Anaesthesia, Pain & Intensive Care最新文献

{"title":"Borescope assisted intubation through Fekry intubating airway; a prospective observational study","authors":"Omnia Y. Kamel, M. Youssef, Ashraf Rady Ahmed Asswa, S. Kassem, Reham Abdelhalim, Inas Farouk Abdul-aal Ali","doi":"10.35975/apic.v26i6.2050","DOIUrl":"https://doi.org/10.35975/apic.v26i6.2050","url":null,"abstract":"Objectives: Airway management starts from the use of a nasal prong for oxygenation to successful endotracheal intubation for the ventilation. Intubation has been one of the most studied subject in anesthesiology. Various methods and gadgets have been advocated for its success. We aimed to evaluate the rate of successful intubations using the ordinary borescope and a stylet through Fekry Oral Intubating Airway (FOIA) in a manikin. \u0000Methodology: This manikin-based study enrolled 35 trainees, who performed endotracheal intubation guided by the borescope and used FOIA as a conduit. Every trainee was allowed two attempts. The primary outcome was to assess the success rate of intubation. Secondary outcomes included the precise time to intubate, number of attempts, and the need for external manipulations. \u0000Results: Our results revealed that 62.9% of the participants performed the intubation successfully (success rate) and 51.43% succeeded to intubate the manikin in the first attempt. External manipulation was needed by 71.4% of the participants in the form of cricoid pressure or laryngeal movement to visualize the glottic view. The time needed for a successful intubation ranged from 16 to 120 sec with a median of 50 sec and a mean of 69.37 ± 42.26 sec. \u0000Conclusion: A combination of Fekry Oral Intubating Airway, a borescope and an intubating stylet can be used for  endotracheal intubation in remote areas, where advanced airway management aids are not available.. Future studies are warranted to optimize this technique. \u0000Trial registration: The ethical approval was obtained from the Research Ethics Committee of Cairo University (Code: MD-79-2019), and registration of the trial was performed on www.clinicaltrials.gov with a registration number (NCT05094453). \u0000Key words: Visually assisted intubation, Borescope, Fekry Oral Intubating Airway. \u0000Citation: Youssef MMI, Kamel OY, Asswa AR, Kassem SM, Abdelhalim RA, Inas Farouk I. Borescope assisted intubation through Fekry intubating airway; a prospective observational study. Anaesth. pain intensive care 2022;26(6):799−802. \u0000DOI: 10.35975/apic.v26i6.2050","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain & Intensive Care","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123845508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-technical factors for recurrence of sacroiliac joint pain after intra-articular steroid injection: a cohort study","authors":"Y. Siahaan, A. Pangestu, V. Sungono","doi":"10.35975/apic.v26i6.2049","DOIUrl":"https://doi.org/10.35975/apic.v26i6.2049","url":null,"abstract":"Background & Objective: The effectiveness of intra-articular corticosteroid injection therapy is still debatable, despite numerous studies which demonstrated the benefits of steroid injections. Injection failure can be caused by a variety of technical factors, some of which have been identified in studies, including the accuracy with the injection location is performed and the pattern of corticosteroid distribution. We investigated the non-technical factors that influence the effectiveness of intra-articular corticosteroid injection at the sacroiliac joint (SIJ) in the past. \u0000Methodology: It was a prospective cohort study to determine non-technical factors associated with recurrence in patients with SIJ pain who had received multidisciplinary treatment for their ailment. A total of 55 patients met the inclusion and exclusion criteria for the study who were followed up. Patients who had SIJ injections before 9 months and, who had no improvement on the pain scale, or there was a worsening of the pain, or the patient returned with SIJ pain complaints on the same side, were included in the trial. The results were analyzed using logistic regression to determine the likelihood of recurrence. \u0000Results: A total of 55 participants was enrolled in the study, with a higher proportion of females (n = 33; 60 %) than males (n = 22; 40 %). Thirty-one patients were returning patients (56.36 %) out of 55 patients. According to the results of the bivariate analysis, age was associated with recurrent SIJ pain. According to the results of the T-test, the mean age of the recurrent patients was 49.32 ± 16.68 y, whereas the mean age of the non-recurrent patients was 56.7 ± 12.76 y. The results of the multivariate analysis revealed that age, NSAID consumption, and unilateral SIJ pain, all had protective values in the context of recurrence of the sacroiliac joint pain. \u0000Conclusions: The use of non-steroidal anti-inflammatory drugs (NSAIDs) and the involvement of a single SI joint are protective factors against the recurrence of SI joint pain. \u0000Abbreviations: COST: European Cooperation in Science and Technology; NSAIDs: Non-steroidal anti-inflammatory drugs; SIJ: Sacroiliac joint; \u0000Key words: Anti-inflammatory agent; Non-technical risk factors; Intra-articular; Age; Recurrent sacroiliac joint pain \u0000Citation: Siahaan YMT, Pangestu AR. Sungono V. Non-technical factors for recurrence of sacroiliac joint pain after intra-articular steroid injection: a cohort study. Anaesth. pain intensive care 2022;26(5):773-777.                           \u0000DOI: 10.35975/apic.v26i6.2049","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain & Intensive Care","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133596028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotection role of cooling helmet on neuron specific enolase (NSE) and post-surgery delirium levels in open heart surgery patients: a randomized controlled trial","authors":"Mohamad Prakoso Adji, J. Hidayat, Aldy Heriwardito","doi":"10.35975/apic.v26i5.1985","DOIUrl":"https://doi.org/10.35975/apic.v26i5.1985","url":null,"abstract":"Background & objective: This study aims to assess the effect of cooling helmet during surgery on neuron specific enolase (NSE) and delirium levels following open heart surgery patients with cardiopulmonary bypass (CPB) using a heart-lung machine. \u0000Methodology: This double-blind randomized clinical trial took place from October to December 2021 in a tertiary care hospital. The research used a modified cooling helmet to decrease brain temperature. Inclusion criteria were adult patients who were scheduled for open heart surgery with CPB. The subjects were randomized into two groups: patients with the cooling helmet on as the treatment group (n = 12) and the patients with the non-cooling helmet on as the control group (n = 13). The differences between NSE and delirium levels in both groups were assessed at specific times. \u0000Results: NSE levels in the treatment group were lower than the control group (7.13 ± 7.63 vs. 12.49 ± 6.81; P < 0.05). Regarding the delirium, no statistically significant difference was found in both groups (P > 0.05). \u0000Conclusion: The hypothermia effect of the cooling helmet is associated with a decrease of neuron specific enolase levels, but it did not significantly correlate to prevent the delirium after open heart surgery patients with the cardiopulmonary bypass machine. \u0000Abbreviations: CABG: coronary artery bypass graft; CPB: Cardiopulmonary Bypass; CMRO2: cerebral metabolic rate of oxygen; HLM: Heart-lung machine; NSE: Neuron Specific Enolase; ROS: reactive oxygen species \u0000Citation: Adji MP, Hidayat JK, Heriwardito A. Neuroprotection role of cooling helmet on neuron specific enolase (NSE) and post-surgery delirium levels in open heart surgery patients: a randomized controlled trial. Anaesth. pain intensive care 2022;26(5):588-594; DOI: 10.35975/apic.v26i5.1985","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116629592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral erector spinae plane block vs quadratus lumborum block for pediatric postoperative pain management after laparoscopic abdominal surgery: a double blinded randomized study","authors":"Hani I. Taman, H. I. Saber, A. Farid, M. M. Elawady","doi":"10.35975/apic.v26i5.2017","DOIUrl":"https://doi.org/10.35975/apic.v26i5.2017","url":null,"abstract":"Background: Postoperative pain management in children can be effectively controlled using regional analgesic techniques. In general, neuraxial blocks pose a higher risk of adverse effects and complications in comparison to peripheral nerve blocks. Recently, both quadratus lumborum block (QLB) and erector spinae plan block (ESPB) have been used to achieve adequate postoperative analgesia in children. We compared the efficacy of both in postoperative pain management after laparoscopic abdominal surgery. \u0000Methodology: Eight five patients with laparoscopic abdominal surgery received either bilateral QLB or ESPB at the level of T8 transverse process with 0.5 ml/kg of 0.25% bupivacaine to achieve adequate postoperative analgesia. FLACC score was used to assess pain score after surgery and the need for rescue opioid analgesia. \u0000Results: The average dose of fentanyl was lower and the time to the first dose of rescue analgesic was longer in QLB group when compared to ESPB group. In addition, FLACC scores were significantly lower in QLB group in comparison to ESPB group at the 6th, 8th, 12th and 20th h after surgery. \u0000Conclusion: Quadratus lumborum block can provide longer and more effective postoperative analgesia in pediatric patients following laparoscopic abdominal surgery in comparison to erector spinae plan