Thalamus and Related Systems最新文献_第3页

Responses of neurons in the rat ventral posterior lateral thalamic nucleus to noxious visceral and cutaneous stimuli 大鼠丘脑腹侧后外侧核神经元对有害内脏和皮肤刺激的反应

Thalamus and Related Systems Pub Date : 2005-03-01 DOI: 10.1017/S1472928805000051

J. Palecek, W. Willis

引用次数: 4

Thalamic oscillations modulate membrane properties of cat thalamic reticular neurons 丘脑振荡调节猫丘脑网状神经元的膜特性

Thalamus and Related Systems Pub Date : 2005-03-01 DOI: 10.1017/S1472928805000087

P. Fuentealba, M. Steriade

引用次数: 3

Early activation of cyclic AMP response element binding protein (CREB) following loose ligation of the sciatic nerve in rats 大鼠坐骨神经松扎后环AMP反应元件结合蛋白(CREB)的早期激活

Thalamus and Related Systems Pub Date : 2005-03-01 DOI: 10.1017/S147292880500004X

T. Miyabe, G. Miletic, V. Miletić

{"title":"Early activation of cyclic AMP response element binding protein (CREB) following loose ligation of the sciatic nerve in rats","authors":"T. Miyabe, G. Miletic, V. Miletić","doi":"10.1017/S147292880500004X","DOIUrl":"https://doi.org/10.1017/S147292880500004X","url":null,"abstract":"Activation of cyclic AMP response element-binding protein (CREB) in the spinal dorsal horn may be a crucial contributor to the activity-dependent synaptic plasticity that is thought to underlie the development of persistent pain following peripheral nerve injury. In this study, we examined the early period of CREB activation following chronic constriction injury (loose ligation) of the sciatic nerve in rats. The estimated levels of Ser133-phosphorylated (activated) CREB significantly increased at 2 hours (424 ± 85%) and remained elevated at 4 hours (349 ± 97%) and 8 hours (258 ± 69%) after sciatic ligation compared with control animals. By contrast, activated CREB levels in sham-operated animals were not significantly greater than in control animals except at 1 hour (176 ± 6%) and 8 hours (288 ± 16%). The maximal ligation-associated activation of CREB at 2 hours occurred bilaterally and was dependent, at least partly, on NMDA-receptor activation because pretreatment with 20 µg MK-801 significantly attenuated the ligation-associated activation of CREB. The levels of non-phosphorylated CREB in ligated and sham-operated animals did not differ significantly from controls at the time-points examined. These data establish a significant, persistent increase in CREB phosphorylation within hours of loose ligation of the sciatic nerve and indicate an early but consequential injury-related shift in the manner in which spinal dorsal horn neurons processed sensory information. The data lend further support to the notion that ligation-associated CREB-dependent synaptic plasticity in the spinal dorsal horn might underlie the development of persistent pain following peripheral nerve injury.","PeriodicalId":114195,"journal":{"name":"Thalamus and Related Systems","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Thalamus in flame: targeting of infectious agents to thalamic nuclei 火焰中的丘脑:传染性因子对丘脑核的靶向

Thalamus and Related Systems Pub Date : 2004-07-01 DOI: 10.1017/S1472928804010015

M. Bentivoglio, K. Kristensson

{"title":"Thalamus in flame: targeting of infectious agents to thalamic nuclei","authors":"M. Bentivoglio, K. Kristensson","doi":"10.1017/S1472928804010015","DOIUrl":"https://doi.org/10.1017/S1472928804010015","url":null,"abstract":"Abstract The involvement of the thalamus in infectious diseases of the nervous system has been hitherto rather neglected by investigators in clinical and basic neuroscience, despite numerous reports indicating that the thalamus, and territories within this region, can be attacked by different types of microbes. This topic is here reviewed. First, an overview is provided on general principles of spread of microbes to the brain (through peripheral nerves, or through the blood or cerebrospinal fluid) and their interactions with neurons and immune cells to cause acute, transient or persistent infections. Examples are given on how non-cytolytic infections can cause long-lasting disturbances in synaptic activities and neuronal networks as a result of a “hit-and-run” mechanism, or as an effect of factors released in the microenvironment to control the neuronal infection. Emerging data on how molecules functioning at the “immunological synapse” (the site of contact between immune cells and target infected cells) may affect nervous system synapses are pointed out. An account is then given of clinical and experimental infections of the thalamus caused by viruses (rabies and herpes viruses, influenza A virus, flaviviruses, HIV virus), the parasite Toxoplasma gondii , and prions. The implications and consequences of the attack of these microbes to the thalamus are discussed. Of special interest is the potential persistence of latent infections in thalamic neurons, which could cause disturbances of neuronal functions in the absence of overt structural lesions. Altogether these data recall attention on the pathogenesis and consequences of acute and persistent infections in the mammalian thalamus.","PeriodicalId":114195,"journal":{"name":"Thalamus and Related Systems","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114053785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Subthalamic nucleus: a clock inside basal ganglia? 丘脑底核:基底神经节内的时钟?

Thalamus and Related Systems Pub Date : 2002-12-01 DOI: 10.1016/S1472-9288(02)00033-X

C. Beurrier, L. Garcia, B. Bioulac, C. Hammond

引用次数: 32

Thalamocortical Assemblies: How Ion Channels, Single Neurons and Large-Scale Networks Organize Sleep Oscillations 丘脑皮质组装:离子通道、单个神经元和大规模网络如何组织睡眠振荡

Thalamus and Related Systems Pub Date : 1900-01-01 DOI: 10.1017/s1472928802000341

R. Llinás

引用次数: 0