Current Treatment Options in Psychiatry最新文献

{"title":"Ketosis as a Treatment for Severe Mental Illness: A Critical Review of Preclinical and Clinical Data.","authors":"Ifeoluwa Oluwasegun Oduguwa, Daniel J Smith, Arish Mudra Rakshasa-Loots","doi":"10.1007/s40501-026-00394-z","DOIUrl":"https://doi.org/10.1007/s40501-026-00394-z","url":null,"abstract":"<p><strong>Purpose: </strong>Ketogenic interventions, including ketogenic diets, are increasingly being explored as potential treatments for severe mental illnesses. Ketosis - the metabolic state characterised by high circulating levels of ketone bodies - is thought to be central to the beneficial effects of these diets. Hence, it is plausible that other interventions that induce ketosis may similarly improve mental health outcomes. Here, we critically appraise the evidence surrounding the use of ketosis-inducing interventions for the treatment of severe mental illness.</p><p><strong>Recent findings: </strong>Several uncontrolled trials suggest beneficial mental and metabolic health effects of ketogenic diets in depression, bipolar disorder and schizophrenia, but are limited by confounders and expectation bias. The only reported randomised controlled clinical trial so far suggested a small, greater between-group difference in antidepressive effect of a modified ketogenic diet over a phytochemical control diet in treatment-resistant depression, that did not reach statistical significance. Additionally, ketone levels did not correlate with psychiatric outcomes. Preclinical studies suggest a beneficial effect of ketogenic diets on psychiatric symptom correlates but largely did not explore ketone-outcome correlations. Exogenous ketone and oral medium-chain triglyceride supplements induce nutritional ketosis, however, they have not been tested in patients with severe mental illness. Fasting and time-restricted eating produce ketosis but it is unclear if this explains their reported mental health and metabolic effects.</p><p><strong>Summary: </strong>Large, randomised controlled clinical trials are needed to examine and compare the effects of different ketogenic interventions in severe mental illness. Trials should be designed to isolate the role of ketosis, investigate the mechanistic basis of beneficial effects observed, assess dose-response relationships, examine treatment adherence in routine clinical settings, ascertain the duration of treatment effects following discontinuation, and clarify the impact of ketosis-inducing interventions on the need for psychiatric medications and standard care.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40501-026-00394-z.</p>","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"13 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Obsessive-Compulsive Disorder: A Systematic Review.","authors":"Jiyeong Kim, Juan Pablo Gonzalez Pacheco, Ashleigh Golden, Elias Aboujaoude, Peter van Roessel, Aayushi Gandhi, Pavithra Mukunda, Tatevik Avanesyan, Haopeng Xue, Ehsan Adeli, Jane Paik Kim, Manish Saggar, Shannon Wiltsey Stirman, Eric Kuhn, Kaustubh Supekar, Kilian M Pohl, Carolyn I Rodriguez","doi":"10.1007/s40501-025-00359-8","DOIUrl":"10.1007/s40501-025-00359-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obsessive-compulsive disorder (OCD) is a chronic and disabling condition, often leading to significant functional impairments. Despite its early onset, there is an average delay of 17 years from symptom onset to diagnosis and treatment, resulting in poorer outcomes. This systematic review aims to synthesize current findings on the application of AI in OCD, highlighting opportunities for early symptom detection, scalable therapy training, clinical decision support, novel therapeutics, computer vision-based approaches, and multimodal biomarker discovery.</p><p><strong>Recent findings: </strong>While previous reviews focused on biomarker-based OCD detection and treatment using machine learning (ML), the findings of the current review add information about novel applications of deep learning technology, specifically generative artificial intelligence (GenAI) and natural language processing (NLP). Among the included 13 articles, most studies (84.6%) utilized secondary data analyses, primarily through GenAI/NLP. Nearly 77% of these studies were published in the past two years, with high quality of evidence. The primary focus areas were enhancing treatment and management, and timely OCD detection (both 38.5%); followed by AI tool development for broader mental health applications.