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Reduction of In-Hospital Preoperative Waiting Time of Elective Surgeries in the Amidst of COVID-19 Pandemic: Experience from Ethiopia. 新冠肺炎疫情下缩短择期手术住院候诊时间:来自埃塞俄比亚的经验
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-10-17 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S371839
Berhanetsehay Teklewold, Engida Abebe, Dagmawi Anteneh, Etsehiwot Haileselassie
{"title":"Reduction of In-Hospital Preoperative Waiting Time of Elective Surgeries in the Amidst of COVID-19 Pandemic: Experience from Ethiopia.","authors":"Berhanetsehay Teklewold,&nbsp;Engida Abebe,&nbsp;Dagmawi Anteneh,&nbsp;Etsehiwot Haileselassie","doi":"10.2147/DHPS.S371839","DOIUrl":"https://doi.org/10.2147/DHPS.S371839","url":null,"abstract":"<p><strong>Background: </strong>The higher demand for surgical services during the advancement of the COVID-19 pandemic has resulted from the need for a pre-admission negative result, the need for extra resources, and a shortage of skilled expertise. This quality improvement project aimed to reduce the in-hospital preoperative waiting time of elective cases to less than 24 hours.</p><p><strong>Methods: </strong>The study was conducted in a tertiary care center. Following the collection of baseline data, we formed a multidisciplinary team to analyze the root causes and intervention ideas of delay using fishbone and driver diagrams, respectively. We prioritize key drivers and implemented several low-cost interventions using Plan-Do-Study-Act (PDSA) model. We monitored the average in-hospital preoperative waiting time of patients.</p><p><strong>Results: </strong>Overall, in-hospital preoperative waiting time for elective cases has been reduced from a baseline of 4.89 days to 1.32 days on average by the end of 10 months of initiating the project. Similarly, monthly elective case cancellation rate due to COVID-19-related reason has been reduced from baseline 62.5% of the total cancellation to 0%. Due to this, the average monthly inpatient bed utilization has increased from 2.21 patients per month during pre-COVID-19 period to 5.9 patients per month in each bed of the surgical ward by the end of the project.</p><p><strong>Conclusion: </strong>The implementation of a quality improvement project can optimize operation theatre efficiency, inpatient bed utilization, and reduce the surgical backlog. Meticulous and rigorous effort has to be laid down to do root cause analysis, generate feasible change ideas, and continuous follow-up, and testing of multiple PDSA cycles is required to impact an improvement and sustain it in the long run. The emergence of COVID-19 pandemic could be used as an opportunity to reduce the length of stay in the hospital.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"185-194"},"PeriodicalIF":1.6,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/dd/dhps-14-185.PMC9585961.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40653473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid Utilization and Management in the Setting of Stewardship During Inpatient Rehab Care. 阿片类药物的使用和管理在管理设置在住院康复护理。
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-09-11 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S360832
Laura Murphy, Kori Leblanc, Souzi Badr, Emily Ching, Lynda Mao, Naomi Steenhof, Bassem Hamandi, Bonita Rubin, Ada Seto, Andrea D Furlan
{"title":"Opioid Utilization and Management in the Setting of Stewardship During Inpatient Rehab Care.","authors":"Laura Murphy,&nbsp;Kori Leblanc,&nbsp;Souzi Badr,&nbsp;Emily Ching,&nbsp;Lynda Mao,&nbsp;Naomi Steenhof,&nbsp;Bassem Hamandi,&nbsp;Bonita Rubin,&nbsp;Ada Seto,&nbsp;Andrea D Furlan","doi":"10.2147/DHPS.S360832","DOIUrl":"https://doi.org/10.2147/DHPS.S360832","url":null,"abstract":"<p><strong>Background: </strong>Opioid utilization and management in an inpatient rehabilitation setting have not been widely described, despite the unique opportunities that exist in this setting to support opioid stewardship across transitions in care. We aimed to characterize opioid utilization and management by interprofessional teams across a large, inpatient rehabilitation setting after incorporation of opioid stewardship principles by pharmacists as part of their daily practice.