New Emirates Medical Journal最新文献_第5页

The Implication of Behavioral and Molecular Factors on COVID-19 Infection 行为和分子因素对COVID-19感染的影响

New Emirates Medical Journal Pub Date : 2023-05-25 DOI: 10.2174/0250688204666230525104823

H. Omran, Safaa M. Imran, M. Almaliki, Q. Mohammed, Duna Alrudani, Mohammed Mossa Imran

{"title":"The Implication of Behavioral and Molecular Factors on COVID-19 Infection","authors":"H. Omran, Safaa M. Imran, M. Almaliki, Q. Mohammed, Duna Alrudani, Mohammed Mossa Imran","doi":"10.2174/0250688204666230525104823","DOIUrl":"https://doi.org/10.2174/0250688204666230525104823","url":null,"abstract":"\u0000\u0000Worldwide, more than 6 million individuals have passed away in the two years since the pandemic began. The mortality and infection rates for men and women differ significantly across the several nations impacted by SARS-CoV-2. Many features of the SARS-CoV-2 replication cycle are influenced by several processes. The numerous ways in which genetic, epigenetic, or behavioral mechanisms affect the viral life cycle and the host's immune response to infection have led to identifying potential markers. COVID-19 causes various symptoms, from minor respiratory symptoms to fatal respiratory syndrome, with men, regardless of age, having a worsened illness course than women and a higher mortality rate.\u0000 Gender differences in illness progression can be attributed to genetic variables like chromosomal characteristics and behavioral factors like hygiene behaviors. In this review, we extracted data from various WHO guidelines and other articles and the main molecular and behavioral mechanisms involved in COVID-19 disease are highlighted. Exploration of these factors may explain why COVID-19 affects gender differently.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129839385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Related Complications During Pregnancy: A Systematic Review 妊娠期COVID-19相关并发症:系统综述

New Emirates Medical Journal Pub Date : 2023-05-19 DOI: 10.2174/0250688204666230519145707

Basheer Abdullah Marzoog

{"title":"COVID-19 Related Complications During Pregnancy: A Systematic Review","authors":"Basheer Abdullah Marzoog","doi":"10.2174/0250688204666230519145707","DOIUrl":"https://doi.org/10.2174/0250688204666230519145707","url":null,"abstract":"\u0000\u0000The topic of COVID-19 (coronavirus disease)-associated complications during pregnancy is poorly postulated and remains an area that requires elucidation for the underlying pathophysiology mechanism in order to evaluate a new therapeutic strategy and optimize current therapies.\u0000\u0000\u0000\u0000The study aimed to assess the proportion of associated complications with COVID-19 and the underlying pathophysiology in pregnant women.\u0000\u0000\u0000\u0000The MedLine and Embase databases were searched for studies relevant to the study topic.\u0000\u0000\u0000\u0000Preterm delivery and C-section have been found to be the most frequently reported complications. Approximately, 28.55% of pregnant women with symptomatic COVID-19 have been reported to require a C-section and 8.8% preterm delivery. In addition, anxiety and depression have also been frequently reported in 57% and 37% of pregnant women, respectively.\u0000\u0000\u0000\u0000Symptomatic pregnant women with COVID-19 have a high risk of preterm labor, mortality and morbidity rates, and C-section requirements. The underlying pathophysiology of COVID-19-associated complications during pregnancy includes homeostatic disturbances of the immune system, pulmonary system, and hemostatic system. In addition to endothelial dysfunction, excessive immune response, coagulopathy, hypoxemia, and hypotension are involved in the pathogenesis that negatively affects neonates' health outcomes.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126448931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Collagenous Colitis associated with Celiac Disease 病例报告:胶原性结肠炎与乳糜泻相关

New Emirates Medical Journal Pub Date : 2023-05-15 DOI: 10.2174/0250688204666230515090441

Maher Malaeb, Sameera Mahboub, A. Howeedy

引用次数: 0

Appraisal of an Innovative Surgical Approach in treating Odontogenic Keratocyst 一种治疗牙源性角化囊肿的创新手术方法的评价

New Emirates Medical Journal Pub Date : 2023-05-15 DOI: 10.2174/0250688204666230515090459

Ananya Bej, Sthitaprajna Lenka, R. Nagarajappa, S. Sahoo, S. Subudhi, Karishma Rathore, Aditi Ava Rath

