{"title":"Guidelines and Recommendations Towards Evidence-Based Management of Systemic Sclerosis","authors":"S. Johnson, K. Devakandan","doi":"10.1007/s40674-019-00120-2","DOIUrl":"https://doi.org/10.1007/s40674-019-00120-2","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"104 1","pages":"115-126"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86260266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interstitial Lung Disease in Systemic Sclerosis: Lessons Learned from Idiopathic Pulmonary Fibrosis","authors":"Augustine Chung, J. English, E. Volkmann","doi":"10.1007/s40674-019-00121-1","DOIUrl":"https://doi.org/10.1007/s40674-019-00121-1","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"92 1","pages":"127-146"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73727523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Insight into the Contrasting Findings of Therapeutic Trials of Digital Ischaemic Manifestations of Systemic Sclerosis","authors":"J. Pauling, V. Nagaraja, D. Khanna","doi":"10.1007/s40674-019-00118-w","DOIUrl":"https://doi.org/10.1007/s40674-019-00118-w","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"130 1","pages":"85-103"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73763618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Diffuse Cutaneous Systemic Sclerosis with Biologics, Small Molecules and Stem Cell Transplantation: What Is the Evidence to Date?","authors":"B. Kersten, M. Vonk","doi":"10.1007/s40674-019-00119-9","DOIUrl":"https://doi.org/10.1007/s40674-019-00119-9","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"15 1","pages":"104-114"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75727921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges and Advances in SLE Autoantibody Detection and Interpretation","authors":"M. Choi, M. Fritzler","doi":"10.1007/s40674-019-00122-0","DOIUrl":"https://doi.org/10.1007/s40674-019-00122-0","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"251 1","pages":"147-167"},"PeriodicalIF":0.0,"publicationDate":"2019-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76343508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Holistic Approach to Pain Management in the Rheumatic Diseases","authors":"Jon Golenbiewski, D. Pisetsky","doi":"10.1007/s40674-019-00116-y","DOIUrl":"https://doi.org/10.1007/s40674-019-00116-y","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"59 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79802066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Update on Treatment of Kawasaki Disease","authors":"R. Pilania, A. Jindal, S. Guleria, Surjit Singh","doi":"10.1007/s40674-019-00115-z","DOIUrl":"https://doi.org/10.1007/s40674-019-00115-z","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"25 1","pages":"36-55"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83662248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Vascular Imaging to Advance Clinical Care and Research in Large-Vessel Vasculitis.","authors":"Kaitlin A Quinn, Peter C Grayson","doi":"10.1007/s40674-019-00114-0","DOIUrl":"10.1007/s40674-019-00114-0","url":null,"abstract":"<p><strong>Purpose of the review: </strong>The two main forms of large-vessel vasculitis (LVV) are giant cell arteritis (GCA) and Takayasu's arteritis (TAK). Vascular imaging can characterize disease activity and disease extent in LVV. This review critically analyzes the clinical utility of vascular imaging in LVV and highlights how imaging may be incorporated into the management and study of these conditions.</p><p><strong>Recent findings: </strong>There are multiple imaging modalities available to assess LVV including ultrasonography, CT angiography (CTA), magnetic resonance angiography (MRA), and <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET). As these techniques are refined, imaging may be increasingly useful to evaluate the cranial arteries and the aorta and its primary branches. In addition, vascular imaging may be useful to monitor disease activity and may have prognostic value to predict future clinical events.</p><p><strong>Summary: </strong>There are strengths and weaknesses associated with vascular imaging that should be considered when evaluating patients with LVV. Vascular imaging will likely play an increasingly important role in the clinical management of patients and the conduct of research in LVV and may ultimately be incorporated as outcome measures in clinical trials in these conditions.</p>","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"53 1","pages":"20-35"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73438498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut disease in systemic sclerosis - new approaches to common problems.","authors":"Jessica Zhu, Tracy Frech","doi":"10.1007/s40674-019-00117-x","DOIUrl":"10.1007/s40674-019-00117-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>The goal of this manuscript is to discuss the new diagnostic and potential treatment options for gut disease in systemic sclerosis (SSc). The concepts of quantification of gut perfusion and motility is reviewed. The risks of empiric therapeutics and challenges of studying the microbiome in SSc is discussed.</p><p><strong>Recent findings: </strong>There are diagnostics that can provide information on gut perfusion and function that are of value in SSc. Easily implemented diagnostic tests are critical to avoid complications of empiric therapy. The role of the microbiome and drugs that target dysmotility are areas of active research.</p><p><strong>Summary: </strong>SSc-related gastrointestinal tract involvement can be heterogeneous in clinical presentation and disease course. Noninvasive gastrointestinal measurement techniques that quantify neural communications with microvasculature in SSc can potentially guide the proper addition and discontinuation of therapeutics. The role of the microbiome and the role of nitric oxide on gut function are important areas of research for understanding gut dysfunction in SSc.</p>","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"9 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84862497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}