Dermatology Research最新文献

{"title":"Sunscreens Percutaneous Absorption and Ingredients Concentration in Human Plasma and Urine: A Systematic Review.","authors":"Farnoosh Seirafianpour, Navid Sadeghi Azad, Atefeh Naeimifar, Milad Dodangeh, Masoud Pourghahramani Koltapeh, Sepideh Safari, H. Maibach, S. S. Alenabi, Parsa Panahi, Bita Mehravi, S. Nafisi","doi":"10.33425/2690-537x.1024","DOIUrl":"https://doi.org/10.33425/2690-537x.1024","url":null,"abstract":"Sunscreen application is widespread and incorporated into daily life. Although FDA has approved 16 sunscreen ingredients, recent studies suggest a revaluation of their potential adverse effects. This systematic review assesses sunscreens’ percutaneous absorption, toxicity, and their ingredients concentration in urine and plasma. The search was conducted in Medline (PubMed), Scopus, Embase, and Cochrane until 05/08/2021. Data from 21 studies with related inclusion criteria were extracted. 18 studies reported sunscreen complications such as rash, irritation, immune system disorders, stratum corneum DNA damage, and hormonal disruption, 4 articles reported maximum concentration of sunscreen ingredients in plasma, and 4 articles reported urinary concentration of ingredients. In 2016, the FDA suggested a plasma concern level of 0.5 ng/mL for sunscreen ingredients. Sunscreen ingredients including avobenzone, octocrylene, ecamsule, homosalate, octisalate, enzacamene, octinoxate, and oxybenzone were detected more than 0.5 ng/mL after in blood 1-4 daily applications. Sunscreen application reduces the risk of sunlight harmful effects but could have advers effects related to their percutaneous penetration. Taken together, related data provide the impetus for detailed analysis of sunscreen toxicology. Also, highly adsorbed ingredients should be replaced with less adsorbed compounds to minimize body accumulation and the associated risks. Also, life time infant and children sunscreen exposure provide furthur impetus for in-depth toxicologic investigations","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82447422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia in Patients with Psoriasis and Psoriatic Arthritis","authors":"Jinan Q. Mohammed, A. Mathkhor, Fahmi T Mardan","doi":"10.33425/2690-537x.1026","DOIUrl":"https://doi.org/10.33425/2690-537x.1026","url":null,"abstract":"Background: Different comorbidities, including metabolic syndrome, altered lipid profile, and an increased cardiovascular risk commonly associated with Psoriasis and psoriatic arthritis (PsA). This study aimed to declare the correlation between dyslipidemia and Psoriasis. Patents and methods: Ninety-tow patients (29 patients with PSA and 63 patients with psoriasis vulgaris) and 88 healthy, age and sex-matched controls were recruited for the study. Serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL), and low-density lipoproteins (LDL) were measured. The severity of Psoriasis and PsA activity was assessed using the Psoriasis Area and Severity Index (PASI) and the Disease Activity Score using 28 joints (DAS28) for patients with Psoriasis and PSA, respectively. Results: HDL level was significantly lower in the patients than in controls. TC, TG, and LDL levels were significantly higher in the patient group than those in the control group. There are no significant differences in serum TC, TG, LDL, and HDL levels in Psoriasis and psoriatic arthritis. The serum TC, TG, LDL, and HDL levels were not related to disease duration but were associated with high disease activity. Conclusion: Dyslipidemia was found in a high percentage of psoriatic and PsA patients than in healthy controls. Dyslipidemia was associated with high disease activity in psoriatic and PsA patients. As Psoriasis and PsA are associated with an increased risk of cardiovascular diseases, thorough lipid levels estimation is required.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82319517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderna Arm Cutaneous Side Effect of Moderna Vaccine among Healthcare Providers in Secondary Hospital in Jakarta - Tangerang, Indonesia.","authors":"Muthia Kamal Putri, Anna Rumaisyah, Ruri D. Pamela, P. K. Esti","doi":"10.33425/2690-537x.1023","DOIUrl":"https://doi.org/10.33425/2690-537x.1023","url":null,"abstract":"Introduction: Since the emerging Delta variant of COVID-19 in 2021, the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) have encouraged world citizens to get booster vaccination. Booster vaccination has been used worldwide to prevent severe COVID-19. Healthcare providers were given the priority to be vaccinated, and the Moderna vaccine was given as chosen booster vaccination. Cutaneous side effect related to the Moderna vaccine has been reported in Public Secondary Hospital