Diabetes & metabolism最新文献

{"title":"Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders","authors":"Wenyu Shao,&nbsp;Yichun Su,&nbsp;Jiayin Liu,&nbsp;Yulong Liu,&nbsp;Jinghui Zhao,&nbsp;Xiaotang Fan","doi":"10.1016/j.diabet.2024.101543","DOIUrl":"10.1016/j.diabet.2024.101543","url":null,"abstract":"<div><p>Autism spectrum disorders (ASD) encompass a collection of neurodevelopmental disorders that exhibit impaired social interactions and repetitive stereotypic behaviors. Although the exact cause of these disorders remains unknown, it is widely accepted that both genetic and environmental factors contribute to their onset and progression. Recent studies have highlighted the potential negative impact of maternal diabetes on embryonic neurodevelopment, suggesting that intrauterine hyperglycemia could pose an additional risk to early brain development and contribute to the development of ASD. This paper presents a comprehensive analysis of the current research on the relationship between various forms of maternal diabetes, such as type 1 diabetes mellitus, type 2 diabetes mellitus, and gestational diabetes mellitus, and the likelihood of ASD in offspring. The study elucidates the potential mechanisms through which maternal hyperglycemia affects fetal development, involving metabolic hormones, immune dysregulation, heightened oxidative stress, and epigenetic alterations. The findings of this review offer valuable insights for potential preventive measures and evidence-based interventions targeting ASD.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 4","pages":"Article 101543"},"PeriodicalIF":7.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma 16:0 ceramide as a marker of cardiovascular risk estimated by carotid intima-media thickness in people with type 2 diabetes","authors":"Damien Denimal ,&nbsp;Laurence Duvillard ,&nbsp;Sarah Béland-Bonenfant ,&nbsp;Béatrice Terriat ,&nbsp;Jean-Paul Pais-de-Barros ,&nbsp;Isabelle Simoneau ,&nbsp;Alexia Rouland ,&nbsp;Lina Houbachi ,&nbsp;Benjamin Bouillet ,&nbsp;Bruno Vergès ,&nbsp;Jean-Michel Petit","doi":"10.1016/j.diabet.2024.101542","DOIUrl":"10.1016/j.diabet.2024.101542","url":null,"abstract":"<div><h3>Aim</h3><p>New tools are required to better assess cardiovascular risk in individuals with type 2 diabetes mellitus (T2DM). Plasma ceramides emerge as promising candidates, given their substantial influence on the pathogenesis of both T2DM and atherosclerosis. The current study aimed to investigate whether plasma ceramides in patients with T2DM are a predictive factor for carotid intima-media thickness (CIMT), a well-established noninvasive marker for atherosclerosis that predicts adverse cardiovascular outcomes.</p></div><div><h3>Methods</h3><p>A lipidomic analysis was carried out on the circulating ceramides of a large cohort consisting of 246 patients with T2DM who underwent a high-resolution real-time B ultrasonography to measure CIMT.</p></div><div><h3>Results</h3><p>Both plasma 16:0 ceramide and the 16:0/24:0 ceramide ratio were positively associated with CIMT, even after adjustment for traditional cardiovascular risk factors [standardized β ± standard error: 0.168 ± 0.072 (<em>P</em> = 0.020) and 0.180 ± 0.068 (<em>P</em> = 0.009), respectively]. Similar independent associations were found with respect to the prediction of CIMT ≥ 0.80 mm [β = 8.07 ± 3.90 (<em>P</em> = 0.038) and 16.5 ± 7.0 (<em>P</em> = 0.019), respectively]. The goodness-of-fit for multivariate models in predicting CIMT was 5.7 and 7.6 times higher when plasma 16:0 ceramide or the 16:0/24:0 ceramide ratio were included in combination with traditional cardiovascular risk factors (<em>P</em> = 0.020 and 0.015, respectively). This reached a 3.1 and 10.0-fold increase regarding the ability to predict CIMT ≥ 0.80 mm (<em>P</em> = 0.039 and 0.008, respectively).