Diagnosis最新文献_第7页

Troponin testing in routine primary care: observations from a dynamic cohort study in the Amsterdam metropolitan area. 常规初级保健中的肌钙蛋白检测：阿姆斯特丹市区动态队列研究观察结果。

IF 3.5

Diagnosis Pub Date : 2024-01-29 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0183

Ralf E Harskamp, Indra M Melessen, Amy Manten, Lukas De Clercq, Wendy P J den Elzen, Jelle C L Himmelreich

{"title":"Troponin testing in routine primary care: observations from a dynamic cohort study in the Amsterdam metropolitan area.","authors":"Ralf E Harskamp, Indra M Melessen, Amy Manten, Lukas De Clercq, Wendy P J den Elzen, Jelle C L Himmelreich","doi":"10.1515/dx-2023-0183","DOIUrl":"10.1515/dx-2023-0183","url":null,"abstract":"Objectives: Troponin testing is indicated in the diagnostic work-up of acute coronary syndrome (ACS) and incorporated in risk stratification pathways. This study aims to gain insights on the use, outcomes, and diagnostic accuracy of troponin testing in routine primary care; a setting that is understudied.Methods: Routine data were used from the academic primary care network in the Amsterdam metropolitan area (968,433 patient records). The study population included adult patients who underwent high-sensitivity troponin I or T (hs-TnI/T) testing between 2011 and 2021. The primary outcome was the reported diagnosis and the secondary outcome was the diagnostic accuracy measured by death or ACS at 30 days.Results: 3,184 patients underwent hs-troponin testing, either with hsTNT (n=2,333) or hsTNI (n=851). Median patients' age was 55 (44-65) years, and 62.3 % were female. Predominant symptoms were chest pain and dyspnea (56.7 %). Additional diagnostic laboratory tests were commonly performed (CRP: 47.7 %, natriuretic peptides: 25.6 %, d-dimer: 21.5 %). Most common diagnoses were musculoskeletal symptoms (21.6 %) and coronary heart disease (7.1 %; 1.1 % ACS). Troponin testing showed sensitivity and specificity of 77.8 % (60.9-89.9) and 94.3 % (93.5-95.1), respectively. Negative and positive predictive values were 99.7 (99.5-99.9) and 13.5 (11.1-16.4), and positive and negative likelihood ratios were 13.7 (10.9-17.1) and 0.24 (0.13-0.43).Conclusions: GPs occasionally use troponin testing in very low-risk patients, often as part of a multi-marker rule-out strategy. The diagnostic characteristics of troponin tests, while promising, warrant prospective validation and implementation to facilitate appropriate use.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"171-177"},"PeriodicalIF":3.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How case reports can be used to improve diagnosis. 如何利用病例报告改进诊断。

IF 2.2

Diagnosis Pub Date : 2024-01-19 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0181

Kosuke Ishizuka, Shun Yamashita, Yuichiro Mine, Yukichika Yamamoto, Hiroki Kojima, Hidehiro Someko, Taiju Miyagami

引用次数: 0

The Future of Diagnosis: Navigating Uncertainty. 诊断的未来：驾驭不确定性。

IF 2.2

Diagnosis Pub Date : 2024-01-19 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0178

引用次数: 0

Clinical assessment of Ortho VITROS SARS-CoV-2 antigen chemiluminescence immunoassay. Ortho VITROS SARS-CoV-2 抗原化学发光免疫测定的临床评估。

IF 3.5

Diagnosis Pub Date : 2024-01-19 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0182

Laura Pighi, Gian Luca Salvagno, Nicole Bertoldi, Brandon M Henry, Giuseppe Lippi

引用次数: 0

The consequences of delayed diagnosis and treatment in persons with multiple sclerosis given autologous hematopoietic stem cell transplantation. 对接受自体造血干细胞移植的多发性硬化症患者进行延迟诊断和治疗的后果。

IF 3.5

Diagnosis Pub Date : 2024-01-18 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0157

