Current Nanomaterials最新文献_第4页

Implementation of Nanocarriers for Brain-Specific Drug Delivery System 脑特异性药物递送系统纳米载体的实现

Current Nanomaterials Pub Date : 2023-08-04 DOI: 10.2174/2405461508666230804102333

M. Alam, Aditya Sharma, Awaneet Kaur

{"title":"Implementation of Nanocarriers for Brain-Specific Drug Delivery System","authors":"M. Alam, Aditya Sharma, Awaneet Kaur","doi":"10.2174/2405461508666230804102333","DOIUrl":"https://doi.org/10.2174/2405461508666230804102333","url":null,"abstract":"\u0000\u0000There are several safeguards in place to protect the brain from injury because of its vulnerability. Two major barriers prevent harmful substances from entering the brain: the blood-brain barrier\u0000(BBB) and the blood-cerebrospinal fluid barrier (BCSFB). Although there has been some success in\u0000devising ways for transporting medicines to the brain, the great majority of the nanoparticles (NPs)\u0000used in these procedures are destroyed in the process. An awareness of the whole scope of the delivery\u0000process and the numerous obstacles it may offer is necessary for the sensible design of brain-targeted\u0000pharmaceutical delivery systems. The blood-brain barrier (BBB) is the best-known physiological barrier affecting both brain access and the efficacy of various pharmacological therapies. Accordingly,\u0000the development of a promising therapy for the treatment of brain disorders requires drug targeting of\u0000the brain, specifically damaged cells. Researchers are looking into nano-carrier systems, also called\u0000surface-modified target-specific novel carrier systems, to determine if they can be used to boost the\u0000effectiveness of brain drugs while minimizing their side effects. These strategies have the potential to\u0000bypass BBB function, leading to increased drug levels in the brain. Numerous physiological parameters, such as active efflux transport, the brain's protein corona, nanocarrier stability and toxicity, physicochemical features, patient-related factors, and others, determine whether or not a novel carrier system is functional.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44436063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meet the Section Editor 见栏目编辑

Current Nanomaterials Pub Date : 2023-08-01 DOI: 10.2174/240546150802221213095311

Khalil Abdelrazek K. Abdelmawgoud

引用次数: 0

Overcoming The Therapeutic Limitation of Ocular Drug Delivery with The Help of Novel Drug Carriers 借助新型药物载体克服眼部给药的治疗局限

Current Nanomaterials Pub Date : 2023-08-01 DOI: 10.2174/2405461508666230801095201

Sumbul Shadab, M. Alam, P. Sharma, D. Paliwal

引用次数: 0

A Review on Nanosponges: An Idiosyncratic Approach for Delivery of Proactive Molecules 纳米海绵：一种独特的主动分子递送方法综述

Current Nanomaterials Pub Date : 2023-07-26 DOI: 10.2174/2405461508666230726163944

N. Minocha, Meenakshi Attri, A. Raghav, K. Rao, P. Pandey

{"title":"A Review on Nanosponges: An Idiosyncratic Approach for Delivery of Proactive Molecules","authors":"N. Minocha, Meenakshi Attri, A. Raghav, K. Rao, P. Pandey","doi":"10.2174/2405461508666230726163944","DOIUrl":"https://doi.org/10.2174/2405461508666230726163944","url":null,"abstract":"\u0000\u0000A lot of work has been done by many researchers to develop a system that is targeted at a specific site. Nanosponges are one of the systems that serve this purpose and have several advantages over other methods.\u0000\u0000\u0000\u0000The article’s strategy is to provide access to data regarding the nanosponges system, including its preparation, evaluation, and advantages in various fields, such as the transportation of proteins, vaccines, biocatalysts, and drugs with enhanced bioavailability. Nanosponges also contribute significantly to the treatment of breast cancer, lung cancer, fungal infection, water treatment, and topical application than other approaches.\u0000\u0000\u0000\u0000Nanosponges contain a solid, porous system in which hydrophilic or lipophilic drugs are loaded at their core in the nanocavity. All the information provided in this article was collected after analysing various reports on nanosponges available on Google Scholar, PubMed, Scopus, Web of Science, and Science Direct. It is concluded that the nanosponges have excellent aqueous solubility properties. Therefore, they can be used as carriers for drugs with poor water solubility. Moreover, greater bioavailability can be achieved by using the nanosponge approach.\u0000\u0000\u0000\u0000Nanosponges possess various outstanding properties that form the unique system of this approach. Nanosponges provide an effective carrier system for enzymes, proteins, vaccines, and therapeutic fields. This review provides a broad overview of the development of nanosponges, their evaluation, and the uses of nanosponges based on cyclodextrin for drug delivery.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49647228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress on Polyolefin/Graphene Nanocomposites with high dielectric constant and low dielectric loss for electrical applications 高介电常数、低介电损耗的聚烯烃/石墨烯纳米复合材料的研究进展

