The Bulletin of Contemporary Clinical Medicine最新文献

{"title":"BIOLOGIC MARKERS OF FIBROGENESIS IN PULMONARY SARCOIDOSIS PATIENTS","authors":"G. Shepelkova, V. Evstifeev, E. Adamovskaya, Evgeniy I. Shmelev, V. V. Yeremeev","doi":"10.20969/vskm.2024.17(2).85-90","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).85-90","url":null,"abstract":"Introduction. Sarcoidosis-associated pulmonary fibrosis still lacks biomarkers to predict progression. Whole-genome association studies and other genetic research over the past few years have identified several single nucleotide polymorphisms that are associated with an increased risk of developing pulmonary fi brosis. In sarcoidosis, relatively reliable predictors of the disease activity include serum angiotensin-converting enzyme, soluble interleukin-2 receptor (sIL-2R) and chitotriosidase. Levels of inetrleukin-5 and, possibly, interleukin-7 were found to be elevated in patients with a fibrotic phenotype. Aim. In the present study, we sought to find the relationship between serum non- coding RNA- microRNA expression in patients with pulmonary sarcoidosis and the likelihood of pulmonary fibrosis developing in these patients. Materials and Methods. A total of 52 research subjects (sarcoidosis patients with/without fibrosis and healthy subjects) were included in the study. RNA samples from two groups of sarcoidosis patients (with and without fibrosis) and the control group were analyzed using the PCR Array. TaqMan QRT-PCR Assay was used for data verification. Results and Discussion. A significant decrease in the lung diffusion capacity was detected in 12 of 15 patients with chest-CT fibrosis signs. Lung diffusion capacity was normal in 17 patients without any fibrosis signs. There was a significant negative correlation among miR-15a, miR-150, and the level of lung diffusion capacity. Сonclusions. A set of non-coding RNA- microRNAs, i. e., miR-15a, miR-22, miR-106b, miR-107, and miR-150, was identified that can be further used as diagnostic markers for sarcoidosis fibrosis.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"427 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADJUSTING THE DRUG THERAPY IN PATIENTS AFTER BARIATRIC SURGERY","authors":"Violetta A. Kosova, Ekaterina A. Meshkova, Amatuni A. Badoian, Polina V. Zakharova","doi":"10.20969/vskm.2024.17(2).104-111","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).104-111","url":null,"abstract":"Introduction. Obesity is classified as a long-term condition with various causes and manifestations and represents a disproportionate accumulation of fat deposits in a human body. It is shown that overweight reduces the life expectancy and increases the likelihood of multiple diseases, even in young people. It is especially important to pay attention to people suffering from extreme obesity. This term refers to a condition in which the body mass index exceeds 40 kg/m2. One of the methods to combat this condition may be a bariatric intervention. Procedures for adjusting drug therapy in patients after bariatric surgery are common and have already proven their effectiveness. Medication management techniques help improve patient care throughout the entire treatment process, from the preparatory phase to the time the patient is ready to leave the hospital. The aim of our study was to systematize approaches to adjusting the drug therapy in patients who have undergone bariatric surgery. Materials and Methods. The object of the study is patients after bariatric surgery. Methodology is based on scientific and medical publications in the field of drug therapy for patients who have undergone bariatric surgery and statistical studies. 50 publications from scientific electronic libraries were studied and analyzed, such as eLibrary, Pubmed, Cyberlenika, and Google Scholar in 2010 and from 2020 to the present. Results and Discussion. In patients who had taken vitamins and minerals on a long-term basis, there was an improvement in the quality of life, an integrated approach to the obesity treatment was developed, and a reduction was found in concomitant risks. Conclusions. This paper describes scientific and practical approaches to the characteristics of drug therapy for patients who have undergone bariatric surgery, which makes it possible to more clearly determine the strategy for their rehabilitation and the characteristics of their future lifestyle.