Current Trends in Biomedical Engineering & Biosciences最新文献_第2页

Impact of Commonly Prescribed Antibiotics on Preterm Gut Microbiome in Necrotising Enterocolitis and Late Onset Sepsis 常用抗生素对坏死性小肠结肠炎和晚发型脓毒症早产儿肠道微生物组的影响

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2020-01-24 DOI: 10.19080/ctbeb.2019.18.555979

A. B.

{"title":"Impact of Commonly Prescribed Antibiotics on Preterm Gut Microbiome in Necrotising Enterocolitis and Late Onset Sepsis","authors":"A. B.","doi":"10.19080/ctbeb.2019.18.555979","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.18.555979","url":null,"abstract":"Background: Antibiotics are usually prescribed to preterm infants during their early days of life in neonatal intensive care units. The effects of this intervention on the developing gut microbiome are poorly understood but might have important consequences for health. We aimed to explore the routinely used antibiotics in a neonatal intensive care unit and to what extent this intervention alters the preterm gut microbiome. Methods: The three most commonly prescribed antibiotic combinations were analysed VCM (Vancomycin, Ceftazidine and Metronidazole), VC (Vancomycin and Ceftazidine) and AFG (Amoxicillin, Flucloxacillin, and Gentamicin). Sampling was performed at four time points: 2-3 days before course started (Pre), last day of administration (During), 1-2 days after antibiotic was given (After), and one week later than or as late as possible before next antibiotic course. In total, 141 stool samples were collected from 38 patients and bacterial profiling was performed by 16SrRNA gene sequencing (Miseq, Illumina) Results: Bacterial diversity increased significantly after the VC course was stopped (P=0.1). Diversity was reduced for all antibiotic treatment during their administration (P>0.05). Generally, VCM and VC were comparable with lower bacterial taxa when compared to AFG which recorded higher bacterial taxa. The result also showed that VC and VCM recovered but AFG does not. Conclusion: The three antibiotics courses differentially affected the preterm gut microbiome, causing reductions in the diversity. Further work is necessary to determine the contribution of these changes to health and how medical intervention can be tailored to achieve optimal outcomes for preterm infants.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83669023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen and Susceptibility of Alzheimer’s Disease 雌激素与阿尔茨海默病的易感性

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-12-16 DOI: 10.19080/ctbeb.2019.19.556019

Jingshan Shi

引用次数: 2

Median Lethal Dose (Ld50) Of Electric Current 电流中位致死剂量(Ld50)

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-11-06 DOI: 10.19080/ctbeb.2019.19.556018

S. Saganuwan

{"title":"Median Lethal Dose (Ld50) Of Electric Current","authors":"S. Saganuwan","doi":"10.19080/ctbeb.2019.19.556018","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556018","url":null,"abstract":"Electrical related deaths are more frequent among school age children as a result of high voltage and lightning strike [1]. Lightening, a transfer of an electrical charge, which results in discharge of static electricity, kills about 1000 people in the US every year [2]. Lightening causes muscular spasm, neurosis, thrombosis, damage of blood vessels, unconsciousness, cardiac arrest, hypoxia, respiratory arrest and death [3]. The types of lightning strikes are intracloud, cloud to ground and ground to cloud [4]. The most important resistor to the flow of current from lightening electricity is skin [5]. Estimated are 50,000 thunderstorms, 8 million lightning flashes [6], with mortality rate of 30% [7] and survival rate of 70% [8], affecting more people of less than 40years of age [9]. The effect depends on the intensity of current, voltage, body exposure among others [10]. A voltage of 30V can cause ventricular fibrillation. Electric shock is a sudden violent response to electric current, which may lead to death (electrocution). Let go phenomenon for high voltage (7600V) could be tolerated for 100 milliseconds or less [11]. Lightning has been considered by some ethnic groups as myth, miracle and mirage [12], which is cruelty to animals, and may be caused by witches [13]. In view of traditional beliefs and toxicity effects associated with lightning and electric current, there is need for acute toxicity study of electric current, with a view to determining the resistance threshold of lightning and electric current in humans and animals.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74565167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Median Lethal Dose (Ld50) Of Electric Current 电流中位致死剂量(Ld50)

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-08-26 DOI: 10.19080/ctbeb.2019.19.556017

E. Peón

引用次数: 0

The Assessment of The Quality, Efficacy and Safety of The Investigational Medicinal Product in The Absence of An Approved Registration Dossier 在没有批准注册档案的情况下，临床试验药品的质量、疗效和安全性评估

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-08-14 DOI: 10.19080/ctbeb.2019.19.556016

V. Ekaterina

引用次数: 0

GATES/GEB as the New Paradigm for Electrolytic Redox Systems GATES/GEB作为电解氧化还原系统的新范例

