Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy最新文献_第6页

Microalbuminuria in early pregnancy in normal and high-risk patients. 正常和高危患者妊娠早期微量白蛋白尿。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-09-01

J Bar, M Hod, A Erman, B Kaplan, J Ovadia, A Schoenfeld

引用次数: 0

Evidence favoring human chorionic gonadotropin as the physiological 'rescuer' of the corpus luteum during early pregnancy. 支持人绒毛膜促性腺激素作为妊娠早期黄体的生理“拯救者”的证据。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-09-01

G D Braunstein

引用次数: 0

Elevation of cyclic AMP levels in mouse embryonic stem cells by insulin related peptides. 胰岛素相关肽对小鼠胚胎干细胞中环AMP水平的影响。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-09-01

M D Parkin, S McNulty, P N Schofield

{"title":"Elevation of cyclic AMP levels in mouse embryonic stem cells by insulin related peptides.","authors":"M D Parkin, S McNulty, P N Schofield","doi":"","DOIUrl":"","url":null,"abstract":"The preimplantation mammalian embryo has been shown to respond to exogenous insulin-like growth factors and insulin itself, however, the most quantitatively important source of these peptides and the receptors through which they exert their effects are unclear. Whilst the type 1 insulin-like growth factor (IGF) receptor is believed to act primarily through tyrosine phosphorylation of the substrate protein alpha IRS-1, evidence for a signalling role for the type 2 receptor is disputed, some evidence pointing to mediation through G protein-dependent calcium ion flux. We have examined the response of murine embryonic stem cells, as a model for the cells of the preimplantation embryo, to IGF-I, IGF-II, insulin and analogs of IGF-II: R6 IGF-II and des (1-6) IGF-II. In response to all of these peptides, except R6 IGF-II, elevation of intracellular cyclic AMP occurs. As R6 IGF-II binds with higher affinity to the type 2 receptor than canonical IGF-II or IGF-I, and insulin fails to interact, this suggests that the elevation of cyclic AMP in response to the other insulin related peptides (IRPs) is not through the type 2 receptor. We conclude that either the type 1 receptor has a previously uncharacterized direct or indirect effect on intracellular cyclic AMP levels, or that there is a further, as yet uncharacterized, receptor active in embryonic stem cells.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"2 3","pages":"191-6"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in human placental 11 beta-dehydrogenase and 11-oxoreductase activities of 11 beta-hydroxysteroid dehydrogenase enzyme during pregnancy. 妊娠期间人胎盘11 β -脱氢酶和11-羟类固醇脱氢酶11-氧还原酶活性的变化。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-09-01

O Muneyyirci-Delale, V Lakshmi, C O McCalla, M Karacan, G Neil, L Camilien

{"title":"Variations in human placental 11 beta-dehydrogenase and 11-oxoreductase activities of 11 beta-hydroxysteroid dehydrogenase enzyme during pregnancy.","authors":"O Muneyyirci-Delale, V Lakshmi, C O McCalla, M Karacan, G Neil, L Camilien","doi":"","DOIUrl":"","url":null,"abstract":"Human placental 11 beta-hydroxysteroid dehydrogenase enzyme has an important role in controlling glucocorticoids reaching the fetus. Excess glucocorticoids impair fetal growth. Recent investigations show that the placenta is rich in NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase activity. Elucidation of the activities of both these isoforms is necessary to understand placental glucocorticoid metabolism. Hence we determined both NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase activities throughout pregnancy. 11 beta-dehydrogenase (oxidative) and 11-oxoreductase (reductive) activities of 11 beta-hydroxysteroid dehydrogenase were determined in 16 first-trimester (9-12 weeks) and 14 second-trimester (13-22 weeks) and 17 term (38-42 weeks) placentae. Both NAD- and NADP-dependent activities increased with pregnancy. The second-trimester NAD-dependent activity was higher than the first-trimester activity (p = 0.02). At term this activity was higher than during the second (p = 0.05) and first (p = 0.0002) trimesters. A similar increase was obtained with NADP isoform except that the difference between first and second trimesters was not significantly different at p = 0.05. The NADH-dependent 11-oxoreductase activity was also detected throughout the pregnancy. However, the activity at term was significantly higher than during the second (p = 0.005) and first (p = 0.001) trimesters. This increase may result in a concomitant increase of cortisol reaching fetus, thus helping fetal lung maturation.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"2 3","pages":"201-6"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of estradiol and progesterone levels to uterine blood flow during early pregnancy. 孕早期雌二醇和黄体酮水平与子宫血流的关系。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