block. \u0000Citation: Taman HI, Saber HIES, Farid AM, Elawady MM. Bilateral erector spinae plane block vs quadratus lumborum block for pediatric postoperative pain management after laparoscopic abdominal surgery: a double blinded randomized study. Anaesth. pain intensive care 2022;26(5):602-607; DOI: 10.35975/apic.v26i5.2017 \u0000 ","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129817666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung ultrasound as an evolving tool in the detection of extravascular lung water following goal-directed fluid therapy in septic cancer patients","authors":"W. Md, M. Md, E. Md, M. Md, E. Md","doi":"10.35975/apic.v26i5.1987","DOIUrl":"https://doi.org/10.35975/apic.v26i5.1987","url":null,"abstract":"Background: Severe sepsis can result in septic shock with a high mortality rate. This study aimed to assess the correlation between B-lines detected by lung ultrasound (LUS) and thoracic fluid content (TFC) and to compare their sensitivity and specificity to predict lung congestion on conventional chest radiograph following early goal-directed fluid therapy in septic cancer patients. \u0000Methods: This study included 30 patients suffering from sepsis admitted to the intensive care unit. They received resuscitation according to the surviving sepsis campaign 2018 guidelines. Lung ultrasonography, TFC, central venous pressure (CVP), and inferior vena cava (IVC) scanning were done upon admission then after 3, 6, and 12 h. Chest X-ray was done after 6 h then at the study end (12 h) and CT chest at 12 h. \u0000Results: B-lines showed a moderate-to-strong positive correlation with TFC, a moderate and positive correlation with CVP, and a negative and weak-to-moderate correlation with IVC collapsibility index. The performance of LUS was good at 6 h (AUC = 0.872, 95% CI = 0.700 to 0.965, P < 0.001), and the optimal cut-off value was 7 with a sensitivity and specificity of 75% and 95.5%, respectively. The sensitivity and specificity increased to reach 100% at 12 h using a cut-off value of 9. Meanwhile TFC had lower AUCs compared to B-lines at the two-time points though the difference was statistically non-significant. \u0000Conclusion: Lung ultrasound can be considered a useful non-invasive bedside tool for early detection of extravascular lung water during the early resuscitation phase of goal-directed fluid therapy in sepsis patients. \u0000Abbreviations: LUS: Lung ultrasound; EVLW: Extravascular Lung Water; TFC: Thoracic fluid content; CVP: Central venous pressure; IVC: Inferior vena cava; AUC: Area under the curve; PAOP: Pulmonary artery occlusion pressure; IVC-CI: Inferior vena cava collapsibility index \u0000Citation: Elsabeeny WY, Ibrahim MA, El Desouky ED, Hamed M, Shaker EH. Lung ultrasound as an evolving tool in the detection of extravascular lung water following goal-directed fluid therapy in septic cancer patients. Anaesth. pain intensive care 2022;26(5):623-632; DOI: 10.35975/apic.v26i5.1987","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"120 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120875706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrathecal bupivacaine-fentanyl and bupivacaine-dexmedetomidine for cesarean section: a randomized controlled trial","authors":"Sana Urooj, A. Mughal, Madiha Shareef, A. Naz, M. Shah, S. Siddiqui","doi":"10.35975/apic.v26i5.2019","DOIUrl":"https://doi.org/10.35975/apic.v26i5.2019","url":null,"abstract":"Background & objectives: Spinal anesthesia is the preferred technique for obstetric patients as it is economical, simple to perform, has a rapid onset and provides complete muscle relaxation. A variety of adjuvants have been used to enhance or prolong its effects. We compared the effects of dexmedetomidine and fentanyl on the onset and recovery times of sensory and motor blockade as well as on hemodynamics, postoperative complications and duration of postoperative analgesia in parturients undergoing lower segment cesarean section (LSCS). Methodology: It was a prospective, double blind, randomized controlled trial. Sixty healthy parturients having cesarean delivery under spinal anesthesia were randomly divided into two equal groups. Group BD was given 10 mg bupivacaine plus 5 µg of dexmedetomidine and Group BF was given 10 mg bupivacaine plus 10 µg of fentanyl. Parturients was then observed for the onset and recovery times of sensorimotor blockade, hemodynamics, postoperative complications and postoperative analgesia. \u0000Results: There was no statistically significant difference in the onset of sensorimotor block between the groups. The time to complete sensory and motor recovery was significantly prolonged in Group BD (P = 0.01 and P = 0.0001 respectively) as compared to Group BF. Both groups did not show significant differences in hemodynamic changes, but there was a reduction in systolic and diastolic