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-07-10 DOI: 10.19080/ctbeb.2019.19.556013

T. Michałowski

引用次数: 1

Anti-Viral Vaccine Activity of Zinc(Ⅱ) for Viral Prevention, Entry, Replication, and Spreading During Pathogenesis Process 锌的抗病毒疫苗活性(Ⅱ)在发病过程中对病毒的预防、进入、复制和传播

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-07-09 DOI: 10.19080/ctbeb.2019.19.556012

T. Ishida

{"title":"Anti-Viral Vaccine Activity of Zinc(Ⅱ) for Viral Prevention, Entry, Replication, and Spreading During Pathogenesis Process","authors":"T. Ishida","doi":"10.19080/ctbeb.2019.19.556012","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556012","url":null,"abstract":"Anti-viral vaccine activity of Zn2+ ions for viral prevention, pathogenesis processes, and ROS generation causing to oxidative stress have been investigated. AZP is efficient for viral prevention by inhibitions of BSCTV and DNA virus replications. The AZP phenotypes show strongly resistant to virus infection and viral DNA replication could be applied to the prevention of virus infections in humans. ZnOTs exhibit the ability to neutralize HSV-2 virions and blocking HSV-2 attachment activity. Zinc salts can mediate antiviral activity on RSV by altering the ability of the cell to support RSV replication. The effect of zinc sulfate on seroconversion after a simple method vaccination had been identified that accelerated HB vaccination can shorten duration of immunization of this clinical trial for showing its effectiveness. The inhibition of zinc binding activity of hMPV M2-1 protein can lead to the development of novel, live attenuated vaccines as well as antiviral drugs for pneumoviruses. The CCHH zinc finger motif provides potential vaccine candidates for the development of live species-specific attenuated influenza virus vaccines. Chelates zinc ions inhibit HIV-1 replication. The LAIVs are attracting attention as several advantages over inactivated vaccines. Zinc finger reactive compounds also inactivate retroviruses. ZOTEN promoted the presentation of bound HSV-2 virions.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"31 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86110790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Prevalence of Hypertension in Women Working in Different Educational Institutes of District Mianwali, Punjab, Pakistan 巴基斯坦旁遮普Mianwali地区不同教育机构工作妇女高血压患病率

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-06-13 DOI: 10.19080/ctbeb.2019.19.556011

S. Habib

{"title":"Prevalence of Hypertension in Women Working in Different Educational Institutes of District Mianwali, Punjab, Pakistan","authors":"S. Habib","doi":"10.19080/ctbeb.2019.19.556011","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556011","url":null,"abstract":"The present study was carried out to checked the elevation of hypertension level and risk factors associated with hypertension in the different educational sectors of Mainwali district. The questionnaire was design to obtained the data, which comprises of three parts i.e. part one comprises of demographic records (Age, weight etc), second were related to life style character (obesity, physical inactivity etc) and third one consist of the elements in blood like calcium, sodium, potassium, ferritin level and HB%. Basic descriptive statistical analysis, Chi – square test and odd square estimation was used to analyse the data. The result showed that the demographic characters are main cause of hypertension. Increasing age (above 40 year), weight (above 63) and body mass index cause elevation of blood pressure. Low level of education and post increase the blood pressure. Urban areas (65%) had higher rate of hypertension. Obese women (67%), physical activity have low prevalence of hypertension (75% in normotensive and 18.35% in hypertensive. Low socioeconomic status also causes prevalence of hypertension. High level of sodium (136.84 mEq/L), calcium (2.22mg/dL) and potassium (4.15 mEq/L) increases the higher risk of hypertension. Mean value of HB level is higher in normotensive (11.40g/dl) and pre-hypertensive (11.15g/dl) individual. Ferritin level was high in normotensive group (118.77ng/ ml) but low in pre-hypertensive (115.74ng/dl) and hypertensive group (114.33ng/dl). The low concentration of HB and ferritin affect the blood pressure and causes prevalence of hypertension. The present study provided data about factors that elevate the blood pressure and caution that will minimize our blood pressure.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73237671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Optimal Inventory Strategies for Pharmaceutical Products Incorporating Carbon Emissions 考虑碳排放的药品最优库存策略

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-06-11 DOI: 10.19080/ctbeb.2019.19.556010

A. O. Adejuwon

引用次数: 0

Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus) 菠萝蛋白酶(菠萝蛋白酶)的抑菌抗癌作用

Current Trends in Biomedical Engineering & Biosciences Pub Date : 2019-06-06 DOI: 10.19080/ctbeb.2019.19.556009

Jermen Mamo

引用次数: 12