Discovery medicine最新文献_第9页

Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment. 肿瘤微环境中髓源性抑制细胞的代谢重编程。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-05-01

Liang Liu, Shuping Huo, Jianghui Liu, Qiaomin Li, Jing Wang

引用次数: 0

Gene Signatures and Prognostic Value of m6A RNA Methylation Regulators in Uterine Corpus Endometrial Carcinoma. m6A RNA甲基化调控因子在子宫内膜癌中的基因特征及预后价值。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-05-01

Yuanling Feng, Chunfang Yao, Jiayu Shen, Jianwei Zhou

{"title":"Gene Signatures and Prognostic Value of m6A RNA Methylation Regulators in Uterine Corpus Endometrial Carcinoma.","authors":"Yuanling Feng, Chunfang Yao, Jiayu Shen, Jianwei Zhou","doi":"","DOIUrl":"","url":null,"abstract":"Background: Uterine corpus endometrial carcinoma (UCEC) is the second most common malignancy of female reproductive system. Though most UCEC are diagnosed at an early age, the mortality has increased. It is important to develop new targets for prognosis evaluation and treatment.Methods: Expression profiles of 19 m6A regulators and UCEC samples' epidemiologic information were obtained from GTEx and TCGA datasets. Nonnegative matrix factorization (NMF) was used to cluster UCEC samples into three groups and overall survival (OS) was compared among them. Multivariate cox proportional hazard model was used to select targets for the construction of m6A-related prognosis prediction signature. A nomogram consisting of m6A-related signature, stage, and histology was provided for clinical application.Results: Eighteen m6A regulators were found to be differentially expressed between normal sample and UCEC samples. There was a significant difference in the OS probability among three clusters with different expression levels of m6A. VIRMA, YTHDF3, and IGF2BP1 were picked as UCEC prognosis prediction signatures and the prognostic value was confirmed. Risk score estimated by this signature was demonstrated to be the independent prognostic factor for UCEC.Conclusion: Aberrant expression of m6A RNA methylation regulators was significantly associated with the development and prognosis of UCEC. A three-gene signature consisting of VIRMA, YTHDF3, and IGF2BP1 may effectively predict the prognosis of UCEC patients.","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"31 164","pages":"111-120"},"PeriodicalIF":1.4,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39651017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mTOR in the Mechanisms of Atherosclerosis and Cardiovascular Disease. mTOR在动脉粥样硬化和心血管疾病中的作用机制

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-05-01

Zhe Liu, Yuxin Fan, Zhongliang Zhang, Yudong Fang, Xin Cheng, Qintong Yang, Jingwen Liu, Jun Xie

引用次数: 0

Efficacy of Remdesivir for COVID-19. 瑞德西韦治疗COVID-19的疗效。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Hongming Zhang, Jibei Chen, Xiyong Wang, Baoan Chen

引用次数: 0

Advanced Techniques in Predicting Breast Tumor Response to Neoadjuvant Chemotherapy. 预测乳腺肿瘤对新辅助化疗反应的先进技术。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Mohamed Abbas

引用次数: 0

Acinar Cells Derived Exosomes Alleviate the Severity of Acute Pancreatitis. 腺泡细胞衍生外泌体减轻急性胰腺炎的严重程度。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Yulin Guo, Feng Cao, Yixuan Ding, Jiongdi Lu, Shuang Liu, Fei Li

{"title":"Acinar Cells Derived Exosomes Alleviate the Severity of Acute Pancreatitis.","authors":"Yulin Guo, Feng Cao, Yixuan Ding, Jiongdi Lu, Shuang Liu, Fei Li","doi":"","DOIUrl":"","url":null,"abstract":"Background: Acute pancreatitis (AP) is a serious and can be lethal disease, with an incidence of 13 to 45 per 100,000 individuals per year. The underlying mechanism of AP is not fully understood. Exosomes have recently been identified as intercellular messengers that can participate in the pathogenesis of various diseases. Exosomes secreted by noninflammatory acinar cells may affect the activated and injured acinar cells during AP.Aim: To investigate the effect of exosomes derived from acinar cells on the pathogenesis of AP.Methods: Nanoparticle tracking analysis was applied to evaluating the exosomes derived from AR42J acinar cells. The viability and apoptosis of AP in vitro model cells were evaluated. Wistar rats were used to establish the in vivo AP rat model and the levels of serum pro-inflammatory cytokines and morphological changes in the pancreatic tissues were assessed. RNA sequencing and Kyoto Encyclopedia of Genes and Genomes databases (KEGG) based RNA enrichment analyses were applied to exploring the mechanisms underlying the effect of exosomes on the pathogenesis of AP.Results: Acinar cell exosomes reduced the level of intracellular ROS production and improved the viability of AP model acinar cells by inhibiting apoptosis during AP. The exosomes decreased the circulating levels of IL-6 and TNF-alpha, and reduced the pathological scores and wet/dry weight ratios of pancreatic tissue in AP in vivo model rats. Among the upregulated and downregulated RNAs analyzed, the MAPK and NF-kappaB signaling pathways might be involved in the mechanisms underlying the protective effects of acinar cell-derived exosomes in AP.Conclusion: Acinar cell-derived exosomes could reduce the apoptosis and ROS production in acinar cells during AP, and may alleviate the severity of AP via the MAPK and NF-kappaB signaling pathways.","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"31 163","pages":"95-105"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's Disease and Parkinson's Disease May Result from Reactivation of Embryologic Pathways Silenced at Birth. 阿尔茨海默病和帕金森病可能是出生时被沉默的胚胎学通路重新激活的结果。