blood pressures ≥ 20% from baseline intraoperative. The VAS at 3 and 4 h postoperatively in the Group BD was significantly lower (P = 0.02 and P = 0.01 respectively). The incidence of complications was found comparable in two groups, except incidence of hypotension and nausea was more in the Group BD compared to Group BF (P = 0.006 and 0.002 respectively). \u0000Conclusion: Although intrathecal dexmedetomidine prolongs the duration of sensory block, with comparable hemodynamic changes and good postoperative analgesia, prolonged motor block due to it, compared to intrathecal fentanyl, is not a desirable outcome particularly in short duration surgeries like LSCS, which can increase discharge time from post anesthesia care unit (PACU) to the ward. \u0000Abbreviations: LSCS: lower segment cesarean section; PACU: post anesthesia care unit; \u0000Citation: Urooj S, Mughal A, Shareef M, Naz A, Shah MU, Siddiqui SZ. Intrathecal bupivacaine-fentanyl vs. bupivacaine-dexmedetomidine for cesarean section: a randomized controlled trial. Anaesth. pain intensive care 2022;26(5):616-622; DOI: 10.35975/apic.v26i5.2019 \u0000 ","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125574588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paravalvular vegetations in prosthetic valve endocarditis with a malignant course: a case report","authors":"A. Lefi, D. Suwanto, Evelyne Chandra, Tony Santoso Putra, Eka Prasetya Budi Mulia","doi":"10.35975/apic.v26i5.2012","DOIUrl":"https://doi.org/10.35975/apic.v26i5.2012","url":null,"abstract":"Prosthetic valve endocarditis (PVE) accounts for 20.1% of all infective endocarditis cases. We report a case of PVE complicated by arrhythmias, embolic phenomenon, and sepsis. A 64-year-old female with history of mitral valve replacement presented to the hospital with febrile episode and malaise. Echocardiography showed vegetation at paravalvular area, and Staphylococcus aureus was found on blood culture. Aggressive intravenous antibiotic cover and hemodynamic support were initiated. The management of PVE remains a challenge due to its malignant course and heterogenous complications. \u0000Citation: Suwanto D, Lefi A, Chandra E, Putra TS, Mulia EPB. Paravalvular vegetations in prosthetic valve endocarditis with a malignant course: a case report. Anaesth. pain intensive care 2022;26(5):723-726. \u0000DOI: 10.35975/apic.v26i5.2012","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115605448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse clinical impact and outcome of inflammation and oxidative stress: Are the antioxidant properties of vitamin C helpful?","authors":"E. Herbert, D. Fournier","doi":"10.35975/apic.v26i5.1993","DOIUrl":"https://doi.org/10.35975/apic.v26i5.1993","url":null,"abstract":"Inflammation and the oxidative stress are two main notorious driving forces behind the disease progression, deterioration and eventually the death of the individuals concerned. When these two aggravating factors have been effectively addressed, then the disorders affecting people can be under control and relief for the treating clinician. The patients can experience an improvement in health-related quality of life, or better total remission. This review evaluates the relation between oxidative stress in critically ill patients, vitamin C intake as an antioxidant and severity of illness. It also highlights the implications of these two processes in major disease areas, such as cancer, intensive care, sepsis, cardiology, rheumatology, and the damaging outcomes of the imbalance between the production of ROS and antioxidants. \u0000Citation: Herbert E, Fournier D. Adverse clinical impact and outcome of inflammation and oxidative stress: Are the antioxidant properties of vitamin C helpful? Anaesth. pain intensive care 2022;26(4):710-719. \u0000DOI: 10.35975/apic.v26i5.1993","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125532384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized study of an evaluation of Trigona honey as immunonutrition among ventilated pneumonia patients in intensive care unit","authors":"S. C. Omar, R. H. M. Zaini, Isma Syarina Binti Ismail, W. W. Wan Hassan, Praveena Seevaunnamtum, C. M. Che Hussin","doi":"10.35975/apic.v26i5.1990","DOIUrl":"https://doi.org/10.35975/apic.v26i5.1990","url":null,"abstract":"Background & Objective: Honey is one of the traditional drugs and has been widely used as a nutrient supplement for centuries. It is known to have antimicrobial, antioxidant and radical scavenging properties. We aimed to prove that natural honey can be added as a supplementary nutrient for its immunoprotective effects to the ventilated pneumonia patients in intensive care unit (ICU). \u0000Methodology: A total of 40 ventilated pneumonia patients were randomized to receive enteral feeding with honey (n = 20) or without honey (n = 20). A bolus of 20 g of honey