R P Dickey, J F Hower

{"title":"Relationship of estradiol and progesterone levels to uterine blood flow during early pregnancy.","authors":"R P Dickey, J F Hower","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to examine the relationship of uterine blood flow to serum estradiol and progesterone during early pregnancy. Recumbent uterine artery average velocity, diameter, blood flow volume and uterine and spiral artery resistance were measured using vaginal Doppler ultrasound 118 times in 43 patients during gestational (postmenstrual) weeks 5 to 16. Relationships to serum progesterone and estrogen were analyzed before and after week 10, when intervillous circulation begins, by multiple linear regression analysis and analysis of covariance (ANCOVA) to correct for the effect of gestational age. After correction for gestational age, estradiol was negatively related to uterine artery flow volume (p < 0.05), diameter (p < 0.05), pulsatility index (p < 0.05) and resistance index (p < 0.01) for weeks 5-16 and to diameter (p < 0.05) after week 9. Progesterone was positively related to volume (p < 0.05) and velocity (p < 0.01) for weeks 5-16 and to volume (p < 0.05) for weeks 5 to 9. Spiral artery indices of resistance were unrelated to hormone levels. These results indicate that before the 10th gestational week, uterine blood flow volume is related to progesterone, but not estradiol levels, and suggest that high estradiol levels during and after the 10th week may be associated with decreased uterine blood flow volume.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"2 2","pages":"113-20"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous and habitual abortion--a pathologist's point of view. 自然流产和习惯性流产——一个病理学家的观点。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

J Hustin, R Kadri, E Jauniaux

引用次数: 0

Advances in the understanding of diabetic embryopathy: signal transduction. 糖尿病胚胎病的认识进展:信号转导。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

M Hod

{"title":"Advances in the understanding of diabetic embryopathy: signal transduction.","authors":"M Hod","doi":"","DOIUrl":"","url":null,"abstract":"Evidence supports the theory that in diabetic pregnant women, it is the degree of metabolic imbalance present during the crucial time of organogenesis that determines the organogenetic congenital defects. The precise mechanism responsible for abnormal fetal organogenesis is unclear, but fuels such as sugars (glucose, galactose, mannose), ketones, fuel-related principles such as somatomedin inhibitors, insulin, trace elements and, lately, myoinositol, arachidonic acid and free oxygen radicals have all been implicated. The plasma-membrane lipids, in addition to serving as barriers that separate intracellular from extracellular fluid, are the actual sources of signal molecules. In one case, the signal molecule (diphosphoinositol) is derived from a variant of a common membrane lipid. This is similar to the situation in which a hormone, or similar extracellular messenger, binds to its membrane receptor and activates an enzyme that hydrolyzes plasma-membrane phospholipids to liberate arachidonic acid, which is a precursor of signal molecules, including the prostaglandins. Disruption of these delicate processes by various agents (metabolites) could result in deficiencies in phosphoinositol turnover or arachidonic acid metabolism, thus leading to congenital anomalies.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"2 2","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostaglandin metabolism in the yolk sacs of normal and diabetic pregnancies. 正常妊娠和糖尿病妊娠卵黄囊中前列腺素的代谢。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

A Schoenfeld, S Warchaizer, A Erman, M Hod

{"title":"Prostaglandin metabolism in the yolk sacs of normal and diabetic pregnancies.","authors":"A Schoenfeld, S Warchaizer, A Erman, M Hod","doi":"","DOIUrl":"","url":null,"abstract":"The malformations commonly found in fetuses of diabetic mothers occur before the 7th week of pregnancy, when fetal nutritional needs are met largely by the yolk sac. The diabetic milieu has been hypothesized to cause a disruption in the metabolism of arachidonic acid and phosphatidylinositol turnover, leading to a reduction in prostaglandin levels. In this study we evaluated how the diabetic milieu affects yolk-sac prostaglandin levels. We used ultrasound to characterize and guide aspiration of the yolk sacs of eight diabetic and 12 healthy women prior to elective abortion. In addition, we studied the yolk sacs of two healthy women in whom pregnancy termination was carried out by hysterectomy. All fetuses were between 8 and 10 weeks gestational age at the time of pregnancy termination. The yolk-sac prostaglandin E2 levels were measured using radioimmunoassay. We found that the yolk-sac diameters of diabetic women were 1.2 mm larger than those of normal women. Furthermore, the mean prostaglandin E2 level in healthy women was 3605 pg/ml, whereas prostaglandin was undetected in all the yolk sacs of diabetic women (p < 0.001). While this study suggests that defective yolk-sac metabolism of prostaglandins is one of the mechanisms responsible for diabetic embryopathy, further research is necessary to place yolk-sac enlargement and the role of prostaglandins in perspective.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"2 2","pages":"129-32"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing biotechnological and pharmacotherapeutic advances in early pregnancy. 发展早期妊娠的生物技术和药物治疗进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

R J Ablin

引用次数: 0

Reflections on early pregnancy: organizing chaos or organized chaos? 早孕反思:有组织的混乱还是有组织的混乱?

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-06-01

E R Barnea, P N Schofield

引用次数: 0