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"73 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE NICOTINE ADDICTION STAGE AND SECONDHAND SMOKE RELATIONSHIP WITH THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE SEVERITY IN SMOKING WOMEN OF REPRODUCTIVE AGE","authors":"Anna V. Dzyubailo, Vyacheslav S. Lotkov","doi":"10.20969/vskm.2024.17(2).40-44","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).40-44","url":null,"abstract":"Introduction. We studied the nicotine addiction stage and secondhand smoke interrelationships with the chronic obstructive pulmonary disease severity in smokers of reproductive age. Aim of the study was to research in the nicotine addiction and secondhand smoke impact upon the development of chronic obstructive pulmonary disease severity in smoking women of reproductive age. Materials and Methods. Using the questionnaire methodology developed, the nicotine addiction stage was analyzed in reproductive women with and without secondhand smoke (based on questionnaire survey outcomes). There were 107 smoking female patients of reproductive age divided into two groups: Those with secondhand smoke and those without it. Observational group consisted of 42 non-smoking women without any chronic diseases. Chronic obstructive pulmonary disease was diagnosed based on the clinical recommendations of the Russian Respiratory Society (2021). The data obtained during the study were analyzed followed by the comparison of the outcomes between the groups of smoking patients with secondhand and non-secondhand smoking, against the observational group. The outcomes led us to determine whether there is a statistically significant relationship between secondhand smoke and nicotine addiction stage in the development of chronic obstructive pulmonary disease. The reliability of the outcomes was assessed using the methods of parametric and nonparametric statistics. Before using all statistical research methods, we checked whether the sampling complied with the Gaussian (normal) distribution law. Variables that did not obey the normal distribution law or those with the uncertain distribution law were analyzed using a nonparametric statistical method, i. e., Pearson criterion. Results and Discussion. Average age of the smoking patients is 26.5 years. Average index of smokers was 6.59 pack-years. The smokers’ index exceeded the middle of the indicator contributing to the chronic obstructive pulmonary disease development (10 pack – years), which is typical for a young age and their smoking experience. It was found that the nicotine addiction stage correlates with the chronic obstructive pulmonary disease severity with a statistically significant reliability. Conclusions. Secondhand smoke in addition to active smoking, reduces the temporal characteristics of chronic obstructive pulmonary disease severity.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"589 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RENAL HEREDITARY TUBULOPATHIES: PHOSPHATE DIABETES (Two clinical cases)","authors":"O. V. Davydova, A. Antonova, Larisa I. Derbeneva, Marina G. Gerner, Alina G. Rabeeva, Zhanna E. Torishneva","doi":"10.20969/vskm.2024.17(2).124-129","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).124-129","url":null,"abstract":"Introduction. Phosphate diabetes is a representative of a group of diseases known as tubulopathies. It is more often of a hereditary nature. The disease manifests at an early age with symptoms similar to alimentary rickets, which creates problems for diagnosing and prescribing an adequate therapy. In this case, the current situation leads to the development of bone deformities and disability, delayed physical development, and the need for surgical treatment, which reduces the quality of life of the patients for a long time. Aim: To consider two clinical cases of phosphate diabetes with typical symptoms, demonstrate the diagnosing challenges, and analyze the treatment effects. Materials and Methods. Two clinical cases of phosphate diabetes are presented. The first patient: 16 years old, observed from the age of 2, and takes vitamin D and inorganic phosphates from the diagnosis date. The geneticist found the autosomal dominant of the pathology. The girl underwent two surgeries for her leg deformity. The second patient, 10 years old, was diagnosed at the age of 4 years. DNA diagnostics detected a mutation in the COL9A3 gene. They refused the complete DNA exome sequencing. From the diagnosis date, the patient is treated with the active vitamin D metabolite and inorganic phosphates. Results and Discussion. Clinician-observed: Patient 1 had leg deformities, painful legs, and disharmonious physical development caused by her growth retardation. Blood concentrations of calcium and phosphorus are within normal, there is hypocalciuria typical of phosphate diabetes in the urine, while phosphates are within normal. The patient’s kidney function is not impaired. Clinician-observed: Patient 2 is physically retarded, there are varus foot deformities and pes planovalgus feet. Kidney function is not impaired, the level of alkaline phosphatase is increased, the total blood calcium levels are decreased with phosphorus indicating normal values, and the urine phosphaturia and hypocalciuria are within normal ranges. Due to the COL9A3 mutation detected, Stickler syndrome was excluded. Orthopedic surgeon recommended surgical treatment of her leg deformities. Conclusions. The examination showed that the therapy allows keeping phosphate diabetes under control and avoiding the side effects of taking vitamin D.