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Adverse dermatologic effects of erdafitinib in a patient with metastatic urothelial carcinoma. 厄达非替尼对转移性尿路上皮癌患者的皮肤不良影响。
Dermatology online journal Pub Date : 2026-03-02 DOI: 10.25251/zj7ws289
Megan Johnson, Marie Clark, Carli Whittington, Edita Newton
{"title":"Adverse dermatologic effects of erdafitinib in a patient with metastatic urothelial carcinoma.","authors":"Megan Johnson, Marie Clark, Carli Whittington, Edita Newton","doi":"10.25251/zj7ws289","DOIUrl":"10.25251/zj7ws289","url":null,"abstract":"<p><p>Erdafitinib is a fibroblast growth factor receptor 1-4 inhibitor used for locally advanced or metastatic urothelial carcinoma in patients who have experienced disease progression after at least 1 prior systemic therapy. Various cutaneous side effects of erdafitinib have been reported, most commonly stomatitis and nail changes such as onycholysis, nail dystrophy, and paronychia. However, onychomadesis is a rarer nail toxicity that can cause significant discomfort and may necessitate treatment interruption. We present the case of a 61-year-old White man with metastatic urothelial carcinoma treated with 8 mg of erdafitinib daily who developed diffuse onychomadesis within a few months of initiating therapy. Awareness of the potential cutaneous side effects of erdafitinib and timely referral for specialty dermatologic care are important to allow treatment continuation.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreign body granuloma following leech therapy in hidradenitis suppurativa: A case complicated by lymphedema. 化脓性汗腺炎水蛭治疗后异物肉芽肿合并淋巴水肿1例。
Dermatology online journal Pub Date : 2026-03-02 DOI: 10.25251/beg3tr50
Zeynep Altan Ferhatoglu, Yusuf Demir, Suheyla Kaya, Burhan Engin, Cuyan Demirkesen
{"title":"Foreign body granuloma following leech therapy in hidradenitis suppurativa: A case complicated by lymphedema.","authors":"Zeynep Altan Ferhatoglu, Yusuf Demir, Suheyla Kaya, Burhan Engin, Cuyan Demirkesen","doi":"10.25251/beg3tr50","DOIUrl":"https://doi.org/10.25251/beg3tr50","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy and trichoscopy in Klippel-Trénaunay syndrome. klippel - trsamnaunay综合征的皮肤镜和毛镜检查。
Dermatology online journal Pub Date : 2026-03-02 DOI: 10.25251/55hfj387
Mariana Orduz Robledo, María José Giraldo Parra, Stephany Arias Linthon, Mariana Estrada Villamizar, Adriana Motta, Mariam Rolon
{"title":"Dermoscopy and trichoscopy in Klippel-Trénaunay syndrome.","authors":"Mariana Orduz Robledo, María José Giraldo Parra, Stephany Arias Linthon, Mariana Estrada Villamizar, Adriana Motta, Mariam Rolon","doi":"10.25251/55hfj387","DOIUrl":"10.25251/55hfj387","url":null,"abstract":"<p><p>Klippel-Trénaunay syndrome (KTS) is a slow-flow vascular malformation characterized by the triad of capillary malformation, limb hypertrophy, and venous malformation, with or without lymphatic malformation. Diagnosis requires the presence of at least 2 of these 3 clinical features; however, there is no consensus regarding dermoscopic or trichoscopic findings. We present the case of a 54-year-old woman with a history of congenital arteriovenous malformation who exhibited clinical, histopathologic, dermoscopic, and trichoscopic findings suggestive of KTS associated with a lower right limb ulcer. We describe a case of KTS diagnosed in adulthood and highlights the potential use of adjunctive diagnostic tools, including trichoscopy and dermoscopy.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive approach to skin protection against ultraviolet radiation: Integrating sunscreens, antioxidants, DNA repair agents, oral supplements, and probiotics. 一个全面的方法来保护皮肤免受紫外线辐射：整合防晒霜，抗氧化剂，DNA修复剂，口服补充剂，和益生菌。
Dermatology online journal Pub Date : 2026-03-02 DOI: 10.25251/mp7v6y10
Mina Ghali, Bishoy Abdelmalik, Logan Rs Hubbert, Helana Ghali, Laurie A Temiz, Zoe M Lipman, Ann Lin, Sharon E Albers
{"title":"A comprehensive approach to skin protection against ultraviolet radiation: Integrating sunscreens, antioxidants, DNA repair agents, oral supplements, and probiotics.","authors":"Mina Ghali, Bishoy Abdelmalik, Logan Rs Hubbert, Helana Ghali, Laurie A Temiz, Zoe M Lipman, Ann Lin, Sharon E Albers","doi":"10.25251/mp7v6y10","DOIUrl":"10.25251/mp7v6y10","url":null,"abstract":"<p><p>As melanoma rates continue to rise, there is an increasing need for comprehensive strategies to mitigate the harmful effects of ultraviolet (UV) radiation. This review explores an integrative approach to photoprotection that combines traditional mineral and chemical UV filters with emerging protective strategies, including antioxidants, oral supplementation, DNA repair agents, and probiotics. By addressing UV-induced damage at multiple levels, this multifaceted approach may enhance skin protection and help reduce the long-term risk of photoaging and skin cancer.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Don't miss the clue in the crease: Recognition of childhood flexural comedones. 不要错过折痕中的线索：儿童屈曲性粉刺的识别。
Dermatology online journal Pub Date : 2026-03-02 DOI: 10.25251/x14pcf74
Jennifer Roux, Sarah J Coates, Deeti J Pithadia