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Steven Lehrer, Peter H Rheinstein

{"title":"Alzheimer's Disease and Parkinson's Disease May Result from Reactivation of Embryologic Pathways Silenced at Birth.","authors":"Steven Lehrer, Peter H Rheinstein","doi":"","DOIUrl":"","url":null,"abstract":"Alzheimer's disease (AD), Lewy Body Dementia (LBD), and Parkinson's disease (PD) form a continuum that may explain multiple aspects of age-related neurodegeneration. Inflammaging, the long-term result of the chronic physiological stimulation of the innate immune system, is integral to this process. The gut microbiome plays an important role in inflammaging, as it can release inflammatory products and communicate with other organs and systems. Although AD and PD are molecularly and clinically distinct disorders, their causes appear to underlie LBD. All three conditions lie on a continuum related to AD, PD, or LBD in vulnerable persons. Inflammation in AD is linked to cytokines and growth factors. Moreover, cytokines and neurotrophins profoundly affect PD and LBD. Growth factors, neurotrophins and cytokines are also involved in embryo neural development. Cytokines influence gene expression, metabolism, cell stress, and apoptosis in the preimplantation embryo. The responsible genes are silenced around birth. But if activated by inflammaging and viruses in the brain decades later, they could destroy the same neural structures they created in utero. For this reason, the pathology and progression of AD, LBD, and PD would be unique. Embryonic reactivation could explain two well documented features of AD. 1) NSAIDs reduce AD risk but fail as a treatment. 2) NSAIDs reduce AD risk because they suppress inflammaging. But they are not a treatment because they cannot silence the embryonic genes that have become active and damage the brain.","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"31 163","pages":"89-94"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717685/pdf/nihms-1720069.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory Biomarkers for the Diagnosis and Management of Patients with COVID-19: an Updated Review. COVID-19患者诊断和管理的实验室生物标志物:最新综述

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Bin-Bin Li, Sheng-Jie Huang, Yi-Long Fu, Zhong-Lin Li, Juan Wang, Jin-Long Wang

引用次数: 0

Dynamic Differences of Immunological Parameters Between Severe and Non-severe COVID-19 Patients. 重症与非重症COVID-19患者免疫参数的动态差异

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-03-01

Qiang Li, Wei Xu, Weixia Li, Chenlu Huang, Ling Fei, Xudong Xie, Liang Chen

{"title":"Dynamic Differences of Immunological Parameters Between Severe and Non-severe COVID-19 Patients.","authors":"Qiang Li, Wei Xu, Weixia Li, Chenlu Huang, Ling Fei, Xudong Xie, Liang Chen","doi":"","DOIUrl":"","url":null,"abstract":"Objective: We aimed to compare the dynamic differences of immunological parameters between severe and non-severe COVID-19 patients.Methods: The cytokine profiles and lymphocyte subsets of 664 patients with COVID-19 (31 severe cases and 633 non-severe cases) were longitudinally analyzed.Results: Compared with non-severe cases, severe cases had a higher age (64 vs. 40 years, p<0.001), more common comorbidity (74.2% vs. 20.5%, p<0.001), and lymphopenia (0.7 vs. 1.4x109/L, p<0.001). Severe cases had markedly higher levels of IL-6, IL-8, and IL-10 from baseline to 35 days after admission than non-severe cases (p<0.001). No significant differences were observed in the dynamic levels of IL-1beta, IL-2, IL-4, IL-5, IL-12, IL-17, TNF-alpha, IFN-alpha, and IFN-gamma between severe and non-severe COVID-19 patients (p>0.05). The absolute counts of lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, and CD45+ T cells were markedly lower in severe patients with COVID-19 compared with those in non-severe patients from baseline to 35 days after admission (p<0.001). No significant differences were observed in the dynamic levels of white cells count, CD19+ B cells count, and NK cells count between severe and non-severe COVID-19 patients (p>0.05). The decrease of T lymphocyte subsets reached its peak at day 1 to 3 after admission, and they gradually increased in the non-severe group, but sustained at low levels in the severe group at day 4 to 35 after admission.Conclusion: The dynamic changes of cytokine profiles and T lymphocyte subsets are related with the severity of COVID-19.","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"31 163","pages":"79-87"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39772769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects of TIM-3 as a Promising Diagnostic and Prognostic Biomarker for Cancer Patients. TIM-3作为癌症患者诊断和预后生物标志物的前景

IF 1.4 4区医学

Discovery medicine Pub Date : 2021-01-01

Fengling Chen, Qiaoying Chen, Liping Zhong, Yongxiang Zhao

引用次数: 0