in both two cities in Indonesia, Jakarta and Tangerang. Material & Methods: The observation for this report took place from August until September 2021. All the patients gave their informed consent to participate in this case report and explicit consent to use their clinical photos. We collected data on 357 cases for 2 months in Dr. Suyoto Hospital (Jakarta) dan Dr. Sitanala Hospital (Tangerang). Results: The total number of healthcare workers who got the booster vaccine was 1370, and the number of experienced Moderna Arm was 350 cases: 321 cases with edema, urtica, and erythematous rash, and 29 cases with ecchymosis in Suyoto Hospital while in Sitanala Hospital 7 cases of urtica & erythematous rash. Conclusion: There were side effects after the Moderna injection, and it was important to inform the recipient about those effects.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73336821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannitol Cream for Itchy Psoriasis, a Case Report","authors":"Hélène Bertrand","doi":"10.33425/2690-537x.1025","DOIUrl":"https://doi.org/10.33425/2690-537x.1025","url":null,"abstract":"78-year-old woman with severely itchy psoriasis, bald from scratching her scalp and pulling out her hair found relief from the itch within five minutes of applying a 30% mannitol cream. After using the cream twice daily for 5 weeks, her scalp psoriasis had subsided and her hair had regrown. The effect of this cream on her lower back psoriasis is documented with photographs. The psoriasis recurred when the cream was no longer available.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73825361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Virgin Coconut Oil Application on Improving The Skin Integrity of Preterm Infants: Systematic Review and Metaanalysis with Neonatal Skin Condition Score as the Parameter","authors":"Syafria Zidni, Diah Adriani Malik, P. Riyanto, Asih Budiastuti, R. Widayati, Muslimin M, Hardian H","doi":"10.33425/2690-537x.1022","DOIUrl":"https://doi.org/10.33425/2690-537x.1022","url":null,"abstract":"Background: Preterm infants have a greater susceptibility to serious infections because their skin barrier has not fully functioned properly. Early birth in preterm infants causes immaturity of the barrier development, in the form of a thinner stratum corneum. Therefore extra care is needed to maintain the integrity of their skin to prevent infection, where the main recommendation is the administration of emollients, such as coconut oil. Virgin coconut oil contains nutrients and lauric acid that are more maintained and higher than coconut oil. Changes in skin integrity can cause extensive skin damage and become risk factors for infection. Erythema or damage to the skin such as erosion, excoriation, or crusting can be an early symptom of life-threatening infection in preterm infants. Assessment of skin integrity can be assessed objectively using the Neonatal Skin Condition Score (NSCS). Virgin coconut oil as an emollient with its antimicrobial activity is expected to allow improvement of the barrier structure of the skin. Aim: The purpose of this study is to review previous studies to provide a systematic summary of the effectiveness of topical coconut oil in improving the skin integrity of premature infants. Methods: Searching the electronic database Pubmed-MEDLINE, Scopus, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar, found five most relevant articles included in the qualitative and two of those five articles included in the meta-analysis. Result: The meta-analysis of the effect of topical VCO compared with control on NSCS values in preterm infants showed the value of heterogeneity test with Tau2=0.04 df=1; p=0.13, I2=55%. The value of the Q statistic was z value = 5.23 (p < 0.001). This shows that the overall administration of topical VCO can significantly improve the value of NSCS on preterm infants. The results of the overall meta-analysis showed that the overall standardized mean difference in NSCS between the intervention group compared to control was -0.93[-1.28 -0.58] (p < 0.001). These results indicate that the overall NSCS value of the intervention group was significantly better than the control group. Conclusion: Data from a systematic review and meta-analysis showed that the application of VCO can provide significantly better results in improving the skin integrity of preterm infants.