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Effective Pharmacotherapy最新文献

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Regression of Rhinophyma on the Background of Photodynamic Therapy of Basal Cell Carcinoma of the Skin of the Tip of the Nose 鼻尖皮肤基底细胞癌光动力疗法背景下鼻赘瘤的消退
Effective Pharmacotherapy Pub Date : 2024-05-20 DOI: 10.33978/2307-3586-2024-20-1-84-88
R.A. Ravodin, L.S. Kruglova, S.P. Seleznev
{"title":"Regression of Rhinophyma on the Background of Photodynamic Therapy of Basal Cell Carcinoma of the Skin of the Tip of the Nose","authors":"R.A. Ravodin, L.S. Kruglova, S.P. Seleznev","doi":"10.33978/2307-3586-2024-20-1-84-88","DOIUrl":"https://doi.org/10.33978/2307-3586-2024-20-1-84-88","url":null,"abstract":"The article describes a case of regression of rhinophyma against the background of photodynamic therapy of basal cell carcinoma of the skin of the nose tip. After a single session of photodynamic therapy using a systemic photosensitizer based on chloride (photoran), there was a significant decrease in the size of the nose (rhinophyma), the disappearance of erythema, puffiness, and the formation of the initial contours of the face of this anatomical area. Despite the marginal recurrence of basal cell carcinoma after six months at the site of previous treatment and a repeat session of photodynamic therapy, after one year of dynamic follow-up, remission of basal cell carcinoma and regression of rhinophyma persist. The described method of treatment is atraumatic, easily reproducible, well tolerated by patients, safe and allows patients with basal cell carcinoma in combination with rhinophyma to achieve complete remission of both diseases.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"95 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern Ideas About Diffuse Alopecia 关于弥漫性脱发的现代理念
Effective Pharmacotherapy Pub Date : 2024-05-20 DOI: 10.33978/2307-3586-2024-20-1-78-80
A.R. Ereshko
{"title":"Modern Ideas About Diffuse Alopecia","authors":"A.R. Ereshko","doi":"10.33978/2307-3586-2024-20-1-78-80","DOIUrl":"https://doi.org/10.33978/2307-3586-2024-20-1-78-80","url":null,"abstract":"This article presents modern ideas about the etiology and pathogenesis of diffuse alopecia. The classification, possible etiological factors, and links of pathogenesis are analyzed in detail. All possible approaches to the reatment of diffuse alopecia are described, including external therapy and physiotherapy techniques.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"79 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern Approaches to the Treatment of Periorbital Veins 治疗眶周静脉的现代方法
Effective Pharmacotherapy Pub Date : 2024-05-20 DOI: 10.33978/2307-3586-2024-20-1-82-83
A.S. Popova
{"title":"Modern Approaches to the Treatment of Periorbital Veins","authors":"A.S. Popova","doi":"10.33978/2307-3586-2024-20-1-82-83","DOIUrl":"https://doi.org/10.33978/2307-3586-2024-20-1-82-83","url":null,"abstract":"This article presents modern approaches to the treatment of periorbital veins. The current methods of periorbital vein removal, such as sclerotherapy, phlebectomy, and laser removal, are described. The advantages and disadvantages of the above-mentioned techniques and therapeutic advantages are described.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"90 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prospect of Photodynamic Therapy in the Treatment of Hypertrophic Onychomycosis 光动力疗法治疗肥厚型甲癣的前景
Effective Pharmacotherapy Pub Date : 2024-05-20 DOI: 10.33978/2307-3586-2024-20-1-72-76
S.I. Surkichin, L.S. Kruglova, R.Yu. Mayorov
{"title":"The Prospect of Photodynamic Therapy in the Treatment of Hypertrophic Onychomycosis","authors":"S.I. Surkichin, L.S. Kruglova, R.Yu. Mayorov","doi":"10.33978/2307-3586-2024-20-1-72-76","DOIUrl":"https://doi.org/10.33978/2307-3586-2024-20-1-72-76","url":null,"abstract":"Onychomycosis is an infectious disease of the nail apparatus caused by pathogenic fungi (dermatophytes, non-dermatophytes and yeasts), clinically manifested most often by onycholysis of the nail plate, its thickening and subungual hyperkeratosis with significant physical, aesthetic and psychosocial consequences. When the prescription of systemic antimycotics is impossible or undesirable, the dermatovenerologist comes to the aid of hardware methods of influencing the affected tissue. Photodynamic therapy (PDT) is a worthy, non-invasive, safe method that will significantly reduce treatment time and reduce the number of relapses. However, it is advisable to use PDT only as part of a therapeutic complex.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"65 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence as a Tool for Population Screening of Skin Tumors 人工智能作为皮肤肿瘤人群筛查的工具
Effective Pharmacotherapy Pub Date : 2024-05-20 DOI: 10.33978/2307-3586-2024-20-1-62-71
K.A. Uskova, O.E. Garanina, A.O. Ukharov, I.A. Klemenova, S.V. Gamayunov, A.M. Mironycheva, V.I. Dardyk, A.V. Burdakov, I.L. Shlivko, Ya.L. Stepanova, V.A. Sayfullina, S.S. Korotkiy