{"title":"Appraisal of an Innovative Surgical Approach in treating Odontogenic Keratocyst","authors":"Ananya Bej, Sthitaprajna Lenka, R. Nagarajappa, S. Sahoo, S. Subudhi, Karishma Rathore, Aditi Ava Rath","doi":"10.2174/0250688204666230515090459","DOIUrl":"https://doi.org/10.2174/0250688204666230515090459","url":null,"abstract":"\u0000\u0000To estimate the recurrence of odontogenic keratocyst (OKCs) and increment of bone height upon an innovative treatment protocol of the OKC, i.e., enucleation along with the adjuvant therapy of Carnoy’s solution, followed by marsupialization.\u0000\u0000\u0000\u0000Twenty cases of OKC treated at the Department of Oral and Maxillofacial Surgery from 2020-2021 were studied retrospectively. Clinical, radiological features and histologic features were reviewed. The patients diagnosed with OKCs were planned for enucleation with the use of Carnoy's solution and followed by marsupialization. Recurrence of the same and bone formation was analyzed concerning sites of involvement, based upon the gender and age group of patients, after undergoing the proposed treatment.\u0000\u0000\u0000\u0000Mean age of the patients was 35.15±13.02, ranging from 11 to 56 years. Most (85%) patients were symptomatic, and the remaining (15%) were asymptomatic and diagnosed on a routine check-up. Males (65%) were mostly affected than females (35%). Mandible (75%) was the most frequent site of occurrence. Most lesions were diagnosed histologically as OKC on incisional biopsy. All patients were followed for six months, an increment of 11.11±1.68mm bone height was seen, and none reported recurrence.\u0000\u0000\u0000\u0000The steady growth of bone without any cases of recurrence was reported. Hence, clinicians can consider enucleation along with adjuvant therapy using Carnoy's solution followed by marsupialization as the treatment of choice.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126498123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 1 diabetes mellitus clinical profile and follow-up - North Emirate hospitals’ experience 1型糖尿病的临床概况和随访-北酋长国医院的经验

New Emirates Medical Journal Pub Date : 2023-05-08 DOI: 10.2174/0250688204666230508115858

M. Jhancy, Ghofran Osman, Areen Yousef, Dana Sarmini, Subhranshu Sekhar Kar

{"title":"Type 1 diabetes mellitus clinical profile and follow-up - North Emirate hospitals’ experience","authors":"M. Jhancy, Ghofran Osman, Areen Yousef, Dana Sarmini, Subhranshu Sekhar Kar","doi":"10.2174/0250688204666230508115858","DOIUrl":"https://doi.org/10.2174/0250688204666230508115858","url":null,"abstract":"\u0000\u0000Type 1 Diabetes mellitus (DM) is a chronic metabolic disorder in children and adolescents due to insulin deficiency. The disease is more common below 19 years of age with two peaks of incidence, one at 4-6 years and the other peak at early puberty (10-14 years). There is a gradual increase in the incidence of type 1 DM and a rise in incidence at 10,200 cases per year in the Middle East. Chronic type-1 diabetic patients develop microvascular and macrovascular complications.\u0000\u0000\u0000\u0000The present retrospective cross-sectional study aims to describe the experience on the clinical profile, morbidity profile, and comorbidities of Type1 DM in children below 15 years of age admitted to the SAQR and Fujairah hospitals in the Northern part of United Arab Emirates (UAE) from 1st January 2017 to 31st December 2019. The study material was the digital medical records of children below 15 years who got admitted to emergency and pediatric wards with type 1 Diabetes mellitus (T1DM) in SAQR and Fujairah hospitals.\u0000\u0000\u0000\u0000Total admissions during the study period were 98. At the time of diagnosis, 12.2% of children were below five years of age, whereas 87.75% were more than five years. All 98 children were UAE nationals, of which 52% were males and 48% were females. 50% of our study population has a strong family history of either type 1 or type 2 diabetes mellitus, of which 12.2% of siblings of the study population had T1DM. The first symptoms in 58% and 57% of children were polyuria and polydipsia. Among 90 % of children under follow-up for three years, one child developed microalbuminuria, three developed systolic hypertension, and 8% were lost to follow-up.\u0000\u0000\u0000\u0000The present study highlights the need for future prospective studies in the UAE to know the actual burden of the disease with an emphasis on early screening.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124015361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Matrix Metalloproteinase-9, Neuron-Specific Enolase, S100 B and Tau Protein Levels in the Patients with Carbon monoxide Poisoning 一氧化碳中毒患者基质金属蛋白酶-9、神经元特异性烯醇化酶、s100b和Tau蛋白水平的变化

