Drug metabolism and personalized therapy最新文献

{"title":"Phytochemical profiling and biological activities of <i>Diplazium esculentum</i> (Retz.) Sw.: an edible vegetable fern.","authors":"Kirti Raina, Alisha Chaudhary, Purnima Sharma, Rohit Sharma, Kanchan Bhardwaj, Pardeep Kumar, Atul Kabra, Sunil Thakur, Ashun Chaudhary, Mamta Prajapati, Pradeep Kumar Prajapati, Rajeev K Singla, Rohit Sharma","doi":"10.1515/dmpt-2023-0035","DOIUrl":"10.1515/dmpt-2023-0035","url":null,"abstract":"<p><strong>Objectives: </strong><i>Diplazium esculentum</i> (Retz.) Sw. is an edible vegetable fern of the Himalayan region with high nutritional and therapeutic value owing to its richness in various secondary metabolites and both macro and micronutrients.</p><p><strong>Content: </strong>This updated review discusses the general traditional use, ethnopharmacology, phytochemistry, nutritional value, pharmacology, and toxicity concerns of <i>D. esculentum.</i></p><p><strong>Summary: </strong>The plant parts, viz. rhizomes, shoots, fronds and leaves, have immense ethnomedicinal importance, being traditionally used to cure several health disorders. Among other pharmacological effects, this botanical reveals excellent anti-inflammatory, analgesic, antifungal, antibacterial, antioxidant, anti-leishmanial, antioxidant, anaphylactic, antipyretic, anthelmintic and hepatoprotective activities, directly attributed to the presence of many secondary metabolites. From a pharmacological point of view, the excellent antioxidant potential of <i>D. esculentum</i> suggests its promising use for nutraceutical or functional food formulation purposes.</p><p><strong>Outlook: </strong>Considering the evidences on popular ethnomedicinal uses of <i>D. esculentum</i> as an edible vegetable, its immense bio-potential, and multiple pharmacological roles, there is a huge need to evaluate its therapeutic applications in light of standard clinical trials.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":" ","pages":"309-322"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Kamini Vidrawan Ras</i> inducing opioid dependence? - understanding the facts.","authors":"Rohit Sharma, Ruchi Sharma, Subhadip Banerjee, Pradeep Kumar Prajapati","doi":"10.1515/dmpt-2023-0044","DOIUrl":"10.1515/dmpt-2023-0044","url":null,"abstract":"","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":" ","pages":"367-368"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modeling of adverse drug reactions to tamoxifen therapy for breast cancer on base of pharmacogenomic testing.","authors":"Ekaterina Olegovna Golubenko, Marina Ivanovna Savelyeva, Zhannet Alimovna Sozaeva, Vera Vyacheslavovna Korennaya, Irina Vladimirovna Poddubnaya, Timur Tejmurazovich Valiev, Svetlana Nikolaevna Kondratenko, Mikhail Vitalyevich Ilyin","doi":"10.1515/dmpt-2023-0027","DOIUrl":"10.1515/dmpt-2023-0027","url":null,"abstract":"<p><strong>Objectives: </strong>The present study investigated the analysis of adverse drug reactions (ADRs) to tamoxifen (TAM) in breast cancer patients in relation to the carriage of genetic polymorphisms of genes encoding enzymes of CYP system and transporters of P-glycoprotein (Pg) and predictive models based on it.</p><p><strong>Methods: </strong>A total of 120 women with breast cancer taking adjuvant TAM were examined for the gene polymorphisms such as <i>CYP2D6*4</i>, <i>CYP3A5*3</i>, <i>CYP2C9*2</i>, <i>CYP2C9*3</i>, <i>CYP2C19*2</i>, <i>CYP2C19*3</i> and <i>ABCB1</i> (<i>C3435T</i>). Allelic variants were determined using the real-time polymerase chain reaction method. The research material was double sampling of buccal epithelium. Medical history data and extracts from case histories were used as sources of medical information, on the basis of which questionnaires specially created by us were filled out.