</p><p><strong>Patients and methods: </strong>This was a retrospective chart review at Toronto Rehab, University Health Network, Toronto, Canada. Patients with admission orders for any opioid from November 2017 to February 2018 were included. Complex continuing care and palliative care patients were excluded. Descriptive statistics were primarily used to describe the data as well as univariate linear regression to compare associations with milligram morphine equivalent (MME) reduction.</p><p><strong>Results: </strong>A total of 448 patients were included. A reduction in total daily MME was seen in 49% (n=219) of the patients during their inpatient stay, with 73% (n=159) of these patients having a reduction of ≥50%. Sixty-nine percent (n=311) of the patients received an opioid prescription at discharge, with most scheduled (90%, n=98) with a supply of less than 30 days. Rehabilitation length of stay was correlated with a MME decrease during rehab (p<0.01), suggesting that longer lengths of stay contributed to a greater reduction in MME. Patients with chronic opioid use prior to acute care admission (p=0.01), and those who started extended-release opioids during acute care (p=0.02) were significantly less likely to discontinue opioids during rehab stay.</p><p><strong>Conclusion: </strong>Opioid utilization and management in the setting of opioid stewardship across inpatient rehab and transitions of care were characterized. Opportunities exist for further quality improvement initiatives within inpatient rehabilitation and acute care settings to identify and support patients with complex pain management needs.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"161-170"},"PeriodicalIF":1.6,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/b2/dhps-14-161.PMC9477087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40365939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Utility and Tolerability of Tolvaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). 托伐普坦治疗常染色体显性多囊肾病(ADPKD)的临床疗效和耐受性
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-09-08 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S338050
Rupesh Raina, Ahmad Houry, Pratik Rath, Guneive Mangat, Davinder Pandher, Muhammad Islam, Ala'a Grace Khattab, Joseph K Kalout, Sumedha Bagga
{"title":"Clinical Utility and Tolerability of Tolvaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD).","authors":"Rupesh Raina,&nbsp;Ahmad Houry,&nbsp;Pratik Rath,&nbsp;Guneive Mangat,&nbsp;Davinder Pandher,&nbsp;Muhammad Islam,&nbsp;Ala'a Grace Khattab,&nbsp;Joseph K Kalout,&nbsp;Sumedha Bagga","doi":"10.2147/DHPS.S338050","DOIUrl":"https://doi.org/10.2147/DHPS.S338050","url":null,"abstract":"<p><p>Autosomal dominant polycystic kidney disease, also known as ADPKD, is the most common hereditary kidney disease, affecting different age groups. ADPKD can eventually lead to end-stage renal disease. The etiology of ADPKD is genetic, resulting in the formation of cysts containing fluids on the kidneys. Patients with ADPKD present a range of symptoms following a decline in kidney function. Pain, stones, proteinuria and osteoporosis are few of the many symptoms, resulting from decreased kidney function. Tolvaptan, a selective V2 receptor antagonist, is the etiological treatment used for ADPKD. In this paper, we conducted a systematic review of the literature between 2011 and 2021 to gather data regarding the tolerability and efficacy of tolvaptan use in ADPKD. A total of 22 trials were reviewed. Tolvaptan efficacy in the trials was measured using changes in eGFR or changes in total kidney volume. Results showed that tolvaptan use in ADPKD was associated with a slower decline in kidney function and a decrease in total kidney volume. Side effects of this drug include polyuria, nocturia and polydipsia along with hepatotoxicity. The two biggest trials, TEMPO and REPRISE, change in eGFR from pre-treatment baseline to post-treatment was 1.3 mL/min/1.73 for REPRISE and 1 mL/min/1.73 for TEMPO 3:4. A mean decrease of 49% in total kidney volume from baseline to post-treatment was found in the TEMPO 3:4 study.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"147-159"},"PeriodicalIF":1.6,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/80/dhps-14-147.PMC9467294.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Describing and Quantifying Wrong-Patient Medication Errors Through a Study of Incident Reports. 通过事件报告的研究来描述和量化错误患者的用药错误。
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-08-23 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S371574