Current Nanomaterials Pub Date : 2023-07-17 DOI: 10.2174/2405461508666230717100734

H. Aldosari, N. Madkhali, Saja Algasser, M. Khairy

{"title":"Progress on Polyolefin/Graphene Nanocomposites with high dielectric constant and low dielectric loss for electrical applications","authors":"H. Aldosari, N. Madkhali, Saja Algasser, M. Khairy","doi":"10.2174/2405461508666230717100734","DOIUrl":"https://doi.org/10.2174/2405461508666230717100734","url":null,"abstract":"\u0000\u0000The attached oxygen functional group in graphene oxide (GO) with layers that are about 1.1 ± 0.2 nm thick, has hindered the performance of electrical characteristics. Diminution of the oxygen functional group, and increasing the carbon/oxygen (C/O) ratio can enhance electrical conductivity.\u0000\u0000\u0000\u0000This study investigated the effect of graphene derivatives (C/O) ratios on the dielectric properties of low-density polyethylene (PE) made of metallocene, as well as polypropylene (PP) and mixtures of them. The oxygen functional groups were reduced by utilizing graphene oxide (GO) and reduced graphene oxide (rGO). The effect of GO and rGO-based polyolefin produced by solution blending while lowering the oxygen functional group is explored.\u0000\u0000\u0000\u0000The surface morphology and chemical structure were examined by using a scanning electron microscope (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). The electrical characteristics of the composite films, such as their loss factor (tan δ) and dielectric constant, permittivity and conductivity, and imaginary permittivity were examined. At room temperature, measurements were performed at frequencies ranging from 300 Hz to 8 MHz. ε^'; the dielectric permittivity and imaginary permittivity (ε^'') of polymer/ reduced graphene oxidehowever, these values rapidly decreased with increasing frequency.\u0000\u0000\u0000\u0000The alternating current conductivity of the composites was likewise shown to increase with increasing frequency.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43233263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Capping Agents and Digestive Ripening for Size Control of Magnetite for Magnetic Fluid Hyperthermia 磁流体热疗用磁铁矿粒径控制的绿色封盖剂和消化成熟

Current Nanomaterials Pub Date : 2023-06-06 DOI: 10.2174/2405461508666230606124615

Hadir Ebraheem, Heba Kahil, Ismail Abd El-Rahim Ali

{"title":"Green Capping Agents and Digestive Ripening for Size Control of Magnetite for Magnetic Fluid Hyperthermia","authors":"Hadir Ebraheem, Heba Kahil, Ismail Abd El-Rahim Ali","doi":"10.2174/2405461508666230606124615","DOIUrl":"https://doi.org/10.2174/2405461508666230606124615","url":null,"abstract":"\u0000\u0000Magnetite is the most recognized iron oxide candidate used for various biological applications.\u0000\u0000\u0000\u0000This work is a complete study that addresses the synthesis of magnetic nanoparticles and investigates the feasibility of using green tea and ascorbic acid as capping agents.\u0000\u0000\u0000\u0000Synthesis of magnetite by two wet chemical methods namely: coprecipitation and solvothermal methods. The samples were characterized using X-ray diffraction (XRD), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM).\u0000\u0000\u0000\u0000The results reveal the impact of coating on the size and morphology of the particles. The study also proves that autoclaving the samples prepared by coprecipitation results in smaller particle size and narrower size distribution due to digestive ripening. In addition, a novel and facile methodology for coating magnetite with polyethylene glycol is presented. The potential of the particles to be used for magnetic fluid hyperthermia is assessed by measuring the specific absorption rate (SAR) of the samples.\u0000\u0000\u0000\u0000The results show that all the prepared magnetite samples showed a promising capacity to be used as magnetic fluid hyperthermia agents.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47332860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The copper metal and magnetite nanoparticles conjugated with salicylic acid composite stimulated wheat defense mechanism and affected cellular components under heat stress 水杨酸复合物偶联的金属铜和磁铁矿纳米粒子在热胁迫下刺激小麦防御机制并影响细胞成分

Current Nanomaterials Pub Date : 2023-06-06 DOI: 10.2174/2405461508666230606123103

