Current topics in membranes最新文献_第4页

Interplay of Ca²⁺ and K⁺ signals in cell physiology and cancer. Ca2+和K+信号在细胞生理和癌症中的相互作用。

4区生物学

Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-09-25 DOI: 10.1016/bs.ctm.2023.09.006

Andrea Becchetti

{"title":"Interplay of Ca2+ and K+ signals in cell physiology and cancer.","authors":"Andrea Becchetti","doi":"10.1016/bs.ctm.2023.09.006","DOIUrl":"10.1016/bs.ctm.2023.09.006","url":null,"abstract":"The cytoplasmic Ca2+ concentration and the activity of K+ channels on the plasma membrane regulate cellular processes ranging from mitosis to oriented migration. The interplay between Ca2+ and K+ signals is intricate, and different cell types rely on peculiar cellular mechanisms. Derangement of these mechanisms accompanies the neoplastic progression. The calcium signals modulated by voltage-gated (KV) and calcium-dependent (KCa) K+ channel activity regulate progression of the cell division cycle, the release of growth factors, apoptosis, cell motility and migration. Moreover, KV channels regulate the cell response to the local microenvironment by assembling with cell adhesion and growth factor receptors. This chapter summarizes the pathophysiological roles of Ca2+ and K+ fluxes in normal and cancer cells, by concentrating on several biological systems in which these functions have been studied in depth, such as early embryos, mammalian cell lines, T lymphocytes, gliomas and colorectal cancer cells. A full understanding of the underlying mechanisms will offer a comprehensive view of the ion channel implication in cancer biology and suggest potential pharmacological targets for novel therapeutic approaches in oncology.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"92 ","pages":"15-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Setting the stage for universal pharmacological targeting of the glycocalyx. 为糖萼的普遍药理靶向奠定了基础。

4区生物学

Current topics in membranes Pub Date : 2023-01-01 DOI: 10.1016/bs.ctm.2023.02.004

Karim Almahayni, Leonhard Möckl

{"title":"Setting the stage for universal pharmacological targeting of the glycocalyx.","authors":"Karim Almahayni, Leonhard Möckl","doi":"10.1016/bs.ctm.2023.02.004","DOIUrl":"https://doi.org/10.1016/bs.ctm.2023.02.004","url":null,"abstract":"All cells in the human body are covered by a complex meshwork of sugars as well as proteins and lipids to which these sugars are attached, collectively termed the glycocalyx. Over the past few decades, the glycocalyx has been implicated in a range of vital cellular processes in health and disease. Therefore, it has attracted considerable interest as a therapeutic target. Considering its omnipresence and its relevance for various areas of cell biology, the glycocalyx should be a versatile platform for therapeutic intervention, however, the full potential of the glycocalyx as therapeutic target is yet to unfold. This might be attributable to the fact that glycocalyx alterations are currently discussed mainly in the context of specific diseases. In this perspective review, we shift the attention away from a disease-centered view of the glycocalyx, focusing on changes in glycocalyx state. Furthermore, we survey important glycocalyx-targeted drugs currently available and finally discuss future steps. We hope that this approach will inspire a unified, holistic view of the glycocalyx in disease, helping to stimulate novel glycocalyx-targeted therapy strategies.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"91 ","pages":"61-88"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The elusive Na_v1.7: From pain to cancer. 难以捉摸的Nav1.7:从疼痛到癌症。

4区生物学

Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-09-23 DOI: 10.1016/bs.ctm.2023.09.003

