特应性皮炎患者外周血单核白细胞糖皮质激素治疗前后糖皮质激素受体浓度升高。

Dermatologica Pub Date : 1991-01-01 DOI:10.1159/000247646
M Rupprecht, R Rupprecht, J Kornhuber, N Wodarz, H U Koch, P Riederer, O P Hornstein
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引用次数: 19

摘要

在基线条件下和经过规定的口服糖皮质激素治疗后,测定了特应性皮炎(AD)患者和健康对照者外周单核白细胞中糖皮质激素结合位点的数量和亲和力。AD患者(n = 15)每个细胞的糖皮质激素受体(GR)明显多于对照组(n = 22),而GR的亲和力没有差异。与患者相比,甲基强的松龙治疗导致类固醇治疗对照组(n = 10)每个细胞的GR位点显著减少。两组的解离常数均未受甲基强的松龙治疗的影响。鉴于糖皮质激素对AD的治疗效果以及cAMP和cAMP-磷酸二酯酶活性异常的发现,AD中GR浓度升高支持了由于内源性皮质醇作用不足或cAMP诱导的GR表达改变而代偿性GR上调的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis.

The number and affinity of glucocorticoid binding sites in peripheral mononuclear leukocytes of patients with atopic dermatitis (AD) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment. Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors (GR) per cell than the control group (n = 22), while the GR affinity did not differ. Methylprednisolone treatment resulted in a significant reduction of the GR sites per cell in the steroid-treated control group (n = 10) in contrast to the patients. The dissociation constant was not affected by methylprednisolone treatment in either group. In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and cAMP-phosphodiesterase activity, the elevated GR concentrations in AD lend support to the hypothesis of a compensatory GR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP-induced GR expression.

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