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Drug reaction with eosinophilia and systemic symptoms (DRESS)with anti-tuberculosis drugs, a rare and serious complication. 抗结核药物伴嗜酸性粒细胞增多和全身症状的药物反应（DRESS）是一种罕见而严重的并发症。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664691
Abir Bouhamdi, Chaimae Bouhamdi, Jean Junior Tassa, Zakia Douhi, Layla Tahiri, Mounia Serraj, Mohammed El Biaze, Mohammed Chakib Benjelloun, Fatima Zahrae Mernissi, Bouchra Amara
{"title":"Drug reaction with eosinophilia and systemic symptoms (DRESS)with anti-tuberculosis drugs, a rare and serious complication.","authors":"Abir Bouhamdi, Chaimae Bouhamdi, Jean Junior Tassa, Zakia Douhi, Layla Tahiri, Mounia Serraj, Mohammed El Biaze, Mohammed Chakib Benjelloun, Fatima Zahrae Mernissi, Bouchra Amara","doi":"10.5070/D330664691","DOIUrl":"10.5070/D330664691","url":null,"abstract":"<p><p>Drug hypersensitivity syndrome or DRESS (drug reaction with eosinophilia and systemic symptoms) is a severe reaction with an estimated mortality of 10%. Antibacillary drugs are rarely incriminated. A 28-year-old patient with tubercular miliaria who developed antibacillary-induced DRESS is presented. The dermatological lesions appeared four weeks after the beginning of the antitubercular treatment. The diagnosis of DRESS was made when all the Registry of Severe Toxidermia (RegiSCAR) criteria were present. The treatment was stopped and the patient was put on symptomatic treatment under supervision in the intensive care unit, with progressive improvement. Substitution with second-line antituberculosis drugs was necessary and was done with caution. DRESS with antituberculosis drugs is rare and its management is not codified.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enfortumab vedotin-induced widespread vesiculobullous eruption mimicking disseminated herpetic infection in a patient with metastatic urothelial carcinoma. 在转移性尿路上皮癌患者中，恩福图单抗维多汀诱导广泛的囊泡性爆发，模拟播散性疱疹感染。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664684
Aman Nihal, Pearl Bacon, Susan Pei
{"title":"Enfortumab vedotin-induced widespread vesiculobullous eruption mimicking disseminated herpetic infection in a patient with metastatic urothelial carcinoma.","authors":"Aman Nihal, Pearl Bacon, Susan Pei","doi":"10.5070/D330664684","DOIUrl":"10.5070/D330664684","url":null,"abstract":"<p><p>Enfortumab vedotin (EV) is a monoclonal antibody drug conjugate composed of antibody against nectin-4 and linked to the microtubule inhibitor monomethyl auristatin E that is used to treat metastatic urothelial carcinoma. Enfortumab vedotin-associated cutaneous adverse events are common and are clinically diverse, ranging from papulosquamous eruption to vesiculobullous eruptions such as Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme-like eruption with vesiculobullae. Despite clinically diverse appearance, histopathology of EV-associated cutaneous adverse reactions often demonstrates interface dermatitis. We present the clinical and histopathologic features in a unique case of EV-associated widespread vesiculobullous eruption initially concerning for disseminated herpetic infection in a patient undergoing treatment of metastatic urothelial carcinoma with EV and pembrolizumab.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actionable avenues for dermatologists to reduce their environmental impact. 皮肤科医生减少对环境影响的可行途径。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664683
Genevieve S Silva, Jeromy W Gotschall, Misha Rosenbach
{"title":"Actionable avenues for dermatologists to reduce their environmental impact.","authors":"Genevieve S Silva, Jeromy W Gotschall, Misha Rosenbach","doi":"10.5070/D330664683","DOIUrl":"https://doi.org/10.5070/D330664683","url":null,"abstract":"<p><p>Climate change poses an increasing threat to human health, with well-documented impacts on dermatologic conditions. However, the U.S. healthcare sector is paradoxically a significant contributor to climate change-worsening greenhouse gas emissions. To address this negative externality, calls to action to decarbonize healthcare delivery have spurred research and