Deutsches Arzteblatt international最新文献

{"title":"Cystic Degeneration of the Pancreas in a Young Male Adult.","authors":"Max Striegler, Martin Sinn","doi":"10.3238/arztebl.m2025.0038","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0038","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 10","pages":"264"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenocarcinoma in a Teratoma 24 Years After Initial Treatment.","authors":"Hinrich Böhner, Franziska Hartmann, Andrea Tannapfel","doi":"10.3238/arztebl.m2025.0057","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0057","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 10","pages":"264"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply.","authors":"Friederike Thomasius","doi":"10.3238/arztebl.m2025.0040","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0040","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 10","pages":"m1036-m1037"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Data on a Non-invasive Prenatal Test (NIPT) for Trisomies 13, 18, and 21: A Retrospective Cohort Study Based on Billing Records of the BARMER Health Insurance Carrier.","authors":"Dagmar Hertle, Danny Wende","doi":"10.3238/arztebl.m2025.0043","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0043","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 10","pages":"283-284"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Approach Should Be Strengthened.","authors":"Cordula Stening","doi":"10.3238/arztebl.m2025.0039","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0039","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 10","pages":"m1036"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Skin Diseases: The Importance of Immunological Signatures.","authors":"Natalie Garzorz-Stark, Stephan Weidinger, Michael Sticherling, Kamran Ghoreschi, Alexander Enk, Kilian Eyerich","doi":"10.3238/arztebl.m2025.0045","DOIUrl":"10.3238/arztebl.m2025.0045","url":null,"abstract":"<p><strong>Background: </strong>The understanding and classification of inflammatory skin diseases is shifting from a historical-descriptive perspective to a molecular-pathophysiological one based on immune response patterns. These are derived from a few key immunological mediators, each of which induces its own characteristic clinical, histopathological, and molecular patterns in the skin.</p><p><strong>Methods: </strong>This discussion of the definition of the immune response patterns of inflammatory skin diseases is based on information from pertinent publications retrieved by a selective literature search. A systematic literature search was also conducted on the response of inflammatory skin diseases to treatment with specific biologic agents.</p><p><strong>Results: </strong>The described immune response patterns are: autoinflammation; type 1, cytotoxic; type 2a, eczematous; type 2b, blistering; type 3, psoriasiform; type 4a, fibrosing; and type 4b, granulomatous. Each signature can usually be treated in a targeted manner. In general, each therapeutic target structure is associated with an adequate treatment response if and only if the skin disease under treatment has the relevant signature type. Hardly any biomarkers are currently available for the determination of immune response patterns in routine clinical practice.</p><p><strong>Conclusion: </strong>The classification of inflammatory skin diseases by their immune response patterns opens up the prospect of specifically targeted immunotherapy for each immune response pattern regardless of the historical-descriptive disease entity. Targeting is intended to improve response rates. Initial findings suggest that this strategy is likely to succeed.</p>","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":" Forthcoming","pages":"277-282"},"PeriodicalIF":6.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scurvy Due to Malnutrition in Autistic Spectrum Disorder.","authors":"Matthias Posch, Anna Erbis, Henrike Pommerening","doi":"10.3238/arztebl.m2025.0033","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0033","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 9","pages":"234"},"PeriodicalIF":6.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic Injury in Outpatient Colonoscopy: Incidence, Risk Factors, Diagnosis, and Treatment.","authors":"Herbert Koop, Christoph Skupnik, Torsten Schnoor, Dirk Horenkamp-Sonntag","doi":"10.3238/arztebl.m2025.0005","DOIUrl":"https://doi.org/10.3238/arztebl.m2025.0005","url":null,"abstract":"","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":"122 9","pages":"247-248"},"PeriodicalIF":6.