Umberto Banderali, Maria Moreno, Marzia Martina

{"title":"The elusive Nav1.7: From pain to cancer.","authors":"Umberto Banderali, Maria Moreno, Marzia Martina","doi":"10.1016/bs.ctm.2023.09.003","DOIUrl":"10.1016/bs.ctm.2023.09.003","url":null,"abstract":"Voltage-gated sodium channels (Nav) are protein complexes that play fundamental roles in the transmission of signals in the nervous system, at the neuromuscular junction and in the heart. They are mainly present in excitable cells where they are responsible for triggering action potentials. Dysfunctions in Nav ion conduction give rise to a wide range of conditions, including neurological disorders, hypertension, arrhythmia, pain and cancer. Nav family 1 is composed of nine members, named numerically from 1 to 9. A Nax family also exists and is involved in body-fluid homeostasis. Of particular interest is Nav1.7 which is highly expressed in the sensory neurons of the dorsal root ganglions, where it is involved in the propagation of pain sensation. Gain-of-function mutations in Nav1.7 cause pathologies associated with increased pain sensitivity, while loss-of-function mutations cause reduced sensitivity to pain. The last decade has seen considerable effort in developing highly specific Nav1.7 blockers as pain medications, nonetheless, sufficient efficacy has yet to be achieved. Evidence is now conclusively showing that Navs are also present in many types of cancer cells, where they are involved in cell migration and invasiveness. Nav1.7 is anomalously expressed in endometrial, ovarian and lung cancers. Nav1.7 is also involved in Chemotherapy Induced Peripheral Neuropathy (CIPN). We propose that the knowledge and tools developed to study the role of Nav1.7 in pain can be exploited to develop novel cancer therapies. In this chapter, we illustrate the various aspects of Nav1.7 function in pain, cancer and CIPN, and outline therapeutic approaches.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"92 ","pages":"47-69"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the condylar volume and skeletal relapse following orthognathic surgery in patients with dentofacial deformity: A retrospective study. 颌面部畸形患者正颌手术后髁突体积的变化和骨骼复发：一项回顾性研究。

IF 1.6 4区生物学

Current topics in membranes Pub Date : 2022-05-04 DOI: 10.1080/08869634.2022.2070333

Namiaki Takahara, Nobuyoshi Tomomatsu, Atsushi Kimura, Machiko Kosugi, Yasuhiro Kurasawa, Kei-Ichi Morita, Tetsuya Yoda

{"title":"Changes in the condylar volume and skeletal relapse following orthognathic surgery in patients with dentofacial deformity: A retrospective study.","authors":"Namiaki Takahara, Nobuyoshi Tomomatsu, Atsushi Kimura, Machiko Kosugi, Yasuhiro Kurasawa, Kei-Ichi Morita, Tetsuya Yoda","doi":"10.1080/08869634.2022.2070333","DOIUrl":"10.1080/08869634.2022.2070333","url":null,"abstract":"Objective: To evaluate the relationship between the changes in condylar volume and maxillofacial skeletal morphology according to sex as well as the relationship between condylar volume reduction and skeletal relapse in patients who underwent orthognathic surgery.Methods: Ninety-five patients were categorized into skeletal Class III, Class II, and facial asymmetry groups. Computed tomography scans taken preoperatively and at 1 year postoperatively were used for quantitative measurement.Results: Postoperative condylar volume was reduced in both the Class II group and the deviated side of the asymmetry group. Both female and Class II deformity were significant predictors of postoperative reduction in the condylar volume. There was a significant correlation between skeletal relapse and postoperative change in condylar volume in the Class II group.Conclusion: Postoperative condylar resorption may be associated with preoperative maxillofacial skeletal morphology and sex and also with skeletal relapse in the Class II group.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"63 1","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78404377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron. TRPV4在控制肾单位血流敏感性中的概念演变。

4区生物学

Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-07-18 DOI: 10.1016/bs.ctm.2022.06.001

