Current Drug Therapy最新文献

{"title":"Exploring the Advance Data Mining tool for Optimization of Nanoparticles Laden in Situ Gel for Ocular Drug Delivery","authors":"P. Shah, Kesha Patel, K. Patel, V. Thakkar, Saloni Dalwadi, T. Gandhi, B. Bhavsar","doi":"10.2174/1574885518666230417085251","DOIUrl":"https://doi.org/10.2174/1574885518666230417085251","url":null,"abstract":"\u0000\u0000Glaucoma is widely treated using eye drops, but around 95% of the drug is lost by the ocular barrier resulting in low bioavailability. The incorporation of polymeric nanoparticles into mucoadhesive polymer containing in situ gel is generally helpful in the retention of nanoparticles on the eye and improves the efficacy of the formulation.\u0000\u0000\u0000\u0000The objective of the present investigation has to develop polymeric brinzolamide (BRZ) nanoparticles laden with timolol maleate (TM) in situ gel formulation.\u0000\u0000\u0000\u0000The optimized BRZ nanoparticles were prepared using PLGA by nanoprecipitation technique utilizing 32 full factorial designs (FFD). Healthy New Zealand White Rabbit (250-300 g) was used for the pharmacokinetic and pharmacodynamic study. Design of the experiment was applied to optimize formulation and validate the model. Some evaluation parameters related to BRZ nanoparticles as well as in-situ gel, have been done.\u0000\u0000\u0000\u0000The results of FFD reveal that the optimized condition for drugs to polymer ratio (1:7) containing 0.98 %w/v for poloxamer 188 results in higher entrapment efficiency and drug release with 156.7 nm particle size. The in-situ gel formulation has been prepared using Gelrite (0.5%w/v), and HPMC K4M (0.5%w/v) shows acceptable results with sustained drug release up to 6±0.1 h. The rabbit model's in-vivo pharmacokinetics and pharmacodynamic data showed sustained release of drugs longer than the marketed formulation.\u0000\u0000\u0000\u0000The proposed formulation could successfully deliver therapeutic concentrations in the eye with prolonged resident time and serve as a potential alternative for the treatment of glaucoma.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41768885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the most important Antiparasitic Compounds effective on Human Fascioliasis from the past until now","authors":"Y. Garedaghi, Y. Firouzivand, H. Hassanzadeh Khanmiri, A. Shabestari Asl","doi":"10.2174/1574885518666230403111528","DOIUrl":"https://doi.org/10.2174/1574885518666230403111528","url":null,"abstract":"\u0000\u0000Fascioliasis is a worldwide parasitic infection caused by a food-borne trematode called Fasciola, and Fasciola infection has been reported in more than 80 countries. Recently, the\u0000WHO has presented a roadmap for overlooked diseases from 2021 to 2030, which aims to increase\u0000the prevention and control of overlooked different diseases such as Fascioliasis.\u0000\u0000\u0000\u0000Our main objective was to conduct a systematic review aiming to summarize recent\u0000knowledge on the Antiparasitic Compounds against Human Fascioliasis. A keyword search was performed in PubMed, Web of Science, to gather relevant literature published between the 17th of April\u00001992 and the 23rd October 2022. A total of 329 records were initially retrieved, with 28 full-text articles retained for the qualitative synthesis.\u0000\u0000\u0000\u0000Up to now, various antiparasitic drugs have been used to treat human fascioliasis, the most\u0000important of which are: Triclabendazole, Albendazole and Bithionol, Praziquantel, Emetine and Dehydroemetine, Mebendazole in combination with Metronidazole and Nitazoxanide, Chloroquine,\u0000Hexylresorcinol. From the past to the present, natural herbal medicines have traditionally been used in\u0000most countries to treat various parasitic diseases in humans and animals so that these are known as active anthelmintic phytochemicals such as Artemisinin, Mirazid, Plumbagin, Lycium chinense.\u0000\u0000\u0000\u0000Although Triclabendazole is an effective and useful drug of choice for the treatment of\u0000human fascioliasis, but due to the gradual resistance of fasciolas to Triclabendazole, further research is\u0000needed to find new drugs. Despite many advances in antiparasitic compounds used against human\u0000fascioliasis, a number of integrated control measures should be implemented as strong management\u0000strategies for fascioliasis.