Megumi Takahashi, Hiroshi Okudera, Masahiro Wakasugi, Mie Sakamoto, Hiromi Shimizu, Tokie Wakabayashi, Tsuneaki Yamanouchi, Hisashi Nagashima
{"title":"Describing and Quantifying Wrong-Patient Medication Errors Through a Study of Incident Reports.","authors":"Megumi Takahashi,&nbsp;Hiroshi Okudera,&nbsp;Masahiro Wakasugi,&nbsp;Mie Sakamoto,&nbsp;Hiromi Shimizu,&nbsp;Tokie Wakabayashi,&nbsp;Tsuneaki Yamanouchi,&nbsp;Hisashi Nagashima","doi":"10.2147/DHPS.S371574","DOIUrl":"https://doi.org/10.2147/DHPS.S371574","url":null,"abstract":"<p><strong>Purpose: </strong>Our aim was to inform a new definition of wrong-patient errors, obtained through an analysis of incident reports related to medication errors.</p><p><strong>Methods: </strong>We investigated wrong-patient medication errors in incident reports voluntarily reported by medical staff using a web-based incident reporting system from 2015 to 2016 at a university hospital in Japan. Incident report content was separately evaluated by four evaluators using investigational methods for clinical incidents from the Clinical Risk Unit and the Association of Litigation and Risk Management. They investigated whether it was the patient or drug that was incorrectly chosen during wrong-patient errors in drug administration in incident reports and assessed contributory factors which affected the error occurrence. The evaluators integrated the results and interpreted them together.</p><p><strong>Results: </strong>Out of a total 4337 IRs, only 30 cases (2%) contained wrong-patient errors in medication administration. The cases where the intended drugs were administered to incorrect patients occurred less frequently than cases where the wrong drugs were administered to the intended patients through the investigation of wrong targets. After a discussion, the evaluators concluded that the patient - drug/CPOE screen mismatch, caused by choosing the wrong patient, drug, or CPOE screen (mix-ups), occurred in the wrong-patient medication errors. These errors were caused by three conditions: (1) where two patients/drugs were listed next to one another, (2) where two patients' last names/drugs' names were the same, and (3) where the patient/drug/CPOE screen in front of the staff involved was believed to be the correct one. Additionally, these errors also involved insufficient confirmation, which led to failure to detect and correct the mismatch occurrences.</p><p><strong>Conclusion: </strong>Based on our study, we propose a new definition of wrong-patient medication errors: they consisted of choosing a wrong target and insufficient confirmation. We will investigate other types of wrong-patient errors to apply this definition.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"135-146"},"PeriodicalIF":1.6,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/69/dhps-14-135.PMC9419808.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33446695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and Perceptions of Nurse Practitioners on Adverse Events Following Immunization and Barriers to Reporting in the Central Region, Eritrea: A Cross-Sectional Study. 在厄立特里亚中部地区,护士从业人员对免疫接种后不良事件的认识和报告障碍:一项横断面研究。
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S363925
Nuru Abdu, Asmerom Mosazghi, Tedros Yehdego, Eyasu H Tesfamariam, Mulugeta Russom
{"title":"Knowledge and Perceptions of Nurse Practitioners on Adverse Events Following Immunization and Barriers to Reporting in the Central Region, Eritrea: A Cross-Sectional Study.","authors":"Nuru Abdu,&nbsp;Asmerom Mosazghi,&nbsp;Tedros Yehdego,&nbsp;Eyasu H Tesfamariam,&nbsp;Mulugeta Russom","doi":"10.2147/DHPS.S363925","DOIUrl":"https://doi.org/10.2147/DHPS.S363925","url":null,"abstract":"<p><strong>Background: </strong>Though vaccines are generally considered extremely safe and effective, they have been associated with some serious adverse events following immunization (AEFIs). AEFIs might be related to either the vaccine, immunization error, anxiety related to immunization, and/or coincidental events. If they are not reported and investigated in timely fashion, they can create rumors and confidence gaps. In the last few years, reporting AEFIs in the Central Region of Eritrea, compared to other regions, has been found to be very low, with the root cause for this variation unknown, making intervention strategies challenging. This study was conducted to assess nurse practitioners' knowledge and perceptions on AEFI surveillance and barriers to reporting in the region.