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Current Pharmacogenomics and Personalized Medicine最新文献

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Tackling Cardiovascular Risk: New Evidence from Personalized Medicine 应对心血管风险:来自个性化医疗的新证据
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-06-23 DOI: 10.2174/1875692115666170508152128
R. Finelli, A. V. Pascale, P. Marotta, A. Guida, M. Ciccarelli
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引用次数: 0
Gender Differences in Response to Therapy for Cardiovascular Diseases 心血管疾病治疗反应的性别差异
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-05-31 DOI: 10.2174/1875692115666170508153322
Corbi Graziamaria, Ambrosino Immacolata, Komici Klara, Cellurale Michele, Lombardi Anna, F. Nicola
{"title":"Gender Differences in Response to Therapy for Cardiovascular Diseases","authors":"Corbi Graziamaria, Ambrosino Immacolata, Komici Klara, Cellurale Michele, Lombardi Anna, F. Nicola","doi":"10.2174/1875692115666170508153322","DOIUrl":"https://doi.org/10.2174/1875692115666170508153322","url":null,"abstract":"DOI: 10.2174/1875692115666170508153322 Abstract: In the last decades, aging of population is becoming even more prevalent, with consequent increasing requirement in health assistance and services. Physical and social environments can affect health directly, or through barriers or incentives conditioning opportunities, decisions and behavior. Moreover, the relationship with environment varies according to several personal characteristics including family background, sex and ethnicity. The impact of these factors is often skewed by these characteristics, leading to inequalities in health. In almost all countries, the older population is predominantly female. The prevalence and incidence of Cardiovascular Diseases (CVD) are reported to be lower in women than in men, increasing with age in both genders, but at advanced ages women outnumber men. Gender-differences in the contribution of various pathophysiological processes, combined with suboptimal recognition of female specificities, may explain sexdifferences in presentation and outcomes of CVD and also partially explain the differences in cardiovascular drug therapy related to gender, where other behavioral and cultural factors can be involved. Starting by the conflicting data in literature, the aim of this article is to summarize the gender differences available on the use of the main cardiovascular drugs, and the possible explanation for these disparities. Till date, data on gender differences in cardiovascular therapy are still controversial, and overall no established factors have been identified to discriminate the different approach in the choice of cardiovascular drugs by gender. Then further more structured and bigger trials should be performed to target these issues, and to better clarify the underlining involved mechanisms.","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"18 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75027763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Novel Drug Targets for the Treatment of Cardiac Diseases 治疗心脏疾病的新药物靶点
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-05-31 DOI: 10.2174/1875692115666170503105402
Marine Pingeon, B. Charlier, F. D. Lise, Francesca Mensitieri, F. Piaz, V. Izzo
{"title":"Novel Drug Targets for the Treatment of Cardiac Diseases","authors":"Marine Pingeon, B. Charlier, F. D. Lise, Francesca Mensitieri, F. Piaz, V. Izzo","doi":"10.2174/1875692115666170503105402","DOIUrl":"https://doi.org/10.2174/1875692115666170503105402","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"106 1","pages":"32-44"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82539610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Impact of New Technologies on Pharmacogenomics 新技术对药物基因组学的影响
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/1875692115666170214152152
M. Isidoro-García, Almudena Sánchez-Martín, B. García‐Berrocal
{"title":"Impact of New Technologies on Pharmacogenomics","authors":"M. Isidoro-García, Almudena Sánchez-Martín, B. García‐Berrocal","doi":"10.2174/1875692115666170214152152","DOIUrl":"https://doi.org/10.2174/1875692115666170214152152","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"31 1","pages":"74-85"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89922438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Editorial: CPPM Onward and Upward: Global Personalized Medicine Guided by Responsible Innovation 社论:CPPM向前和向上:以负责任的创新为指导的全球个性化医疗
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/187569211402170424205258
A. Llerena, V. Ozdemir
{"title":"Editorial: CPPM Onward and Upward: Global Personalized Medicine Guided by Responsible Innovation","authors":"A. Llerena, V. Ozdemir","doi":"10.2174/187569211402170424205258","DOIUrl":"https://doi.org/10.2174/187569211402170424205258","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"1 1","pages":"66-67"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80889644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Developments of Differentiation Therapy of Acute Myeloid Leukemia 急性髓系白血病分化治疗的新进展
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/1875692115666170224094023
G. Castelli, E. Pelosi, U. Testa
{"title":"New Developments of Differentiation Therapy of Acute Myeloid Leukemia","authors":"G. Castelli, E. Pelosi, U. Testa","doi":"10.2174/1875692115666170224094023","DOIUrl":"https://doi.org/10.2174/1875692115666170224094023","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"59 1","pages":"86-105"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89081844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-drug Conjugates for Site-specific Delivery in Anti-cancer Therapy 抗癌治疗中靶向递送的dna -药物缀合物
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/1875692115666170208121925
K. Pramod
{"title":"DNA-drug Conjugates for Site-specific Delivery in Anti-cancer Therapy","authors":"K. Pramod","doi":"10.2174/1875692115666170208121925","DOIUrl":"https://doi.org/10.2174/1875692115666170208121925","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"11 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76233166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs 个性化和循证医学的新见解- MicroRNAs的作用
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/1875692115666170403101207
Upinder Kaur, S. Chakrabarti, I. Gambhir
{"title":"Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs","authors":"Upinder Kaur, S. Chakrabarti, I. Gambhir","doi":"10.2174/1875692115666170403101207","DOIUrl":"https://doi.org/10.2174/1875692115666170403101207","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"51 2 1","pages":"106-123"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87699046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exome Sequencing of Ovarian Cancer Patients to Identify Variants Predictive of Sensitivity to Platinum-based Chemotherapy 卵巢癌患者外显子组测序鉴定预测铂基化疗敏感性的变异
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-04-24 DOI: 10.2174/1875692115666170126152349
A. Semaan, K. Delfino, A. Wilber, Thomas K. Mathews, Kathy Robinson, L. Brard, S. Alanee
{"title":"Exome Sequencing of Ovarian Cancer Patients to Identify Variants Predictive of Sensitivity to Platinum-based Chemotherapy","authors":"A. Semaan, K. Delfino, A. Wilber, Thomas K. Mathews, Kathy Robinson, L. Brard, S. Alanee","doi":"10.2174/1875692115666170126152349","DOIUrl":"https://doi.org/10.2174/1875692115666170126152349","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"73 1","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79488181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population 雅库特健康人群CYP2D6、CYP3A5和DPYD基因多态性的等位基因频率
Current Pharmacogenomics and Personalized Medicine Pub Date : 2017-01-16 DOI: 10.2174/1875692114666160801151257
F. F. Vasilyev, D. A. Danilova, V. Kaimonov, Y. Chertovskih, N. Maksimova
{"title":"Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population","authors":"F. F. Vasilyev, D. A. Danilova, V. Kaimonov, Y. Chertovskih, N. Maksimova","doi":"10.2174/1875692114666160801151257","DOIUrl":"https://doi.org/10.2174/1875692114666160801151257","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"25 1","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2017-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76649678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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