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45745284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of beta-lactoglobulin nanocapsules containing astaxanthin and 5-fluorouracil on the antioxidant enzymes activity of superoxide dismutase, catalase and glutathione peroxidase in HCT116 colorectal cancer cell line","authors":"Sadegh Zarei, H. Gholami, R. Abbasalipourkabir, N. Ziamajidi, A. Divsalar, M. Saeidifar","doi":"10.2174/1574885518666230403111101","DOIUrl":"https://doi.org/10.2174/1574885518666230403111101","url":null,"abstract":"\u0000\u0000The use of nanoparticle drug delivery systems to enhance the therapeutic efficacy and reduce the side effects of anticancer drugs is taken into consideration. Astaxanthin (ATX) is a natural xanthophyll carotenoid with antioxidant, anti-inflammatory, and antiapoptotic properties used to prevent and treat some cancers.\u0000\u0000\u0000\u0000The use of nanoparticle drug delivery systems to enhance the therapeutic efficacy and reduce the side effects of anti-cancer drugs is taken into consideration. Astaxanthin (ATX) is a natural xanthophyll carotenoid with antioxidant, anti-inflammatory, and anti-apoptotic properties that has been used in the prevention and treatment of some cancers.\u0000\u0000\u0000\u0000In the present study, the antioxidant effect of beta-lactoglobulin (β-LG) nanocapsules containing ATX and 5-fluorouracil (5-FU; the first-line therapy for colorectal cancer) on the antioxidant enzymes activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in HCT116 colorectal cancer cell line was examined.\u0000\u0000\u0000\u0000In the present study, the antioxidant effect of beta-lactoglobulin (β-LG) nanocapsules containing ATX and 5-fluorouracil (5-FU; the first-line therapy for colorectal cancer) on the antioxidant enzymes activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in HCT116 colorectal cancer cell line was examined.\u0000\u0000\u0000\u0000In this experimental study, HCT116 cells were treated with different treatments of encapsulation of ATX in β-LG, encapsulation 5-FU in β-LG, co-encapsulation of ATX and 5-FU in β-LG, free ATX, free 5-FU, free ATX and free 5-FU, or β-LG nanocapsules without drugs for 24, 48 and 72 hours. There is a control group in which HCT116 cells were not treated with any drug. Then, 50% inhibitory concentration (IC50) and cell viability were determined using an MTT assay. The antioxidant enzyme activity of SOD, CAT, and GPX was measured by a colorimetric method in HCT116 cells.\u0000\u0000\u0000\u0000In this experimental study, HCT116 cells were treated with different treatments of encapsulation of ATX in β-LG, encapsulation 5-FU in β-LG, co-encapsulation of ATX and 5-FU in β-LG, free ATX, free 5-FU, free ATX and free 5-FU, or β-LG nanocapsules without drugs for 24, 48 and 72 hours. There is a control group that HCT116 cells not treated with any drug. Then, 50% inhibitory concentration (IC50) and cell viability were determined using an MTT assay. The antioxidant enzyme activity of SOD, CAT and GPX was measured by colorimetric methods in HCT116 cells.\u0000\u0000\u0000\u0000Different treatments reduced the cell viability and increased apoptotic cells in a time-dependent manner, which was significant for beta-lactoglobulin nanocapsules treatment (P<0.05). It means receiving more 5-FU or ATX in the encapsulated form by HCT116 cells. The antioxidant enzyme activity of SOD, CAT, and GPX in HCT116 cells treated with beta-lactoglobulin nanocapsule treatment significantly increased compared to the control group (P<0.001). Moreover, the antioxidant activity of these enz","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42431176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Characterization of Febuxostat loaded floating beads as Gastro-Retentive Drug Delivery System in the treatment of Gout: A Statistical Approach","authors":"Chetna Modi, Ravina Kathota, Ayushi G. Patel, V. Thakkar, Hardik B. Rana","doi":"10.2174/1574885518666230331084428","DOIUrl":"https://doi.org/10.2174/1574885518666230331084428","url":null,"abstract":"\u0000\u0000Febuxostat is a BCS class-II drug, used in the treatment of gout. However, because of its lower solubility, a higher and more frequent dose of the drug is required in the treatment.\u0000\u0000\u0000\u0000Febuxostat is a BCS class-II drug, used in the treatment of gout. Therapeutic window of Febuxostat is at site of stomach. But because of its lower solubility, higher and frequent dose of drug is required in the treatment.\u0000\u0000\u0000\u0000The objective of this research was to develop and evaluate febuxostat-loaded floating beads as a gastro-retentive drug delivery system (GRDDS) to target drug release up to 24hr in order to enhance bioavailability.\u0000\u0000\u0000\u0000The objective of this research was to develop and evaluate febuxostat loaded floating beads as Gastro-retentive drug delivery system (GRDDS) to target drug release up to 24hr in order of enhancement of bioavailability.