</p><p><strong>Summary: </strong>AI technologies offer transformative potential for improvements related to OCD if diagnosis occurs earlier after onset; thereby lessening the consequential economic burden. Prioritizing investment in ethically sound AI research could significantly improve OCD outcomes in mental health care.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40501-025-00359-8.</p>","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"12 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating the Mitochondria for Mood Disorders: Emerging Evidence for Transcranial Photobiomodulation in Major Depressive Disorder","authors":"Naomi L. Gaggi, Zamfira Parincu, Kari Siu, Katherine A. Collins, D. Iosifescu","doi":"10.1007/s40501-024-00321-0","DOIUrl":"https://doi.org/10.1007/s40501-024-00321-0","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"38 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Military Moral Injury: Current Controversies and Future Care","authors":"Chris J. Antal, Julie Byrnes, Kelly Denton‐Borhaug, Jack Saul","doi":"10.1007/s40501-024-00317-w","DOIUrl":"https://doi.org/10.1007/s40501-024-00317-w","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"108 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Digital Interventions for Relapse Prevention, Illness Self‑Management, and Health Promotion In Schizophrenia: Recent Advances, Continued Challenges, and Future Opportunities","authors":"Anand Chukka, Soumya Choudhary, Siddharth Dutt, A. Bondre, Preethi Reddy, D. Tugnawat, A. R. Rozatkar, U. Mehta, N. Manjunatha, M. Keshavan, Vikram Patel, S. Math, Channaveerachari Naveen Kumar, J. Thirthalli, A. Bhan, John Torous, John A. Naslund","doi":"10.1007/s40501-024-00320-1","DOIUrl":"https://doi.org/10.1007/s40501-024-00320-1","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"59 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Interventions for Adolescents and Young Adults Experiencing Self-Injurious Thoughts and Behaviors","authors":"K. P. Kruzan, Candice Biernesser, Jennifer A. Hoffmann, J. Meyerhoff","doi":"10.1007/s40501-024-00318-9","DOIUrl":"https://doi.org/10.1007/s40501-024-00318-9","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"58 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Digital Media to Promote Youth Mental Health: Flipping the Script on Social Media-Related Risk","authors":"Jessica L. Hamilton, John Torous, Hannah S. Szlyk, C. Biernesser, K. P. Kruzan, Michaeline Jensen, Jazmin Reyes-Portillo, Brian A. Primack, Jamie Zelazny, Paul Weigle","doi":"10.1007/s40501-024-00315-y","DOIUrl":"https://doi.org/10.1007/s40501-024-00315-y","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"35 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media and Early Psychosis Intervention: A Comprehensive Review of the Literature","authors":"Iris Li, Abram Estafanous, M. de Choudhury, Mario Alvarez-Jimenez, Michael L. Birnbaum","doi":"10.1007/s40501-024-00314-z","DOIUrl":"https://doi.org/10.1007/s40501-024-00314-z","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"36 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of the Components of Moral Resilience: Its Role in Addressing Moral Injury or Moral Distress for High-Risk Occupation Workers","authors":"Temitope Osifeso, Sierra J. Crocker, L. Lentz, Lorraine Smith-MacDonald, Merna Seliman, Gojjam Limenih, Renée S. MacPhee, G. Anderson, S. Brémault-Phillips, David Malloy, R. Carleton","doi":"10.1007/s40501-023-00310-9","DOIUrl":"https://doi.org/10.1007/s40501-023-00310-9","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139002525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Interventions for Relapse Prevention, Illness Self-Management, and Health Promotion In Schizophrenia: Recent Advances, Continued Challenges, and Future Opportunities","authors":"Anand Chukka, Soumya Choudhary, Siddharth Dutt, A. Bondre, Preethi Reddy, D. Tugnawat, Abhijit R. Rozatkar, U. Mehta, N. Manjunatha, M. Keshavan, Vikram Patel, S. Math, C. Kumar, J. Thirthalli, A. Bhan, J. Torous, John A. Naslund","doi":"10.1007/s40501-023-00309-2","DOIUrl":"https://doi.org/10.1007/s40501-023-00309-2","url":null,"abstract":"","PeriodicalId":11088,"journal":{"name":"Current Treatment Options in Psychiatry","volume":"71 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138604515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}