</p><p><strong>Methods: </strong>An analytical cross-sectional study was conducted among all nurse practitioners who were directly or indirectly involved in immunization services working in all health facilities of the region. Data were collected between October 2019 and February 2020 using an interview-based questionnaire. Percentages and medians (IQR) were used as descriptive statistics, and Mann-Whitney and Kruskal-Wallis tests were used as inferential tools.</p><p><strong>Results: </strong>A total of 130 respondents with a median age of 40 (IQR 23) years were included in the study. The overall median (IQR) knowledge score of the respondents on AEFI surveillance was 87.50 (19) out of 100. Furthermore, median (IQR) comprehensive perception score was 70 (20) out of 100 (range 40-95). Shortage of motivation and not knowing how to report were identified as the main barriers to reporting AEFIs.</p><p><strong>Conclusion: </strong>Knowledge and perceptions of nurse practitioners in the Central Region on AEFI surveillance were generally encouraging. They should however need to be further trained on the basics of AEFI surveillance to bridge the identified barriers to reporting.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"125-134"},"PeriodicalIF":1.6,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/50/dhps-14-125.PMC9338432.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40662771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity. 磺胺致超敏反应的临床表现及遗传影响。
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-07-21 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S347522
Pungki Afifah Asyraf, Ivanna Fauziyah Kusnadi, Jonathan Stefanus, Miski Aghnia Khairinisa, Rizky Abdulah
{"title":"Clinical Manifestations and Genetic Influences in Sulfonamide-Induced Hypersensitivity.","authors":"Pungki Afifah Asyraf,&nbsp;Ivanna Fauziyah Kusnadi,&nbsp;Jonathan Stefanus,&nbsp;Miski Aghnia Khairinisa,&nbsp;Rizky Abdulah","doi":"10.2147/DHPS.S347522","DOIUrl":"https://doi.org/10.2147/DHPS.S347522","url":null,"abstract":"<p><p>Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. This antibacterial agent works by competitively inhibiting folic acid synthesis, which prevents the growth and proliferation of microorganisms. In its use as antibiotics, sulfonamides can also cause adverse reactions in specific individuals. It has been widely reported that sulfonamide antimicrobials cause hypersensitivity reactions mediated by IgE or T cells. This review identifies symptoms or signs that can appear, as well as genes associated with sulfonamide hypersensitivity reactions, as sulfonamide may cause hypersensitivity in the form of uveitis, skin rash, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), parotitis, angioedema, drug reaction with eosinophilia and systemic symptoms (DRESS), and pruritus. In addition, several genes were found to be associated with sulfonamide hypersensitivity, including HLA-A29, HLA-B12, HLA-DR7, HLA-B44, and HLA A*11:01.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"113-124"},"PeriodicalIF":1.6,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/7e/dhps-14-113.PMC9315057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Clinical Efficacy, Safety, Tolerability, and Real-World Data of Patiromer for the Treatment of Hyperkalemia. Patiromer治疗高钾血症的临床疗效、安全性、耐受性和真实世界数据。
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-07-14 eCollection Date: 2022-01-01 DOI: 10.2147/DHPS.S338579
Gates Colbert, Shilpa Sannapaneni, Edgar V Lerma
{"title":"Clinical Efficacy, Safety, Tolerability, and Real-World Data of Patiromer for the Treatment of Hyperkalemia.","authors":"Gates Colbert,&nbsp;Shilpa Sannapaneni,&nbsp;Edgar V Lerma","doi":"10.2147/DHPS.S338579","DOIUrl":"https://doi.org/10.2147/DHPS.S338579","url":null,"abstract":"<p><p>Hyperkalemia remains one of the most difficult consequences of disease state and treatment for patients with chronic kidney disease, heart failure, and diabetes. Controlling hyperkalemia can be difficult, but has become easier with the introduction of novel oral potassium binders. Patiromer was approved in 2015 for the treatment of hyperkalemia by the FDA in the United States. Several pivotal trials proved its efficacy, safety, and improved tolerability compared with previous hyperkalemia treatments. Additionally, many real-world publications and trials have given deeper insights into the capabilities of patiromer. We discuss improved disease state outcomes with combining patiromer with RAASi. This paper will also highlight new trials forthcoming that are highly anticipated to expand the possibilities in using patiromer to improve outcomes and populations.