</p></div><div><h3>Conclusions</h3><p>Our findings suggest that 16:0 ceramide and the 16:0/24:0 ceramide ratio may serve as plasma biomarkers to improve cardiovascular risk assessment in individuals with T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 4","pages":"Article 101542"},"PeriodicalIF":7.2,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S126236362400034X/pdfft?md5=6dd6dda1006545cc52403e0d3d490413&pid=1-s2.0-S126236362400034X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of renal events in people with diabetic foot disease: A longitudinal observational study","authors":"Fadi Alkhami,&nbsp;Sébastien Rubin,&nbsp;Gauthier Borderie,&nbsp;Ninon Foussard,&nbsp;Alice Larroumet,&nbsp;Laurence Blanco,&nbsp;Marie-Amélie Barbet-Massin,&nbsp;Frédéric Domenge,&nbsp;Kamel Mohammedi,&nbsp;Vincent Rigalleau","doi":"10.1016/j.diabet.2024.101536","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101536","url":null,"abstract":"<div><h3>Objective</h3><p>Diabetic kidney disease favors diabetic foot ulcers, however we do not know whether the reverse relation exists. We investigated whether diabetic foot disease (DFD) related to an increased risk of developing renal events.</p></div><div><h3>Research design and methods</h3><p>We conducted a retrospective analysis of a cohort of patients hospitalized for type 2 diabetes mellitus (T2DM) between 2009 and 2017, stratified for the risk of diabetic foot ulcer grades 0 (no risk), 1 and 2 (at risk), and 3 (DFD) according to the International Work Group on Diabetic Foot (IWGDF) classification. We highlighted new renal events (end-stage renal disease or a doubling of serum creatinine) in their medical records until December 2020. The relationship between DFD and later renal events was analyzed by multivariable Cox regression model.</p></div><div><h3>Results</h3><p>Among 519 patients, 142 (27 %) had a DFD at baseline, and 159 (30 %) were classified as Grades 1 or 2. Thirty-six renal events occurred during the 54 ± 27 months of follow-up: 19 subjects started dialysis, 1 had a renal transplantation, and 16 had a doubling of serum creatinine: 15 each in subjects with DFD and subjects at risk, versus 6 in subjects with Grade 0 DFD (logrank: <em>P</em> = 0.001). Adjusted for <em>i</em>) age and sex; <em>ii</em>) hyperglycemic exposure; <em>iii</em>) conventional cardiovascular risk factors; <em>iv</em>) renal parameters: and <em>v</em>) new diabetic foot ulcers during follow-up, DFD (HR 2.7 to 5.9) and being at risk of DFD Grades 1–2 (HR 2.8 to 5.1) were significantly related to new renal events.</p></div><div><h3>Conclusion</h3><p>The risk of renal events was increased in people with T2DM and DFD.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 4","pages":"Article 101536"},"PeriodicalIF":7.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes","authors":"Laurence Duvillard ,&nbsp;Jean-Paul Pais de Barros ,&nbsp;Alexia Rouland ,&nbsp;Isabelle Simoneau ,&nbsp;Damien Denimal ,&nbsp;Benjamin Bouillet ,&nbsp;Jean-Michel Petit ,&nbsp;Bruno Vergès","doi":"10.1016/j.diabet.2024.101535","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101535","url":null,"abstract":"<div><h3>Aim</h3><p>The catabolism of high density lipoprotein (HDL) apolipoprotein AI (apoAI) is accelerated in patients with type 2 diabetes (T2D), related to hypertriglyceridemia, insulin resistance and low plasma adiponectin levels. Since liraglutide is likely to partly correct these abnormalities, we hypothesized that it might have a beneficial effect on HDL apoAI kinetics in patients with T2D.</p></div><div><h3>Methods</h3><p>An <em>in vivo</em> kinetic study of HDL apoAI was performed in 10 patients with T2D before and after 6 months of treatment with 1.2 mg/day of liraglutide, using a bolus of l-[1–¹³C]leucine followed by a 16-hour constant infusion.</p></div><div><h3>Results</h3><p>Liraglutide reduced BMI (34.9 ± 4.7 <em>vs</em> 36.6 ± 4.9 kg/m², <em>P</em> = 0.012), HbA1c (7.1 ± 1.1 <em>vs</em> 9.6 ± 2.6%, <em>P</em> = 0.003), HOMA-IR (5.5 ± 1.9 <em>vs</em> 11.6 ± 11.2, <em>P</em> = 0.003), fasting triglycerides (1.76 ± 0.37 <em>vs</em> 2.48 ± 0.69 mmol/l, <em>P</em> &lt; 0.001) and triglycerides during kinetics (2.34 ± 0.81 <em>vs</em> 2.66 ± 0.65 mmol/l, <em>P</em> = 0.053). Plasma HDL cholesterol and adiponectin concentrations were unchanged (respectively 0.97 ± 0.26 <em>vs</em> 0.97 ± 0.19 mmol/l, <em>P</em> = 1; 3169 ± 1561 <em>vs</em> 2618 ± 1651 µg/l, <em>P</em> = 0.160), similar to triglyceride content in HDL (5.13 ± 1.73 vs 5.39 ± 1.07%, <em>P</em> = 0.386). Liraglutide modified neither HDL apoAI fractional catabolic rate (0.35 ± 0.11 vs 0.38 ± 0.11 pool/day, <em>P</em> = 0.375), nor its production rate (0.44 ± 0.13 vs 0.49 ± 0.15 g/l/day, <em>P</em> = 0.375), nor its plasma concentration (1.26 ± 0.19 vs 1.29 ± 0.14 g/l, <em>P</em> = 0.386).