Drug Target Insights最新文献_第7页

Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery. 庆大霉素浸渍胶原蛋白海绵预防高危心脏手术胸骨伤口感染的效果。

IF 2.7

Drug Target Insights Pub Date : 2016-05-29 eCollection Date: 2016-01-01 DOI: 10.4137/DTI.S39077

Filippo Rapetto, Vito D Bruno, Gustavo Guida, Roberto Marsico, Pierpaolo Chivasso, Carlo Zebele

引用次数: 15

A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab. 1例组织性肺炎(OP)与派姆单抗相关

IF 2.7

Drug Target Insights Pub Date : 2016-05-22 eCollection Date: 2016-01-01 DOI: 10.4137/DTI.S31565

Paraskevi Fragkou, Maria Souli, Maria Theochari, Christina Kontopoulou, Stelios Loukides, Anna Koumarianou

引用次数: 31

Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis 导论:药物洗脱支架还是药物洗脱移植物?来自蛋白质组学分析的见解

IF 2.7

Drug Target Insights Pub Date : 2016-01-03 DOI: 10.33393/dti.2016.1424

引用次数: 0

Effects and Safety of Linagliptin as an Add-on Therapy in Advanced-Stage Diabetic Nephropathy Patients Taking Renin–Angiotensin–Aldosterone System Blockers 利格列汀在使用肾素-血管紧张素-醛固酮系统阻滞剂的晚期糖尿病肾病患者中的疗效和安全性

IF 2.7

Drug Target Insights Pub Date : 2016-01-01 DOI: 10.4137/DTI.S38339

Yuichiro Ueda, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, K. Ito, Keiji Hirai, Y. Kaku, H. Mori, T. Hoshino, S. Ookawara, M. Kakei, K. Tabei, Yoshiyuki Morishita

{"title":"Effects and Safety of Linagliptin as an Add-on Therapy in Advanced-Stage Diabetic Nephropathy Patients Taking Renin–Angiotensin–Aldosterone System Blockers","authors":"Yuichiro Ueda, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, K. Ito, Keiji Hirai, Y. Kaku, H. Mori, T. Hoshino, S. Ookawara, M. Kakei, K. Tabei, Yoshiyuki Morishita","doi":"10.4137/DTI.S38339","DOIUrl":"https://doi.org/10.4137/DTI.S38339","url":null,"abstract":"Background We investigated the effects and safety of linagliptin as an add-on therapy in patients with advanced-stage diabetic nephropathy (DMN) taking renin–angiotensin–aldosterone system (RAAS) blockers. Method Twenty advanced-stage DMN patients (estimated glomerular filtration rate (eGFR): 24.5 ± 13.4 mL/min/1.73 m2) taking RAAS blockers were administered 5 mg/day linagliptin for 52 weeks. Changes in glucose and lipid metabolism and renal function were evaluated. Results Linagliptin decreased glycosylated hemoglobin levels (from 7.32 ± 0.77% to 6.85 ± 0.87%, P < 0.05) without changing fasting blood glucose levels, and significantly decreased total cholesterol levels (from 189.6 ± 49.0 to 170.2 ± 39.2 mg/dL, P < 0.05) and low-density lipoprotein cholesterol levels (from 107.1 ± 32.4 to 90.2 ± 31.0 mg/dL, P < 0.05) without changing high-density lipoprotein cholesterol and triglyceride levels. Urine protein/creatinine ratio and annual change in eGFR remained unchanged. No adverse effects were observed. Conclusion Linagliptin as an add-on therapy had beneficial effects on glucose and lipid metabolism without impairment of renal function, and did not have any adverse effects in this population of patients with advanced-stage DMN taking RAAS blockers.","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"10 1","pages":"13 - 18"},"PeriodicalIF":2.7,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/DTI.S38339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70698731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CURRENT DEVELOPMENTS IN DRUG ELUTING DEVICES: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis 药物洗脱装置的最新进展:导论:药物洗脱支架还是药物洗脱移植物?来自蛋白质组学分析的见解

IF 2.7

Drug Target Insights Pub Date : 2016-01-01 DOI: 10.4137/DTI.S41240

C. Spadaccio, F. Nappi, N. Al-Attar, R. Coccia, M. Perluigi, F. Di Domenico

引用次数: 7

Immunoinformatics Approach in Designing Epitope-based Vaccine Against Meningitis-inducing Bacteria (Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae Type b) 设计基于表位的抗脑膜炎诱导细菌(肺炎链球菌、脑膜炎奈瑟菌和b型流感嗜血杆菌)疫苗的免疫信息学方法