</p><p><strong>Results: </strong>An associative analysis showed association with the development of ADRs to TAM indicating their clinical significance from different genetic polymorphisms of <i>CYP2D6</i>, <i>CYP3A5</i>, <i>CYP2C9</i> and <i>ABCB1</i>. The complex associative analysis performed using mathematical modeling made it possible to build predictive risk models for the development of ADRs such as hot flashes, dyspepsia, bone pain, and asthenia.</p><p><strong>Conclusions: </strong>Models that include both genetic and non-genetic determinants of ADRs of TAM may further improve the prediction of individual response to TAM.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":" ","pages":"339-347"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9829420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients.","authors":"Natalia P Denisenko,&nbsp;Anastasia A Kachanova,&nbsp;Ivan V Sychev,&nbsp;Gregory N Shuev,&nbsp;Oksana M Perfilieva,&nbsp;Reis H Mukhamadiev,&nbsp;Ruslan E Kazakov,&nbsp;Olga I Milyutina,&nbsp;Olga V Konenkova,&nbsp;Sergey A Ryzhkin,&nbsp;Elena M Zhmaeva,&nbsp;Sergey L Kirienko,&nbsp;Dmitriy V Ivashchenko,&nbsp;Irina V Bure,&nbsp;Alexander S Ametov,&nbsp;Irina V Poddubnaya,&nbsp;Karin B Mirzaev,&nbsp;Dmitry A Sychev","doi":"10.1515/dmdi-2023-0007","DOIUrl":"https://doi.org/10.1515/dmdi-2023-0007","url":null,"abstract":"<p><strong>Objectives: </strong>Radioactive iodine therapy is considered for patients with certain clinicopathological factors that predict a significant risk of recurrence, distant metastases of thyroid cancer or disease-specific mortality. The aim of the study was to investigate the association between polymorphisms of genes, products of which are involved in the processes of DNA damage response and autophagy, and the adverse reactions of radioiodine therapy in thyroid cancer patients.</p><p><strong>Methods: </strong>The study included 181 patients (37 men, 144 women; median age 56 [41; 66.3] years) with histologically confirmed thyroid cancer and a history of thyroidectomy who received radioiodine therapy. <i>NFKB1</i>, <i>ATM</i>, <i>ATG16L2</i>, <i>ATG10</i>, <i>TGFB1</i>, and <i>TNF</i> polymorphisms were determined by allele-specific realtime-PCR.</p><p><strong>Results: </strong>The frequency of adverse reactions was the following: gastrointestinal symptoms - 57.9 %, local symptoms - 65.8 %, cerebral symptoms - 46.8 %, fatigue - 54.4 %; signs of sialoadenitis six months after radioiodine therapy - 25.2 %. TT genotype carriers of <i>ATG10</i> rs1864183 had higher frequency of gastrointestinal symptoms (vs. CC+CT), the CC genotype carriers of <i>ATG10</i> rs10514231 had significantly more frequent cerebral symptoms (vs. CT+TT), as well as AA genotype carriers of <i>TGFB1</i> rs1800469 (vs. AG+GG). CC genotype of <i>ATG10</i> rs10514231 increased the incidence of radioiodine-induced fatigue, whereas GA genotype of the <i>ATM</i> rs11212570 had a protective role against fatigue. <i>TGFB1</i> rs1800469 was associated with signs of sialoadenitis six months after radioiodine therapy.</p><p><strong>Conclusions: </strong>Genetic factors may contribute to the occurrence of adverse reactions of radioiodine therapy in thyroid cancer patients.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional analysis and antimicrobial activity of <i>Adhatoda vasica</i>: a traditional medicinal plant.","authors":"Maryam Fatima, Imran Zafar, Qurat Ul Ain, Muhammad Masood Anwar, Waqas Yousaf, Mohd Ashraf Rather, Firzan Nainu, Rohit Sharma","doi":"10.1515/dmpt-2023-0012","DOIUrl":"10.1515/dmpt-2023-0012","url":null,"abstract":"<p><strong>Objectives: </strong>Antibiotic resistance is rising, prompting innovative strategies for eradicating the epidemic. This study investigated the antibacterial properties of the leaves of a widely used medicinal plant, <i>Adhatoda vasica</i>.