\u0000\u0000\u0000\u0000Gastro-retentive floating beads were formulated using the ionotropic gelation method. Screening of lipids was carried out based on the shape and texture of floating beads. Drug-excipient compatibility study was done using DSC analysis. Further optimization of gastro-retentive floating beads of febuxostat was performed by Box-Behnken design using gelucire 43/01, lactose, and soluplus as independent variables and %drug entrapment and %drug release after 24 hr as dependent variables. Evaluation of the optimized batch was performed for in vitro buoyancy, %drug entrapment, %drug release, FTIR, and SEM study.\u0000\u0000\u0000\u0000Gastro-retentive floating beads were formulated using ionotropic gelation method. Screening of lipids was carried out on the basis of shape and texture of floating beads. Drug-excipient compatibility study was done using DSC analysis. Further optimization of gastro-retentive floating beads of febuxostat was done by Box-Behnken Design using Gelucire 43/01, lactose, soluplus as independent variables and %Drug entrapment and %drug release after 24 hr as dependent variables. Evaluation of optimized batch was performed for in vitro buoyancy, %drug entrapment, %drug release, FTIR and SEM study.\u0000\u0000\u0000\u0000In the ANOVA, contour plots, and 3D surface plots, the optimized batch showed 93.95±0.29 % drug entrapment and 88.14±0.58 % drug release after 24 hr with 98%±1% in-vitro buoyancy. Overlay plots and checkpoint batches were accompanied to confirm the optimization. Polynomial equations proved the positive effect of lipids on drug entrapment and drug release. SEM images explained porous and microstructures on beads.\u0000\u0000\u0000\u0000From the ANOVA table, Contour plots and 3D surface plots, Optimized batch showed 93.95±0.29 %drug entrapment, 88.14±0.58 % drug release after 24 hr, with 98%±1% in-vitro buoyancy. Overlay plot and check point batches were accompanied to confirm the optimization. Polynomial equations prove positive effect of lipid on drug entrapment and drug release. SEM images explained porous and micro structure on beads.\u0000\u0000\u0000\u0000In conclusion, gastro-retentive febuxostat floating beads were successfully developed and characterized ","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42598619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miscellaneous naturally derived anticancer agents","authors":"Rashmi Saxena Pal, Saranya Punniyakotti, K. Khera, Deepti Katiyar","doi":"10.2174/1574885518666230330162748","DOIUrl":"https://doi.org/10.2174/1574885518666230330162748","url":null,"abstract":"\u0000\u0000Secondary metabolites of natural origin exhibit numerous pharmacological activities like anti-inflammatory and anti-oxidant effects. Lipid peroxidation is observed to be prevented by terminating free radical chains and chelating redox active metal ions. These properties of the secondary products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed with plenty of unexplored phytometabolites, which contain the probability to carry huge anti-neoplastic potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and series of developmental methods. They are very powerful apoptosis inducers and can regulate the exclusion of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule that can be found in both natural and manufactured products. Marine species, which are also examples of naturally derived drug sources such as algae, sponges, tunicates, and bryozoans have emerged as important components of choice for the separation of novel anticancer drugs obtained from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic targets, which are being explored to unprecedented heights and they have proven to be sources of various medicinal agents such as antibiotics etc. Numerous secondary metabolites have been isolated from marine fungi, that were active biologically and unique structural and also therapeutically beneficial. So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive to lichens. This mini-review aims for the discussion of different aspects related to the natural derivatives obtained from various sources, which play a pivotal role as anti-neoplastic agents.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46353388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Herbal Extracts as Sunscreens and Antihyperpigmentation Treatment","authors":"L. Kothapalli, Komal Bhosale, Asha B. Thomas, Pooja Sawant","doi":"10.2174/1574885518666230330114431","DOIUrl":"https://doi.org/10.2174/1574885518666230330114431","url":null,"abstract":"\u0000\u0000Skin pigmentation is one of the most serious problems in the adult population of all races. The underlying factors of skin pigmentation are excessive exposure to UV radiation, oxidative stress, and other provocative causes that cause melasma, black spots, and post-inflammatory hyperpigmentation. Hence, treating hyperpigmentation disorders is challenging.