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"201 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL MANIFESTATION FEATURES OF CHIARI TYPE 0, 1, AND “BORDERLINE” MALFORMATIONS","authors":"Tatyana G. Sakovets, N. L. Rybkina","doi":"10.20969/vskm.2024.17(2).112-117","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).112-117","url":null,"abstract":"Introduction. Introduction of advanced neuroimaging methods has made it possible to identify subtle structural features of the posterior cranial fossa and craniovertebral junction, as well as the dislocation of cerebellar tonsils into the foramen magnum, which have clinically overt and subclinical forms. Aim: To study the clinical manifestation features of Chiari type 0, 1, and “borderline” malformations. Materials and Methods. For literature analysis, the sources were used from international databases, such as Web of Science, Scopus, and PubMed, and the Russian library system, eLibrary. Results and Discussion. The most common pathology of the posterior cranial fossa is Chiari type 1 malformation associated with a mesodermal defect and with discrepancies between the sizes of the posterior cranial fossa and the neural structures that fill it. To assess the Chiari malformation grade, it is advisable to specify the dislocation grades of cerebellar tonsils. There is a common classification of cerebellar tonsil dislocations, in which the dislocation grade 1 of cerebellar tonsils is characterized by the descent of cerebellar tonsils below the foramen magnum level; grade 2 is inherent in dislocation of the cerebellar tonsils down to the C2 vertebra level in combination with displacing the pons and medulla oblongata below the Twining line. Grade 3 dislocation of the cerebellar tonsils is where the cerebellum tonsil displacement is combined with intracranial hypertension. In case of the degree 4 dislocation of the cerebellar tonsils, cerebellar hypoplasia is observed, accompanied by a displacement of the medulla oblongata. The occurrence of syringomyelia in Chiari type 0 malformation is associated with liquor dynamic disorders in the craniovertebral junction region; the similar liquor circulation disorders are detected in Chiari type 1 malformation. Chiari type 1 and “borderline”- type malformations manifest as persistent cranialgia, pain in the cervical spine, otoneurologic and visual disorders, respiratory, psychological, and cognitive disorders, damage to the cerebellar and stem structures of the brain, damage to the spinal cord, and other, more rare signs of damage to the central nervous system. Conclusions. Thus, it is necessary to further study the features of developing clinical symptoms in Chiari type 1, 0, and “borderline” malformations to assess the changes in the course of the disease and select an adequate treatment strategy.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"47 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETECTION RATE OF INCREASED ANNEXIN LEVELS OVER TIME IN PATIENTS WITH SARS-COV-2-ASSOCIATED PNEUMONIA","authors":"A.S. Kurmaeva, T. Prokofieva, O. S. Polunina, E. Polunina, I. V. Sevostyanova","doi":"10.20969/vskm.2024.17(2).52-57","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).52-57","url":null,"abstract":"Introduction. In the current state of the art in medicine, it is relevant to search for convincing markers involved in the pathogenesis of lung damage and significant in determining the prognosis of SARS-CoV-2-associated pneumonia. One of the significant pathogenetic elements in the development of lung lesions, including SARS-CoV-2-associated pneumonia, is the intensification of apoptosis. Annexin A5 (ANXA5) is a protein that allows inferring the level of cells at the early apoptosis stage. Aim: To determine the detection rate of increased annexin levels in patients with SARS- CoV-2-associated pneumonia and to assess its dynamics at the inpatient stage of treatment. Materials and Methods: 90 residents of the Astrakhan region were examined, all diagnosed with the coronavirus infection COVID-19 (virus identified). The patients were aged 47 [39; 57] years, 47 men and 43 women. ANXA5 levels (ng/ml) in blood serum were evaluated using immunoassay analyzer Uniplan AIFR-01, manufactured by Picon, Russia. The data obtained were processed statistically using SPSS 26.0. Results and Discussion. On admission to the hospital, ANXA5 levels were statistically higher in patients with SARS-CoV-2-associated pneumonia than those in the group of somatically healthy individuals. Increased annexin levels were detected in 76.7% of patients. The chance of detecting increased annexin levels in patients with SARS-CoV-2-associated pneumonia was 2.4 times higher than in the group of somatically healthy individuals (OR 2.43; 95% CI 1.75-3.37). During the treatment period, ANXA5 levels decreased statistically. However, even at discharge, increased annexin levels were detected in most patients (74.4%). Detection rate of increased annexin levels throughout hospitalization was higher in patients with large lung tissue lesions. Conclusions: The data obtained indicate the intensification of apoptotic processes in patients with SARS-CoV-2-associated pneumonia and suggest the study of the ANXA5 prognostic role in the coronavirus infection course and outcomes.