Dermatologica最新文献_第9页

Prevalence of atopy in vitiligo. A preliminary report. 白癜风的特应性患病率。初步报告。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247798

L Perfetti, M Cespa, A Nume, G Orecchia

引用次数: 21

Skin bioengineering in the noninvasive assessment of cutaneous aging. 皮肤生物工程在皮肤老化无创评估中的应用。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247727

E Berardesca, N Farinelli, G Rabbiosi, H I Maibach

引用次数: 30

Immunohistochemical evidence of skin immune system involvement in vulvar lichen sclerosus et atrophicus. 外阴硬化及萎缩性地衣皮肤免疫系统受累的免疫组化证据。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247730

P Carli, A Cattaneo, N Pimpinelli, A Cozza, G Bracco, B Giannotti

引用次数: 46

Circumscribed pilary dysembryoplasia of the palms. 手掌有局限的毛胚发育不良。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247741

F Camacho, R G Cámpora

引用次数: 1

Tumor of follicular infundibulum. 滤泡漏斗肿瘤。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247640

B Koch, T Rufli

引用次数: 6

Neutrophilic eccrine hidradenitis. 中性粒细胞分泌性汗腺炎。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247641

B Vion, H Alvero

引用次数: 14

CO2 laser therapy for steatocystoma multiplex. 二氧化碳激光治疗多发性脂肪囊瘤。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247704

A Krähenbühl, A Eichmann, M Pfaltz

引用次数: 28

Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis. 特应性皮炎患者外周血单核白细胞糖皮质激素治疗前后糖皮质激素受体浓度升高。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247646

M Rupprecht, R Rupprecht, J Kornhuber, N Wodarz, H U Koch, P Riederer, O P Hornstein

{"title":"Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis.","authors":"M Rupprecht, R Rupprecht, J Kornhuber, N Wodarz, H U Koch, P Riederer, O P Hornstein","doi":"10.1159/000247646","DOIUrl":"https://doi.org/10.1159/000247646","url":null,"abstract":"The number and affinity of glucocorticoid binding sites in peripheral mononuclear leukocytes of patients with atopic dermatitis (AD) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment. Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors (GR) per cell than the control group (n = 22), while the GR affinity did not differ. Methylprednisolone treatment resulted in a significant reduction of the GR sites per cell in the steroid-treated control group (n = 10) in contrast to the patients. The dissociation constant was not affected by methylprednisolone treatment in either group. In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and cAMP-phosphodiesterase activity, the elevated GR concentrations in AD lend support to the hypothesis of a compensatory GR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP-induced GR expression.","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247646","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12825769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Lack of correlation between in vitro immunological alterations and the development of scleroderma-like skin lesions in toxic oil syndrome patients. 体外免疫改变与中毒性油综合征患者硬皮病样皮肤病变发展之间缺乏相关性。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247651

C Gutiérrez, M J Aparicio, M J Sánchez, E Cabrero

{"title":"Lack of correlation between in vitro immunological alterations and the development of scleroderma-like skin lesions in toxic oil syndrome patients.","authors":"C Gutiérrez, M J Aparicio, M J Sánchez, E Cabrero","doi":"10.1159/000247651","DOIUrl":"https://doi.org/10.1159/000247651","url":null,"abstract":"We examined whether immunological disturbances could influence the development of scleroderma-like skin lesions in patients affected by the Spanish toxic oil syndrome (TOS). To this end, peripheral blood mononuclear cells (PBMC) were collected from 13 chronic patients and 8 control subjects. All patients had suffered a toxic-induced severe neuromyopathy, and 6, in addition, had developed sclerodermoid skin manifestations. The phenotypic profile and the concentrations of interleukin-2 (IL-2) and of molecules with B cell differentiation factor IgG activity (BCDF-IgG) in supernatants of phytohemagglutinin-stimulated lymphocytes were analyzed both in patients and in normal controls. Molecules with BCDF-IgG activity were found increased in supernatants of mitogen-stimulated lymphocytes from TOS patients. Concentrations of IgG secreted by staphylococcus aureus-SAC-B blasts in the presence of TOS PBMC supernatant was 88 +/- 32.62 ng/ml (mean +/- 1 SD) versus 53 +/- 5.34 ng/ml in the presence of control supernatant (p less than 0.01). Levels of BCDF-IgG activity in TOS PBMC supernatants positively correlated with IgG serum levels (r = 0.69, p less than 0.01). The phenotypic profile of lymphocyte populations and the production of IL-2 were not altered in TOS subjects. No statistically significant differences were observed in the lymphocyte distribution nor in the IL-2 and BCDF-IgG production when comparing patients with or without scleroderma-like skin lesions. The results indicate that there was a dysfunction of the immune response in TOS subjects, which, however, was not sufficient for the development of the sclerodermoid lesions.","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12906415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of topical calcipotriol on calcium metabolism in psoriatic patients: comparison with oral calcitriol. 局部钙三醇对银屑病患者钙代谢的影响:与口服骨化三醇的比较。

Dermatologica Pub Date : 1991-01-01 DOI: 10.1159/000247699

D Gumowski-Sunek, R Rizzoli, J H Saurat

{"title":"Effects of topical calcipotriol on calcium metabolism in psoriatic patients: comparison with oral calcitriol.","authors":"D Gumowski-Sunek, R Rizzoli, J H Saurat","doi":"10.1159/000247699","DOIUrl":"https://doi.org/10.1159/000247699","url":null,"abstract":"The analogue of calcitriol, calcipotriol (MC 903, Daivonex) has been proven effective in the treatment of psoriasis, when given topically. However, the possible influence of cutaneously absorbed MC 903 on calcium metabolism is still unclear. We evaluated various parameters of calcium metabolism in 17 psoriatic patients treated for 5.4 +/- 2.3 (mean +/- SD) weeks with MC 903, on 16 +/- 6% of the body surface. The dose administered (100 g of Daivonex corresponding to 5 mg of MC 903) decreased the PASI score by 40.9 +/- 20.0% (p less than 0.001). Among these patients, 12 were studied before and after MC 903 therapy. In none could be detected any change in protein-adjusted calcium, ionized Ca, plasma levels of creatinine, alkaline phosphatase, osteocalcin, intact parathyroid hormone (PTH), calcidiol and calcitriol, or in daily or fasting urinary excretion of Ca or cAMP. After an MC-903-free period, 9 patients received 1.5 micrograms/day of calcitriol orally for 7 days. Whereas this treatment did not control the skin relapse in most of the patients, it induced a significant increase in plasma levels of protein-adjusted Ca and calcitriol, and in 24-hour urinary Ca excretion, as well as a significant fall in PTH as compared with pretreatment values. These results indicate that 150 micrograms/day of MC 903, despite a possible 1% absorption, i.e. a systemic dose of 1.5 micrograms, did not produce any detectable alteration of Ca metabolism, whereas an equivalent dose of oral calcitriol was associated with significant changes. The threshold dose of topical calcipotriol that might induce alterations similar to 1.5 micrograms/day of oral calcitriol remains to be evaluated.","PeriodicalId":11117,"journal":{"name":"Dermatologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000247699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12970566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18