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ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)最新文献

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Nucleotidases Exhibit Enzymatic Activities Toward the Pharmacologically Active Metabolites of Gemcitabine and Emtricitabine 核苷酸酶对吉西他滨和恩曲他滨的药理活性代谢物表现出酶活性
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.540660
H. Seneviratne, N. R. Phulara, C. Ishida, P. Espenshade
{"title":"Nucleotidases Exhibit Enzymatic Activities Toward the Pharmacologically Active Metabolites of Gemcitabine and Emtricitabine","authors":"H. Seneviratne, N. R. Phulara, C. Ishida, P. Espenshade","doi":"10.1124/jpet.122.540660","DOIUrl":"https://doi.org/10.1124/jpet.122.540660","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130672016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing Drug Interactions Involving the Over-the-Counter Opioid Loperamide through Physiologically Based Pharmacokinetic Modeling 通过基于生理的药代动力学模型管理涉及非处方阿片类药物洛哌丁胺的药物相互作用
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.266210
Zhu Zhou, Mengyao Li, P. Zhao, J. Dinh, M. Paine
{"title":"Managing Drug Interactions Involving the Over-the-Counter Opioid Loperamide through Physiologically Based Pharmacokinetic Modeling","authors":"Zhu Zhou, Mengyao Li, P. Zhao, J. Dinh, M. Paine","doi":"10.1124/jpet.122.266210","DOIUrl":"https://doi.org/10.1124/jpet.122.266210","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129971909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Zonal Distribution of Hepatic Drug Metabolizing Enzymes and Transporters in Mice by Single Cell Transcriptomics 用单细胞转录组学分析小鼠肝脏药物代谢酶和转运体的地带性分布
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.161490
J. Lim, C. Klaassen, J. Cui
{"title":"Deciphering the Zonal Distribution of Hepatic Drug Metabolizing Enzymes and Transporters in Mice by Single Cell Transcriptomics","authors":"J. Lim, C. Klaassen, J. Cui","doi":"10.1124/jpet.122.161490","DOIUrl":"https://doi.org/10.1124/jpet.122.161490","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131482272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation 酮康唑通过抑制CYP17A1治疗类固醇生成抑制的药理作用可能涉及MicroRNA调控
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.218670
B. Ning, Dongying Li, Bridgett Knox, Weida Tong
{"title":"Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation","authors":"B. Ning, Dongying Li, Bridgett Knox, Weida Tong","doi":"10.1124/jpet.122.218670","DOIUrl":"https://doi.org/10.1124/jpet.122.218670","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133277412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Application of Hydrolase Reaction Phenotyping in Early Discovery Research 水解酶反应表型在早期发现研究中的体外应用
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.528790
G. Zhong, Julie M. Lade, Armina Abbasi
{"title":"In Vitro Application of Hydrolase Reaction Phenotyping in Early Discovery Research","authors":"G. Zhong, Julie M. Lade, Armina Abbasi","doi":"10.1124/jpet.122.528790","DOIUrl":"https://doi.org/10.1124/jpet.122.528790","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127618387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorogenic Chemical Tools to Improve Prodrug Treatment Outcomes 荧光化学工具改善药物前治疗结果
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.135840
Michael Beck
{"title":"Fluorogenic Chemical Tools to Improve Prodrug Treatment Outcomes","authors":"Michael Beck","doi":"10.1124/jpet.122.135840","DOIUrl":"https://doi.org/10.1124/jpet.122.135840","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115845791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CYP11A1 substrates vitamin D3 and cholesterol induce changes in protein conformation and protein-protein interactions with Adrenodoxin CYP11A1底物维生素D3和胆固醇诱导蛋白构象和蛋白与肾上腺素的相互作用的变化
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.231030
Janie E. McGlohon, D. F. Estrada
{"title":"The CYP11A1 substrates vitamin D3 and cholesterol induce changes in protein conformation and protein-protein interactions with Adrenodoxin","authors":"Janie E. McGlohon, D. F. Estrada","doi":"10.1124/jpet.122.231030","DOIUrl":"https://doi.org/10.1124/jpet.122.231030","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114388692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of Drug Binding to Liver Fatty Acid Binding Protein (FABP1) and Its Effect on Diclofenac Metabolism by CYP2C9 肝脏脂肪酸结合蛋白(FABP1)与药物结合的表征及CYP2C9对双氯芬酸代谢的影响
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.276480
King B. Yabut, Ben Zercher, M. F. Bush, N. Isoherranen
{"title":"Characterization of Drug Binding to Liver Fatty Acid Binding Protein (FABP1) and Its Effect on Diclofenac Metabolism by CYP2C9","authors":"King B. Yabut, Ben Zercher, M. F. Bush, N. Isoherranen","doi":"10.1124/jpet.122.276480","DOIUrl":"https://doi.org/10.1124/jpet.122.276480","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121931550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of a novel bifunctional cytochrome P450 enzyme CYP107 from bacteriumSebekia benihana 一种新型双功能细胞色素P450酶CYP107的鉴定
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.260550
Layne Jensen, D. F. Estrada
{"title":"Characterization of a novel bifunctional cytochrome P450 enzyme CYP107 from bacteriumSebekia benihana","authors":"Layne Jensen, D. F. Estrada","doi":"10.1124/jpet.122.260550","DOIUrl":"https://doi.org/10.1124/jpet.122.260550","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128364591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Characterization of Chemical Tools to Study Ester Drug Metabolic Enzymes in Live Cells 研究活细胞中酯类药物代谢酶的化学工具的开发与表征
ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.182480
Carolyn J. Karns, Makenzie R. Walk, Anchal Singh, Mingze Gao, Taylor P. Spidle, Michael Beck
{"title":"Development and Characterization of Chemical Tools to Study Ester Drug Metabolic Enzymes in Live Cells","authors":"Carolyn J. Karns, Makenzie R. Walk, Anchal Singh, Mingze Gao, Taylor P. Spidle, Michael Beck","doi":"10.1124/jpet.122.182480","DOIUrl":"https://doi.org/10.1124/jpet.122.182480","url":null,"abstract":"","PeriodicalId":112046,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129272643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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