María de Lourdes Pastelín-Martínez, Moisés Manuel Gallardo-Pérez, Andrés Gómez-de-León, Juan Carlos Olivares-Gazca, Edgar Jared Hernández-Flores, Daniela Sánchez-Bonilla, Merittzel Montes-Robles, Max Robles-Nasta, Guillermo Ocaña-Ramm, Silvia Soto-Olvera, David Gómez-Almaguer, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles

{"title":"The consequences of delayed diagnosis and treatment in persons with multiple sclerosis given autologous hematopoietic stem cell transplantation.","authors":"María de Lourdes Pastelín-Martínez, Moisés Manuel Gallardo-Pérez, Andrés Gómez-de-León, Juan Carlos Olivares-Gazca, Edgar Jared Hernández-Flores, Daniela Sánchez-Bonilla, Merittzel Montes-Robles, Max Robles-Nasta, Guillermo Ocaña-Ramm, Silvia Soto-Olvera, David Gómez-Almaguer, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles","doi":"10.1515/dx-2023-0157","DOIUrl":"10.1515/dx-2023-0157","url":null,"abstract":"Objectives: We have analyzed the association of delayed both diagnosis and treatment of persons with MS with the long-term results of patients given autologous hematopoietic stem cell transplantation (aHSCT).Methods: Patients with MS referred to the HSCT-Mexico program were included in the study; in 103, detailed pre- and post-transplant evolution could be recorded. Two groups of patients were analyzed according to the time of evolution between the onset of symptoms and the definite diagnosis of MS: more than 8 months (delayed diagnosis, DD), or less than 8 months (non-delayed diagnosis, NDD). The progression of MS was assessed by changes in the expanded disability status scale (EDSS).Results: The time elapsed between the onset of symptoms and the correct diagnosis was lower for the NDD group (1.55 vs. 35.87 months, p<0.05). Both groups of patients showed a similar EDSS score at diagnosis (1.5 vs. 1.5); however, the EDSS at the time of the transplant was higher in the DD group (4.5 vs. 3.0, p=0.3) and the response of the EDSS score to the transplant was significantly better for the NDD group, the last EDSS scores being 2.5 vs. 4.25 (p=0.03). Both groups of patients responded to aHSCT by diminishing the EDSS, but the response was significantly better in the NDD group.Conclusions: These data indicate that both the pre-transplant progression of the disease and the response to aHSCT were significantly worse in the DD group. An early diagnosis and an early aHSCT intervention are critical for a good prognosis, in terms of lowering and stabilizing the motor disability in MS patients given autografts.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"164-170"},"PeriodicalIF":3.5,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of saliva-based qPCR diagnostics for the accurate, rapid, and inexpensive detection of strep throat. 利用基于唾液的 qPCR 诊断技术，准确、快速、低成本地检测链球菌咽喉炎。

IF 3.5

Diagnosis Pub Date : 2024-01-05 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0134

Madeline H Peachey, Kristopher E Kubow, Kristina B Blyer, Julia A Halterman

{"title":"Use of saliva-based qPCR diagnostics for the accurate, rapid, and inexpensive detection of strep throat.","authors":"Madeline H Peachey, Kristopher E Kubow, Kristina B Blyer, Julia A Halterman","doi":"10.1515/dx-2023-0134","DOIUrl":"10.1515/dx-2023-0134","url":null,"abstract":"Objectives: Outpatient health care facilities are essential for quickly diagnosing common infectious diseases such as bacterial and viral pharyngitis. The only form of pharyngitis requiring antibiotics is strep throat (ST); however, antibiotic prescription rates are much higher than ST prevalence, suggesting antibiotics are being inappropriately prescribed. Current rapid ST diagnostics may be contributing to this problem due to the low sensitivity and variable specificity of these tests. It is best practice to verify a negative ST diagnosis with a group A Streptococcus (GAS) culture, but many clinics do not perform this test due to the additional cost and 24-72 h required to obtain results. This indicates there is great need for more accurate rapid diagnostic tools in outpatient facilities. We hypothesized that next generation qPCR technology could be adapted to detect GAS DNA from saliva samples (instead of the traditional throat swab) by creating a simple, fast, and inexpensive protocol.Methods: Saliva specimens collected from patients at James Madison University Health Center were used to test the effectiveness of our Chelex 100-based rapid DNA extraction method, followed by a fast protocol developed for the Open qPCR machine to accurately detect ST.Results: Our final saliva processing and qPCR protocol required no specialized training to perform and was able to detect ST with 100 % sensitivity and 100 % specificity (n=102) in 22-26 min, costing only $1.12 per sample.Conclusions: Saliva can be rapidly analyzed via qPCR for the accurate and inexpensive detection of ST.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"178-185"},"PeriodicalIF":3.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journal Reputation Factor. 期刊声誉因子。

