Digestive Surgery最新文献_第9页

Effectiveness of Intraoperative Endoscopy for Localization of Early Gastric Cancer during Laparoscopic Distal Gastrectomy 腹腔镜远端胃切除术中术中内镜对早期胃癌定位的疗效

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-04-27 DOI: 10.1159/000524565

Y. Oh, Seung Geun Yang, W. Han, B. Eom, H. Yoon, Young-Woo Kim, K. Ryu

{"title":"Effectiveness of Intraoperative Endoscopy for Localization of Early Gastric Cancer during Laparoscopic Distal Gastrectomy","authors":"Y. Oh, Seung Geun Yang, W. Han, B. Eom, H. Yoon, Young-Woo Kim, K. Ryu","doi":"10.1159/000524565","DOIUrl":"https://doi.org/10.1159/000524565","url":null,"abstract":"Introduction: Intraoperative localization of tumors has been considered crucial in determining adequate resection margins during laparoscopic gastrectomy for early gastric cancer (EGC). This study has evaluated the effectiveness of intraoperative endoscopy for localization of EGC during the totally laparoscopic distal gastrectomy. Methods: Patients with EGC who received totally laparoscopic distal gastrectomy from January 2018 to March 2020 were included in this study. Except the tumors located in the antrum, the patients were categorized into two groups: no localization procedure (n = 144) and intraoperative endoscopy (n = 65). To evaluate the effectiveness of the localization procedure, proximal resection margin (PRM) involvement by the tumor and approximation of optimal PRM were compared, including their postoperative outcomes. Results: There were 3 patients (2.1%) with tumor involvement of the PRM at the initial gastric resection in the no localization group. Distance from the tumor to the PRM was determined to be not significantly different between the no localization group and intraoperative endoscopy group. The PRM distribution pattern and reconstruction method were also not significantly different between the two groups. Discussion/Conclusion: Intraoperative endoscopy for localization of EGC is an effective method to avoid tumor involvement at the resection margin during the laparoscopic gastrectomy with intracorporeal gastric resection and reconstruction.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"92 - 98"},"PeriodicalIF":2.7,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46471100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Values of Drain Fluid Epidermal Growth Factor and Transforming Growth Factor-Beta Are Associated with the Development of Pancreatic Fistula after Pancreatoduodenectomy 引流液表皮生长因子和转化生长因子- β的高值与胰十二指肠切除术后胰瘘的发生有关

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-04-25 DOI: 10.1159/000524678

G. Marchegiani, G. Perri, F. Giovinazzo, S. Zanini, G. Turri, G. Innamorati, R. Salvia, C. Bassi

{"title":"High Values of Drain Fluid Epidermal Growth Factor and Transforming Growth Factor-Beta Are Associated with the Development of Pancreatic Fistula after Pancreatoduodenectomy","authors":"G. Marchegiani, G. Perri, F. Giovinazzo, S. Zanini, G. Turri, G. Innamorati, R. Salvia, C. Bassi","doi":"10.1159/000524678","DOIUrl":"https://doi.org/10.1159/000524678","url":null,"abstract":"Introduction: Postoperative inflammatory response may act as a major determinant of anastomotic failure after pancreaticoduodenectomy. In this pilot study, we investigated the potential role of drain fluid cytokines in predicting postoperative pancreatic fistula (POPF). Methods: Drain fluid TGF-β, IGF-1, EGF, and IL-6, together with serum amylase and drain fluid amylase, were measured on POD1 and correlated with the development of POPF. Results: The study population consisted of 66 patients. POPF and Clavien-Dindo ≥3 morbidity rates were 12.1% and 9.1%, respectively. Patients developing POPF presented significantly higher values of POD1 serum amylase level (477 vs. 54 UI/L, p < 0.001), drain fluid amylase (7,500 vs. 127 UI/L, p < 0.001), TGFβ (94 vs. 40 pg/g, p = 0.045), and EGF (17 vs. 13, p = 0.015). There were no differences in terms of IGF-1 and IL-6 values. Conclusion: Assessing the local inflammatory response after pancreatoduodenectomy could represent a promising field of research since both TGFβ and EGF seem to be associated with the occurrence of POPF.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"125 - 132"},"PeriodicalIF":2.7,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44360403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Patients with Left-Sided Obstructive Colorectal Cancer: Comparison between Self-Expandable Metallic Stent and Other Treatment Methods 左侧梗阻性结直肠癌患者的预后:自膨胀金属支架与其他治疗方法的比较