Kyrylo Pyrshev, Anna Stavniichuk, Viktor N Tomilin, Oleg Zaika, Oleh Pochynyuk

{"title":"Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron.","authors":"Kyrylo Pyrshev, Anna Stavniichuk, Viktor N Tomilin, Oleg Zaika, Oleh Pochynyuk","doi":"10.1016/bs.ctm.2022.06.001","DOIUrl":"https://doi.org/10.1016/bs.ctm.2022.06.001","url":null,"abstract":"Kidneys are central for whole body water and electrolyte balance by first filtering plasma at the glomeruli and then processing the filtrate along the renal nephron until the final urine is produced. Renal nephron epithelial cells mediate transport of water and solutes which is under the control of systemic hormones as well as local mechanical stimuli arising from alterations in fluid flow. TRPV4 is a mechanosensitive Ca2+ channel abundantly expressed in different segments of the renal nephron. The accumulated evidence suggests a critical role for TRPV4 in sensing variations in flow rates. In turn, TRPV4 activation triggers numerous downstream cellular responses stimulated by elevated intracellular Ca2+ concentrations [Ca2+]i. In this review, we discuss the recent concepts in flow-mediated regulation of solute homeostasis by TRPV4 in different segments of renal nephron. Specifically, we summarize the evidence for TRPV4 involvement in endocytosis-mediated albumin uptake in the proximal tubule, reactive oxygen species (ROS) generation in the ascending loop of Henle, and maintaining K+ homeostasis in the connecting tubule/collecting duct. Finally, we outline the function and significance of TRPV4 in the setting of polycystic kidney disease.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":" ","pages":"75-94"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33494116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Function and regulation of thermosensitive ion channel TRPV4 in the immune system. 热敏离子通道TRPV4在免疫系统中的功能及调控。

4区生物学

Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-08-01 DOI: 10.1016/bs.ctm.2022.07.002

Tusar Kanta Acharya, Ram Prasad Sahu, Satish Kumar, Shamit Kumar, Tejas Pravin Rokade, Ranabir Chakraborty, Nishant Kumar Dubey, Deep Shikha, Saurabh Chawla, Chandan Goswami

{"title":"Function and regulation of thermosensitive ion channel TRPV4 in the immune system.","authors":"Tusar Kanta Acharya, Ram Prasad Sahu, Satish Kumar, Shamit Kumar, Tejas Pravin Rokade, Ranabir Chakraborty, Nishant Kumar Dubey, Deep Shikha, Saurabh Chawla, Chandan Goswami","doi":"10.1016/bs.ctm.2022.07.002","DOIUrl":"https://doi.org/10.1016/bs.ctm.2022.07.002","url":null,"abstract":"Transient receptor potential vanilloid sub-type 4 (TRPV4) is a six transmembrane protein that acts as a non-selective Ca2+ channel. Notably, TRPV4 is present in almost all animals, from lower eukaryotes to humans and is expressed in diverse tissue and cell types. Accordingly, TRPV4 is endogenously expressed in several types of immune cells that represent both innate and adaptive immune systems of higher organism. TRPV4 is known to be activated by physiological temperature, suggesting that it acts as a molecular temperature sensor and thus plays a key role in temperature-dependent immune activation. It is also activated by diverse endogenous ligands, lipid metabolites, physical and mechanical stimuli. Both expression and function of TRPV4 in various immune cells, including T cells and macrophages, are also modulated by multiple pro- and anti-inflammatory compounds. The results from several laboratories suggest that TRPV4 is involved in the immune activation, a phenomenon with evolutionary significance. Because of its diverse engagement in the neuronal and immune systems, TRPV4 is a potential therapeutic target for several immune-related disorders.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":" ","pages":"155-188"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33494617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cardiac TRPV4 channels. 心脏TRPV4通道。

4区生物学

Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-08-01 DOI: 10.1016/bs.ctm.2022.06.004

Vivian C Onyali, Timothy L Domeier

引用次数: 1

Specificity of Ca²⁺-activated K⁺ channel modulation in atherosclerosis and aerobic exercise training. Ca2+激活的K+通道调节在动脉粥样硬化和有氧运动训练中的特异性。

4区生物学

Current topics in membranes Pub Date : 2022-01-01 DOI: 10.1016/bs.ctm.2022.09.005