IF 2.7

Drug Target Insights Pub Date : 2016-01-01 DOI: 10.4137/DTI.S38458

H. Zahroh, Ahmad Ma’rup, U. S. Tambunan, A. A. Parikesit

{"title":"Immunoinformatics Approach in Designing Epitope-based Vaccine Against Meningitis-inducing Bacteria (Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae Type b)","authors":"H. Zahroh, Ahmad Ma’rup, U. S. Tambunan, A. A. Parikesit","doi":"10.4137/DTI.S38458","DOIUrl":"https://doi.org/10.4137/DTI.S38458","url":null,"abstract":"Meningitis infection is one of the major threats during Hajj season in Mecca. Meningitis vaccines are available, but their uses are limited in some countries due to religious reasons. Furthermore, they only give protection to certain serogroups, not to all types of meningitis-inducing bacteria. Recently, research on epitope-based vaccines has been developed intensively. Such vaccines have potential advantages over conventional vaccines in that they are safer to use and well responded to the antibody. In this study, we developed epitope-based vaccine candidates against various meningitis-inducing bacteria, including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b. The epitopes were selected from their protein of polysaccharide capsule. B-cell epitopes were predicted by using BCPred, while T-cell epitope for major histocompatibility complex (MHC) class I was predicted using PAProC, TAPPred, and Immune Epitope Database. Immune Epitope Database was also used to predict T-cell epitope for MHC class II. Population coverage and molecular docking simulation were predicted against previously generated epitope vaccine candidates. The best candidates for MHC class I- and class II-restricted T-cell epitopes were MQYGDKTTF, MKEQNTLEI, ECTEGEPDY, DLSIVVPIY, YPMAMMWRNASNRAI, TLQMTLLGIVPNLNK, ETSLHHIPGISNYFI, and SLLYILEKNAEMEFD, which showed 80% population coverage. The complexes of class I T-cell epitopes-HLA-C*03:03 and class II T-cell epitopes-HLA-DRB1*11:01 showed better affinity than standards as evaluated from their δGbinding value and the binding interaction between epitopes and HLA molecules. These peptide constructs may further be undergone in vitro and in vivo testings for the development of targeted vaccine against meningitis infection.","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"10 1","pages":"19 - 29"},"PeriodicalIF":2.7,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/DTI.S38458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70698864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose 脑组胺n -甲基转移酶作为甲基苯丙胺过量治疗的可能靶点

IF 2.7

Drug Target Insights Pub Date : 2016-01-01 DOI: 10.4137/DTI.S38342

J. Kitanaka, N. Kitanaka, F. Hall, G. Uhl, M. Takemura

引用次数: 9

Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques 结合静电纺丝和增材制造技术的混合装甲血管移植物的初步体内评价

IF 2.7

Drug Target Insights Pub Date : 2016-01-01 DOI: 10.4137/DTI.S35202

C. Spadaccio, F. Nappi, F. De Marco, P. Sedati, Fraser W. H. Sutherland, M. Chello, M. Trombetta, A. Rainer

引用次数: 32

Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection. 非活动性炎性肠病患者肠切除术后基础血浆Copeptin水平升高

IF 2.7

Drug Target Insights Pub Date : 2015-07-13 eCollection Date: 2015-01-01 DOI: 10.4137/DTI.S26589

Bodil Ohlsson, Olle Melander

{"title":"Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.","authors":"Bodil Ohlsson, Olle Melander","doi":"10.4137/DTI.S26589","DOIUrl":"https://doi.org/10.4137/DTI.S26589","url":null,"abstract":"<p><p>Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference between patients and controls was higher copeptin levels in the patients compared with controls (P = 0.006), with higher copeptin levels in resected than unresected patients (P = 0.020). There was no difference in any precursor levels between Crohn's disease and ulcerative colitis, between different distributions of disease lesions, or between different treatments. </p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":"9 ","pages":"21-7"},"PeriodicalIF":2.7,"publicationDate":"2015-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/DTI.S26589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33897047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division. 药用植物:靶向细胞分裂化合物的潜在来源。

IF 2.7

Drug Target Insights Pub Date : 2015-06-15 eCollection Date: 2015-01-01 DOI: 10.4137/DTI.S24946

Ihsan N Zulkipli, Sheba R David, Rajan Rajabalaya, Adi Idris

引用次数: 32