</p><p><strong>Methods: </strong>The plant's polar (water, methanol) and non-polar (hexane) extracts were tested against several different bacterial strains using the disc diffusion technique.</p><p><strong>Results: </strong>In a study, it was found that the water extract had the greatest inhibitory effect on <i>Staphylococcus simulans</i> and <i>Staphylococcus aureus</i>, with minimum inhibitory concentrations of 16.444 and 19.315 g/mL, respectively. Gram-negative strains were more susceptible to plant extracts than Gram-positive strains. The phytochemical analysis indicated the presence of secondary metabolites such as alkaloids, saponins, flavonoids, tannins, and steroids, where absorbance was recorded at 415 nm. The water extract had the highest amount of phenolics, with a total phenolic content of 53.92 0.47 mg and a total flavonoid content of 7.25 0.08 mg. Results suggest that the extract may have potential therapeutic applications for antimicrobial properties.</p><p><strong>Conclusions: </strong>The study concluded that the extract's phenolic group of secondary metabolites were responsible for its antibacterial activity. The study highlights <i>A. vasica</i> as a promising source for discovering new and effective antibacterial compounds.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":" ","pages":"359-366"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients.","authors":"Natalia P Denisenko,&nbsp;Anastasia A Kachanova,&nbsp;Ivan V Sychev,&nbsp;Gregory N Shuev,&nbsp;Oksana M Perfilieva,&nbsp;Reis H Mukhamadiev,&nbsp;Ruslan E Kazakov,&nbsp;Olga I Milyutina,&nbsp;Olga V Konenkova,&nbsp;Sergey A Ryzhkin,&nbsp;Elena M Zhmaeva,&nbsp;Sergey L Kirienko,&nbsp;Dmitriy V Ivashchenko,&nbsp;Irina V Bure,&nbsp;Alexander S Ametov,&nbsp;Irina V Poddubnaya,&nbsp;Karin B Mirzaev,&nbsp;Dmitry A Sychev","doi":"10.1515/dmpt-2023-0007","DOIUrl":"10.1515/dmpt-2023-0007","url":null,"abstract":"<p><strong>Objectives: </strong>Radioactive iodine therapy is considered for patients with certain clinicopathological factors that predict a significant risk of recurrence, distant metastases of thyroid cancer or disease-specific mortality. The aim of the study was to investigate the association between polymorphisms of genes, products of which are involved in the processes of DNA damage response and autophagy, and the adverse reactions of radioiodine therapy in thyroid cancer patients.</p><p><strong>Methods: </strong>The study included 181 patients (37 men, 144 women; median age 56 [41; 66.3] years) with histologically confirmed thyroid cancer and a history of thyroidectomy who received radioiodine therapy. <i>NFKB1</i>, <i>ATM</i>, <i>ATG16L2</i>, <i>ATG10</i>, <i>TGFB1</i>, and <i>TNF</i> polymorphisms were determined by allele-specific realtime-PCR.</p><p><strong>Results: </strong>The frequency of adverse reactions was the following: gastrointestinal symptoms - 57.9 %, local symptoms - 65.8 %, cerebral symptoms - 46.8 %, fatigue - 54.4 %; signs of sialoadenitis six months after radioiodine therapy - 25.2 %. TT genotype carriers of <i>ATG10</i> rs1864183 had higher frequency of gastrointestinal symptoms (vs. CC+CT), the CC genotype carriers of <i>ATG10</i> rs10514231 had significantly more frequent cerebral symptoms (vs. CT+TT), as well as AA genotype carriers of <i>TGFB1</i> rs1800469 (vs. AG+GG). CC genotype of <i>ATG10</i> rs10514231 increased the incidence of radioiodine-induced fatigue, whereas GA genotype of the <i>ATM</i> rs11212570 had a protective role against fatigue. <i>TGFB1</i> rs1800469 was associated with signs of sialoadenitis six months after radioiodine therapy.