JBR Journal of Interdisciplinary Medicine and Dental Science最新文献_第3页

Saliva as a Biomarker of Heat Shock Protein in Chronic Renal Disease 唾液作为慢性肾脏疾病热休克蛋白的生物标志物

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-04-30 DOI: 10.4172/2376-032X.1000195

M. Hegde, Nireeksha, S. Shetty

{"title":"Saliva as a Biomarker of Heat Shock Protein in Chronic Renal Disease","authors":"M. Hegde, Nireeksha, S. Shetty","doi":"10.4172/2376-032X.1000195","DOIUrl":"https://doi.org/10.4172/2376-032X.1000195","url":null,"abstract":"Background and Objective: Heat shock protein 70 usually located in the cytoplasm, it plays an important role has a chaperone. It said to have anti- proinflammatory effect, as shown in experimental model. These play an extended role in immunity and implication in pathogenesis of systemic conditions. In chronic renal kidney disease the complexity of underlying disturbances is an ideal example for persistent multifactorial stress. The combination of uremic toxins, mediators of inflammation, oxygen species, apoptosis and renal dialysis. The role of heat shock proteins in chronic renal damage, their protective and deleterious effect is of prime importance for the future perspectives of optimizing renal therapy the aim of this study was to evaluate the circulatory and salivary heat shock protein level 70 in healthy individuals and individuals undergoing renal dialysis with chronic renal disease. \u0000Method: 40 patients attending to the department of nephrology, K. S. Hegde Medical hospital diagnosed with chronic renal disease, undergoing renal dialysis in the age group of 35-60 yrs were included in the study. Individuals with other active infections, pregnant and lactating women’s, smokers were excluded from the study. The study was conducted among Control (n = 40) and Experimental group (n = 40). Saliva and serum samples were evaluated for Heat shock protein 70 by ELIZA Method (Enzyme -linked immunoassay for heat shock protein 70) and statistical analysis was done with independent student‘t’ test. P < 0.05 was considered to be statistically significant. \u0000Conclusion: Salivary and circulatory Heat Shock protein 70 showed significant increase in Individuals undergoing renal dialysis .Thus, Circulatory and salivary Heat Shock Protein 70 is an efficient stress marker in chronic renal disease condition.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124683706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Proposed Classification for the Palatal Perforation (Dr. Santosh PatilClassification) 腭穿孔的建议分类(Dr. Santosh PatilClassification)

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-04-06 DOI: 10.4172/2376-032X.1000192

S. Patil

{"title":"Proposed Classification for the Palatal Perforation (Dr. Santosh PatilClassification)","authors":"S. Patil","doi":"10.4172/2376-032X.1000192","DOIUrl":"https://doi.org/10.4172/2376-032X.1000192","url":null,"abstract":"The palate is an integral part of the oral cavity constituting various tissue types that give rise to different types of pathological conditions. Palatal perforation can be defined as a communication between the nasal cavities and the oral cavity. Palatal perforation is a rare condition encountered in the routine dental practice. It is well understood that the palatal perforation can pose a difficult diagnostic dilemma for the clinician. The perforation may present with the common characteristics and may be indistinguishable clinically. Emphasis is placed on the importance of obtaining a thorough and comprehensive history and collecting relevant laboratory information. Palatal perforation may be known to arise secondary congenital or acquired causes. During the sixth week of prenatal period palatal shelves may fail to fuse leading to cleft palate [1]. Acquired palatal perforations may be seen due to trauma, infectious disease, granulomatous disease, drug abuse, collagen vascular diseases and neoplastic conditions. Adenoid cystic carcinoma is reported to cause palatal perforation in many cases [2]. Tumors from maxillary sinus or nasal cavity may extend to palate leading to its perforation [3,4]. Although these neoplasms usually form a mass, but in advance cases perforation of palate may occur in course of disease or following treatment [5,6]. Various cases of palatal perforation due to narcotics abuse are reported in literature [7-9] (Table 1). Surgical procedures such as maxillectomy, septoplasty or intubation may lead to palatal perforation [10,11]. Till date there is no classification given for the palatal perforation, classification of disease makes it easier to study and understand which helps in timely diagnosis leading to the best prognosis for the patient. With this objective the following classification based on the etiological conditions has been proposed after a brief review of various causative factors for palatal perforations existing literature.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115736180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Maltitol and Xylitol Sweetened Chewing-Gums Could Modulate SalivaryParameters Involved in Dental Caries Prevention 麦芽糖醇和木糖醇加糖口香糖可调节唾液参数参与龋齿预防

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-04-02 DOI: 10.4172/2376-032X.1000191

Thabuis Clementine, C. Yue, Wang Xiaoling, Pochat Marine, Han Alex, Miller Larry, Wils Daniel, Guerin-Deremaux Laëtitia