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-04-22 DOI: 10.1159/000524645

A. Kondo, K. Kumamoto, H. Kobara, Teruya Nagahara, M. Wato, M. Shibatoge, Takuya Minato, Tsutomu Masaki, K. Okano

{"title":"Outcomes of Patients with Left-Sided Obstructive Colorectal Cancer: Comparison between Self-Expandable Metallic Stent and Other Treatment Methods","authors":"A. Kondo, K. Kumamoto, H. Kobara, Teruya Nagahara, M. Wato, M. Shibatoge, Takuya Minato, Tsutomu Masaki, K. Okano","doi":"10.1159/000524645","DOIUrl":"https://doi.org/10.1159/000524645","url":null,"abstract":"Introduction: This multi-institutional retrospective study aimed to evaluate the efficacy of preoperative self-expandable metallic stent (SEMS) placement for patients with left-sided obstructive colorectal cancer (OCRC). Methods: Overall, 520 consecutive patients who received treatment for OCRC were enrolled. Of these, the data of 253 patients who underwent primary tumour resection for left-sided OCRC were reviewed. The short- and long-term outcomes were compared between the SEMS group and other three groups: transanal decompression tube (TaDT), decompressing stoma (DS), and emergency resection (ER). Results: The SEMS group had a higher frequency of laparoscopic surgery (p < 0.001), lesser frequency of postoperative stoma (p < 0.001), and more dissected lymph nodes (p < 0.001) than the other groups. Moreover, the SEMS group had shorter postoperative hospital stays than the TaDT, DS, and ER groups (p = 0.005, p = 0.037, and p < 0.001, respectively). The Kaplan-Meier survival curves of recurrence-free survival and overall survival did not differ significantly between the SEMS group and the other three groups in patients with stage II and III diseases. Discussion/Conclusion: Elective surgery after SEMS placement may improve short-term outcomes compared to other treatment strategies, with similar long-term outcomes.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"117 - 124"},"PeriodicalIF":2.7,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42294443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic Factors Affecting Short- and Long-Term Outcomes of Gastrectomy for Gastric Cancer in Older Patients 影响老年癌症胃切除术中短期和长期疗效的预后因素

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-04-19 DOI: 10.1159/000524609

Nobuhiro Tsuchiya, C. Kunisaki, Hiroki Kondo, Sho Sato, Kei Sato, J. Watanabe, K. Takeda, T. Kosaka, H. Akiyama, I. Endo

{"title":"Prognostic Factors Affecting Short- and Long-Term Outcomes of Gastrectomy for Gastric Cancer in Older Patients","authors":"Nobuhiro Tsuchiya, C. Kunisaki, Hiroki Kondo, Sho Sato, Kei Sato, J. Watanabe, K. Takeda, T. Kosaka, H. Akiyama, I. Endo","doi":"10.1159/000524609","DOIUrl":"https://doi.org/10.1159/000524609","url":null,"abstract":"Introduction: The benefits of surgery in older patients with gastric cancer are controversial. This single-institution retrospective study in Japan aimed to evaluate the impact of gastrectomy in older patients with gastric cancer. Methods: A series of 234 patients aged ≥80 years with histologically confirmed gastric cancer had indications for surgical treatment at the Gastroenterological Center, Yokohama City University Medical Center, between April 2002 and December 2018. Patients who were lost to follow-up (n = 27), had tumors not eligible for surgery (n = 14), and could not achieve R0 resection (n = 7) were excluded from this retrospective study. The remaining 186 patients were included. Patient characteristics, intraoperative outcomes, postoperative complications, and long-term survival were evaluated. Results: The incidence of postoperative complications with Clavien–Dindo grade ≥ II was observed in 61 patients (32.8%). The 5-year relapse-free survival and overall survival (OS) rates were 84.2% and 63.4%, respectively. Multivariate analysis showed that geriatric nutritional risk index (<98) (odds ratio, 1.97; p = 0.047), neutrophil/lymphocyte ratio (>2.36) (odds ratio, 1.94; 95% confidence interval, 1.02–3.67; p = 0.043), and total gastrectomy (TG) (odds ratio, 1.97; p = 0.042) significantly predicted postoperative complications. Moreover, TG (hazard ratio, 1.91; p = 0.036) was an independent prognostic factor of OS. Conclusions: Poor immunonutritional status and TG led to worse short-term outcomes. Moreover, TG was an independent prognostic factor of OS in older patients with gastric cancer. It is necessary to provide effective perioperative care, including nutritional support, to clarify whether short-term outcomes would be improved.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"109 - 116"},"PeriodicalIF":2.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49510890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Crohn’s Disease-Related Stoma Complications and Their Impact on Postsurgical Course 克罗恩病相关的口腔并发症及其对术后进程的影响

