Dermatosen in Beruf und Umwelt. Occupation and environment最新文献_第7页

[Sensitization to nickel sulfate in patients with ileitis terminalis (Crohn disease)]. [终末回肠炎(克罗恩病)患者对硫酸镍的致敏]。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-09-01

H Schöfer, G Rosenberger, C Hottenrott, W D Strohm, H J Burmester, B Gonnermann, O Hensel

引用次数: 0

[Determination of the irritating potential of environmental substances in an epidermal cell suspension in vitro]. [体外测定表皮细胞悬浮液中环境物质的刺激电位]。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-09-01

B Wilke, I Hoth, B Bandemir

{"title":"[Determination of the irritating potential of environmental substances in an epidermal cell suspension in vitro].","authors":"B Wilke, I Hoth, B Bandemir","doi":"","DOIUrl":"","url":null,"abstract":"A simple in vitro screening method was established, which allows estimation of the effect of environmental products on cell alteration or irritative potential. Primary cell suspensions, prepared from the epidermis of guinea pig ears through trypsination (0.2%) over night at 4 degrees C, were used. The cell suspension (3 mill./ml) and test substances were mixed in equal portions (500 microliters) and incubated at room temperature for approximately 90 min. The degree of cell alteration was determined by the trypan blue exclusion test. Chemically defined substances as well as disinfectants were employed. The cell alteration was clearly dependent upon substance concentration as well as incubation time. On the basis of the mean alteration time (AT50) measured in vitro, and the mean irritation time (IT50) determined in the patch test in vivo, the substances were ranked according to strength of cell alteration or irritative potency in vitro and in vivo. A good correlation (Spearman's rank correlation, rs = 0.76) was found between the in vitro and in vivo results. Thus, this method is suited for the screening of chemical products especially in industrial laboratories.","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"36 5","pages":"147-52"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14363274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational contact psoriasis. 职业性接触性牛皮癣。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-09-01

P Moroni, R Cazzaniga, F Pierini, V Panella, R Zerboni

引用次数: 0

[Tattooing dyes]. (纹身染料)。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-09-01

G Lehmann, P Pierchalla

引用次数: 0

Adverse reactions of externally applied drugs and inert substances. 外用药物和惰性物质的不良反应。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-07-01

A Zesch

{"title":"Adverse reactions of externally applied drugs and inert substances.","authors":"A Zesch","doi":"","DOIUrl":"","url":null,"abstract":"The lack of a first-pass effect for locally-applied substances is often not considered. This is especially true for such central nervous system agents as salicylic acid, hexachlorophene or caffeine which have a relatively low toxicity when applied orally. Manifestation of dermal irritation, such as a beginning rash or inflammation, are often tolerated because the beneficial effects of some topically applied substances outweight the damage (Dithranol, 5-Fluorouracil). This applies to some anti-phlogistics as well, which may also cause skin irritation. Some substances, such as benzoyl peroxide, vitamin-A acid and beta-estradiol have direct or indirect desiccative effects so that skin irritations may occur. Other substances, such as tar, for example, are applied locally although they may have a carcinogenic potential when misused, or when contraindications for its use are disregarded. Local risks can be recognized in clinical-experimental and clinical testing of dermatological products. One must, however, look carefully for an intensification of possible risks related to the method of application, the condition of the skin, the site of application, supporting therapeutic measures or changes in the composition of the vehicle. Lanolin, cetyl alcohol and myristyl alcohol, sorbitol, isopropyl-myristate as well as polyethylene glycols (PEG) penetrate the skin like active substances. Some have been connected with skin allergies. In addition, some preservatives have mutagenic properties. Many vehicles cause dehydration of the horny layer and thus result in chronic surface damage. This is true for hygroscopic substances such as PEG as well as for liquid paraffins, lipid solvents (alcohol, acetone), solvents such as propylene glycol and for some O/W emulsifiers.","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"36 4","pages":"128-33"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14107261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Occupationally-induced allergic and photoallergic reactions to epoxide resins in railroad employees]. 铁路职工对环氧树脂的职业致敏和光过敏反应。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-07-01

B Bachurzewska, I Borucka, E Ogonowski

引用次数: 0

[Are contact allergies increasing?]. [接触性过敏正在增加吗?]

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-07-01

H Ippen

引用次数: 0

[The incidence of occupationally-induced allergic skin diseases in a large flower market]. [某大型花卉市场职业性过敏性皮肤病的发病率分析]。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-07-01

B M Hausen, G Oestmann

引用次数: 0

[Allergic contact dermatitis caused by Asteraceae. Identification of an 8,9-epoxythymol-diester as the contact allergen of Arnica sachalinensis]. 菊科植物引起的过敏性接触性皮炎。山金车接触性过敏原8,9-环氧戊二酯的鉴定[j]。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-05-01

C M Passreiter, M Florack, G Willuhn, G Goerz

引用次数: 0

Skin disorders and prick and patch test reactivity in Finnish reindeer herders. 芬兰驯鹿牧民的皮肤病和针刺和斑贴试验反应性。

Dermatosen in Beruf und Umwelt. Occupation and environment Pub Date : 1988-05-01

E Larmi, K Reijula, M Hannuksela, S Pikkarainen, J Hassi

引用次数: 0