</p><p><strong>Conclusions: </strong>Genetic factors may contribute to the occurrence of adverse reactions of radioiodine therapy in thyroid cancer patients.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":"38 3","pages":"255-265"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FCGR2A R131H, FCGR3A F158V and FCGR3B NA1/NA2 polymorphisms on response to Fc-containing TNF inhibitors in Tunisian rheumatoid arthritis patients.","authors":"Mahmoud Ines,&nbsp;Moalla Myriam,&nbsp;Ben Tekaya Aicha,&nbsp;Bouden Selma,&nbsp;Rouached Leila,&nbsp;Tekaya Rawdha,&nbsp;Saidane Olfa,&nbsp;Gorji Yousr,&nbsp;Elleuch Mohamed,&nbsp;Laatar Ahmed,&nbsp;Hamdi Wafa,&nbsp;Abdelmoula Leila,&nbsp;Sfar Imen","doi":"10.1515/dmpt-2022-0176","DOIUrl":"https://doi.org/10.1515/dmpt-2022-0176","url":null,"abstract":"<p><strong>Objectives: </strong>Single nucleotid polymorphisms (SNPs) of Fc-gamma receptors (FcgRs), by inducing a variation of their affinity to the Fc-region of immunoglobulins, might influence the efficacy of Fc-containing biologics prescribed in rheumatoid arthritis (RA). Our aim was to investigate associations of <i>FCGR2A</i>, <i>FCGR3A</i> and <i>FCGR3B</i> SNPs with TNF-inhibitors (TNFi)' response in Tunisian RA patients.</p><p><strong>Methods: </strong>A cross-sectional, observational and analytic multicentric cohort study was conducted in a group of 47 Tunisian RA patients treated with (etanercept [ETA], adalimumab [ADL] and infliximab [IFX]). Treatment outcome was evaluated after 6 months. <i>R131H-FCGR2A</i>, <i>F158V-FCGR3A</i> and <i>NA1/NA2-FCGR3B</i> SNPs were genotyped.</p><p><strong>Results: </strong>The analytic study including all types of TNFi showed that <i>FCGR3A-F/F</i> low-affinity receptor was associated with a greater decrease of DAS28, while <i>FCGR3B-NA1/NA1</i> high-affinity receptor was associated with a lower decrease of DAS28 in ADL group. Furthermore, both of high affinity receptors <i>FCGR3B-NA1/NA1</i> and <i>FCGR3A-V/V</i> were more prevalent in non-responders to ADL, according to EULAR criteria.</p><p><strong>Conclusions: </strong>Identifying reliable biomarkers of response to biologics in RA is necessary to improve responsiveness, preserve joints' functions and structure, and reduce treatment's cost. Our study showed that FCGR3A and FCGR3B polymorphisms might have an impact on TNFis' response in RA Tunisian patients since bad response was more frequent in homozygous carriers of high affinity alleles FCGR3A-V and FCGR3B-NA1.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":"38 2","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9629860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>CYP2C9</i> gene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study.","authors":"Irina I Sinitsina,&nbsp;Alexey V Boyarko,&nbsp;Ilyas I Temirbulatov,&nbsp;Dmitry A Sychev,&nbsp;Kristina A Akmalova,&nbsp;Zhannet A Sozaeva,&nbsp;Elena A Grishina,&nbsp;Karin B Mirzaev,&nbsp;Anastasiia V Asoskova,&nbsp;Vladimir P Fisenko","doi":"10.1515/dmpt-2022-0115","DOIUrl":"https://doi.org/10.1515/dmpt-2022-0115","url":null,"abstract":"<p><strong>Objectives: </strong><i>CYP2C9</i> gene polymorphic variants can decrease the effects of losartan, reducing active metabolite (E-3174) formation. Study aims to determine the influence of <i>*2</i> (+430C>T; rs799853) and *3 (+1075A>C; rs1057910) <i>CYP2C9</i> gene polymorphic variants on the hypotensive and uricosuric effect of losartan on patients with arterial hypertension.</p><p><strong>Methods: </strong>Eighty one patients with stage 1-2 arterial hypertension newly diagnosed with ABMP were enrolled in the study. Physicians started losartan treatment and then we measured urine concentration of E-3174/losartan to estimate CYP2C9 activity. After 3-month losartan treatment we compared effectiveness of the therapy with ABPM and plasma uric acid level between carriers of <i>CYP2C9 *1/*1</i> and <i>CYP2C9</i> gene polymorphic variants (<i>*2</i> and <i>*3</i>).