IF 3.5

Diagnosis Pub Date : 2024-01-01 eCollection Date: 2024-02-01 DOI: 10.1515/dx-2023-0165

Eleftherios P Diamandis

引用次数: 0

Pre-analytical errors in coagulation testing: a case series. 凝血检测中的分析前误差：病例系列。

IF 3.5

Diagnosis Pub Date : 2024-01-01 eCollection Date: 2024-02-01 DOI: 10.1515/dx-2023-0110

Mala Mahto, Visesh Kumar, Ayan Banerjee, Sushil Kumar, Anurag Kumar

{"title":"Pre-analytical errors in coagulation testing: a case series.","authors":"Mala Mahto, Visesh Kumar, Ayan Banerjee, Sushil Kumar, Anurag Kumar","doi":"10.1515/dx-2023-0110","DOIUrl":"10.1515/dx-2023-0110","url":null,"abstract":"Objectives: Prevention of pre-analytical issues in coagulation testing is of paramount importance for good laboratory performance. In addition to common issues like hemolysed, icteric, or lipemic samples, some specific pre-analytical errors of coagulation testing include clotted specimens, improper blood-to-anticoagulant ratio, contamination with other anticoagulants, etc. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are very commonly affected tests due to pre-analytical variables. The impact these parameters possess on surgical decision-making and various life-saving interventions are substantial therefore we cannot afford laxity and casual mistakes in carrying out these critical investigations at all.Case presentation: In this case series, a total of 4 cases of unexpectedly deranged coagulation profiles have been described which were reported incorrectly due to the overall casual approach towards these critical investigations. We have also mentioned how the treating clinician and lab physician retrospectively accessed relevant information in the nick of time to bring back reassurance.Conclusions: Like every other critical investigation, analytical errors can occur in coagulation parameters due to various avoidable pre-analytical variables. The release of spurious results for coagulation parameters sets alarm bells ringing causing much agony to the treating doctor and patient. Only a disciplined and careful approach taken by hospital and lab staff towards each sample regardless of its criticality can negate these stressful errors to a large extent.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"114-119"},"PeriodicalIF":3.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk. 白细胞介素-6、肿瘤坏死因子-α 和高敏 C 反应蛋白可优化与生活方式有关的心肾风险的免疫代谢分析。

IF 3.5

Diagnosis Pub Date : 2024-01-01 eCollection Date: 2024-02-01 DOI: 10.1515/dx-2023-0159

Georgina Noel Marchiori, María Daniela Defagó, María Lucía Baraquet, Sebastián Del Rosso, Nilda Raquel Perovic, Elio Andrés Soria