{"title":"Maltitol and Xylitol Sweetened Chewing-Gums Could Modulate SalivaryParameters Involved in Dental Caries Prevention","authors":"Thabuis Clementine, C. Yue, Wang Xiaoling, Pochat Marine, Han Alex, Miller Larry, Wils Daniel, Guerin-Deremaux Laëtitia","doi":"10.4172/2376-032X.1000191","DOIUrl":"https://doi.org/10.4172/2376-032X.1000191","url":null,"abstract":"Objectives \u0000The effects of sugar-free chewing-gums (CG) sweetened with either 100% maltitol or 100% xylitol on salivary parameters were assessed in order to better understand the role polyols can play in dental caries prevention. \u0000Methods \u0000A double-blind, parallel, randomized, controlled study was conducted in China. Subjects (N = 258, age = 13 to 15 years old) were divided into 4 groups: 2 receiving polyols CG, containing respectively SweetPearl®-maltitol or XYLISORB®-xylitol, one placebo group receiving gum base and a negative control group not receiving any gum. CG were chewed for 30 days. Salivary parameters (flow rate, pH, glucan sucrase activity and free sialic acid concentration) were measured throughout the experimental period. \u0000Results \u0000All studied parameters were significantly modified with gum base compared with no-gum: salivary flow and pH increased. Glucan sucrase activity and saliva concentrations in free sialic acids decreased. Maltitol and xylitol CG showed even stronger effects on these parameters than gum base and led to a better resistance of the oral ecosystem to a sucrose challenge. This was tested in standardized in-vitro conditions. \u0000Conclusion \u0000Sugar-free CG sweetened with either maltitol or xylitol can similarly improve several parameters involved in global oral health and more specifically in dental caries prevention compared to gum base. The use of a gum base placebo allowed us to isolate the effects due to maltitol and xylitol themselves from those due to mastication, and to show that the effects were similar for both polyols.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125328306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Maxillary First Molar with One C-Shaped Fused Root Diagnosed with Cone-Beam Computed Tomography: A Case Report 上颌第一磨牙一c形融合根的锥束ct诊断1例

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-03-08 DOI: 10.4172/2376-032X.1000190

Xiujun Tan, X. Liao, L. Ye, Chenglin Wang

引用次数: 0

Further Evidence of GWAS Signals in Non-Syndromic Orofacial Clefts fromWestern Han Chinese 西汉非综合征性口面裂GWAS信号的进一步证据

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-02-26 DOI: 10.4172/2376-032X.1000189

S. Duan, B. Shi, Jia‐yu Shi, Fan Feng, Z. Jia

{"title":"Further Evidence of GWAS Signals in Non-Syndromic Orofacial Clefts fromWestern Han Chinese","authors":"S. Duan, B. Shi, Jia‐yu Shi, Fan Feng, Z. Jia","doi":"10.4172/2376-032X.1000189","DOIUrl":"https://doi.org/10.4172/2376-032X.1000189","url":null,"abstract":"Background \u0000Non-syndromic orofacial clefts (NSOCs) are the major human congenital defects with a complex etiology. Several candidate genes and environmental factors, and their interactions were assumed for the susceptibility to NSOCs. Previous GWAS have identified numerous susceptible loci from different populations. However, few loci have been replicated among Western Han Chinese yet. This study aimed to validate this findings in NSOCs from Western Han Chinese population. \u0000Methods \u0000We selected two SNPs (rs4147811 and rs481931) on 1p22 and recruited 440 case-parent trios with NSOCs for this study. The SNPs were genotyped by using SNPscan method. To evaluate the association, we performed transmission disequilibrium test (TDT), parent-of-origin effect and gene-gene interaction analysis. \u0000Results \u0000Rs481931 G allele (Z=2.05, P=0.016) and G/G homozygotes (Z=2.62, P=0.009) were over-transmitted for NSCL/P. Rs4147811 C allele (Z=2.16, P=0.030) and C/C homozygotes (Z=2.29, P=0.020) were over-transmitted for NSCL/P. Rs481931 G allele was also paternal over-transmitted for NSCL/P (P=0.030) and maternal over-transmitted for NSCPO (P=0.036). \u0000Conclusions \u0000Our results confirmed the previous GWAS findings of these two SNPs in the etiology of NSOCs among Western Han Chinese.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"208 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116526169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Interlink of Two Syndromes - Demarquay-van der Woude and PoplitealPterygium in One Family Group Demarquay-van der Woude和popliteal翼状胬肉两证在一个家族群中的联系

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-02-01 DOI: 10.4172/2376-032X.1000188