{"title":"Artificial Intelligence as a Tool for Population Screening of Skin Tumors","authors":"K.A. Uskova, O.E. Garanina, A.O. Ukharov, I.A. Klemenova, S.V. Gamayunov, A.M. Mironycheva, V.I. Dardyk, A.V. Burdakov, I.L. Shlivko, Ya.L. Stepanova, V.A. Sayfullina, S.S. Korotkiy","doi":"10.33978/2307-3586-2024-20-1-62-71","DOIUrl":"https://doi.org/10.33978/2307-3586-2024-20-1-62-71","url":null,"abstract":"BCC/SCC and melanoma are the most common types of skin cancer. Low public awareness, unavailability of local professional dermatological expertise, and ineffective screening programs prevent early detection critical for successful treatment. Aim. Evaluate capabilities of AI-powered mobile application for population screening. Materials and methods. We proposed a free mobile application for regular skin self-examination based on AI analysis of photos taken using a smartphone enriched with demographic data and risk factors. Our model provides a binary output (malignant/benign), encouraging people to see dermatologists for an in-depth examination if a risk of a malignant skin tumor is detected. Results. We received and processed 500,000+ images of skin neoplasms taken by 290,000 users from 86 regions of the Russian Federation from 01.2021 to 12.2022. The images were accompanied by demographic data and responses to a questionnaire on cancer risk factors. 5,957 cases of BCC/SCC and 7,622 cases of melanoma were detected. Analysis of the campaign results revealed a significantly higher prevalence of malignant skin tumors per 100,000 population. Our results exposed a much younger average age of skin cancer patients in both men and women populations compared to official statistics, with a difference of 15 years. Conclusion. The AI-based mobile application proved to be a feasible vehicle for skin cancer mass screening campaigns requiring no significant investment from the public health authorities. The proposed tool provides an efficient way to increase public awareness about skin cancer and associated risk factors as well as encourages people to seek dermatologists’ help in case of skin cancer risk.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"54 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal Uterine Bleeding in Adolescents and COVID-19: Etiology and Pathogenesis 青少年异常子宫出血与 COVID-19：病因和发病机制
Effective Pharmacotherapy Pub Date : 2023-10-19 DOI: 10.33978/2307-3586-2023-19-37-58-64
A.Yu. Kurmangaleeva, Ye.V. Sibirskaya, S. Korotkova, G. Osipova
{"title":"Abnormal Uterine Bleeding in Adolescents and COVID-19: Etiology and Pathogenesis","authors":"A.Yu. Kurmangaleeva, Ye.V. Sibirskaya, S. Korotkova, G. Osipova","doi":"10.33978/2307-3586-2023-19-37-58-64","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-37-58-64","url":null,"abstract":"The analysis of scientific papers published in eLibrary, PubMed, Google Scholar for 2020–2023 is carried out. The clinical recommendations ‘Abnormal uterine bleeding in puberty’, methodological recommendations of the Ministry of Health of the Russian Federation ‘Features of clinical manifestations and treatment of the disease caused by a new coronavirus infection (COVID-19) in children’ and temporary methodological recommendations of the Ministry of Health of the Russian Federation ‘Prevention, diagnosis and treatment of a new coronavirus infection (COVID-19)’ were analyzed. There is a clear link between the increase in the number of hospitalized girls of early reproductive age with abnormal uterine bleeding of the puberty period (AUB PP) and the transferred COVID-19. In order to improve, predict and optimize the tactics of management and treatment of girls with AUB PP and coronavirus infection, the impact of COVID-19, the features of their etiology and pathogenesis were analyzed. Given the high degree of chronic course and the tendency to relapse, it is necessary to develop a methodology to assess the likelihood of a repeat case of AUB PP, including based on the pathogenetic features of the impact of COVID-19 on the menstrual cycle","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Pathogenetic Aspects of Thoracic Endometriosis 胸腔子宫内膜异位症的临床和病理方面
Effective Pharmacotherapy Pub Date : 2023-10-19 DOI: 10.33978/2307-3586-2023-19-37-12-18
V.F. Bezhenar, V.A. Linde, N.Yu. Krylova, Ye.A. Ivanova, A. Pichurov, B. V. Arakelyan, A.N. Plekhanov, A.Yu. Lyogonkaya