{"title":"Interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein for optimal immunometabolic profiling of the lifestyle-related cardiorenal risk.","authors":"Georgina Noel Marchiori, María Daniela Defagó, María Lucía Baraquet, Sebastián Del Rosso, Nilda Raquel Perovic, Elio Andrés Soria","doi":"10.1515/dx-2023-0159","DOIUrl":"10.1515/dx-2023-0159","url":null,"abstract":"Objectives: The present study aimed to identify optimal inflammatory biomarkers involved in cardiorenal risk in response to major lifestyle factors.Methods: One hundred and twenty-nine adults aged 35-77 years participated voluntarily from 2017 to 2019 (Córdoba, Argentina) in a cross-sectional study to collect sociodemographic, clinical, and lifestyle data. Blood biomarkers (different cytokines, monocyte chemoattractant protein-1 [MCP-1], and high-sensitivity C-reactive protein [hs-CRP]) were measured using standard methods and then evaluated by principal component analysis and structural equation modeling (SEM) according to Mediterranean diet adherence, physical activity level, and waist circumference, while cardiorenal risk involved blood diastolic pressure, HDL-cholesterol, triacylglycerols, creatinine, and glycosylated hemoglobin.Results: A principal component included TNF-α (tumor necrosis factor-alpha), IL-8 (interleukin-8), IL-6 (interleukin-6), hs-CRP, and MCP-1, with absolute rotated factor loadings >0.10. SEM showed that IL-6 (β=0.38, 95 % IC=0.08-0.68), hs-CRP (β=0.33, 95 % IC=0.17-0.48), and TNF-α (β=0.22, 95 % IC=0.11-0.32) were the mediators that better explained an inflammatory profile positively related to waist circumference (β=0.77, 95 % IC=0.61-0.94). Moreover, this profile was associated with an increased cardiorenal risk (β=0.78, 95 % IC=0.61-0.94), which was well-defined by the variable used.Conclusions: Immune mediators are key elements in profiling the cardiorenal risk associated with lifestyle factors, for which the combination of hs-CRP, IL-6, and TNF-α has emerged as a robust indicator. This work reaffirms the need for biomarker optimization for early diagnosis and risk assessment.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"82-90"},"PeriodicalIF":3.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a diagnosis flow draft based on appearance impression for detection of vulvar disease. 应用基于外观印象的诊断流程图检测外阴疾病。

IF 3.5

Diagnosis Pub Date : 2023-12-26 eCollection Date: 2024-05-01 DOI: 10.1515/dx-2023-0146

Qi Zhou, Fang Chen, Yan Wang, Wenjie Qu, Yingxin Gong, Yuankui Cao, Hongwei Zhang, Qing Wang, Limei Chen, Qing Cong, Lin Lin, Jiayin Mo, Tianyi Bi, Jingxin Ding, Long Sui, Yanyun Li

{"title":"Application of a diagnosis flow draft based on appearance impression for detection of vulvar disease.","authors":"Qi Zhou, Fang Chen, Yan Wang, Wenjie Qu, Yingxin Gong, Yuankui Cao, Hongwei Zhang, Qing Wang, Limei Chen, Qing Cong, Lin Lin, Jiayin Mo, Tianyi Bi, Jingxin Ding, Long Sui, Yanyun Li","doi":"10.1515/dx-2023-0146","DOIUrl":"10.1515/dx-2023-0146","url":null,"abstract":"Objectives: The aims of this retrospective study were to evaluate the clinical applicability of the latest International Society for the Study of Vulvovaginal Disease (ISSVD) and International Federation for Cervical Pathology and Colposcopy (IFCPC) terminology for vulvar diseases, and to explore a new evaluation flow to optimize decision-making on diagnosis.Methods: A total of 1,068 patients with 5,340 qualified vulvar images were evaluated by observers using 2011 ISSVD and 2011 IFCPC terminology systems. The sensitivity, specificity, positive predictive value, negative predictive value, Youden Index and Overall Diagnostic Value (ODV) were calculated for each finding in the two systems. Then the disease diagnosis order and a diagnosis flow draft (DFD) were obtained.Results: A total of 15 kinds of vulvar diseases were diagnosed. The proportion of patients accompanied with cervical or vaginal intraepithelial neoplasia was highest (83.3 %) in vulvar Paget's disease group (p<0.001). Total area of lesions was larger in vulvar Paget's disease, lichen simplex chronicus and lichen sclerosus group (p<0.001). Among the top five findings of ODV, some findings inferred several (≥6) kinds of diseases, while some findings only exist in a certain disease. When the DFD was used, the agreement between the initial impression and histopathology diagnosis was 68.8 %, higher than those when ISSVD an IFCPC terminology systems used (p=0.028), and it didn't change with the experience of the observer (p=0.178).Conclusions: Based on the findings in ISSVD and IFCPC terminology systems, we explored a DFD for observers with different experience on the detection of vulvar disease.","PeriodicalId":11273,"journal":{"name":"Diagnosis","volume":" ","pages":"151-163"},"PeriodicalIF":3.5,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0