was given every day for 5 days together with normal enteral nutrition. The baseline vital signs, ventilator settings, blood samples for C-reactive protein (CRP), white blood cell (WBC), interleukin-6 (IL-6), interleukin-10 (IL-10), immunoglobulin A (IgA) and blood sugar level were taken on the day of recruitment (Day 0) and subsequently on Day 3 and Day 6. \u0000Results: There were significant changes in IL-6 level over time in honey group with mean decrease of IL-6 from 265.1 pg/ml on Day 0 to 101.8 pg/ml on Day 6 (P < 0.001). There was no significant effect on CRP (P = 0.22), IL-10 (P = 0.548), IgA (P = 0.197), WBC count (P = 0.640) and blood sugar level between both groups (P > 0.05). Duration of antibiotic use between the two groups showed no statistically significant difference with P = 0.075 and length of ICU stay. \u0000Conclusion: Trigona honey showed the beneficial effect of immunonutrition to ventilated pneumonia patients in ICU by significantly decreasing the level of IL-6. \u0000Abbreviations: CAP: community acquired pneumonia; CRP: C-reactive protein; DHA: docosahexaenoic acid; HAC: hospital acquired pneumonia; ICU: intensive care unit; IL-6: interleukin-6; Ig-A: immunoglobulin A; NGT: Nasogastric tube; RBS: random blood sugar; VAP: ventilator associated pneumonia \u0000Citation: Zaini RHM, Omar SC, Binti Ismail IS, Wan Hassan WMN, Seevaunnamtum P, Che Hussin CM. A randomized study of an evaluation of Trigona honey as immunonutrition among ventilated pneumonia patients in intensive care unit. Anaesth. pain intensive care 2022;26(5):649-655; DOI: 10.35975/apic.v26i5.1990 \u0000 ","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125599175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of total lymphocytes, neutrophils to lymphocytes ratio, and C-reactive protein in vaccinated and non-vaccinated severe COVID-19 patients","authors":"Komang Ardiana Pramana, R. W. Sudjud, Ardi Zulfariansyah","doi":"10.35975/apic.v26i5.2018","DOIUrl":"https://doi.org/10.35975/apic.v26i5.2018","url":null,"abstract":"Background & objective: SARS-CoV-2 virus caused acute respiratory illness called COVID-19 with rising case mortality rates. One of the preventive measures to arrest the spread of a contagious disease is the use of vaccines. We assessed the effectiveness of the inactivated vaccine (Coronavac) through three inflammatory parameters e.g., total lymphocyte count, neutrophil-lymphocyte ratio, and C-reactive protein (CRP), in severe COVID-19 patients. \u0000Methodology: This study was an observational study with a retrospective cross-sectional design. The study was conducted in the Intensive Care Unit (ICU) of Hasan Sadikin Hospital Bandung, from January 2021 to December 2021. The data of total lymphocyte count, neutrophil-lymphocyte ratio, and C-reactive protein, was collected retrospectively from the medical record documents of 54 patients of COVID-19. The assessment was performed on severe COVID-19 subjects on the 7th day of illness. Data normality test was done using the Shapiro Wilk test. Study data were not normally distributed, and statistical analyses were performed using the Mann-Whitney test for numerical data and the Chi-Square test for categorical data. \u0000Results: There were significant differences in inflammation parameters, e.g., total lymphocyte count, neutrophil-lymphocyte ratio, and CRP, between the two groups (P < 0.0001) and the subject outcome between two groups (P < 0.0001). Total lymphocyte count in severe vaccinated COVID-19 patients was higher than in non-vaccinated patients, while neutrophil-lymphocyte ratio and CRP were lower in vaccinated subjects. Mortality was also lower in the vaccinated patients compared to unvaccinated patients. \u0000Conclusion: The inactivated vaccine (Coronavac) effectively reduces the mortality rate of severe COVID-19 patients based on inflammatory parameters including total lymphocyte count, neutrophil-lymphocyte ratio, and C-reactive protein. \u0000Abbreviations: ACE: Angiotensin Converting Enzyme; ARB: Angiotensin Receptor Blocker; ARDS: Acute Respiratory Distress Syndrome; BMI: Body Mass Index; CFR: Case Fatality Rate; COVID-19: Coronaviruses Disease 2019; CRP: C-Reactive Protein; IL: Interleukin; NLR: Neutrophil Lymphocyte Ratio; SPSS: Statistical Product Service Solution; TLC: Total Lymphocyte Count; TNF: Tumor Necrosis Factor; VEGF: Vascular Endothelial Growth Factor \u0000Citation: Sudjud RW, Zulfariansyah A, Ardiana K. Comparison of total lymphocytes, neutrophils to lymphocytes ratio, and C-reactive protein in vaccinated and unvaccinated severe COVID-19 patients. Anaesth. pain intensive care 2022;26(5):656-662; DOI: 10.35975/apic.v26i5.2018","PeriodicalId":108815,"journal":{"name":"Anaesthesia, Pain &amp; Intensive Care","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128050990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}