Eric A Mokelke, Mouhamad Alloosh, Michael Sturek

{"title":"Specificity of Ca2+-activated K+ channel modulation in atherosclerosis and aerobic exercise training.","authors":"Eric A Mokelke, Mouhamad Alloosh, Michael Sturek","doi":"10.1016/bs.ctm.2022.09.005","DOIUrl":"https://doi.org/10.1016/bs.ctm.2022.09.005","url":null,"abstract":"Vascular smooth muscle cells express several isoforms of a number of classes of K+ channels. Potassium channels play critical roles in the regulation of vascular smooth muscle contraction as well as vascular smooth muscle cell proliferation or phenotypic modulation. There is ample evidence that it is Ca2+ that enables these two seemingly disparate functions to be tightly coupled both in healthy and disease processes. Because of the central position that potassium channels have in vasocontraction, vasorelaxation, membrane potential, and smooth muscle cell proliferation, these channels continue to possess the potential to serve as novel therapeutic targets in cardiovascular disease. While there are questions that remain regarding the complete interactions between K+ channels, vascular regulation, smooth muscle cell proliferation, and phenotypic modulation in physiological and pathophysiological conditions, a broad understanding of the contributions of each class of K+ channel to contractile and proliferative states of the vasculature has been reached. This brief review will discuss the current understanding of the role of K+ channels in vascular smooth muscle cells in health and disease using the porcine vascular smooth muscle cell model with particular attention to new scientific discoveries contributed by the authors regarding the effect of endurance exercise on the function of the K+ channels.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"90 ","pages":"123-139"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiphasic changes in smooth muscle Ca²⁺ transporters during the progression of coronary atherosclerosis. 冠状动脉粥样硬化过程中平滑肌Ca2+转运蛋白的多相变化。

4区生物学

Current topics in membranes Pub Date : 2022-01-01 DOI: 10.1016/bs.ctm.2022.09.007

Jill Badin, Stacey Rodenbeck, Mikaela L McKenney-Drake, Michael Sturek

{"title":"Multiphasic changes in smooth muscle Ca2+ transporters during the progression of coronary atherosclerosis.","authors":"Jill Badin, Stacey Rodenbeck, Mikaela L McKenney-Drake, Michael Sturek","doi":"10.1016/bs.ctm.2022.09.007","DOIUrl":"https://doi.org/10.1016/bs.ctm.2022.09.007","url":null,"abstract":"Ischemic heart disease due to macrovascular atherosclerosis and microvascular dysfunction is the major cause of death worldwide and the unabated increase in metabolic syndrome is a major reason why this will continue. Intracellular free Ca2+ ([Ca2+]i) regulates a variety of cellular functions including contraction, proliferation, migration, and transcription. It follows that studies of vascular Ca2+ regulation in reductionist models and translational animal models are vital to understanding vascular health and disease. Swine with metabolic syndrome (MetS) develop the full range of coronary atherosclerosis from mild to severe disease. Intravascular imaging enables quantitative measurement of atherosclerosis in vivo, so viable coronary smooth muscle (CSM) cells can be dispersed from the arteries to enable Ca2+ transport studies in native cells. Transition of CSM from the contractile phenotype in the healthy swine to the proliferative phenotype in mild atherosclerosis was associated with increases in SERCA activity, sarcoplasmic reticulum Ca2+, and voltage-gated Ca2+ channel function. In vitro organ culture confirmed that SERCA activation induces CSM proliferation. Transition from the proliferative to a more osteogenic phenotype was associated with decreases in all three Ca2+ transporters. Overall, there was a biphasic change in Ca2+ transporters over the progression of atherosclerosis in the swine model and this was confirmed in CSM from failing explanted hearts of humans. A major determinant of endolysosome content in human CSM is the severity of atherosclerosis. In swine CSM endolysosome Ca2+ release occurred through the TPC2 channel. We propose a multiphasic change in Ca2+ transporters over the progression of coronary atherosclerosis.","PeriodicalId":11029,"journal":{"name":"Current topics in membranes","volume":"90 ","pages":"95-121"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 序言

4区生物学

Current topics in membranes Pub Date : 2022-01-01 DOI: 10.1016/S1063-5823(22)00036-9

引用次数: 0