</p>","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":" ","pages":"87-96"},"PeriodicalIF":1.6,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/9c/dhps-14-87.PMC9292454.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40541101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Influence of Medical Education on Medicine Use and Self-Medication Among Medical Students: A Cross-Sectional Study from Kabul 医学教育对医学生用药和自我用药的影响——来自喀布尔的横断面研究
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-05-01 DOI: 10.2147/DHPS.S360072
A. Daanish, Ershad Ahmad Mushkani
{"title":"Influence of Medical Education on Medicine Use and Self-Medication Among Medical Students: A Cross-Sectional Study from Kabul","authors":"A. Daanish, Ershad Ahmad Mushkani","doi":"10.2147/DHPS.S360072","DOIUrl":"https://doi.org/10.2147/DHPS.S360072","url":null,"abstract":"Objective To compare the prevalence of self-medication among first- and fifth-year medical students at Kabul University of Medical Sciences. Methods A cross-sectional study was conducted with the participation of all first- and fifth-year medical students by using a short, self-administered questionnaire. The prevalence of self-medication was estimated in the entire study population and also in those who had used medicines in the preceding one week. Results Of the total 302 students, the prevalence of medicine use was 38%. The prevalence of self-medication in all study population was 25.16%, whereas in those who had used medicines was 64.9%. Prescription-only medicines consisted of 59.2% of self-medication. The practice of self-medication and the use of prescription-only medicines were more prevalent among students in their fifth year and among males. While the prevalence of medicine use was the same among males and females, it differed between students in the fifth and first year. Paracetamol, anti-infectives, and non-steroidal anti-inflammatory drugs (NSAIDs) were more frequently used medicines. Conclusion The use of medicines, self-medication and the use of prescription-only medicines were more prevalent among fifth-year students compared to those in the first-year. This apparently reflects the effect of medical education and training. More specific studies are required to address the issue in more detail and to facilitate interventions. The estimation of the prevalence of self-medication by using a short acceptable recall period, confined in those who had used medicines, seems to be more reasonable and accurate than by using a longer recall period in the entire study population. The prevalence of prescription-only medicines in self-medication could also be a useful indicator.","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":"14 1","pages":"79 - 85"},"PeriodicalIF":1.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44451614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Pancytopenia Due to Possible Drug–Drug Interactions Between Low-Dose Methotrexate and Proton Pump Inhibitors 低剂量甲氨蝶呤和质子泵抑制剂之间可能的药物相互作用引起的全血细胞减少症
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-05-01 DOI: 10.2147/DHPS.S350194
D. Tao, Hui Wang, Fangfang Xia, Wenlu Ma
{"title":"Pancytopenia Due to Possible Drug–Drug Interactions Between Low-Dose Methotrexate and Proton Pump Inhibitors","authors":"D. Tao, Hui Wang, Fangfang Xia, Wenlu Ma","doi":"10.2147/DHPS.S350194","DOIUrl":"https://doi.org/10.2147/DHPS.S350194","url":null,"abstract":"Abstract Methotrexate (MTX) has been widely used with a wide range of doses in the treatment of certain neoplastic diseases, severe psoriasis, and rheumatoid arthritis. At higher dose, monitoring of serum MTX elimination is performed because delayed elimination can result in serious and potentially life-threatening toxicities. A number of medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, phenylbutazone, phenytoin, sulfonamides, and some oral antibiotics, are known to interact with MTX therapy through various mechanisms. Accumulating evidence suggests that concomitant use of MTX (primarily at high doses) and proton pump inhibitors (PPIs) such as omeprazole, esomeprazole, and