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-03-16 DOI: 10.1159/000524036

I. Angriman, G. Buzzi, Edoardo Giorato, M. Barbierato, Francesco Cavallin, C. Ruffolo, S. Degasperi, V. Mari, O. De Simoni, Michela Campi, Francesca Zingales, G. Roveron, M. Iafrate, S. Pucciarelli, R. Bardini, M. Scarpa

{"title":"Crohn’s Disease-Related Stoma Complications and Their Impact on Postsurgical Course","authors":"I. Angriman, G. Buzzi, Edoardo Giorato, M. Barbierato, Francesco Cavallin, C. Ruffolo, S. Degasperi, V. Mari, O. De Simoni, Michela Campi, Francesca Zingales, G. Roveron, M. Iafrate, S. Pucciarelli, R. Bardini, M. Scarpa","doi":"10.1159/000524036","DOIUrl":"https://doi.org/10.1159/000524036","url":null,"abstract":"Introduction: Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. The diversion through a colostomy or an ileostomy is sometimes required for disease control. In these patients, common stoma-related complications sum up with CD-related complications and often require revisional surgery. Methods: The aim of the study was to assess stoma morbidity after surgery for CD and to identify the burden of CD-related or CD-associated complications. Thus, details of past medical history, surgery, and follow-up of 54 consecutive patients operated on for CD with any sort of stoma were retrieved from the stoma therapist prospectively maintained database. Results: In our series, 23 patients had a colostomy, and 31 patients had an ileostomy. Complications occurred after stoma creation in 38 patients (70%) at a median of 1.3 months (interquartile range 0.6–7.2). CD-related complications arose in 8 patients (including pyoderma gangrenosum in 3 patients, peristomal fistulae in 2, granulomas in 2, and peristomal abscess in 1). Patients with CD-related complications tended to have a shorter disease duration (p = 0.07) and higher occurrence of CD-related complications was associated with end-stoma (p = 0.006). In this cohort, 11 cases had to be surgically treated for peristomal fistulae or abscess, parastomal hernia, prolapse, pyoderma gangrenosum, and recurrent CD. Discussion/Conclusions: In patients with CD, stoma creation is burdened by a high rate of postoperative complication and a relevant rate is specifically related to CD. Often these patients are required to be reoperated on to redo the stoma. Moreover, end-stoma configuration and aggressive CD phenotype are associated to a higher rate of complications.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"83 - 91"},"PeriodicalIF":2.7,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49572890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HBPD Table of Contents HBPD目录

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-03-01 DOI: 10.1159/000523745

引用次数: 0

Front & Back Matter 正面和背面事项

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-03-01 DOI: 10.1159/000524083

D. O’Toole

引用次数: 0

EDS Society News EDS社会新闻

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-03-01 DOI: 10.1159/000523744

引用次数: 0

Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma. 预测肝细胞癌预后的枢纽基因的鉴定和验证。

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-01-01 Epub Date: 2021-11-17 DOI: 10.1159/000520893