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features in Patients With Early-Onset Colorectal Cancer: An Evaluation of Data From the StuDoQ Database.","authors":"Ulrich Wirth, Josefine Schardey, Florian Scholz, Tobias Niedermaier, Christoph-Thomas Germer, Anton J Kroesen, Dimitrios Pantelis, Christoph Reissfelder, Markus Rentsch, Jörg-Peter Ritz, Nico Schäfer, Joachim Andrassy, Jens Werner, Florian Kühn","doi":"10.3238/arztebl.m2025.0018","DOIUrl":"10.3238/arztebl.m2025.0018","url":null,"abstract":"<p><strong>Background: </strong>The incidence of colorectal cancer (CRC) in patients who are less than 50 years old (early-onset colorectal cancer, EO-CRC) has risen markedly around the world in recent decades. Because of a lack of early detection programs for young patients, EO-CRC is often not detected until it has reached an advanced stage. In this study, we compared surgical patients with EO-CRC to those with so-called average-onset CRC (> 50 years; AO-CRC) using data from a large patient collective.</p><p><strong>Methods: </strong>63 565 cases of CRC from the years 2013-2022 were identified in the StuDoQ database of the German Society for General and Visceral Surgery (Deutsche Gesellschaft für Allgemeinund Viszeralchirurgie, DGAV) and were analyzed on the basis of tumor-related and perioperative data for each of two groups, EO-CRC (3549 patients) and AO-CRC (60 016 patients).</p><p><strong>Results: </strong>The mean age in the two groups was 42.50 ± 6.3 and 71.59 ± 10.3 years. In the EO-CRC group, 26.2% of the patients were under 40, and 50.4% were under 45. Men predominated in both groups. The distribution of tumor sites differed, with more rectal carcinoma and left-sided CRC in the EO-CRC group. More patients had nodal or distant metastases in the EO-CRC group. Compared to patients in the AO-CRC group, those in the EO-CRC group much more commonly had inflammatory bowel disease (OR 5.83, 95% confidence interval [4.73; 7.16]), a genetic predisposition (OR 4.36 [3.54;5.35]), or a positive family history (OR 4.54 [4.17; 4.95]).</p><p><strong>Conclusion: </strong>This analysis reveals that patients with EO-CRC differ markedly from those with AO-CRC in tumor-related data, multimodal treatment approaches, and perioperative outcomes. Risk-based, individualized early detection programs should be established to prevent the progression of undetected EO-CRC.</p>","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":" Forthcoming","pages":"235-239"},"PeriodicalIF":7.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnosis and Treatment of Degenerative Changes of the Lumbar Spine.","authors":"Frank Beyer, Peer Eysel, Jan Bredow","doi":"10.3238/arztebl.m2025.0056","DOIUrl":"10.3238/arztebl.m2025.0056","url":null,"abstract":"<p><strong>Background: </strong>Certain specific degenerative changes of the lumbar spine call for a meticulous assessment of the patient's symptoms and of the findings on physical examination and diagnostic imaging. Degenerative disc disease, spinal canal stenosis, facet joint arthrosis, and the resulting deformities are discussed here, along with the appropriate treatment for each condition.</p><p><strong>Methods: </strong>This narrative review is based on information from pertinent publications retrieved by a search in PubMed.</p><p><strong>Results: </strong>The history and physical examination are determinative. The findings of imaging studies are not necessarily correlated with the clinical manifestations. In the absence of red flags such as a new neurologic deficit or a suspected tumor, the patient can be treated conservatively with analgesics, physiotherapy, or specific infiltrations. If no improvement ensues, or if there is an absolute indication for surgery, decompressive and/or fusion techniques are used, depending on the particular abnormality that is present. A randomized controlled trial has shown the superiority of decompression over nonsurgical management for lumbar spinal canal stenosis (Oswestry Disability Index [ODI] mean difference 7.8, 95% confidence interval [0.8; 14.9]). On the other hand, a study of pooled data on fusion procedures yielded a mean difference of -7.39 points in the ODI score favoring surgery [-20.26; 5.47] [p = 0.26]).</p><p><strong>Conclusion: </strong>For many surgical techniques, the supporting scientific evidence is sparse. The authors recommend treatment in a specialized center.</p>","PeriodicalId":11258,"journal":{"name":"Deutsches Arzteblatt international","volume":" Forthcoming","pages":"249-256"},"PeriodicalIF":6.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}