Current Pharmacology Reports最新文献_第8页

Biomarkers from Secondary Complications in Spinal Cord Injury. 脊髓损伤继发性并发症的生物标志物。

Current Pharmacology Reports Pub Date : 2022-02-01 Epub Date: 2021-12-02 DOI: 10.1007/s40495-021-00268-3

Hani Alostaz, Li Cai

{"title":"Biomarkers from Secondary Complications in Spinal Cord Injury.","authors":"Hani Alostaz, Li Cai","doi":"10.1007/s40495-021-00268-3","DOIUrl":"https://doi.org/10.1007/s40495-021-00268-3","url":null,"abstract":"Purpose of review: In the USA, spinal cord injury (SCI) occurs in 40 people per million every year due to events such as car accidents, falls, violence, or sports injury. Secondary complications that arise from SCI are life-threatening and should be treated as early as possible. In some cases, it is not completely obvious what complication a patient may have until it is too late. Therefore, biomarkers are required to assess the levels of secondary complications after SCI. As there are several complications that pose different warning signs, different biomarkers may be beneficial in early detection, maintenance, and long-term care for patients with SCI.Recent findings: Numerous studies have been conducted on biomarkers in various SCI and its related complications, such as neuropathic pain and deep vein thrombosis. In recent years, research has expanded with biomarkers discovered by cellular and molecular, genome-wide transcriptomic analysis, bioinformatics, and clinical studies. Biomarkers have allowed early prediction of the severity of secondary complications due to SCI.Summary: In this review, we summarize recent studies on the common biomarkers for the secondary complications related to SCI. We highlight the reliable biomarkers that have been tested, e.g., sclerostin, NGF, D-dimer, oncostatin M (OSM), microbiota, and C-reactive protein, which are valuable and with clinical importance. This review also emphasizes continuing research in biomarkers as they can provide valuable cellular and molecular insight into secondary complications after SCI.","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"8 1","pages":"20-30"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491488/pdf/nihms-1835858.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phytochemicals in Breast Cancer-Induced Osteoclastogenesis and Bone Resorption: Mechanism and Future Perspective 植物化学物质在乳腺癌诱导的破骨细胞发生和骨吸收中的作用:机制和未来展望

Current Pharmacology Reports Pub Date : 2022-01-22 DOI: 10.1007/s40495-021-00279-0

S. Pore, Eun-Ryeong Hahm

引用次数: 1

Emicizumab: an FDA-Approved Monoclonal Antibody in the Treatment of Hemophilia A Emicizumab: fda批准的用于治疗血友病A的单克隆抗体

Current Pharmacology Reports Pub Date : 2022-01-19 DOI: 10.1007/s40495-021-00275-4

Doddolla Lingamaiah, Sunitha Ns, K. Murti, Sanjiv Singh, V. Ravichandiran, Sameer Dhingra

引用次数: 1

Role of Pharmacogenomics in Reducing the Risk of Drug-Related Iatrogenesis 药物基因组学在降低药物相关Iatrogenesis风险中的作用

Current Pharmacology Reports Pub Date : 2022-01-17 DOI: 10.1007/s40495-021-00280-7

V. Michaud, Lucy I. Darakjian, Pamela Dow, J. Turgeon

引用次数: 1

Status Epilepticus: an Overview for Neuroscientists 癫痫状态：神经科学家综述

Current Pharmacology Reports Pub Date : 2022-01-11 DOI: 10.1007/s40495-021-00272-7

Neha Raina, M. Yadav, R. Rani, B. Ojha, Bigul Yogeshver Bhardwaj, Madhu Gupta

引用次数: 0

A Comprehensive Review on Medicinal Herb Withania somnifera (L.) Dunal in Women’s Health: a Rejuvenator From Siddha Medicine 悉达医学的一个新生力量——女性健康中草药紫苏的综述

Current Pharmacology Reports Pub Date : 2022-01-10 DOI: 10.1007/s40495-021-00274-5

M. S.

引用次数: 1

The Impact of Coenzyme Q10 on Neurodegeneration: a Comprehensive Review 辅酶Q10对神经退行性疾病的影响:一项综合综述

Current Pharmacology Reports Pub Date : 2022-01-06 DOI: 10.1007/s40495-021-00273-6

Monika Kadian, G. Sharma, S. Pandita, Kritika Sharma, Kanishka Shrivasatava, N. Saini, Ashok Kumar

引用次数: 3

Endophthalmitis: Types and Recent Trends in Diagnosis 眼内炎:类型和诊断的最新趋势

Current Pharmacology Reports Pub Date : 2022-01-05 DOI: 10.1007/s40495-021-00278-1

Suryanarayan Sharma, R. Bansal, Sunil Kumar

引用次数: 0

Green Synthesis-Mediated Nanoparticles and Their Curative Character Against Post COVID-19 Skin Diseases. 绿色合成介导的纳米颗粒及其对COVID-19后皮肤病的治疗作用