{"title":"Clinical and Pathogenetic Aspects of Thoracic Endometriosis","authors":"V.F. Bezhenar, V.A. Linde, N.Yu. Krylova, Ye.A. Ivanova, A. Pichurov, B. V. Arakelyan, A.N. Plekhanov, A.Yu. Lyogonkaya","doi":"10.33978/2307-3586-2023-19-37-12-18","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-37-12-18","url":null,"abstract":"Thoracic endometriosis is a rare pathology that significantly affects the quality of life of women. The pathogenesis of endometriosis continues to be intensively studied. One of the latest achievements in its study is the identification of oxidative stress as an active link in the development of a pathological condition. The nitric oxide molecule is a free radical and, as a result, an important component of oxidative processes. Violation of its metabolism makes a significant contribution to the occurrence of oxidative stress. The NOS3 endothelial synthase gene controls nitric oxide metabolism. We have studied the polymorphism of the NOS3 endothelial synthase gene at points 786 T/C and 894 G/T. The data obtained indicate the active participation of the NOS3 endothelial synthase gene at points 786 T/C and 894 G/T in the pathogenesis of various forms of endometriosis. The difficulties of diagnosing and treating this disease at the present stage are not least due to the fact that the problem of thoracic endometriosis is at the junction of the specialties of obstetrics-gynecology and thoracic surgery, which in other situations practically do not intersect. Our observations make it possible to consider thoracic endometriosis as a pathological process that is not associated with fertility and parity of patients. At the same time, thoracic endometriosis is most likely associated with genital endometriosis, which has a negative impact on fertility. The most common complaints of patients with thoracic endometriosis are pain and discomfort in the chest area associated with menstruation and dry cough. Histological verification of the disease is difficult. A promising method for preventing exacerbations of the disease is the combined prescription of аGnRG and dienogest.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Placental Proteins in the Development of Preeclampsia in Pregnant Women with Metabolic Disorders 胎盘蛋白在代谢紊乱孕妇子痫前期发病中的作用
Effective Pharmacotherapy Pub Date : 2023-10-19 DOI: 10.33978/2307-3586-2023-19-37-20-24
S. Tsakhilova, Y. Stepanova, Ye.S. Lyashko, N. Sakvarelidze, N.V. Niyazova, S.D. Osmanova, D.A. Kazaryan
{"title":"The Role of Placental Proteins in the Development of Preeclampsia in Pregnant Women with Metabolic Disorders","authors":"S. Tsakhilova, Y. Stepanova, Ye.S. Lyashko, N. Sakvarelidze, N.V. Niyazova, S.D. Osmanova, D.A. Kazaryan","doi":"10.33978/2307-3586-2023-19-37-20-24","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-37-20-24","url":null,"abstract":"Preeclampsia refers to multifactorial diseases that lead to multiple organ disorders. The disorders are based on dysfunctions of both maternal and placental vessels. At the present stage, the study of the state of the fetoplacental hemostasis system in physiological and pathological pregnancy remains relevant. Complications of gestation develop due to metabolic disorders in the placenta. Specific placental proteins play an important role in the function of the fetoplacental complex","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern View on the Etiology and Pathogenesis of Primary Dysmenorrhea 原发性痛经病因和发病机制的现代观点
Effective Pharmacotherapy Pub Date : 2023-10-19 DOI: 10.33978/2307-3586-2023-19-37-54-57
Ye.V. Sibirskaya, M.A. Filatova, K.S. Rashoyan
{"title":"Modern View on the Etiology and Pathogenesis of Primary Dysmenorrhea","authors":"Ye.V. Sibirskaya, M.A. Filatova, K.S. Rashoyan","doi":"10.33978/2307-3586-2023-19-37-54-57","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-37-54-57","url":null,"abstract":"The article discusses the causes of dysmenorrhea, analyzes risk factors and their impact on the pathogenesis of the disease.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and Treatment of Polycystic Ovary Syndrome in Adolescents 青少年多囊卵巢综合症的诊断和治疗
Effective Pharmacotherapy Pub Date : 2023-10-19 DOI: 10.33978/2307-3586-2023-19-37-28-31
Ye.V. Sibirskaya, Ye.A. Volkova, V.V. x Bdoyan, Ye.D. Burkhanskaya, L.G. Papyan
{"title":"Diagnosis and Treatment of Polycystic Ovary Syndrome in Adolescents","authors":"Ye.V. Sibirskaya, Ye.A. Volkova, V.V. x Bdoyan, Ye.D. Burkhanskaya, L.G. Papyan","doi":"10.33978/2307-3586-2023-19-37-28-31","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-37-28-31","url":null,"abstract":"The article analyzes the issues related to the timely detection, treatment and prevention of polycystic ovary syndrome (PCOS), determining the optimal management tactics of patients, assessing the acceptability of the use of classical criteria for PCOS among adolescents. The search and evaluation of international and Russian scientific publications over the past five years – from 2017 to 2022 was carried out. The Cochrane Library, PubMed, Embase, and Google Academy databases were used for the search. Based on systematic reviews, the generally accepted criteria for PCOS in relation to adolescents are analyzed. It is shown that the diagnosis of PCOS in childhood and adulthood differs in many ways. Validated diagnostic criteria for the disease in adolescents have not yet been developed, and the available parameters only allow us to suspect the formation of PCOS and formulate criteria for patients ‘at risk of developing PCOS’","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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