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"481 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOMYOCYTE APOPTOSIS AS A DEVELOPMENT FACTOR OF CORONARY HEART DISEASE","authors":"E. A. Zakharyan, Iuliana I. Shramko, Ani M. Arzumanyan, Ekaterina R. Golovina","doi":"10.20969/vskm.2024.17(2).98-103","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).98-103","url":null,"abstract":"Introduction. Coronary heart disease is a common pathology, playing a key role in cardiovascular mortality. Damage of circulatory system affects people of all ages, including the active population, which provides an adverse impact on the socio-economic state of society. In this research, we analyzed the processes of cardiomyocyte apoptosis and their effects on myocardial ischemic damage. Aim was to identify the role of cardiomyocyte apoptosis in the development of coronary heart disease. Materials and Methods. A meta-analysis of 50 literary sources was performed in the PubMed database over the past 11 years. Results and Discussion. Meta-analysis has demonstrated that prevention of cardiomyocyte apoptosis is an extremely important therapeutic goal today. Ischemia/reperfusion, exercise- induced hypertrophy, and post-infarct myocardial remodeling are associated with myocyte apoptosis. This indicates that current treatments proven effective in these diseases may interfere with apoptosis. Conclusions. Studying apoptosis and its regulation is important for both understanding the pathogenesis of cardiovascular diseases and developing new therapeutic approaches. Apoptosis, i. e., controlled cell death, is of great importance in cardiac pathology. For instance, it plays a key role in ischemia/reperfusion, myocardial hypertrophy, and post-infarct remodeling. Key words: ischemic heart disease, apoptosis, cardiomyocytes.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"142 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIFE QUALITY OF MYOCARDIAL INFARCTION PATIENTS ACCORDING TO THE PRESENCE OF TYPE D PERSONALITY","authors":"E. G. Mutalova, Velena R. Galyautdinova, Gulnara J. Kamaltdinova, Liana I. Samigullina","doi":"10.20969/vskm.2024.17(2).64-70","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(2).64-70","url":null,"abstract":"Introduction. Type D personality, or distress personality, i. e., a combination of negative affectivity and social inhibition, as well as poor life quality, are considered the predictors of cardiovascular morbidity and mortality. However, there is insufficient data on the role of Type D personality as a determinant of life quality in myocardial infarction patients. Aim is to assess the Q-positive myocardial infarction patients’ life quality and its association with Type D personality. Materials and Methods. The study included 158 patients aged 58.2±2.5 years, who were admitted to the hospital for ST-segment elevation myocardial infarction. ST-segment elevation myocardial infarction was diagnosed in accordance with the Clinical Guidelines of the Russian Society of Cardiology, 2020. Пациентам анализируемых групп проведено определение общеклинических параметров, психологическое тестирование с применением оценочных шкал тревоги и депрессии, опросников DS-14 и SF-36. Patients of the groups studied were tested for general clinical parameters and psychological characteristics using anxiety and depression rating scales, DS-14 and SF-36 questionnaires. Individuals with and without Type D personality were identified in the group of myocardial infarction patients. Results and Discussion. Type D personality was detected in 29.1% of myocardial infarction patients. In this group, an unfavorable psychological profile is noted: Their negative excitability, social suppression, depression, and personal/situational anxiety levels are higher than in the group without Type D personality. In patients with myocardial infarction and Type D personality, a lower quality of life and a decrease in the integral indicators of physical and psychologic components. Conclusions. Type D personality was proven to provide an adverse effect on the life quality in myocardial infarction patients. Cardiac rehabilitation programs should include interventions to reduce the Type D personality traits, especially social inhibition.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"197 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF CARDIOVASCULAR RISK IN PATIENTS WITH PSORIATIC ARTHRITIS","authors":"E. G. Mutalova, Renata M. Arslanova, Zarema R. Khismatullina, Albina E. Nigmatullina, Velena R. Galyautdinova, Gulnara J. Kamaltdinova, Gulnara V. Asadullina, Liana I. Samigullina, Z. Y. Rustyamova, E. SADIKOVA R, Svetlana A. Frid, Eldar R. Kamaltdinov, Flarisa S. Musina","doi":"10.20969/vskm.2024.17(1).35-43","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(1).35-43","url":null,"abstract":"Abstract. Introduction. Patients with psoriatic arthritis are exposed to a higher risk of developing cardiovascular complications. Development and progression of these disorders are based on a complex of closely interrelated factors, such as traditional cardiovascular risk factors, cardiovascular toxicity of some antirheumatic drugs, primarily