Ziyan Chen, Haitao Yu, Lijun Wu, Sina Zhang, Zhihui Lin, Tuo Deng, Bangjie He, Zhengping Yu, Gang Chen, Fang Wu

{"title":"Identification and Validation of Hub Genes Predicting Prognosis of Hepatocellular Carcinoma.","authors":"Ziyan Chen, Haitao Yu, Lijun Wu, Sina Zhang, Zhihui Lin, Tuo Deng, Bangjie He, Zhengping Yu, Gang Chen, Fang Wu","doi":"10.1159/000520893","DOIUrl":"https://doi.org/10.1159/000520893","url":null,"abstract":"Introduction: The aim of this study is selecting the hub genes associated with hepatocellular carcinoma (HCC) to construct a Cox regression model for predicting prognosis in HCC patients.Methods: Using HCC patient data from the ICGC and TCGA databases, screened for 40 core genes highly correlated with histological grade of HCC. Univariate and multivariate Cox regression analyses were performed on the genes highly associated with HCC prognosis, and the model was established. The expression of those genes was measured by immunohistochemistry in 110 HCC patients who underwent the surgery in the First Affiliated Hospital of Wenzhou Medical University. The survival of HCC patients was analyzed by the Kaplan-Meier method.Results: Eight genes (CDC45, CENPA, MCM10, MELK, CDC20, ASF1B, FANCD2, and NCAPH) were correlated with prognosis, and the same result was observed in 110 HCC patients. Using the regression model, the HCC patients in the training set were classified as high- and low-risk groups. The overall survival of patients in the high-risk group was shorter than that in the low-risk group, and the same results were obtained in the verification set.Conclusion: This study found that the risk model according to these 8 genes can be used as a predictor of prognosis in HCC. These genes may become alternative biomarkers and therapeutic targets and provide new therapeutic strategies for HCC.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 1","pages":"24-31"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prognostic Impact of Inflammation-Based Scores for Extrahepatic Cholangiocarcinoma. 肝外胆管癌炎症评分对预后的影响。

IF 2.7 3区医学

Digestive Surgery Pub Date : 2022-01-01 Epub Date: 2022-01-20 DOI: 10.1159/000521969

Riki Asakura, Hiroaki Yanagimoto, Tetsuo Ajiki, Daisuke Tsugawa, Takuya Mizumoto, Shinichi So, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Kaori Kuramitsu, Tadahiro Goto, Sadaki Asari, Masahiro Kido, Hirochika Toyama, Takumi Fukumoto

{"title":"Prognostic Impact of Inflammation-Based Scores for Extrahepatic Cholangiocarcinoma.","authors":"Riki Asakura, Hiroaki Yanagimoto, Tetsuo Ajiki, Daisuke Tsugawa, Takuya Mizumoto, Shinichi So, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Kaori Kuramitsu, Tadahiro Goto, Sadaki Asari, Masahiro Kido, Hirochika Toyama, Takumi Fukumoto","doi":"10.1159/000521969","DOIUrl":"https://doi.org/10.1159/000521969","url":null,"abstract":"Introduction: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma.Methods: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019. The usefulness of the following inflammation-based scores as prognostic factor was investigated: glasgow prognostic score (GPS), modified GPS, neutrophil-to-lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte-to-monocyte ratio, prognostic nutrition index, C-reactive protein to albumin ratio (CAR), controlling nutritional status (CONUT), and prognostic index.Results: A total of 169 patients were enrolled in this study. Of the nine scores, CAR and CONUT indicated prognostic value. Furthermore, multivariate analysis for overall survival revealed that high CAR (>0.23) was an independent prognostic factor (hazard ratio: 1.816, 95% confidence interval: 1.135-2.906, p = 0.0129), along with lymph node metastasis and curability. There was no difference in tumor staging and short-term outcomes between the low CAR (≤0.23) and high CAR groups.Conclusions: CAR was the most valuable prognostic score in patients with resected extrahepatic cholangiocarcinoma.","PeriodicalId":11241,"journal":{"name":"Digestive Surgery","volume":"39 2-3","pages":"65-74"},"PeriodicalIF":2.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6