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Recent updates from the BNF (BNF 86). BNF的最新更新（BNF 86）。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.1136/dtb.2023.000050
{"title":"Recent updates from the <i>BNF</i> (<i>BNF 86</i>).","authors":"","doi":"10.1136/dtb.2023.000050","DOIUrl":"10.1136/dtb.2023.000050","url":null,"abstract":"<p><p>The <i>BNF</i> is jointly published by the Royal Pharmaceutical Society and BMJ. <i>BNF</i> is published in print twice a year and interim updates are issued and published monthly in the digital versions. The following summary provides a brief description of some of the key changes that have been made to <i>BNF</i> content.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"166-167"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41114524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Missing information in US accelerated approval drug labels. 美国加速审批药品标签中缺少信息。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-09-21 DOI: 10.1136/dtb.2023.000047
{"title":"Missing information in US accelerated approval drug labels.","authors":"","doi":"10.1136/dtb.2023.000047","DOIUrl":"10.1136/dtb.2023.000047","url":null,"abstract":"<p><p><b>Overview of:</b> Ballreich J, Socal M, Bennett CL, et al. Accelerated approval drug labels often lack information for clinical decision-making. <i>Pharmacotherapy</i> 2023;43:300-4.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"164"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart failure associated with ustekinumab therapy for treatment of Crohn's Disease. 与ustekinumab治疗克罗恩病相关的心力衰竭。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-06-30 DOI: 10.1136/dtb.2023.250376rep
Erica Morgenweck, Brian Park, Richard Bower
{"title":"Heart failure associated with ustekinumab therapy for treatment of Crohn's Disease.","authors":"Erica Morgenweck,&nbsp;Brian Park,&nbsp;Richard Bower","doi":"10.1136/dtb.2023.250376rep","DOIUrl":"10.1136/dtb.2023.250376rep","url":null,"abstract":"A man in his 60s with penetrating ileocolonic Crohn’s disease (CD), recently started on ustekinumab therapy, presented with new onset dyspnoea, paroxysmal nocturnal dyspnoea and dependent oedema. He was diagnosed with heart failure (HF) 10 months after starting ustekinumab therapy. His symptoms resolved with discontinuation of ustekinumab and he had recovery of his cardiac function. Though initial studies that led to the U.S Food and Drug Administration (FDA)approval for ustekinumab did not detect a signal for HF, postmarketing surveillance has detected rare cases of HF after initiation of the medication. This is one of the few reported cases of HF associated with ustekinumab therapy for CD.","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"173-175"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to pharmacogenetics. 药物遗传学导论。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-10-03 DOI: 10.1136/dtb.2023.000009
John Henry McDermott, William Newman
{"title":"Introduction to pharmacogenetics.","authors":"John Henry McDermott,&nbsp;William Newman","doi":"10.1136/dtb.2023.000009","DOIUrl":"10.1136/dtb.2023.000009","url":null,"abstract":"<p><p>There is considerable interindividual variability in the effectiveness and safety of medicines. Although the reasons for this are multifactorial, it is well recognised that genetic changes impacting the absorption or metabolism of these drugs play a significant contributory role. Understanding how these pharmacogenetic variants impact response to medicines, and leveraging this knowledge to guide prescribing, could have significant benefits for patients and health services. This article provides an introduction to the field of pharmacogenetics, including its nomenclature, the existing evidence base and the current state of implementation globally. We discuss the challenges in translating pharmacogenetic research into clinical practice and highlight the considerable benefits which can emerge in those health services where implementation is successful.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"168-172"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
No benefit of vitamin D on cognition in older adults. 维生素D对老年人的认知没有好处。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-08-24 DOI: 10.1136/dtb.2023.000043
