clarify the effectiveness of tamsulosin and α1 subtypes in pharmacotherapy of nightmares.","PeriodicalId":11451,"journal":{"name":"Drug Research","volume":" ","pages":"53-59"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0