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78579977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Micronutrient Levels In Premature Canities: A Systematic Review and Meta-analysis.","authors":"N. Camelia, Diah Adriani Malik, P. Riyanto, Asih Budiastuti, R. Widayati, Muslimin M, Hardian H","doi":"10.33425/2690-537x.1021","DOIUrl":"https://doi.org/10.33425/2690-537x.1021","url":null,"abstract":"Background: Premature canities, also known as premature graying of hair, is the graying of hair before 20 years old in Caucasians, before 25 years old in Asians, and before 30 years old in African–Americans. The risk factors for premature canities are multifactorial. The role of micronutrient deficiency has long been suggested to be involved in the etiopathogenesis of premature canities. The management of premature canities remains limited and far from satisfactory; hence, knowing what vitamins and minerals can help in treating premature canities is vital. Aim: This study aims to analyze serum vitamin B12, iron, ferritin, copper, calcium, and zinc levels in premature canities. Methods: The MEDLINE/PubMed electronic database, Cochrane library, ClinicalTrials.gov, EBSCO, Scopus, ProQuest, Cambridge Core, reference lists, conference proceedings, and researchers in fields of eligible studies were searched. Twelve studies (n = 1791 subjects) were included in qualitative analysis of which nine studies (n = 1381 subjects) were included in meta-analysis. Serum levels of micronutrients (vitamin B12, iron, ferritin, copper, calcium, and zinc) were compared in the premature canities and nonpremature canities groups. Result: Pooling of data using fixed-effects model found the overall effect mean difference serum vitamin B12 level was −0.697 ± 0.105 (95% CI = −0.904 to −0.490), p < 0.001. The overall mean difference serum iron level was 0.146 ± 0.105 (95% CI = −0.058 to 0.350), p = 0.161. The overall mean difference serum ferritin level was 0.720 ± 0.071 (95% CI = 0.585 to 0.854), p < 0.001. The overall mean difference serum copper level was 0.230 ± 0.118 (95% CI = −0.003 to 0.463, p = 0.053. The overall mean difference serum calcium level was −0.443 ± 0.114 (95% CI = −0.655 to −0.212), p < 0.001. The overall mean difference serum zinc level was −0.104 ± 0.138 (95% CI = 0.377 to 0.170, p = 0.457. Qualitative analysis showed that vitamin B12 plays an important role in DNA synthesis in the proliferation of hair follicle cells and in melanogenesis. Iron, ferritin, copper, calcium, and zinc also play important roles in stabilizing and increasing tyrosinase activity in several stages of the melanogenesis process. Conclusion: The meta-analysis showed that serum levels of vitamin B12, ferritin, and calcium were significantly lower in premature canities. Although the lower serum iron, copper, and zinc levels were not significantly different in premature canities compared with nonpremature canities. Qualitative analysis found that deficiency of vitamin B12, iron, ferritin, zinc, copper, and calcium can affect the physiology of hair melanogenesis that causing premature canities.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87114305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-analysis of the Effectiveness of Topical Aloe vera on Diaper Dermatitis with Parameters Degree of Diaper Dermatitis with Scale","authors":"Rinda Gita Atikasari, Diah Adriani Malik, R. Widayati, P. Riyanto, Asih Budiastuti, Muslimin M, Hardian H","doi":"10.33425/2690-537x.1020","DOIUrl":"https://doi.org/10.33425/2690-537x.1020","url":null,"abstract":"Background: For toddlers younger than 36 months, most of them still use diapers, so diaper rashes frequently appear in the diaper area. To improve the skin barrier, a moisturizer is needed to repair the skin barrier. Besides, the ceramide gold standard of moisturizer for diaper dermatitis, topical ingredients with natural ingredients can be used, for example, topical Aloe vera. Objective: To prove the effectiveness of topical Aloe vera moisturizer compared to other topical ingredients against diaper dermatitis. Methods: The results of the electronic database search Medline Pubmed, Scopus, EBSCOhost, ProQuest, Cochrane library, ClinicalTrials.gov, found 5 articles were included in the qualitative review (n = 289 subjects) and 4 articles (n = 214 subjects) were included in the meta-analysis. Results: Meta-analysis showed that after the administration of topical Aloe vera, there was a mean difference in the score of the degree of diaper dermatitis before and after therapy, the result showed negative value in the studies which were included the treatment group with Aloe vera. This indicates a decrease in the degree of diaper dermatitis after treatment with Aloe vera. The control group also showed that the mean score difference in the degree of diaper dermatitis after administration of control therapy was all negative. This shows that after the administration of therapy in the control group there was also a decrease in the score of the degree of dermatitis. The biggest decrease in the degree of diaper dermatitis was in the study conducted by Murni 2020, which