New Emirates Medical Journal Pub Date : 2023-05-08 DOI: 10.2174/0250688204666230508115135

M. Boğan, B. Can, S. Zengin, Şevki Hakan Eren, M. Sabak, Bedia Gülen, H. Ulusal, Mehmet Mustafa Sunar, Muhammet Esat Karaduman, S. Taysı

{"title":"Matrix Metalloproteinase-9, Neuron-Specific Enolase, S100 B and Tau Protein Levels in the Patients with Carbon monoxide Poisoning","authors":"M. Boğan, B. Can, S. Zengin, Şevki Hakan Eren, M. Sabak, Bedia Gülen, H. Ulusal, Mehmet Mustafa Sunar, Muhammet Esat Karaduman, S. Taysı","doi":"10.2174/0250688204666230508115135","DOIUrl":"https://doi.org/10.2174/0250688204666230508115135","url":null,"abstract":"\u0000\u0000S100B, NSE, MMP-9, and Tau protein levels increase in cases causing hypoxic cell damage. The diagnosis of the severity of carbon monoxide (CO) poisoning in the early period of these parameters was studied.\u0000\u0000\u0000\u0000COHb level measurement was made using a signal capture CO-pulse oximeter (Masimo's SET Rainbow, Masimo's Co, USA) at the first admission of the patients. Then, COHb levels were confirmed by arterial blood gas(ABG) analysis. The patients were divided into two groups as mild and moderate-severe, according to their Glasgow coma scores (GCS) [Mild (14–15); Moderate (9–13) or Severe (3–8)]. The control group was composed of 16 healthy and non-smoking volunteers.\u0000\u0000\u0000\u0000The serum S100B protein and MMP-9 values at 0 hr of admission in the hospital and 3hr of treatment were not significantly different in the patient group as compared to the control group. Tau protein levels were significantly higher in the patient group at 0 and 3 hours (p> 0.05) as compared to healthy person.\u0000\u0000\u0000\u0000There was no relationship between CO poisoning and MMP-9 and S100B protein levels. NSE and Tau protein were significantly higher in the patient group than the control group. Tau protein may be more useful marker as compared to neuron-specific enolase.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117335042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caveolae’s Behavior in Norm and Pathology 规范与病理中的小窝行为

New Emirates Medical Journal Pub Date : 2023-05-08 DOI: 10.2174/0250688204666230508112229

Basheer Abdullah Marzoog

{"title":"Caveolae’s Behavior in Norm and Pathology","authors":"Basheer Abdullah Marzoog","doi":"10.2174/0250688204666230508112229","DOIUrl":"https://doi.org/10.2174/0250688204666230508112229","url":null,"abstract":"\u0000\u0000Caveolins are universal multifunctional physiologically active microparticles that collaborate in the caveolae formation to maintain the metabolic homeostatic balance of the cells. In fact, remarkable advances in the molecular biopathology of caveolae have been made in recent years by exploring the role of caveolae in norm and physiopathology.\u0000\u0000\u0000\u0000The current literature data on the caveolae behavior in norm and pathology were revised.\u0000\u0000\u0000\u0000Caveolae are expressed in various cell types, highly concentrated in endothelial cells, cardiomyocytes, and epithelial cells. Physiologically, caveolae contribute to maintaining a signaling balance between the various homeostatic processes, including pro-growth and pro-survival, such as endothelial nitric oxide synthase, glycogen synthase kinase-3β, p42/p44 mitogen-activated protein kinase, PKA, SFK, PKC, Akt through regulation of tyrosine kinases, G protein-coupled receptor, endothelial nitric oxide synthase, and MAPK pathways, and their signaling dysfunction is directly attributed to the pathogenesis of cardiovascular diseases, regeneration inhibition, neurodegenerative diseases, infection, osteoporosis, diabetes, and tumour induction and progression.\u0000\u0000\u0000\u0000Regulation of the ratio and penetrance of caveolae activity/expression is a clinically significant potential therapeutic strategy to enhance the current therapies and eliminate the etiopathogenetic pathway of rising homeostatic disorders.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132018300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of Cardiac Cell Injury in Post-Covid-19 Syndrome covid -19综合征后心肌细胞损伤的病理生理学研究

