{"title":"Prenatal use of antiepileptic drugs and childhood psychiatric disorders","authors":"BMJ Publishing Group Ltd","doi":"10.1136/dtb.2024.000026","DOIUrl":"https://doi.org/10.1136/dtb.2024.000026","url":null,"abstract":"### Key learning points A registry-based study has reinforced the need for safety warnings against using valproate during pregnancy because of an increased risk of early-onset developmental disorders in exposed children.1 This prospective cohort study used data on live-born singleton children of mothers with epilepsy from five Nordic countries to examine the association between prenatal use of antiepileptic medication and psychiatric and developmental disorders in exposed offspring.1 Children were followed up from birth until the …","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cytisine for smoking cessation.","authors":"","doi":"10.1136/dtb.2024.000009","DOIUrl":"https://doi.org/10.1136/dtb.2024.000009","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"10 7","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent updates from the <i>BNF</i> (<i>BNF</i> 87).","authors":"","doi":"10.1136/dtb.2024.000018","DOIUrl":"10.1136/dtb.2024.000018","url":null,"abstract":"<p><p>The BNF is jointly published by the Royal Pharmaceutical Society and BMJ. BNF is published in print twice a year and interim updates are issued and published monthly in the digital versions. The following summary provides a brief description of some recent key changes that have been made to BNF content.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sasank Konda, Nayha Shetty, Ben Friedman, Jesse Veenstra
{"title":"Delayed drug hypersensitivity reaction to secukinumab in a patient with hidradenitis suppurativa.","authors":"Sasank Konda, Nayha Shetty, Ben Friedman, Jesse Veenstra","doi":"10.1136/dtb.2023.249684rep","DOIUrl":"10.1136/dtb.2023.249684rep","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"77-79"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicines and global warming: a complex problem","authors":"James A Cave","doi":"10.1136/dtb.2024.000003","DOIUrl":"https://doi.org/10.1136/dtb.2024.000003","url":null,"abstract":"The healthcare sector is responsible for 4.6% of global greenhouse gas emissions.1 Significant contributors to this carbon footprint are the biotech and pharmaceutical industries, directly from the running of these companies (sometimes called scope 1 emissions) and indirectly from purchased energy consumed (scope 2 emissions) and all other emissions indirectly associated with the companies—such as supply chains (scope 3 emissions).2 It is estimated that scope 1, 2 and 3 emissions of biotech and pharmaceutical companies accounted for 260 million tons of carbon dioxide equivalent emissions in 2021, higher than global emissions from the forestry and paper industry.2 There are particular …","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140593984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MHRA issues further update on fluoroquinolone safety","authors":"BMJ Publishing Group Ltd","doi":"10.1136/dtb.2024.000021","DOIUrl":"https://doi.org/10.1136/dtb.2024.000021","url":null,"abstract":"### Key learning points The licensed indications for all systemic fluoroquinolones have been updated to restrict their use to situations in which other commonly recommended antibiotics are inappropriate.1 In August and September 2023, the Medicines and Healthcare products Regulatory Agency (MHRA) issued two safety updates on the use of fluoroquinolone antibiotics.1–3 The first update reminded healthcare professionals that systemic fluoroquinolone antibiotics are associated with a risk of …","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140594014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Donanemab in early symptomatic Alzheimer’s disease","authors":"BMJ Publishing Group Ltd","doi":"10.1136/dtb.2024.000020","DOIUrl":"https://doi.org/10.1136/dtb.2024.000020","url":null,"abstract":"### Key learning points The authors of a phase 3 trial involving people with early Alzheimer’s disease (AD) reported that although donanemab produced a small reduction in clinical progression compared with placebo, it was associated with some serious adverse effects.1 The TRAILBLAZER-ALZ 2 trial was a 76-week, phase 3, randomised, double-blind, placebo-controlled study that recruited participants aged 60–85 years with early symptomatic AD, a Mini-Mental State Examination score of 20–28 and confirmed amyloid and tau pathology assessed by positron emission tomography (PET) scans.1 A total of 1736 …","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140593996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do regulatory safety warnings on medicines miss the mark?","authors":"Barbara Mintzes","doi":"10.1136/dtb.2023.000053","DOIUrl":"10.1136/dtb.2023.000053","url":null,"abstract":"","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety update: valproate safety and educational materials.","authors":"","doi":"10.1136/dtb.2024.000013","DOIUrl":"10.1136/dtb.2024.000013","url":null,"abstract":"<p><p><b>Overview of:</b> Medicines and Healthcare products Regulatory Agency. Valproate (Belvo, Convulex, Depakote, Dyzantil, Epilim, Epilim Chrono or Chronosphere, Episenta, Epival and Syonell▼): new safety and educational materials to support regulatory measures in men and women under 55 years of age. Drug Safety Update 2024;17:1.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":" ","pages":"53"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does oseltamivir prevent hospitalisation in people with influenza?","authors":"","doi":"10.1136/dtb.2024.000016","DOIUrl":"10.1136/dtb.2024.000016","url":null,"abstract":"<p><p><b>Overview of:</b> Hanula R, Bortolussi-Courval É, Mendel A, et al. Evaluation of oseltamivir used to prevent hospitalization in outpatients with influenza: a systematic review and meta-analysis. JAMA Internal Medicine 2024;184:18-27.</p>","PeriodicalId":11277,"journal":{"name":"Drug and Therapeutics Bulletin","volume":"62 4","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}