</p><p><strong>Results: </strong>Carriage of <i>CYP2C9*2</i> and <i>CYP2C9*3</i> alleles reduced the hypotensive effect of losartan (p<0.001, OR=8.13 (95% CI, 2.75-23.97)). Analysis of the ABPM data revealed that blood pressure was significantly higher in patients with polymorphic genotypes. There was no significant difference in uric acid level in plasma and losartan and its metabolite concentration in urine between genotypes.</p><p><strong>Conclusions: </strong>Carriage of low function polymorphic variants of the <i>CYP2C9</i> gene (<i>*2</i> and <i>*3</i>) reduced the hypotensive effect of losartan according to ABPM and don't affect uric acid level in plasma and E-3174/losartan in urine.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":"38 2","pages":"163-168"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenetics and ethnicity: \"Dr. José María Cantú\" award announcement.","authors":"Ingrid Fricke-Galindo,&nbsp;Adrián LLerena","doi":"10.1515/dmpt-2023-0037","DOIUrl":"https://doi.org/10.1515/dmpt-2023-0037","url":null,"abstract":"","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":"38 2","pages":"121-122"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9683585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of antioxidant potential of selected homeopathic preparations in clinical practice.","authors":"Arun Kumar,&nbsp;Suneel Prajapati,&nbsp;Mahima Sharma,&nbsp;Tejveer Singh,&nbsp;Neha Choudhary,&nbsp;Alok C Bharti,&nbsp;Rohit Sharma,&nbsp;Pankaj Gupta","doi":"10.1515/dmpt-2022-0169","DOIUrl":"https://doi.org/10.1515/dmpt-2022-0169","url":null,"abstract":"<p><strong>Objectives: </strong>Antioxidant property like radical scavenging is a primary target to elucidate the efficacy mechanism of a drug against diseases linked to oxidative stress such as cancer, metabolic disorders, rheumatoid arthritis, etc. In alternative therapies, homeopathy is one of the preferred choices by patients and clinicians due to its potential to cure chronic and complex illnesses. However, the efficacy of homeopathic preparations at high diluted potencies attracts rational criticism due to insufficient scientific knowledge supporting the mechanism of action. Therefore, an attempt was made to estimate the total phenolic content (TPC) and radical scavenging activity of clinically prescribed homeopathic drugs.</p><p><strong>Methods: </strong>With gallic acid as a reference control, mother tinctures (MTs) and different potencies of <i>Eucalyptus globulus</i> (EG), <i>Syzygium jambolanum</i> (SJ), <i>Ruta graveolens</i> (RG), and <i>Thuja occidentalis</i> (TO) were used to perform Folin-Ciocalteu test, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays.</p><p><strong>Results: </strong>The results showed TPC of MTs equivalent to µg/mL of gallic acid viz; EG (4,872.5 ± 133.2), SJ (8,840.5 ± 14.8), RG (985.6 ± 39.1), and TO (341.5 ± 19.5) with significant ABTS and DPPH radical scavenging potential. Whereas 30C and 200C potencies of each homeopathic drug showed undetectable phenolic content and insignificant radical scavenging potential compared to vehicle control, i.e., alcohol 90% (2.0 ± 1.5).</p><p><strong>Conclusions: </strong>The reported efficacy of 30C and 200C potencies of homeopathic medicines against oxidative stress-related illnesses might be due to mechanisms other than radical scavenging. Furthermore, the assays studied can be helpful in drug standardization and quality control of MTs that are used as starting material in homeopathic preparations.</p>","PeriodicalId":11332,"journal":{"name":"Drug metabolism and personalized therapy","volume":"38 2","pages":"179-190"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}