{"title":"Don't miss the clue in the crease: Recognition of childhood flexural comedones.","authors":"Jennifer Roux, Sarah J Coates, Deeti J Pithadia","doi":"10.25251/x14pcf74","DOIUrl":"https://doi.org/10.25251/x14pcf74","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New World disease: Dual diagnostic challenges in travelers returning from Costa Rica. 一种新的世界疾病：从哥斯达黎加返回的旅行者面临双重诊断挑战。
Dermatology online journal Pub Date : 2026-01-05 DOI: 10.25251/gab6mm81
Cláudia Brazão, João Borges-Costa, Sofia Antunes-Duarte, Dora Mancha, Lanyu Sun, Tiago Marques, Maria João Gargaté, Anabela Vilares, Tânia Reis, Pedro de Vasconcelos, Luís Soares-de-Almeida, Paulo Filipe
{"title":"A New World disease: Dual diagnostic challenges in travelers returning from Costa Rica.","authors":"Cláudia Brazão, João Borges-Costa, Sofia Antunes-Duarte, Dora Mancha, Lanyu Sun, Tiago Marques, Maria João Gargaté, Anabela Vilares, Tânia Reis, Pedro de Vasconcelos, Luís Soares-de-Almeida, Paulo Filipe","doi":"10.25251/gab6mm81","DOIUrl":"10.25251/gab6mm81","url":null,"abstract":"<p><p>Cutaneous diseases in returning travelers encompass a wide spectrum of etiologies and often pose diagnostic challenges. We present the cases of a 50-year-old man and a 57-year-old woman who presented with a 3-month history of erythematous, ulcerated plaques with well-defined elevated borders and a necrotic center on the lower limbs that began 3 weeks after returning from vacation in Costa Rica. Cutaneous biopsy revealed epidermal ulceration and extensive caseating granulomas throughout the full thickness of the dermis. Giemsa staining revealed no amastigotes. Microbiological examinations identified Leishmania braziliensis and excluded mycobacteria and fungi. The diagnosis of cutaneous leishmaniasis was established. Owing to clinical severity and antimonial unavailability, the man was treated with liposomal amphotericin B. The woman underwent surgical excision of the single lesion, along with oral fluconazole. Complete resolution was documented in both patients. These cases, which posed diagnostic and therapeutic challenges, highlight that cutaneous leishmaniasis, in all its versatile and often perplexing presentations, is a parasitic infection that should always be considered in dermatologic patients returning from vacation in endemic countries.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the scalpel: rare and experimental nonsurgical treatments for basal cell carcinoma. 手术刀之外：罕见的实验性非手术治疗基底细胞癌。
Dermatology online journal Pub Date : 2026-01-05 DOI: 10.25251/z041c253
Elen Deng, Amor Khachemoune
{"title":"Beyond the scalpel: rare and experimental nonsurgical treatments for basal cell carcinoma.","authors":"Elen Deng, Amor Khachemoune","doi":"10.25251/z041c253","DOIUrl":"10.25251/z041c253","url":null,"abstract":"<p><p>Basal cell carcinoma (BCC) is typically found on sun-exposed skin and is the most common form of skin cancer. Risk factors include male sex, fair skin, increased ultraviolet radiation exposure, prior history of BCC, chronic arsenic exposure, genetic predisposition, and immunosuppression. BCC is a slow-growing tumor that typically presents as a shiny and pink papule or nodule with telangiectasias. However, its presentation varies depending on the histological type, which can be confirmed by biopsy. First-line therapies for low-risk BCC include standard surgical excision and curettage and electrodesiccation, whereas the gold standard for high-risk BCC is Mohs microscopic surgery. This review summarizes the current guidelines for BCC treatment and discusses the mechanism of action and clinical implications of alternative rare, experimental, and anecdotal treatments in the literature.</p>","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis. 斑秃与COVID-19疫苗接种的关系：疫苗不良事件报告系统分析。
Dermatology online journal Pub Date : 2026-01-05 DOI: 10.25251/p2njr764
Aarushi K Parikh, Shari R Lipner
{"title":"Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis.","authors":"Aarushi K Parikh, Shari R Lipner","doi":"10.25251/p2njr764","DOIUrl":"https://doi.org/10.25251/p2njr764","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pellagra associated with iron deficiency. 糙皮病与缺铁有关。
Dermatology online journal Pub Date : 2026-01-05 DOI: 10.25251/04cxb449
Jonathan Young, Alison Bonello Boffa, Daniel Micallef, Michael J Boffa
{"title":"Pellagra associated with iron deficiency.","authors":"Jonathan Young, Alison Bonello Boffa, Daniel Micallef, Michael J Boffa","doi":"10.25251/04cxb449","DOIUrl":"https://doi.org/10.25251/04cxb449","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging. 5%米诺地尔泡沫的性别价格差异：通用替代品和散装包装的影响。
Dermatology online journal Pub Date : 2026-01-05 DOI: 10.25251/yfttck65
Lauren N McGrath, Steven R Feldman
{"title":"Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging.","authors":"Lauren N McGrath, Steven R Feldman","doi":"10.25251/yfttck65","DOIUrl":"https://doi.org/10.25251/yfttck65","url":null,"abstract":"","PeriodicalId":11040,"journal":{"name":"Dermatology online journal","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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