was -2.10 ± 1.39. The lowest decrease in the degree of diaper dermatitis was found in the study conducted by Badelbuu 2019 B which received Chamomile, which was -0.93 ± 1.08. Meanwhile, in the Panahi’s study, the heterogeneity test results showed the value of Q=5,324 df=43; p=0,256, I2=24,866. This shows that the data is homogeneous, it is in line with the results of the statistical Q test and heterogeneity, the results of the I2 test obtained p < 0.001 which also indicates the data is homogeneous. The analysis was carried out using a fixed effect model because the data were homogeneous. The results of the meta-analysis showed that the statistical Q value was z value = -0.969 (p = 0.047). It has quite meaningful results. Conclusion: The meta-analysis showed that statistically there were only slight differences, but there were also studies that provided significant results. Topical application of Aloe vera appears to be more effective. The results of qualitative analysis on other skin barrier function parameters indicate that topical Aloe vera can improve skin barrier function in diaper dermatitis patients. In addition, it provides the same results as standard therapy and several other topical therapies that had been studied which had a good effect on repairing the skin barrier.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83025848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Syphilitic Chancre of the Tongue","authors":"Galdava G, Liluashvili S, Kvirkvelia V","doi":"10.33425/2690-537x.1018","DOIUrl":"https://doi.org/10.33425/2690-537x.1018","url":null,"abstract":"Initial presentation of syphilis may be the oral cavity. Because oral lesions are highly contagious, it is vital to make correct diagnosis and start therapy because interrupt chain of infection. In this article, we report a case of primary syphilis with extra genital chancre on the tongue.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74682443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 Spike Glycoprotein Binds Heparan Sulfate Chains and N-Glycans in Psoriatic Keratinocytes: A Hypothesis.","authors":"Arciniegas Enrique, Carrillo Luz Marina, Salgado Antonio, Piquero Jaime, O. Diana","doi":"10.33425/2690-537x.1019","DOIUrl":"https://doi.org/10.33425/2690-537x.1019","url":null,"abstract":"Psoriasis vulgaris, the most common form of psoriasis, is a chronic inflammatory skin disease that affects 2-3% of the worldwide population. It has been reported in patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suggesting the percutaneous transmission of this infection which may cause the exacerbation of psoriasis. Interestingly, elevated expression of ACE2 receptor on differentiating keratinocytes and basal cell layer of the epidermis of patients with psoriasis and COVID-19 involving pro inflammatory cytokines such as IFN-γ and IL-17, has been reported; however little is known about the participation of other receptors expressed on the surface of psoriatic keratinocytes, in the SARS-CoV-2 infection. Here we hypothesize that, in the skin of patients with psoriasis who have been diagnosed with COVID-19, the interaction of the SARS-CoV-2 S glycoprotein with the HSPGs Synd-1 and CD44 through their HS side chains and N-linked glycan, and Gal-3 and Gal-8 through the N- glycans located on the ACE2, integrin-β1, CD147, IFN-γR and IL-17A-R, would generate a Gal-glycan lattice at the surface of SARS-CoV-2 virus and psoriatic keratinocyte. Such Gal-glycan lattice in addition to influence keratinocyte proliferation and terminal differentiation, might induce conformational changes in the SARS-CoV-2 S glycoprotein facilitating the attachment and virus entry. We consider that future work will be required to understand the mechanisms regulating Gal-glycan lattice assembly during psoriatic keratinocyte and SARS-CoV-2 interaction as well as for the development of new inhibitors of virus attachment and internalization.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89261313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Varicose Veins with Neodymium: Yag Laser","authors":"A. Huacuja, Dafne Arellano Montalvo, A. A. Montalvo","doi":"10.33425/2690-537x.1017","DOIUrl":"https://doi.org/10.33425/2690-537x.1017","url":null,"abstract":"In the year of 1998, we started with the treatment of vascular lesions that occur in both legs and face in skins type III, IV and V in greater numbers. The use of this equipment has allowed good results in reticular veins, telangiectasias and hair lesions. And important results in hemangiomas and nevus flameus, (Port Winne Stain) and Sturge Weber, as well as in Rosacea and Poikiloderma de Civatte.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85413557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}