{"title":"The Influence of Orally Given Lead Acetate on the Expression of TNF-a and IL-6 of Fallopian Tube Epithet Cell of the Wistar Female Rat (Darrus Norvegicus)","authors":"Fany, Yanuarti","doi":"10.46828/ijrisat.v3i3.69","DOIUrl":"https://doi.org/10.46828/ijrisat.v3i3.69","url":null,"abstract":"Objective: This research aims at proving the influence o1 orally give lead acetate on TNF-a and IL-6 a] fallopian tube epithel cell of The Wistar Female Rat (Tal/us Norvegicus). Method: Using rrue experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age a] 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting a] 1 control grup and 3 d groups with lead dosage a] 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight a] the rat were weighed, and expression of TNF-a and IL-6 with immunohistochemistry. Result: There were significant decrease o] body weight difference of the treated groups compared with the control group, signi1icant increase a] TNF-a expression on the dosage o] 30 ppm and 100 ppm and statistically insignificant increase o] IL-6 with dosage o] 300 ppm. Conclusion: The lead given orally can increase the expression of TNF-a and IL-6 a] the 1aIIopian tube epithel.","PeriodicalId":108832,"journal":{"name":"Jurnal Dharma Praja","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127987051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}