The Influence of Orally Given Lead Acetate on the Expression of TNF-a and IL-6 of Fallopian Tube Epithet Cell of the Wistar Female Rat (Darrus Norvegicus)

Abstract

Objective: This research aims at proving the influence o1 orally give lead acetate on TNF-a and IL-6 a] fallopian tube epithel cell of The Wistar Female Rat (Tal/us Norvegicus). Method: Using rrue experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age a] 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting a] 1 control grup and 3 d groups with lead dosage a] 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight a] the rat were weighed, and expression of TNF-a and IL-6 with immunohistochemistry. Result: There were significant decrease o] body weight difference of the treated groups compared with the control group, signi1icant increase a] TNF-a expression on the dosage o] 30 ppm and 100 ppm and statistically insignificant increase o] IL-6 with dosage o] 300 ppm. Conclusion: The lead given orally can increase the expression of TNF-a and IL-6 a] the 1aIIopian tube epithel.