initiatives around improving the environmental sustainability of medicine. Published sustainability recommendations for dermatologic practices have addressed themes such as renewable energy, single-use disposable materials, regulated medical waste, and clinician advocacy. Our current commentary provides an analysis of the potential of existing recommendations and outlines additional, novel, and actionable interventions. We highlight recently released decarbonization resources and regulatory changes. We emphasize the importance of reassessing procedure kits, minimizing medication waste, and implementing green procurement policies. We also address nuances in promoting environmentally-conscious transit, maximizing the efficient use of technology, supporting alternatives to single-use items, leveraging resources for patient education, assessing appropriate use of carbon credits, and bolstering community climate resilience.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mohs micrographic surgery for superficial leiomyosarcoma: a systematic review. 莫氏显微手术治疗浅表平滑肌肉瘤：系统回顾。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664681
Eric C Olsen, Steven A Svoboda
{"title":"Mohs micrographic surgery for superficial leiomyosarcoma: a systematic review.","authors":"Eric C Olsen, Steven A Svoboda","doi":"10.5070/D330664681","DOIUrl":"https://doi.org/10.5070/D330664681","url":null,"abstract":"<p><p>Superficial leiomyosarcoma is a rare malignancy of muscular origin arising in the skin and soft tissues. Although wide local excision is the standard of care for these tumors, Mohs micrographic surgery is a promising treatment option as it provides for optimal margin control. The object of this systematic review is to examine the efficacy of micrographic surgery in the management of superficial leiomyosarcoma. A literature search was conducted using the PubMed/Medline and Cochrane databases; 14 studies representing 66 patients were included. Analysis demonstrated a notably low rate of recurrence (1.5%) and metastasis (0.0%) in tumors treated with micrographic surgery, contrasting with increased rates of recurrence and metastasis in tumors treated with wide local excision. These data may be influenced by a shortage of subcutaneous leiomyosarcoma in the included patients, as subcutaneous tumors are more likely to recur and metastasize. Further research is warranted to determine the value of Mohs micrographic surgery in treating superficial leiomyosarcoma and specifically, the subcutaneous variant.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing localized perioral solar elastosis: a common finding often overlooked. 识别局部口腔周围太阳弹性：一种经常被忽视的常见发现。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664705
Sydney A Keatts, Riley Shin, T Austin Black, Rashid M Rashid
{"title":"Recognizing localized perioral solar elastosis: a common finding often overlooked.","authors":"Sydney A Keatts, Riley Shin, T Austin Black, Rashid M Rashid","doi":"10.5070/D330664705","DOIUrl":"10.5070/D330664705","url":null,"abstract":"<p><p>Solar elastosis is a form of photoaging theorized to result from long-term exposure to ultraviolet radiation. Clinically, solar elastosis manifests as yellow, atrophic, rhytid skin with a leathery appearance, most commonly affecting sun-exposed areas such as the face, neck, chest, or arms. Owing to its well-documented association with an elevated risk of skin cancer, recognizing the presence of solar elastosis is essential for clinicians. In this case, we evaluate a presentation of solar elastosis confined strictly to the perioral region, sparing the remainder of sun-exposed facial areas.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of blastomycosis presenting as a non-healing unifocal ulcerative nodule on the jawline. 一例芽孢菌病表现为一个不愈合的单灶性溃疡结节在下颌线上。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664687
Katherine Snow, Mackenzie Poole, Sino Mehrmal, Pooria Khoshnoodi, Nicole Burkemper, Sofia B Chaudhry