non- steroidal anti-inflammatory drugs and glucocorticoids, and chronic autoimmune inflammation, which, according to many researchers, is the leading pathogenetic mechanism of atherosclerotic vascular lesions. The aim of the study was to assess the prevalence of traditional risk factors, the state of the blood lipid spectrum, and atherosclerotic remodeling of peripheral arteries in patients with psoriatic arthritis. Materials and Methods. We examined 84 patients (41 women and 43 men) aged 20 to 65 years. Arthritis was diagnosed based on the CASPAR criteria. Patients were assessed regarding traditional risk factors, such as hypertension, obesity, smoking, aggravated family history of CVD, diabetes, physical inactivity, and dyslipidemia; ten-year total coronary risk was calculated using the SCORE scale. To diagnose subclinical atherosclerosis, the patients underwent Doppler ultrasound of the carotid arteries with an assessment of the intima-media complex thickness. Results and Discussion. Assessment of disease development risk factors showed that all patients with psoriatic arthritis had from one to five risk factors. More common risk factors were smoking in 50 (59.5 %) patients, AO in 44 (52.4 %), dyslipidemia in 48 (57.1 %), and arterial hypertension. Patients with a long history of the disease have a higher prevalence of risk factors. According to the results of calculating the ten-year total coronary risk (SCORE scale), most patients were in the group of low (46.4 %) and moderate (38 %) risk. An association was found between the level of total coronary risk and arthritis activity in groups of patients with low and moderate risk. The average intima-media complex thickness of the common carotid artery in the group of patients with psoriatic arthritis was statistically significantly higher than in those in the control group (p=0.0361).Conclusions. An increased risk of cardiovascular complications was found in patients with psoriatic arthritis, while most patients have several risk factors in various proportions. According to the risk assessment on the SCORE scale, it was found to be statistically significant in the group of patients with psoriatic arthritis, which correlates with disease activity. The presence of subclinical atherosclerosis was detected in form of a statistically significant increase in the intima-media complex thickness of the carotid arteries. All the above indicates the current problem of psoriasis comorbidity, which dictates a personalized comprehensive approach to therapy for the selection of safe and adequate therapy for all diseases diagnosed in an individual patient.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"119 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF DENTAL MORBIDITY PREVALENCE IN PRESCHOOL CHILDREN LIVING IN NUCLEAR AND RECONSTITUTED FAMILIES","authors":"M. Khadyeva, A. Galiullin, J. Yakimova","doi":"10.20969/vskm.2024.17(1).53-62","DOIUrl":"https://doi.org/10.20969/vskm.2024.17(1).53-62","url":null,"abstract":"Abstract. Introduction. Dental diseases in preschool children do not appear to tend downward. According to the literature, the prevalence of dental decay and its complications in preschool children reaches 70%, dental abnormalities more than 80%, and periodontal diseases and oral mucosa diseases up to 98%. There are some data described in literature, regarding how family types affect the overall incidence in children. At the same time, the impact of family type on the children dental health has not been studied a lot so far. Taking this into account, this paper provides data on dental morbidity in preschool children living in nuclear and reconstituted families. The aim of the study is to examine the pattern of prevalence of major dental diseases in preschool children living in nuclear or reconstituted families. Materials and Methods. Preschool children of different ages and their parents took part in this study. During the study, we identified reconstituted and nuclear families, the children from which families constituted the subject of the study. In total, the study examined 1,929 children from 1,842 nuclear families and 166 children from 146 reconstituted children. Results and Discussions. The study found that the most important dental diseases occur in children of the earliest age, before 1 year of life. With the passage of time and the child’s growth, their dental morbidity progresses and reaches its peak among preschool children aged 4.6-6 years. Children living in reconstituted families were significantly more susceptible to the onset and progression of major dental diseases than those from nuclear families. Conclusions. The impact of family type on dental morbidity in preschool children should be considered while planning the prevention and medical examination programs, which will help identify dental diseases at an early stage, prevent the development of complications, and optimize health care costs for the treatment and prevention of dental diseases in preschool children","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"157 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}