New Emirates Medical Journal Pub Date : 2023-04-28 DOI: 10.2174/0250688204666230428120808

Basheer Abdullah Marzoog

引用次数: 1

Veno-occlusive Priapism: An Undesirable Outcome of Warfarin Therapy: A Case Report 静脉闭塞性阴茎勃起:华法林治疗的不良后果:一例报告

New Emirates Medical Journal Pub Date : 2023-04-26 DOI: 10.2174/0250688204666230426122302

Mohd Zulkimi Roslly, Shameem Sulaiman, Anis Suhana Hashim

{"title":"Veno-occlusive Priapism: An Undesirable Outcome of Warfarin Therapy: A Case Report","authors":"Mohd Zulkimi Roslly, Shameem Sulaiman, Anis Suhana Hashim","doi":"10.2174/0250688204666230426122302","DOIUrl":"https://doi.org/10.2174/0250688204666230426122302","url":null,"abstract":"\u0000\u0000Priapism is one of the urological emergencies requiring prompt medical or surgical intervention. The clinical diagnosis is made with adjunct cavernosal blood gas analysis and colour doppler ultrasound to determine the underlying aetiology; ischaemic or non-ischaemic, and the majority are veno-occlusive in origin (ischaemic). The occurrence of warfarin-induced priapism complicated with penile necrosis is a rare occurrence, and many cases are related to protein C deficiency.\u0000\u0000\u0000\u0000We report a case of warfarin therapy initiation following a thromboembolic event as a sequela of Covid-19 infection, subsequently developed veno-occlusive priapism complicated with penile gangrene despite being in an overwarfarinized state. The penis was non-salvageable following the gangrenous event, even with prior cavernosal blood aspiration. Thrombophilia panel screening, which includes Protein C activity, was done, where the protein C activity was low, measuring 23%. Unfortunately, he succumbed to death due to severe cardiorespiratory complications before this blood result was ready.\u0000\u0000\u0000\u0000Prompt diagnosis and treatment of priapism is needed to prevent loss of penile function. Priapism as a sequela of anticoagulant therapy should be suspected in a patient with recent anticoagulant initiation. Thus, immediate treatment can be administered to correct the underlying coagulation disorder.\u0000\u0000\u0000\u0000The development of veno-occlusive priapism and penile gangrene in a patient on warfarin therapy raises a concern about protein C deficiency.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"32 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114098671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial Infection in Head and Neck Space Regions: A Narrative Review 头颈间隙区细菌感染:叙述性回顾

New Emirates Medical Journal Pub Date : 2023-04-17 DOI: 10.2174/0250688204666230417083058

Shakti Rath, S. Lenka, S. Kumar Swain, Debasmita Dubey

{"title":"Bacterial Infection in Head and Neck Space Regions: A Narrative Review","authors":"Shakti Rath, S. Lenka, S. Kumar Swain, Debasmita Dubey","doi":"10.2174/0250688204666230417083058","DOIUrl":"https://doi.org/10.2174/0250688204666230417083058","url":null,"abstract":"\u0000\u0000Head and neck infection (HNI) is more complicated, as most of the sites of infection in the head and neck regions are very complex. Bacterial head and neck infections can usually originate through the upper airway, sinusitis, and dental or oral cavity and then extend deeper into other head and neck compartment sites. Both aerobic and anaerobic bacteria induce bacterial head and neck infections. This narrative review discusses the bacterial association, sites of infection, host-pathogen interaction, and secondary complications of head and neck bacterial infection. Staphylococcus aureus, Klebsiella, Escherichia coli, Peptostreptococcus, Pseudomonas putida, Pseudomonas aeruginosa, Acinetobacter, Citrobacter freundii, Streptococcus gordonii Enterobacter, Gemella haemolysans, Haemophilus influenzae, and Enterococcus, Fusobacterium are commonly responsible bacteria behind the bacterial head and neck infection (BHNI). Immunosuppression, alcohol consumption, and smoking risk factors are associated with it. The immune cell maintains a defense mechanism in host-pathogen interaction. Antibiotic-resistant genes in mucoid biofilm raise multidrug resistance activity against pathogenic bacteria. Inflammatory condition of the complete head and neck region can be demonstrated by computed tomography (CT) scan. The secondary complication may lead to induce cancer. Microbial invasions can be bacterial, fungal, or viral.\u0000","PeriodicalId":110816,"journal":{"name":"New Emirates Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123342403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0