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Drug and Therapeutics Bulletin最新文献

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Statistical versus clinical significance: what is the (clinically important) difference? 统计学意义与临床意义：（临床重要）差异是什么？
Drug and Therapeutics Bulletin Pub Date : 2026-02-24 DOI: 10.1136/dtb.2025.000055
Jacoby Patterson
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引用次数: 0
VTE risk of newer contraceptives. 新避孕药具的静脉血栓栓塞风险。
Drug and Therapeutics Bulletin Pub Date : 2026-01-28 DOI: 10.1136/dtb.2025.000058
{"title":"VTE risk of newer contraceptives.","authors":"","doi":"10.1136/dtb.2025.000058","DOIUrl":"10.1136/dtb.2025.000058","url":null,"abstract":"<p><p><b>Overview of:</b> Yonis HGH, Mørch LS, Løkkegaard E, <i>et al</i> Contemporary Hormonal Contraception and Risk of Venous Thromboembolism. <i>JAMA</i> 2025;333:1358-61.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted studies in systematic reviews and meta-analyses. 在系统综述和荟萃分析中撤回的研究。
Drug and Therapeutics Bulletin Pub Date : 2026-01-28 DOI: 10.1136/dtb.2025.000054
{"title":"Retracted studies in systematic reviews and meta-analyses.","authors":"","doi":"10.1136/dtb.2025.000054","DOIUrl":"10.1136/dtb.2025.000054","url":null,"abstract":"<p><p><b>Overview of:</b> Possamai CG, Cabanac G, Perrodeau E, <i>et al</i> Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions: A Systematic Review and Meta-Analysis. <i>JAMA Intern Med</i> 2025;185:702-9.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the benefits and harms of GLP-1 and GLP-1/GIP agonists in obesity. GLP-1和GLP-1/GIP激动剂治疗肥胖症的利弊
Drug and Therapeutics Bulletin Pub Date : 2026-01-28 DOI: 10.1136/dtb.2025.000039
Raymond O'Connor
{"title":"Navigating the benefits and harms of GLP-1 and GLP-1/GIP agonists in obesity.","authors":"Raymond O'Connor","doi":"10.1136/dtb.2025.000039","DOIUrl":"10.1136/dtb.2025.000039","url":null,"abstract":"<p><p>Obesity is becoming increasingly common worldwide. Glucagon-like peptide-1 receptor agonist (GLP-1 RA) type drugs have the potential to help patients achieve considerable weight loss. Several benefits have been described in the short term, especially relating to diseases associated with obesity, where rapid weight loss results in undoubted improvements. These conditions include type 2 diabetes mellitus, cardiovascular disease and metabolic dysfunction-associated steatotic liver disease. Known adverse effects include gastrointestinal (nausea, vomiting, acute pancreatitis, dehydration and malnutrition), reduced efficacy of oral contraceptives and allergic reactions. Rarer adverse effects include thyroid cell tumours and non-arteritic anterior ischaemic optic neuropathy. Up to 33% of the weight lost is lean tissue mass (muscle and bone). Discontinuation rates can be up to 80% after 2 years. Subsequent weight regain can be up to two-thirds of prior weight loss. There is a risk of much of this regain being fatty tissue. To avoid this and associated malnutrition, GLP-1 RAs should only be initiated along with a supervised exercise programme and individualised dietetic advice. Subsequent patient monitoring to detect cessation, malnutrition and inappropriate fatty tissue weight gain is recommended.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperbolic tapering of antidepressants: where are we now? 抗抑郁药的双曲递减：我们现在在哪里？
Drug and Therapeutics Bulletin Pub Date : 2025-12-22 DOI: 10.1136/dtb.2024.000065
Mark Horowitz, Michael Wilcock
{"title":"Hyperbolic tapering of antidepressants: where are we now?","authors":"Mark Horowitz, Michael Wilcock","doi":"10.1136/dtb.2024.000065","DOIUrl":"10.1136/dtb.2024.000065","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroidal effusion after initiation of topical dorzolamide treatment. 局部多唑胺治疗开始后脉络膜积液。
Drug and Therapeutics Bulletin Pub Date : 2025-12-22 DOI: 10.1136/dtb.2025.262168rep
Derrick James Wang, Peter Feng Chen, Weilin Chan, Gloria P Fleming
{"title":"Choroidal effusion after initiation of topical dorzolamide treatment.","authors":"Derrick James Wang, Peter Feng Chen, Weilin Chan, Gloria P Fleming","doi":"10.1136/dtb.2025.262168rep","DOIUrl":"10.1136/dtb.2025.262168rep","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"13-15"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disinformation and misinformation: what can we do? 虚假信息和错误信息：我们能做些什么？
Drug and Therapeutics Bulletin Pub Date : 2025-12-22 DOI: 10.1136/dtb.2025.000047
Syba Sunny
{"title":"Disinformation and misinformation: what can we do?","authors":"Syba Sunny","doi":"10.1136/dtb.2025.000047","DOIUrl":"https://doi.org/10.1136/dtb.2025.000047","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"64 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral contraception and GLP-1 agonists. 口服避孕药和GLP-1激动剂。
Drug and Therapeutics Bulletin Pub Date : 2025-12-22 DOI: 10.1136/dtb.2025.000049
{"title":"Oral contraception and GLP-1 agonists.","authors":"","doi":"10.1136/dtb.2025.000049","DOIUrl":"10.1136/dtb.2025.000049","url":null,"abstract":"<p><p><b>Overview of:</b> Faculty of Sexual and Reproductive Healthcare. FSRH statement: Glucagon-like peptide-1 (GLP-1) agonists and oral contraception [online], 2025. Available: https://www.cosrh.org/Public/Documents/FSRH-statement-Glucagon-like-peptide-1-agonists-and-oral-contraception-Feb-2025.aspx [Accessed 26 September 2025].</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topiramate-induced acute eosinophilic pneumonia. 托吡酯诱导的急性嗜酸性肺炎。
Drug and Therapeutics Bulletin Pub Date : 2025-12-22 DOI: 10.1136/dtb.2025.261220rep
Rahul Tyagi, Monika Aggarwal, Utkarsh Suyal, Indramani Pandey
{"title":"Topiramate-induced acute eosinophilic pneumonia.","authors":"Rahul Tyagi, Monika Aggarwal, Utkarsh Suyal, Indramani Pandey","doi":"10.1136/dtb.2025.261220rep","DOIUrl":"10.1136/dtb.2025.261220rep","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prioritising prevention: can primary care systems cope? 优先预防：初级保健系统能否应对？
Drug and Therapeutics Bulletin Pub Date : 2025-12-03 DOI: 10.1136/dtb.2025.000026
Julian Treadwell
{"title":"Prioritising prevention: can primary care systems cope?","authors":"Julian Treadwell","doi":"10.1136/dtb.2025.000026","DOIUrl":"https://doi.org/10.1136/dtb.2025.000026","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"63 12","pages":"178"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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