</p></div><div><h3>Conclusion</h3><p>Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101535"},"PeriodicalIF":7.2,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1262363624000272/pdfft?md5=919dc39fbfcf1c9138f9637d0e35003d&pid=1-s2.0-S1262363624000272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography","authors":"Gyuri Kim ,&nbsp;Tae Yang Yu ,&nbsp;Jae Hwan Jee ,&nbsp;Ji Cheol Bae ,&nbsp;Mira Kang ,&nbsp;Jae Hyeon Kim","doi":"10.1016/j.diabet.2024.101534","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101534","url":null,"abstract":"<div><h3>Aim</h3><p>Left ventricular diastolic dysfunction (LVDD) has been observed in people with nonalcoholic fatty liver disease (NAFLD) in cross-sectional studies but the causal relationship is unclear. This study aimed to investigate the impact of NAFLD and the fibrotic progression of the disease on the development of LVDD, assessed by serial echocardiography, in a large population over a 7-year longitudinal setting.</p></div><div><h3>Methods</h3><p>This retrospective cohort study included the data of 3,380 subjects from a medical health check-up program. We defined subjects having NAFLD by abdominal ultrasonography and assessed significant liver fibrosis by the aspartate transaminase (AST) to platelet ratio index (APRI), the NAFLD fibrosis score (NFS), and the fibrosis-4 (FIB-4) index. LVDD was defined using serial echocardiography. A parametric Cox proportional hazards model was used.</p></div><div><h3>Results</h3><p>During 11,327 person-years of follow-up, there were 560 (16.0 %) incident cases of LVDD. After adjustment for multiple risk factors, subjects with NAFLD showed an increased adjusted hazard ratio (aHR) of 1.21 (95 % confidence interval [CI]=1.02–1.43) for incident LVDD compared to those without. The risk of LV diastolic dysfunction increased progressively with increasing degree of hepatic steatosis (<em>P</em> <em>&lt;</em> 0.001). Compared to subjects without NAFLD, the multivariable-aHR (95 % CI) for LVDD in subjects with APRI &lt; 0.5 and APRI ≥ 0.5 were 1.20 (1.01–1.42) and 1.36 (0.90–2.06), respectively (<em>P</em> <em>=</em> 0.036), while other fibrosis prediction models (NFS and FIB-4 index) showed insignificant results.</p></div><div><h3>Conclusions</h3><p>This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101534"},"PeriodicalIF":7.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association of endothelial lipase and aldose reductase polymorphisms with proliferative diabetic retinopathy: Results of the French prospective multicenter REDIAGEN study","authors":"Adrien HENRY ,&nbsp;Tiffany BOIGELOT ,&nbsp;Thomas FERREIRA DE MOURA ,&nbsp;Isabelle LECLERCQ ,&nbsp;Coralie BARBE ,&nbsp;Aurore THIERY ,&nbsp;Zoubir DJERADA ,&nbsp;Pierre NAZEYROLLAS ,&nbsp;Christine CLAVEL ,&nbsp;Pascale CORNILLET-LEFEBVRE ,&nbsp;Jean-Paul BERROD ,&nbsp;Catherine CREUZOT-GARCHER ,&nbsp;Laurent MEYER ,&nbsp;David GAUCHER ,&nbsp;Bruno GUERCI ,&nbsp;Patrick LENOBLE ,&nbsp;Solange MILAZZO ,&nbsp;Jean-Marc PERONE ,&nbsp;Carl ARNDT ,&nbsp;Vincent DURLACH","doi":"10.1016/j.diabet.2024.101533","DOIUrl":"https://doi.org/10.1016/j.diabet.2024.101533","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101533"},"PeriodicalIF":7.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140540483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of social isolation and loneliness and the risk of incident type 2 diabetes mellitus across genetic risk score","authors":"Yilin Chen ,&nbsp;Huachen Xue ,&nbsp;Sizhi Ai ,&nbsp;Yaping Liu ,&nbsp;Yu Nie ,&nbsp;Qi-Yong H. Ai ,&nbsp;Jihui Zhang ,&nbsp;Yannis Yan Liang","doi":"10.1016/j.diabet.2024.101526","DOIUrl":"10.1016/j.diabet.2024.101526","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to investigate the association of social isolation, loneliness, and their trajectory with the risk of developing type 2 diabetes mellitus (T2DM) across genetic risk.