\u0000\u0000\u0000\u0000Skin pigmentation occurs as a process of melanin biosynthesis triggered by UV exposure. Tyrosinase, an enzyme that catalyzes the rate-confining step in melanogenesis, if inhibited, can cause skin hypopigmentation. This has evoked an interest in reviewing plant extracts/ phytoconstituents, which can serve the purpose of sun protection and treat hyperpigmentation, ensuring skin glow for a better quality of life.\u0000\u0000\u0000\u0000A literature search on Medline, PubMed, Embase, and Scopus databases was done using various keywords like hyperpigmentation, melasma, skin-lightening agents, and sunscreen.\u0000\u0000\u0000\u0000Sun protection products for canopy with photo-aging and skin pigmentation are recommended. Tyrosinase inhibitors are first-line topical medicines available as single or combined topical formulations. Hydroquinone, retinoids, corticosteroids, and kojic acid are clinically proven as exceptionally powerful. However, the adverse effects reported with these small molecules largely impact skin appearance, dermatitis, and exogenous ochronosis. Currently, there is a rising trend towards comfortable, fascinating, and well-endured skin depigmenting agents from natural products that might be utilized by a wide populace.\u0000\u0000\u0000\u0000This present study aimed at exploring plant and fruit extracts together with their active ingredients as potential multitargeted anti-hyperpigmentation agents with sunscreen properties, tyrosinase inhibition, and skin whitening effects.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46267775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis, Characterization, and Biomedical Applications of Copper and Copper Oxide Nanoparticles of Plant Origin","authors":"S. Dhir, R. Verma, S. Bhatt, Vandana Garg, R. Dutt","doi":"10.2174/1574885518666230328150208","DOIUrl":"https://doi.org/10.2174/1574885518666230328150208","url":null,"abstract":"\u0000\u0000The green synthesis approach using plants for the formation of metal/metal oxide nanoparticles is biologically safe and environment-friendly as compared to various physical and chemical methods. Various phytoconstituents present in the plants such as phenols, flavonoids, alkaloids, tannins, and proteins act as a potential bioresource for the formation of metal/metal oxide nanoparticles. The most common metals/metal oxides used are silver (Ag), copper (Cu), zinc, iron and gold. Amongst the above, copper is a comparably cheap metal as compared to gold and silver. Copper oxide nanoparticles have diverse applications in various fields of therapeutics. This review provides insights regarding the bio-mediated synthesis of copper/copper oxide nanoparticles, factors affecting the synthesis, their characterization, and the biomedical applications mainly the antibacterial, antifungal, and anticancer activity. Still, more research is needed focusing on different ways to minimize toxicity and improve biological efficacy. Although many trials and research have already been conducted and it seems that the potential for developing copper and copper oxide nanoparticles as a future drug is very bright.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49498052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saraca Asoca: From Traditional Herb To Modern Drug As A Cure For Various Diseases","authors":"S. Husain, Faiza Fathima, R. Parveen, M. Khan, Z. Malik, S. Mustafa, Sheersh Massey, Sayeed Ahmad","doi":"10.2174/1574885518666230316111902","DOIUrl":"https://doi.org/10.2174/1574885518666230316111902","url":null,"abstract":"\u0000\u0000Saraca asoca (Ashoka, family; Caesalpiniaceae) is an indigenous sacred tree, native to India. It has been used in various traditional medicinal systems and is one such plant that is highly therapeutic but its use in disease management is underrated in today’s era and has lost its importance.\u0000\u0000\u0000\u0000This narrative review is written to provide the information on medicinal importance of S. asoca and the significance of S. asoca in various traditional medicinal systems\u0000\u0000\u0000\u0000Different databases were searched to gather information. Research articles, abstracts, and reviews are included in this review.\u0000\u0000\u0000\u0000Saraca asoca is known for its unique pharmacological role in treating various uterine complications, menstrual disorders, and bacterial infections, bleeding hemorrhoids, urinary and dermatological problems. The stem bark of the tree is the principal constituent for treating menorrhagia and genito-urinary disorders. The stem bark, leaves, and seeds of S. asoca are known to contain flavonoids, tannins, alkaloids, glycosides, polyphenolics, fatty acids, and saponins. The reported major phytoconstituents responsible for its therapeutic uses are epicatechin, procyanidin B2, lyoniside, nudiposide, catechin, leucocyanidin, and leucopelargonidin. Various pharmacological activities of this plant are discussed in this review.