{"title":"A case of blastomycosis presenting as a non-healing unifocal ulcerative nodule on the jawline.","authors":"Katherine Snow, Mackenzie Poole, Sino Mehrmal, Pooria Khoshnoodi, Nicole Burkemper, Sofia B Chaudhry","doi":"10.5070/D330664687","DOIUrl":"10.5070/D330664687","url":null,"abstract":"<p><p>Blastomyces dermatitidis is a dimorphic fungus that can disseminate in the immunocompetent and immunodeficient. Many infected patients display heterogenous cutaneous findings, making it one of dermatology's great clinical mimics. Cases presenting as single lesions are often mistaken for neoplasms or other infections. We report a patient with diabetes mellitus who presented to the emergency department with a two-month history of an ulcerated jawline nodule. Treatment with incision/drainage and doxycycline for presumed bacterial abscess was unsuccessful. Upon re-presentation 10 days later, biopsy and fungal culture of the tumor confirmed infection with B. dermatitidis. Chest computed tomography revealed disease dissemination. Halfway through a 6-month course of itraconazole, cutaneous and pulmonary findings were notably improved. Diabetes is an emerging risk factor for dissemination that likely contributed to the severity in our case. Early biopsy can prevent potentially life-threatening treatment delays, highlighting the need for blastomycosis to be considered in the differential diagnosis of non-healing wounds.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atrichia with papular lesions mimicking alopecia areata universalis. 非洲斑疹与丘疹病变模拟斑秃。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664700
Gajanand M Antakanavar, Vineet Relhan, Neha Chauhan
{"title":"Atrichia with papular lesions mimicking alopecia areata universalis.","authors":"Gajanand M Antakanavar, Vineet Relhan, Neha Chauhan","doi":"10.5070/D330664700","DOIUrl":"https://doi.org/10.5070/D330664700","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basics of building a private dermatology practice--a startup guide. 建立私人皮肤科诊所的基础知识——创业指南。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664704
Abhinav Birda, Mallory L Zaino, Michael H Gold, Steven R Feldman, Brad A Yentzer
{"title":"Basics of building a private dermatology practice--a startup guide.","authors":"Abhinav Birda, Mallory L Zaino, Michael H Gold, Steven R Feldman, Brad A Yentzer","doi":"10.5070/D330664704","DOIUrl":"https://doi.org/10.5070/D330664704","url":null,"abstract":"<p><p>The growing demand for dermatologic services and shortage of dermatologic providers sets the stage for favorable market conditions to open a private dermatology practice. However, business-related education in medicine is lacking and the concept of starting a new practice may be daunting for dermatologists in any stage of training. We describe key components of starting a private dermatology practice. Topics include strategies to build a business plan, find a location, explore financial options, structure a legal framework, and incorporate branding and marketing.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From squats to spots: vitiligo koebnerization triggered by powerlifting. 从深蹲到斑点：举重引发的白癜风。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664702
Katherine Snow, Mackenzie Poole, Sino Mehrmal, Aibing Mary Guo
{"title":"From squats to spots: vitiligo koebnerization triggered by powerlifting.","authors":"Katherine Snow, Mackenzie Poole, Sino Mehrmal, Aibing Mary Guo","doi":"10.5070/D330664702","DOIUrl":"https://doi.org/10.5070/D330664702","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythematous-purpuric lesions in a one-year-old child revealing a case of acute hemorrhagic edema of childhood. 红斑紫癜病变在一个一岁的孩子揭示了儿童急性出血性水肿的情况。
Dermatology online journal Pub Date : 2024-12-15 DOI: 10.5070/D330664703
Aline Schultz Klitzke, Roberto Andre Goral, Carolina Airao Destefani, Sandra Maria Barbosa
{"title":"Erythematous-purpuric lesions in a one-year-old child revealing a case of acute hemorrhagic edema of childhood.","authors":"Aline Schultz Klitzke, Roberto Andre Goral, Carolina Airao Destefani, Sandra Maria Barbosa","doi":"10.5070/D330664703","DOIUrl":"https://doi.org/10.5070/D330664703","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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