{"title":"No benefit of vitamin D on cognition in older adults.","authors":"","doi":"10.1136/dtb.2023.000043","DOIUrl":"10.1136/dtb.2023.000043","url":null,"abstract":"<p><p><b>Overview of:</b> Pham H, Waterhouse M, Rahman S, et al. Vitamin D supplementation and cognition- results from analyses of the D-Health trial. <i>J Am Geriatr Soc</i> 2023;7:1773-84.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"163"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10057603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coroners' reports, medicines and preventable deaths. 验尸报告、药物和可预防的死亡。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.1136/dtb.2023.000048
{"title":"Coroners' reports, medicines and preventable deaths.","authors":"","doi":"10.1136/dtb.2023.000048","DOIUrl":"10.1136/dtb.2023.000048","url":null,"abstract":"<p><p><b>Overview of:</b> France hs, aronson JK, heneghan c, et al. preventable deaths involving medicines: a systematic case series of coroners' reports 2013- 22. <i>Drug Saf</i> 2023;46:335-42.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"165"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moving with the times. 与时俱进。
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 DOI: 10.1136/dtb.2023.000055
David Phizackerley
{"title":"Moving with the times.","authors":"David Phizackerley","doi":"10.1136/dtb.2023.000055","DOIUrl":"10.1136/dtb.2023.000055","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"61 11","pages":"162"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to treat the climate and nature crisis as one indivisible global health emergency. 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件了。
Drug and Therapeutics Bulletin Pub Date : 2023-10-25 DOI: 10.1136/dtb.2023.000060
{"title":"Time to treat the climate and nature crisis as one indivisible global health emergency.","authors":"","doi":"10.1136/dtb.2023.000060","DOIUrl":"https://doi.org/10.1136/dtb.2023.000060","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous vitamin injections: where is the evidence? 静脉注射维生素：证据在哪里？
Drug and Therapeutics Bulletin Pub Date : 2023-10-01 Epub Date: 2023-08-28 DOI: 10.1136/dtb.2023.000006
{"title":"Intravenous vitamin injections: where is the evidence?","authors":"","doi":"10.1136/dtb.2023.000006","DOIUrl":"10.1136/dtb.2023.000006","url":null,"abstract":"<p><p>The body needs small daily quantities of vitamins and minerals, which are usually obtained from the diet. Intravenous vitamins are used for a few serious medical conditions (eg, malabsorption syndromes with severe vitamin depletion, Wernicke's encephalopathy or critical illness). Intravenous drips containing high doses of various vitamins and minerals (eg, the so-called 'Myers' cocktail') have been promoted in popular culture to 'reduce stress', 'increase energy' or 'boost immunity', with claims that the intravenous route allows faster absorption of vitamins into the bloodstream than if they are taken orally. There is a lack of high-quality evidence to suggest that high-dose vitamin infusions are necessary or offer any health benefit in the absence of a specific vitamin deficiency or medical condition. There may be harms from taking high (non-physiological) quantities of some vitamins and minerals. Licensed forms of injectable vitamins that are prescription-only medicines should not be advertised to the public and should only be supplied and administered by appropriately qualified healthcare professionals.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"151-155"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valacyclovir-associated acute kidney injury. 伐昔洛韦相关急性肾损伤。
Drug and Therapeutics Bulletin Pub Date : 2023-10-01 Epub Date: 2023-06-30 DOI: 10.1136/dtb.2023.249552rep
James Kirkland, Pathmanathan Suganthan
{"title":"Valacyclovir-associated acute kidney injury.","authors":"James Kirkland,&nbsp;Pathmanathan Suganthan","doi":"10.1136/dtb.2023.249552rep","DOIUrl":"10.1136/dtb.2023.249552rep","url":null,"abstract":"Summary A man in his 70s presented to hospital with an acute kidney injury. He recently had started taking valacyclovir for treatment of shingles. The valacyclovir was stopped and his acute kidney injury improved. Work-up for other causes of acute kidney injury was negative and he was diagnosed with valacyclovir-associated acute kidney injury. He was discharged home after four days in the hospital with improving renal function.","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"156-159"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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