\u0000\u0000\u0000\u0000It has been proved that Saraca asoca possesses several pharmacological properties and is useful in treating various diseases. More studies on quality control, standardization, and clinical trials on S. asoca should be performed, so that this plant could be utilized as an effective anti-cancer drug which could be a promising source for the herbal and pharmaceutical industry\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44176750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Genistein in Sanfilippo Syndrome - A Systematic Review","authors":"Mohd Ashif Khan, Haya Majid, M. Masoom, Aakriti Garg","doi":"10.2174/1574885518666230313145936","DOIUrl":"https://doi.org/10.2174/1574885518666230313145936","url":null,"abstract":"\u0000\u0000Sanfilippo syndrome, commonly known as mucopolysaccharidosis type III (MPS III), is a rare autosomal recessive lysosomal storage disease that primarily affects the brain and spinal cord. It is caused by a deficiency of enzymes involved in the catabolism of glycosaminoglycan (GAG) and heparin sulfate (HS). Although Genistein has been presented as a potential therapeutic, its safety and efficacy for the treatment of Sanfilippo syndrome are not well established.\u0000\u0000\u0000\u0000This systematic review aims to evaluate the safety and efficacy of Genistein with a primary endpoint of providing an inference whether the medication is producing any improvements when administered in patients suffering from Sanfilippo syndrome.\u0000\u0000\u0000\u0000An intensive computerized literature search was performed according to PRISMA guidelines in major databases such as PubMed, ScienceDirect, Embase, Science Citation Index Expanded, The Cochrane Library, and Web of Science until 30 April 2022. Studies evaluating the efficacy and safety of genistein in patients with Sanfilippo Syndrome were included. The quality of the included studies was assessed using the New Castle Ottawa Scale.\u0000\u0000\u0000\u0000A total of 558 studies were identified in the initial search. After removing duplicates, 25 studies were screened based on title and abstract, of which 06 studies were included in this systematic review. Among them, 02 studies were of high quality and 04 studies were of moderate quality. After administration of genistein, a decrease in urinary GAG levels and HS levels was observed.\u0000\u0000\u0000\u0000Based on the limited evidence present in the literature, this systematic review suggests that genistein can be safely used to treat Sanfilippo syndrome as it lowers GAG levels. However, data on the long-term benefit profile of genistein and high-quality evidence are still needed as a conclusive result could not be withdrawn.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effectiveness of Remdesivir in the Treatment of COVID-19 Outpatients: A retrospective cohort study","authors":"A. Asghari, Seyed Yaser Foroughi Ghomi, A. Mohammadbeigi, A. Ahmadi, S. Ahmadpour, M. Shakeri, S. Adeli, Jamshid Vafaei Manesh, Reihane Tabaraii, R. Shajari, M. Vahedian","doi":"10.2174/1574885518666230228120343","DOIUrl":"https://doi.org/10.2174/1574885518666230228120343","url":null,"abstract":"\u0000\u0000The outbreak of acute respiratory syndrome with novel coronavirus 2019 (COVID-19) in December 2019 in Wuhan, China, caused a worldwide outbreak of the disease. To treat the disease, some drugs were identified and introduced that did not show a significant effect on the recovery of the disease. Due to the need to manage inpatient beds, this study was conducted to evaluate the effectiveness of Remdesivir in the treatment of outpatients with moderate to severe COVID-19.\u0000\u0000\u0000\u0000The present study was a retrospective cohort with a convenience sampling method. It was conducted by referring to the records of COVID-19 patients who were referred to the respiratory clinic of Shahid Beheshti Hospital as outpatients in the period from April to August 2021.\u0000\u0000\u0000\u0000This study was conducted on 263 COVID-19 patients with a mean age of 51.16±14.39 years from 19 and 90 years old. Data were collected through a researcher-made checklist and analyzed using SPSS 20. Kolmogorov-Smirnov test, paired t-test, and Mc Nemar's test were used to evaluate the data. The significance level was considered at the level of 0.05.\u0000\u0000\u0000\u0000Findings revealed that no clear correlation was found between hospitalization and death rate compared to other patients. In our study, the risk factors for severe COVID-19 did not affect the rate of hospitalization or death of patients.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46318273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}