Asmaa A. Mahdi, T. Salaheldin, M. Hendawey, Nahla S Hassan

{"title":"The copper metal and magnetite nanoparticles conjugated with salicylic acid composite stimulated wheat defense mechanism and affected cellular components under heat stress","authors":"Asmaa A. Mahdi, T. Salaheldin, M. Hendawey, Nahla S Hassan","doi":"10.2174/2405461508666230606123103","DOIUrl":"https://doi.org/10.2174/2405461508666230606123103","url":null,"abstract":"\u0000\u0000This study aimed to examine the effect of magnetite coating of salicylic acid and Cu metal nanoparticles on yield, cellular contents, and some biochemical constituents of wheat subjected to heat stress.\u0000\u0000\u0000\u0000An applied experiment was conducted over two seasons at the Agricultural Experimental Station of Desert Research Center (DRC), which was supervised by the El Wadi El Gadeed Governorate in Egypt. The grains of wheat cultivars Sids1 (tolerant) and Gimmeza7 (sensitive) were treated with copper metal as NPs (Cu NPs) (0.25, 0.50, 0.75, 1.0, and 10ppm) and magnetite NPs (0.25, 0.50, 0.75, 1.0 and 10ppm) coated with salicylic acid at 100ppm (Fe NPs+SA).\u0000\u0000\u0000\u0000The objective of this study was to examine wheat tolerance to heat stress and subsequently yield by comparing two wheat cultivars under the same conditions.\u0000\u0000\u0000\u0000The chemically formulated nanoparticles were well characterized and applied in two wheat cultivars subjected to heat stress.\u0000\u0000\u0000\u0000The results showed that all NPs treatments had a positive impact on all physiological parameters and grain yield. Sids1 surpassed Gemmeiza7 in the quality of wheat grains (essential, non-essential amino acids). However, Gimmeza7 exceeded Sids1 in yield quantity, especially with the application of SA+Fe NPs at 0.50 ppm. These effects were associated with heat tolerance and the best survival in wheat cultivars. There was an increase in glutathione content, antioxidant enzymes (Glutathione -S- Transferase), and/or a decline in malondialdehyde content.\u0000\u0000\u0000\u0000Conclusion: Fe NPs+SA (0.5ppm) helped the Gimmeza7 cultivar to mitigate the effects of heat stress through activating growth, glutathione, and glutathione S transferase, enhancing yield quantity in two wheat cultivars (Misr1 and Gimmeza11), and decreasing their MDA content.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41795201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Countries' And Brazil's Contributions To Nanotechnology 中部国家和巴西对纳米技术的贡献

Current Nanomaterials Pub Date : 2023-05-25 DOI: 10.2174/2405461508666230525124138

F. G. de Souza, Jonas Farias Santos, Leydi del R. Silva-Calpa, Krishnendu Pal

{"title":"Central Countries' And Brazil's Contributions To Nanotechnology","authors":"F. G. de Souza, Jonas Farias Santos, Leydi del R. Silva-Calpa, Krishnendu Pal","doi":"10.2174/2405461508666230525124138","DOIUrl":"https://doi.org/10.2174/2405461508666230525124138","url":null,"abstract":"\u0000\u0000Nanotechnology is a cornerstone of the scientific advances witnessed over the past few years. Nanotechnology applications are extensively broad, and an overview of the main trends worldwide can give an insight into the most researched areas and gaps to be covered.\u0000\u0000\u0000\u0000This document presents an overview of the trend topics of the three leading countries studying in this area, as well as Brazil for comparison.\u0000\u0000\u0000\u0000The data mining was made from the Scopus database and analyzed using the VOSviewer and Voyant Tools software.\u0000\u0000\u0000\u0000More than 44.000 indexed articles published from 2010 to 2020 revealed that the countries responsible for the highest number of published articles are The United States, China, and India, while Brazil is in the fifteenth position. Thematic global networks revealed that the standing-out research topics are health science, energy, wastewater treatment, and electronics. In a temporal observation, the primary topics of research are: India (2020), which was devoted to facing SARS-COV 2; Brazil (2019), which is developing promising strategies to combat cancer; China (2018), whit research on nanomedicine and triboelectric nanogenerators; the United States (2017) and the Global tendencies (2018) are also related to the development of triboelectric nanogenerators. The collected data are available on GitHub.\u0000\u0000\u0000\u0000This study demonstrates the innovative use of data-mining technologies to gain a comprehensive understanding of nanotechnology's contributions and trends and highlights the diverse priorities of nations in this cutting-edge field.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42778590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Antimicrobial Activity of Cu/CuxO Composites Synthesized byThermal Oxidation of Copper Tablets 铜片热氧化法制备Cu/CuxO复合材料的抗菌活性

Current Nanomaterials Pub Date : 2023-05-16 DOI: 10.2174/2405461508666230502161945

K. Kayed, G. Mansour, Esaaf Alsoki

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Preparation of Nano-Metal-Oxide Incorporated Biochar for Remediation of Water Pollution 纳米金属氧化物生物炭的制备及其对水污染的修复作用

Current Nanomaterials Pub Date : 2023-05-12 DOI: 10.2174/2405461508666230512160837

Özgür Arar

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