pantoprazole may decrease MTX clearance. The majority of the reported cases occurred with the administration of high-dose MTX in patients receiving doses of 300 mg/m2 to 12 g/m2. However, there were also cases of patients taking PPI and experiencing toxicity at doses as low as 10 mg of MTX per week. Although the dosage of MTX is small, the presence of side effect may be delayed and still dangerous. After literature review, it was found that common toxicities associated with low-dose MTX used for inflammatory arthritis include gastrointestinal adverse effects (>10%; ie nausea, stomatitis) and central nervous system toxicity (~20%; ie fatigue, malaise, dizziness, impaired cognition) with weekly administration. Bone marrow suppression (<3%; ie leukopenia, neutropenia, thrombocytopenia) and hepatotoxicity (~15%; ie reversible elevations in transaminases) are less common, and rarely MTX can also cause pulmonary (<1%) and other toxicities. Here, we report two cases who presented with severe pancytopenia 8 and 13 days after taking low-dose MTX and PPI. We highlight that in absence of risk/benefit ratio correctly set, an assessment of appropriateness of PPI prescription before MTX therapy can limit an iatrogenic risk.","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":"14 1","pages":"75 - 78"},"PeriodicalIF":1.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48918498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Obstacles and Opportunities in Information Transfer Regarding Medications at Discharge – A Focus Group Study with Hospital Physicians 出院时药物信息传递的障碍和机会——与医院医生的焦点小组研究
IF 1.6
Drug, Healthcare and Patient Safety Pub Date : 2022-05-01 DOI: 10.2147/DHPS.S362189
Maria Glans, P. Midlöv, Annika Kragh Ekstam, Å. Bondesson, A. Brorsson
{"title":"Obstacles and Opportunities in Information Transfer Regarding Medications at Discharge – A Focus Group Study with Hospital Physicians","authors":"Maria Glans, P. Midlöv, Annika Kragh Ekstam, Å. Bondesson, A. Brorsson","doi":"10.2147/DHPS.S362189","DOIUrl":"https://doi.org/10.2147/DHPS.S362189","url":null,"abstract":"Purpose This qualitative study aimed to investigate experiences and perceptions of hospital physicians regarding the discharging process, focusing on information transfer regarding medications. Methods By purposive sampling three focus groups were formed. To facilitate discussions and maintain consistency, a semi-structured interview guide was used. Discussions were audio recorded and transcribed verbatim. Qualitative content analysis was used to analyze the anonymized data. A confirmatory analysis concluded that the main findings were supported by data. Results Identified obstacles were divided into three categories with two sub-categories each: Infrastructure; IT-systems currently used are suboptimal and complex. Hospital and primary care use different electronic medical records, complicating matters. The work organization is not helping with time scarcity and lack of continuity. Distinct routines could help create continuity but are not always in place, known, and/or followed. Physician: knowledge and education in the systems is not always provided nor prioritized. Understanding the consequences of not following routines and taking responsibility regarding the medications list is important. Not everyone has the self-reliance or willingness to do so. Patient/next of kin: For patients to provide information on medications used is not always easy when hospitalized. Understanding information provided can be hard, especially when medical jargon is used and there is no one available to provide support. A central theme, “We're only human”, encompasses how physicians do their best despite difficult conditions. Conclusion There are several obstacles in transferring information regarding medications at discharge. Issues regarding infrastructure are seldom possible for the individual physician to influence. However, several issues raised by the participating physicians are possible to act upon. In doing so medication errors in care transitions might decrease and information transfer at discharge might improve.","PeriodicalId":11377,"journal":{"name":"Drug, Healthcare and Patient Safety","volume":"14 1","pages":"61 - 73"},"PeriodicalIF":1.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44617358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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