Current Pharmacology Reports Pub Date : 2022-01-01 Epub Date: 2022-09-09 DOI: 10.1007/s40495-022-00303-x

Nivedhitha Kabeerdass, Selvankumar Thangaswamy, Vaithilingam Mohanasrinivasan, Chandrasekaran Rajasekaran, Selvakumar Sundaram, Thajuddin Nooruddin, Maghimaa Mathanmohun

{"title":"Green Synthesis-Mediated Nanoparticles and Their Curative Character Against Post COVID-19 Skin Diseases.","authors":"Nivedhitha Kabeerdass, Selvankumar Thangaswamy, Vaithilingam Mohanasrinivasan, Chandrasekaran Rajasekaran, Selvakumar Sundaram, Thajuddin Nooruddin, Maghimaa Mathanmohun","doi":"10.1007/s40495-022-00303-x","DOIUrl":"https://doi.org/10.1007/s40495-022-00303-x","url":null,"abstract":"Purpose of review: This article provides the explanatory manuscript regarding the SARS-Corona virus 2. Sub-titled as the history of single-stranded RNA, internal characters of COVID-19, resource, the life cycle of COVID-19, reservoir of the disease, secondary infections of COVID-19 and nano herbal remedy.Recent findings: The skin is not the main target of the SARS-corona virus 2 infections but somehow directly or indirectly, it causes exacerbating eruptions on the skin. Recent research shows that curcumin-mediated synthesized AgNPs show its potential character in the entry of respiratory syncytial virus (RSV), blocks interaction with the viral surface, and damages the viral protein. In modern days, molecular docking studies fabricated copper iodide flower extract (CuI-FE) which shows tough inhibitory action against COVID-19. Many articles show green synthesis-mediated nanoparticles like silver, gold, zinc, copper, iron, titanium dioxide, selenium, and cadmium which possess high anti-viricidal activity.Summary: The anti-oxidant, anti-viral, anti-inflammatory, anti-hive rich plant-mediated nanoparticle synthesis might be an alternative betterment, cost-effective, and eco-friendly medication for the skin disease caused by SARS-corona virus 2 (the viral clinical signs are itchy, hives, rashes, papules, psoriasis, and inflammation) and (non-viral clinical signs-pressure urticaria, contact dermatitis, and acne) that occurred as the result of COVID-19.","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"8 6","pages":"409-417"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40357656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Nutritional Aspects of People Living with HIV (PLHIV) Amidst COVID-19 Pandemic: an Insight. 艾滋病毒感染者（PLHIV）在 COVID-19 大流行中的营养问题：透视。

Current Pharmacology Reports Pub Date : 2022-01-01 Epub Date: 2022-08-06 DOI: 10.1007/s40495-022-00301-z

Fathima A S, Maxima Madhu, V Udaya Kumar, Sameer Dhingra, Nitesh Kumar, Sanjiv Singh, V Ravichandiran, Krishna Murti

{"title":"Nutritional Aspects of People Living with HIV (PLHIV) Amidst COVID-19 Pandemic: an Insight.","authors":"Fathima A S, Maxima Madhu, V Udaya Kumar, Sameer Dhingra, Nitesh Kumar, Sanjiv Singh, V Ravichandiran, Krishna Murti","doi":"10.1007/s40495-022-00301-z","DOIUrl":"10.1007/s40495-022-00301-z","url":null,"abstract":"Purpose of review: This review elaborates the role of malnutrition in PLHIV (people living with HIV) in the context of COVID-19 and emphasis the need of supplementation, dietary intervention, and nutritional counselling in the post-COVID era. One of the most critical challenges among HIV/AIDS patients is malnutrition since it weakens the immune system and increases risk to opportunistic infections. In HIV (human immunodeficiency virus) infection, weight loss is prevalent due to reduced nutritional consumption, malabsorption, abnormal metabolism, and antiretroviral therapy. Sufficient nutrition is required for optimal immune function, as a result, food therapy is now considered an important adjuvant in the treatment of HIV patients.Recent findings: Nutritional intervention, such as the use of dietary supplements, can help to prevent nutrient deficiency, lowering the death risk among malnourished HIV population. Immunocompromised individuals are at very high risk for COVID-19 and malnutrition increases the risk of infection by multiple folds. Interventions, such as nutrition education and counselling are important, to improve the condition of HIV Patients by optimising their nutritional status.Summary: A balanced diet should be one of the most important priorities in preventing PLHIV against the potentially deadly consequences of COVID-19. It is to be ensured that HIV-positive persons continue to get enough and appropriate assistance, such as nutrition and psychological counselling, in the context of COVID-19 infection. The use of telemedicine to maintain nutritional intervention can be beneficial. To meet their nutritional needs and minimise future difficulties, PLHIV infected with COVID-19 should get specialised nutritional education and counselling.Graphical abstract: ","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"8 5","pages":"350-364"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40697410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0