</p></div><div><h3>Methods</h3><p>We included 439,337 participants (mean age 56.3 ± 8.1 years) enrolled in the UK Biobank study who were followed up until May 31, 2021. Social isolation and loneliness were self-reported and were further categorized into never, transient, incident, and persistent patterns.</p></div><div><h3>Results</h3><p>During a median follow-up of 12.7 years, 15,258 incident T2DM cases were documented. Social isolation (versus no social isolation: hazard ratio (HR) 95 % confidence interval (CI) 1.04 [1.00;1.09]) and loneliness (versus no loneliness: 1.26 [1.19;1.34]) were associated with an increased T2DM risk, independent of the genetic risk for T2DM. The interactions existed between social isolation and loneliness (<em>P</em> _interaction &lt; 0.05); the increased T2DM risk associated with social isolation was only significant among participants without loneliness. In the longitudinal analysis, only persistent social isolation (versus never social isolation: 1.22 [1.02;1.45]) was associated with an increased T2DM risk, whereas incident loneliness (versus never loneliness: 1.95 [1.40;2.71]) and persistent loneliness (2.00 [1.31;3.04]) were associated with higher T2DM risks.</p></div><div><h3>Conclusion</h3><p>Social isolation and loneliness, especially their persistent pattern, were independently associated with an increased incident T2DM risk, irrespective of an individual's genetic risk. Loneliness modified the association between social isolation and incident T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101526"},"PeriodicalIF":7.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140055893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ketone bodies with incident CKD and death: A UK Biobank study","authors":"Chan-Young Jung ,&nbsp;Hee Byung Koh ,&nbsp;Ga Young Heo ,&nbsp;Byounghwi Ko ,&nbsp;Hyung Woo Kim ,&nbsp;Jung Tak Park ,&nbsp;Tae-Hyun Yoo ,&nbsp;Shin-Wook Kang ,&nbsp;Seung Hyeok Han","doi":"10.1016/j.diabet.2024.101527","DOIUrl":"10.1016/j.diabet.2024.101527","url":null,"abstract":"<div><h3>Aims</h3><p>Although cellular and animal models have suggested a protective effect of ketone bodies (KBs), clinical data are still lacking to support these findings. This study aimed to investigate the association of KB levels with incident chronic kidney disease (CKD) and death.</p></div><div><h3>Methods</h3><p>This was a prospective cohort study of 87,899 UK Biobank participants without baseline CKD who had plasma levels of β-hydroxybutyrate, acetoacetate, and acetone levels measured at the time of enrollment. The main predictor was plasma total KB, which was the sum of the aforementioned three KBs. The primary outcome was a composite of incident CKD, or all-cause mortality. Secondary outcomes included the individual components of the primary outcome.</p></div><div><h3>Results</h3><p>During a median follow-up of 11.9 years, a total of 8,145 primary outcome events occurred (incidence rate 8.0/1,000 person-years). In the multivariable Cox model, a 1-standard deviation increase in log total KB was associated with a 7 % [adjusted hazard ratio (aHR), 1.07; 95 % confidence interval (CI), 1.05–1.10] higher risk of the primary outcome. When stratified into quartiles, the aHR (95 % CI) for Q4 versus Q1 was 1.18 (1.11–1.27). This association was consistent for incident CKD (aHR, 1.04; 95 % CI, 1.01–1.07), and all-cause mortality (aHR, 1.10; 95 % CI, 1.07–1.13). Compared with Q1, Q4 was associated with a 12 % (aHR 1.12; 95 % CI 1.02–1.24) and 26 % (aHR 1.26; 95 % CI 1.15–1.37) higher risk of incident CKD and all-cause mortality, respectively.</p></div><div><h3>Conclusions</h3><p>Higher KB levels were independently associated with higher risk of incident CKD and death.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101527"},"PeriodicalIF":7.