S. Htun, K. Bütow, H. Engelbrecht, E. Honey

{"title":"Interlink of Two Syndromes - Demarquay-van der Woude and PoplitealPterygium in One Family Group","authors":"S. Htun, K. Bütow, H. Engelbrecht, E. Honey","doi":"10.4172/2376-032X.1000188","DOIUrl":"https://doi.org/10.4172/2376-032X.1000188","url":null,"abstract":"Background and Objective: Demarquay-van der Woude (DVWS) and Popliteal Pterygium (PPS) syndromes are distinct autosomal dominant conditions generally presenting with a cleft lip and/or cleft palate. Both syndromes are genetically associated with mutations of the gene coding for Interferon Regulatory Factor 6 (IRF6) and grouped together as the IRF6-Related Disorder. In addition to a cleft, DVWS characteristically includes generally two labial pits on the lower lip. The pits may be symmetrical or asymmetrical, with saliva draining from them, or may also be abnormally flabby or conical-shaped mucosal elevations without distinct pitting. In PPS, the cleft patient commonly presents with an extensive single lower lip pit with salivary drainage, as well as popliteal webs/pterygia of the lower limb/limbs. Additional defects may include intraoral synechial web, syndactyly and genito-urinary malformations. Methods: One case (infant) with two family members presented with overlapping deformities associated with DVWS, as well as PPS. Sequencing of the IRF6- gene was performed on one of the members. Results: The surgical records of 4182 patients of a major cleft lip and palate clinic recorded 71 (1.70%) patients diagnosed with DVWS, 12 (0.29%) with PPS and one infant (0.02%) as an interlinked DVWS-PPS. In the family of the baby presented in this paper, all three affected individuals are females and each the third child in the family, who have lip pits typically associated with DVWS that are both bilateral and symmetrical. The grandmother and grandchild, but not the mother, has underdeveloped or minor unilateral popliteal webs. All three have syndactyly of their feet with hypoplastic toenails (involving one to three phalanges) and pyramidal-shaped (or redundant) skin above the hallux nail of the main phalanges. Conclusion: The infant and two family members are identified as interlinked DVWS-PPS.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125595809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Universal Health Coverage and Oral Health 全民健康覆盖和口腔健康

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2016-01-20 DOI: 10.4172/2376-032X.1000E106

Z. Danial, K. Mh, S. Mirhashemi, H. Khoshmohabat, N. Danial

引用次数: 9

Predicting Transmitted Light Radiant Exposure of Fiber Dowel Cross Sections from Dowel Diameter and Length 从榫直径和长度预测光纤榫截面的透射光辐射暴露

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2015-10-30 DOI: 10.4172/2376-032X.1000187

T. Marghalani

{"title":"Predicting Transmitted Light Radiant Exposure of Fiber Dowel Cross Sections from Dowel Diameter and Length","authors":"T. Marghalani","doi":"10.4172/2376-032X.1000187","DOIUrl":"https://doi.org/10.4172/2376-032X.1000187","url":null,"abstract":"Purpose: To determine whether dowel diameter and length predict a significant amount of variance in transmitted light radiant exposure (TLRE) while controlling for possible dowel system effects. \u0000Materials and methods: Fiber dowels (Fiber Kleer sizes 1.25, 1.375, and 1.5; Postec Plus sizes 0, 1, and 3) were used. Ten fiber dowels from each system and size were embedded in C&B temporary resin cylinders. The detector of a radiometer was placed on the apical end of each embedded dowel, and the probe tip of an LED curing light was placed on the coronal end. The light cure machine was activated for 40s. The cylinders were shortened in 1-mm increments and TLRE (in mill joules/centimeter squared) was measured at each increment. TLRE values were analyzed using hierarchical multiple linear regression (α = 0.001) with SPSS software. \u0000Results: Dowel system effects explained 0.3% of the variance in TLRE. The total variance explained by the model as a whole was 44% (p < 0.001). Dowel diameter and length explained an additional 43.6% of the variance in TLRE after controlling for dowel system effects [R2 change = 0.436, p < 0.001]. The beta value for dowel length (beta = -0.517, p < 0.001) was larger than that for dowel diameter (beta = 0.208, p < 0.001). \u0000Conclusion: Dowel diameter and length and length can predict TLRE at the apical end of a dowel cross section after controlling for dowel system effects. Dowel system effects did not contribute significantly.","PeriodicalId":110010,"journal":{"name":"JBR Journal of Interdisciplinary Medicine and Dental Science","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128878201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Orthodontic Services in Yemen 也门的牙齿矫正服务

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2015-10-19 DOI: 10.4172/2376-032X.1000E105

N. Al-Zubair

引用次数: 0

Incorporation of Hydroxyapatite-Silica Nano-Powder for Enhancement of Glass Ionomer Cement (GIC) 羟基磷灰石-二氧化硅纳米粉的掺入增强玻璃离子水泥(GIC)

JBR Journal of Interdisciplinary Medicine and Dental Science Pub Date : 2015-09-11 DOI: 10.4172/2376-032X.1000E104

Norhayati Luddin

引用次数: 5