{"title":"口服醋酸铅对Wistar雌性大鼠输卵管上皮细胞TNF-a和IL-6表达的影响","authors":"Fany, Yanuarti","doi":"10.46828/ijrisat.v3i3.69","DOIUrl":null,"url":null,"abstract":"Objective: This research aims at proving the influence o1 orally give lead acetate on TNF-a and IL-6 a] fallopian tube epithel cell of The Wistar Female Rat (Tal/us Norvegicus). Method: Using rrue experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age a] 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting a] 1 control grup and 3 d groups with lead dosage a] 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight a] the rat were weighed, and expression of TNF-a and IL-6 with immunohistochemistry. Result: There were significant decrease o] body weight difference of the treated groups compared with the control group, signi1icant increase a] TNF-a expression on the dosage o] 30 ppm and 100 ppm and statistically insignificant increase o] IL-6 with dosage o] 300 ppm. Conclusion: The lead given orally can increase the expression of TNF-a and IL-6 a] the 1aIIopian tube epithel.","PeriodicalId":108832,"journal":{"name":"Jurnal Dharma Praja","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Influence of Orally Given Lead Acetate on the Expression of TNF-a and IL-6 of Fallopian Tube Epithet Cell of the Wistar Female Rat (Darrus Norvegicus)\",\"authors\":\"Fany, Yanuarti\",\"doi\":\"10.46828/ijrisat.v3i3.69\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: This research aims at proving the influence o1 orally give lead acetate on TNF-a and IL-6 a] fallopian tube epithel cell of The Wistar Female Rat (Tal/us Norvegicus). Method: Using rrue experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age a] 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting a] 1 control grup and 3 d groups with lead dosage a] 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight a] the rat were weighed, and expression of TNF-a and IL-6 with immunohistochemistry. Result: There were significant decrease o] body weight difference of the treated groups compared with the control group, signi1icant increase a] TNF-a expression on the dosage o] 30 ppm and 100 ppm and statistically insignificant increase o] IL-6 with dosage o] 300 ppm. Conclusion: The lead given orally can increase the expression of TNF-a and IL-6 a] the 1aIIopian tube epithel.\",\"PeriodicalId\":108832,\"journal\":{\"name\":\"Jurnal Dharma Praja\",\"volume\":\"4 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jurnal Dharma Praja\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46828/ijrisat.v3i3.69\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Dharma Praja","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46828/ijrisat.v3i3.69","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Influence of Orally Given Lead Acetate on the Expression of TNF-a and IL-6 of Fallopian Tube Epithet Cell of the Wistar Female Rat (Darrus Norvegicus)
Objective: This research aims at proving the influence o1 orally give lead acetate on TNF-a and IL-6 a] fallopian tube epithel cell of The Wistar Female Rat (Tal/us Norvegicus). Method: Using rrue experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age a] 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting a] 1 control grup and 3 d groups with lead dosage a] 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight a] the rat were weighed, and expression of TNF-a and IL-6 with immunohistochemistry. Result: There were significant decrease o] body weight difference of the treated groups compared with the control group, signi1icant increase a] TNF-a expression on the dosage o] 30 ppm and 100 ppm and statistically insignificant increase o] IL-6 with dosage o] 300 ppm. Conclusion: The lead given orally can increase the expression of TNF-a and IL-6 a] the 1aIIopian tube epithel.
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