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BedBiopsy: Diagnostic performance of bedside ultrasound-guided bone biopsies for the management of diabetic foot infection","authors":"Nolan Hassold ,&nbsp;Hélène Bihan ,&nbsp;Yolène Pambo Moumba ,&nbsp;Isabelle Poilane ,&nbsp;Frédéric Méchaï ,&nbsp;Nabil Assad ,&nbsp;Véronique Labbe-Gentils ,&nbsp;Meriem Sal ,&nbsp;Omar Nouhou Koutcha ,&nbsp;Antoine Martin ,&nbsp;Dana Radu ,&nbsp;Emmanuel Martinod ,&nbsp;Hugues Cordel ,&nbsp;Nicolas Vignier ,&nbsp;Sopio Tatulashvili ,&nbsp;Narimane Berkane ,&nbsp;Etienne Carbonnelle ,&nbsp;Olivier Bouchaud ,&nbsp;Emmanuel Cosson","doi":"10.1016/j.diabet.2024.101525","DOIUrl":"10.1016/j.diabet.2024.101525","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery.</p></div><div><h3>Research Design and Methods</h3><p>In this retrospective monocentric study, we compared the performance of ultrasound-guided (<em>n</em> = 29 consecutive patients, Dec.2020-Oct.2022) versus surgical (<em>n</em> = 24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome).</p></div><div><h3>Results</h3><p>Patient characteristics were similar in the two intervention groups, including arteritis prevalence (62.3 %), SINBAD score, and wound location (phalanges 36 %, metatarsus 43 %, and calcaneus 21 %). However, the ultrasound-guided group was older (67 ± 11 versus 60 ± 13 years respectively, <em>P</em> = 0.047) and had more type 2 diabetes (97 % versus 75 %, <em>P</em> = 0.038). Diagnostic performance (i.e., capacity to confirm or rule out suspected osteitis) was similar for ultrasound-guided (28/29 cases: 25 confirmations, 3 invalidations) and surgical (24 confirmations/24) biopsies, <em>P</em> = 0.358. No biopsy-related side effect or complication was observed for either intervention, even for patients on antiaggregation and/or anticoagulation therapy. The mean (± standard deviation) time necessary to perform the biopsy was shorter in the ultrasound-guided group (2.6 ± 3.0 versus 7.2 ± 5.8 days, respectively, <em>P</em> &lt; 0.001) and wound evolution at three months was more favorable (83.3 versus 41.2 %, <em>P</em> = 0.005) (94.4 % versus 66.7 %, respectively, patients with new surgical procedure within six months excluded; <em>P</em> = 0.055). Even though not statistically significant, healing rates in terms of wound and osteitis at six months were also better in the ultrasound-guided group (wound: 40.9 % versus 36.8 %; <em>P</em> = 0.790, and osteitis: 81.8 vs 55.6 % <em>P</em> = 0.071).</p></div><div><h3>Conclusion</h3><p>In diabetic patients with suspected foot osteitis not requiring surgery, bedside ultrasound-guided bone biopsies may constitute a promising alternative to surgical biopsies. This intervention provided excellent tolerance and microbiological documentation, short lead-times, and more favorable wound prognosis.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 3","pages":"Article 101525"},"PeriodicalIF":7.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S126236362400017X/pdfft?md5=9cd9269cb51ef1e69ce6f23096a21c4b&pid=1-s2.0-S126236362400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study","authors":"Fadi Alkhami,&nbsp;Gauthier Borderie,&nbsp;Ninon Foussard,&nbsp;Alice Larroumet,&nbsp;Laurence Blanco,&nbsp;Marie-Amélie Barbet-Massin,&nbsp;Amandine Ferriere,&nbsp;Claire Ducos,&nbsp;Kamel Mohammedi,&nbsp;Sami Fawaz,&nbsp;Thierry Couffinhal,&nbsp;Vincent Rigalleau","doi":"10.1016/j.diabet.2024.101524","DOIUrl":"10.1016/j.diabet.2024.101524","url":null,"abstract":"<div><h3>Background</h3><p>Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM.</p></div><div><h3>Research design and methods</h3><p>We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline.</p></div><div><h3>Findings</h3><p>During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, <em>P</em> = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: <em>P</em> = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: <em>P</em> = 0.016).</p></div><div><h3>Conclusion</h3><p>SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 2","pages":"Article 101524"},"PeriodicalIF":7.2,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}